Monolithic integration of optical traps and microfluidic channels
Lead Research Organisation:
University of St Andrews
Department Name: Physics and Astronomy
Abstract
The key motivation for the project is to make the optical trapping toolkit more accessible to the life sciences community. By integrating optical traps directly into microfluidic circuitry, we will add functionality to Lab-on-a-chip type devices, thus taking them a step closer to real applications. We will reach this aim by developing the concept of an integrated optical trap that we have demonstrated recently. The trap will be made more versatile by increasing its power output and by using beamshaping to increase the intensity in the optical trap, thus being able to control a large number of different cell types. An optical chromatography device that offers the fast and simple fractionation of a cell population will be developed, with integrated separation channels that are optically addressed. Realising circuits at other wavelengths, namely 780 nm for Raman spectroscopy and 635 as well as 410 nm for fluorescence excitation, will highlight the potential of the integrated trap concept further.
Organisations
Publications
Scullion M
(2012)
Slotted photonic crystals for biosensing applications
Scullion M
(2011)
Slotted photonic crystals for sensing applications
Di Falco A
(2008)
Slotted Photonic Crystal Waveguides and Cavities
Scullion MG
(2013)
Slotted photonic crystal sensors.
in Sensors (Basel, Switzerland)
Scullion MG
(2014)
Contra-directional coupling into slotted photonic crystals for spectrometric applications.
in Optics letters
Ashok PC
(2011)
Near infrared spectroscopic analysis of single malt Scotch whisky on an optofluidic chip.
in Optics express
Ashok PC
(2010)
Optical chromatography using a photonic crystal fiber with on-chip fluorescence excitation.
in Optics express
Scullion M
(2015)
Enhancement of optical forces using slow light in a photonic crystal waveguide
in Optica
Ploschner M
(2012)
Bidirectional Optical Sorting of Gold Nanoparticles
in Nano Letters
James T
(2011)
Valve controlled fluorescence detection system for remote sensing applications
in Microfluidics and Nanofluidics
Ashok PC
(2011)
Waveguide confined Raman spectroscopy for microfluidic interrogation.
in Lab on a chip
Scullion MG
(2011)
Slotted photonic crystal cavities with integrated microfluidics for biosensing applications.
in Biosensors & bioelectronics
Conteduca D
(2017)
Photonic and Plasmonic Nanotweezing of Nano- and Microscale Particles.
in Applied spectroscopy
Cižmár T
(2011)
Interference-free superposition of nonzero order light modes: Functionalized optical landscapes
in Applied Physics Letters
Conteduca D
(2016)
Design of a high-performance optical tweezer for nanoparticle trapping
in Applied Physics A
Fischer M
(2016)
Optical Sensing of Microbial Life on Surfaces
in Applied and Environmental Microbiology
Conteduca D
(2017)
Ultra-high Q/V hybrid cavity for strong light-matter interaction
in APL Photonics
| Description | The project has laid the foundation for our nanoscale biosensor work that is now being developed further, in collaboration with biologists, medical researchers and clinicians, for tackling societal issues such as chronic wounds and antimicrobial resistance. |
| Exploitation Route | 1. We are now actively collaborating with biomedical researchers and providing them with new tools for addressing important societal questions. 2. We are discussing with industrial collaborators of how to apply the technology to applications in disease and contamination monitoring in veterinary practise, agriculture, food & drink. |
| Sectors | Agriculture, Food and Drink,Environment,Healthcare |
| Description | EPSRC |
| Amount | £376,285 (GBP) |
| Funding ID | EP/G029733/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2009 |
| End | 11/2012 |