PREVENTING VENTILATOR-ASSOCIATED LUNG INJURY USING FEEDBACK CONTROL ENGINEERING
Lead Research Organisation:
University of Nottingham
Department Name: Div of Anaesthesia and Intensive Care
Abstract
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People |
ORCID iD |
| Jonathan Hardman (Principal Investigator) |
Publications
Das A
(2013)
Optimization of mechanical ventilator settings for pulmonary disease states.
in IEEE transactions on bio-medical engineering
Das A
(2011)
A systems engineering approach to validation of a pulmonary physiology simulator for clinical applications.
in Journal of the Royal Society, Interface
Das A
(2017)
Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome.
in BMC pulmonary medicine
Das A
(2015)
Evaluation of lung recruitment maneuvers in acute respiratory distress syndrome using computer simulation.
in Critical care (London, England)
Daudre-Vignier C
(2021)
Identification of an optimal CPR chest compression protocol
Declan Gerard Bates
(2011)
Optimization of Mechanical Ventilator Settings
Haque M
(2019)
Primary blast lung injury simulator: a new computerised model.
in Journal of the Royal Army Medical Corps
Laviola M
(2019)
Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea.
in British journal of anaesthesia
Mistry S
(2022)
Pre-hospital continuous positive airway pressure after blast lung injury and hypovolaemic shock: a modelling study
in British Journal of Anaesthesia
Scott TE
(2019)
Efficacy of continuous positive airway pressure in casualties suffering from primary blast lung injury: A modeling study.
in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Wang W
(2015)
Computational simulation indicates that moderately high-frequency ventilation can allow safe reduction of tidal volumes and airway pressures in ARDS patients.
in Intensive care medicine experimental
| Description | We have demonstrated that lung injury, which occurs during during mechanical ventilation in critically ill patients, is associated with specific patterns of lung inflation and deflation. We have demonstrated optimal methods of maintaining the "open lung" (i.e. preventing collapse of the microscopic air sacs). |
| Exploitation Route | The findings already influence policy and practice in intensive care units. Subsequent work will aim to personalise treatments for individual patients. |
| Sectors | Healthcare |
| Description | Healthcare Impact Partnerships |
| Amount | £866 (GBP) |
| Funding ID | EP/P023444/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2017 |
| End | 05/2020 |
| Description | MRC Cardiovascular Group |
| Amount | £170,000 (GBP) |
| Funding ID | G1002017 |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Cardiovascular Group |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2011 |
| End | 04/2012 |
| Description | MRC Cardiovascular Group |
| Amount | £170,000 (GBP) |
| Funding ID | G1002017 |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Cardiovascular Group |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2011 |
| End | 04/2012 |
| Description | Modelling research group |
| Organisation | University of Exeter |
| Department | Centre for Systems, Dynamics and Control |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My team (Nottingham) provides medical and physiological expertise, along with design of models. |
| Collaborator Contribution | Declan Bates' team (Exeter) provides engineering and computational expertise, particular in validation & verification of models. |
| Impact | Several research manuscripts, employed post-doctoral staff and successful grant applications. |
| Start Year | 2006 |
| Description | Modelling research group |
| Organisation | University of Warwick |
| Department | School of Engineering |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My team (Nottingham) provides medical and physiological expertise, along with design of models. |
| Collaborator Contribution | Declan Bates' team (Exeter) provides engineering and computational expertise, particular in validation & verification of models. |
| Impact | Several research manuscripts, employed post-doctoral staff and successful grant applications. |
| Start Year | 2006 |