500 MHz NMR Spectrometer to Support Organic, Bio-organic and Inorganic Chemistry
Lead Research Organisation:
University of Bath
Department Name: Chemistry
Abstract
NMR spectroscopy is a key tool in the elucidation of chemical structure. A new NMR spectrometer operating at higher field (500 MHz) than currently available is required by a group of synthetic chemists interested in organic, bio-organic and inorganic chemistry. This spectrometer will facilitate new research areas in the Department of Chemistry at Bath by providing access to NMR facilities with (a) high sensitivity (somewhere in the region of a 40% increase over our current 400 MHz NMR spectrometer will be provided), (b) greater resolution that will allow resonances from more complex molecules to be separated out and (c) new hardware (for example, lower frequency nuclei can be studied, while an inverse detection probe will give higher proton sensitivity, allowing compounds only available in very small amounts to be characterised and and their structures established). Specific areas that will be enabled include the synthesis of chiral molecules, modification of peptides and proteins and the development of new catalysts.
Organisations
Publications
Ampt KA
(2006)
Photochemical isomerization of N-heterocyclic carbene ruthenium hydride complexes: in situ photolysis, parahydrogen, and computational studies.
in Journal of the American Chemical Society
Armstrong R
(2010)
Ring-Expanded N-Heterocyclic Carbene Complexes of Ruthenium
in Organometallics
Batool M
(2012)
Photochemistry of Cp'Mn(CO) 2 (NHC) (Cp' = ? 5 -C 5 H 4 Me) Species: Synthesis, Time-Resolved IR Spectroscopy, and DFT Calculations
in Organometallics
Batool M
(2011)
Comparison of the photochemistry of organometallic N-heterocyclic carbene and phosphine complexes of manganese.
in Chemical communications (Cambridge, England)
Bramananthan N
(2012)
Formation of Cyclometallated N-Heterocyclic Carbene (NHC) Complexes from L n RuCl 2 (L = Cyclooctadiene, PPh 3 , DMSO) Precursors
in European Journal of Inorganic Chemistry
Bramananthan N
(2014)
Rh-FHF and Rh-F Complexes Containing Small N -Alkyl Substituted Six-Membered Ring N-Heterocyclic Carbenes
in Organometallics
Burling S
(2009)
The influence of N-heterocyclic carbenes (NHC) on the reactivity of [Ru(NHC)(4)H](+) with H(2), N(2), CO and O(2).
in Chemistry (Weinheim an der Bergstrasse, Germany)
Burling S
(2006)
Cationic Tris N-Heterocyclic Carbene Rhodium Carbonyl Complexes: Molecular Structures and Solution NMR Studies
in Organometallics
Burling S
(2007)
C-H activation reactions of ruthenium N-heterocyclic carbene complexes: application in a catalytic tandem reaction involving C-C bond formation from alcohols.
in Journal of the American Chemical Society
Chantler VL
(2008)
Stoichiometric and catalytic reactivity of the N-heterocyclic carbene ruthenium hydride complexes [Ru(NHC)(L)(CO)HCl] and [Ru(NHC)(L)(CO)H(eta2-BH4)] (L=NHC, PPh3).
in Dalton transactions (Cambridge, England : 2003)
Chatwin S
(2010)
Reactivity of the N-heterocyclic carbene complexes [Ru(IMes)2(CO)HX] (X=OH, Cl) with alkynes
in Inorganica Chimica Acta
Collins L
(2014)
Use of Ring-Expanded Diamino- and Diamidocarbene Ligands in Copper Catalyzed Azide-Alkyne "Click" Reactions
in Organometallics
Collins LR
(2014)
Copper diamidocarbene complexes: characterization of monomeric to tetrameric species.
in Inorganic chemistry
Crittall MR
(2008)
Abnormal coordination of Arduengo's carbene upon reaction with M(3)(CO)(12) (M = Ru, Os).
in Dalton transactions (Cambridge, England : 2003)
Davies C
(2013)
Synthesis and Small Molecule Reactivity of trans -Dihydride Isomers of Ru(NHC) 2 (PPh 3 ) 2 H 2 (NHC = N-Heterocyclic Carbene)
in Organometallics
Davies CJ
(2010)
Ni(I) and Ni(II) ring-expanded N-heterocyclic carbene complexes: C-H activation, indole elimination and catalytic hydrodehalogenation.
in Chemical communications (Cambridge, England)
Ellul CE
(2007)
Abnormally bound N-heterocyclic carbene complexes of ruthenium: C-H activation of both c4 and c5 positions in the same ligand.
in Angewandte Chemie (International ed. in English)
Guard L
(2011)
[Ru(NHC)(P-P)(CO)HF] (NHC = N-heterocyclic carbene; P-P = xantphos, dppf) complexes: Efforts to prepare new hydrodefluorination catalysts
in Journal of Organometallic Chemistry
Holdroyd R
(2010)
Intramolecular C-H insertion in ring-expanded N-heterocyclic carbenes
in Tetrahedron Letters
Häller LJ
(2010)
Experimental and computational investigation of C-N bond activation in ruthenium N-heterocyclic carbene complexes.
in Journal of the American Chemical Society
Häller LJ
(2009)
Activation of an alkyl C-H bond geminal to an agostic interaction: an unusual mode of base-induced C-H activation.
in Journal of the American Chemical Society
L. Häller L
(2009)
Formation of [Ru(NHC) 4 (? 2 -O 2 )H] + : An Unusual, High Frequency Hydride Chemical Shift and Facile, Reversible Coordination of O 2
in Journal of the American Chemical Society
Description | Range of projects covered by the instrument ranging from inorganic, organic, materials, pharmaceuticals and bilogical chemistry. |
Exploitation Route | Follow on funding as well as citations of the results by other acdemics in the literature. |
Sectors | Chemicals |
Description | Findings from research instrumentation have been used in both academic and industrial environments. Multi-user instrument so PI does not have exact details for each user. |
First Year Of Impact | 2006 |
Sector | Chemicals |
Impact Types | Societal |