Enzyme Responsive Materials for Biology and Medicine
Lead Research Organisation:
University of Manchester
Department Name: Materials
Abstract
This proposal is to develop new routes to rationally designed Enzyme Responsive Materials (ERMs) for biomedical applications. These materials can change properties, for example they can swell/collapse or change from a solution to a gel in response to biochemical reactions. These materials may have applications in the controlled release of drugs in response to disease specific enzymes. They may also be used in triggered assembly of matrixes for cell growth, with applications in tissue engineering. The outcomes of this project will be (i) the development and full characterisation of new interactive biomaterials, (ii) increased fundamental understanding of structure/function relationships in molecular hydrogels, (iii) proof of concept applications in enzyme triggered assembly of scaffolds for 3D cell culture and (iv) enzyme triggered drug delivery.
Organisations
People |
ORCID iD |
| Rein Ulijn (Principal Investigator) |
Publications
Cousins BG
(2009)
Enzyme-activated surfactants for dispersion of carbon nanotubes.
in Small (Weinheim an der Bergstrasse, Germany)
Das AK
(2009)
Evolving nanomaterials using enzyme-driven dynamic peptide libraries (eDPL).
in Faraday discussions
Hirst AR
(2010)
Biocatalytic induction of supramolecular order.
in Nature chemistry
Hughes M
(2011)
Biocatalytic self-assembly of 2D peptide-based nanostructures
in Soft Matter
Javid N
(2011)
Supramolecular Structures of Enzyme Clusters.
in The journal of physical chemistry letters
Laromaine A
(2007)
Protease-triggered dispersion of nanoparticle assemblies.
in Journal of the American Chemical Society
Li Y
(2009)
A study of the dynamic interaction of surfactants with graphite and carbon nanotubes using Fmoc-amino acids as a model system.
in Langmuir : the ACS journal of surfaces and colloids
Thornton K
(2009)
Controlling stiffness in nanostructured hydrogels produced by enzymatic dephosphorylation.
in Biochemical Society transactions
Thornton P
(2007)
Enzyme-Responsive Polymer Hydrogel Particles for Controlled Release
in Advanced Materials
Thornton PD
(2008)
Enzyme-responsive hydrogel particles for the controlled release of proteins: designing peptide actuators to match payload.
in Soft matter
Todd SJ
(2009)
Enzyme-activated RGD ligands on functionalized poly(ethylene glycol) monolayers: surface analysis and cellular response.
in Langmuir : the ACS journal of surfaces and colloids
Williams RJ
(2009)
Enzyme-assisted self-assembly under thermodynamic control.
in Nature nanotechnology
Zhou M
(2009)
Self-assembled peptide-based hydrogels as scaffolds for anchorage-dependent cells.
in Biomaterials