Centre for Rapid Online Analysis of Reactions (ROAR), Phase II

Lead Research Organisation: Imperial College London
Department Name: Dept of Chemistry

Abstract

The Centre for Rapid Online Analysis of Reactions (ROAR) at Imperial College London was established in 2018, with the award of a strategic equipment grant, and offers three main capabilities: High-throughput automated reaction platforms (robots) for screening reactions in parallel; in situ analytics for studying reaction progress (kinetics); and continuous flow reactors. The primary objective of ROAR is to provide access to capital equipment to support data-led research, including statistical approaches and data analysis associated with kinetic and high-throughput experimentation.

During the first phase of its operation, ROAR has successfully established itself as a UK Flagship facility for the EPSRC Dial-a-Molecule Grand Challenge, and recognised by Imperial College as a Centre of Excellence. During this period ROAR has provided support to both Imperial College research groups and external users via open calls for proposals, fostering the growth of a user community that brings together over 85 groups from across the UK, including SME's, as well as global companies looking for the unique technological capabilities.

In Phase II of the project, we wish to expand our activities to provide more training material for centres for doctoral training, and to support a new academic strategy at Imperial (DigiFAB Institute). The Resources Only award will allow us to expand our Operations Team, needed to implement workflows to improve sharing and accessibility of our equipment, by operating an equipment loan pool, and remote experiments. Over this period, we will also be assessing the user demand and feedback, to identify sustainable pathways forward.

Publications

10 25 50
 
Description BASF Studentships 2021-2025 Intake
Amount £334,612 (GBP)
Organisation BASF 
Sector Private
Country Germany
Start 09/2021 
End 09/2025
 
Description High-throughput approach for improving RNA nanoparticles as drug delivery agents
Amount £125,763 (GBP)
Funding ID 75525 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 02/2021 
End 01/2023
 
Description Industrial React CDT Studentship Contribution
Amount £37,400 (GBP)
Organisation AstraZeneca 
Sector Private
Country United Kingdom
Start 09/2021 
End 09/2025
 
Description Industrial React CDT Studentship Contribution
Amount £51,562 (GBP)
Organisation Johnson & Johnson 
Sector Private
Country United States
Start 09/2021 
End 09/2025
 
Description Industrial React CDT Studentship Contribution (2021-2025)
Amount £50,251 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 09/2021 
End 09/2025
 
Description Invited lecture by B Deadman at The Applied Catalysis Group (ACG) & UK Catalysis Hub Meeting 2021 (17 Mar 2021) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Dr Ben Deadman (ROAR Facility Manager) was invited to present the work of the ROAR facility at The Applied Catalysis Group (ACG) & UK Catalysis Hub Meeting 2021 (17 Mar 2021). This online meeting, themed around Applied Characterisation of Catalysts, was attended by members of the Applied Catalysis Group (ACG) and UK Catalysis Hubs.
Year(s) Of Engagement Activity 2021
URL https://ukcatalysishub.co.uk/the-applied-catalysis-group-acg-uk-catalysis-hub-meeting-2021/
 
Description Invited lecture by B Deadman at UKQSAR Autumn 2020 Meeting (15 Oct 2020) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Ben Deadman (ROAR Facility Manager) was invited to present the work of the ROAR facility at the UKQSAR Autumn 2020 meeting. This online meeting was attended by members of the UK Quantitative Structure-Activity Relationship (QSAR) and Cheminformatics Group, and the Medicines Discovery Catapults.
Year(s) Of Engagement Activity 2021
URL https://ukqsar.org/index.php/2020/12/09/ukqsar-autumn-2020-meeting-15th-october-2020-virtual-meeting...
 
Description Invited lecture by B Deadman at the RSC Process Chemistry and Technology Group Meeting - How can Process Chemistry and Technology Enable Sustainability? (18-19 Nov 2021) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Ben Deadman (ROAR Facility Manager) was invited to present the work of the ROAR facility at the RSC Process Chemistry and Technology Group 2021 Meeting (18-19 Nov 2021). This online meeting, titled "How can Process Chemistry and Technology Enable Sustainability?" brought together the process chemistry community to discuss the importance of sustainability in the chemical industries.
Year(s) Of Engagement Activity 2021
URL https://www.rsc.org/events/detail/48088/how-can-process-chemistry-and-technology-enable-sustainabili...
 
Description Invited lecture by Prof. Mimi Hii at the 6th Swiss Chemical Society Syngenta Symposium: Chemistry lab of the future 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Invited Lecture, Swiss Chemical Society-Syngenta 2021 Symposium: "Chemistry lab of the future", November 26, 2021, virtual. The event was attended by PG students, as well as researchers from academia and industry, but the virtual event was also attended by participants from other European countries, particularly UK (where Syngenta also has a R&D site). The talk specifically addressed the challenges in training the next generation of scientist and engineers in new chemical technology, with exemplars drawn from our work with the ROAR facility.
Year(s) Of Engagement Activity 2021
URL https://syngenta21.scg.ch/
 
Description Public engagement activity at the Great Exhibition Road Festival (9-10 October 2021) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Dr Ben Deadman (ROAR Facility Manager) teamed up with the EPSRC Centre for Doctoral Training in Next Generation Synthesis & Reaction Technology to run a public engagement activity at the Great Exhibition Road Festival (9-10 October 2021 in the Science Museum). The activity was targeted at children and families, and involved two activities which highlighted the importance of synthetic chemistry in making everyday products. In the first acitvity the visitors got to smell several fragrance chemicals and attempt to guess what they smelled like, and whether they were synthetic or natural fragrances. In the second activity the audience was shown chemical structures of several household chemicals and challenged to separate them into synthetic and naturally sourced chemicals. Over 1,000 children and parents were engaged with over the weekend, with many having thoughtful conversations with the CDT students about the importance of synthetic chemistry. Science Museum organisers reported afterwards that the 'guess the fragrance' activity was the most talked about of all the activities at the wider event.
Year(s) Of Engagement Activity 2021
URL https://www.greatexhibitionroadfestival.co.uk/
 
Description The Analytical Wavelength. Episode 4: The Future of Chemistry Education 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A podcast on the future of chemical education, including perspectives on the future of chemistry and how to teach programing.
Year(s) Of Engagement Activity 2021
URL https://www.acdlabs.com/resources/podcasts/the-analytical-wavelength/04-the-future-of-chemistry-educ...