Signal Amplification in MR achieved through novel inorganic templates
Lead Research Organisation:
University of York
Department Name: Chemistry
Abstract
Nuclear magnetic resonance (NMR) is arguably one of the most important methods for characterising materials in solution. It relies on the fact that certain nuclei possess the property of magnetism. Consequently when they are placed in a uniform magnetic field a precise amount of energy is required to change their magnetic orientation and this is exploited to inform on their local physical and chemical environment. The most widely recognised use of this phenomenon is found the clinical application of Magnetic Resonance Imaging (MRI) which offers unparalleled non-invasive insights into the state and health of the body. In normal conditions the behaviour of nuclei in a magnetic field creates one of the major drawbacks of both NMR and MRI : poor sensitivity. This lack of sensitivity arises because the distribution of magnetic orientations in a sample is such that the effects of only a very few of the molecules can be observed as a signal. Hyperpolarisation, the subject of this proposal, is a method for altering the magnetic distribution so that the observed signal can be increased by several orders of magnitude. Until recently effective hyperpolarisation could be achieved either by a lengthy and small scale process of transferring magnetisation from electrons to nuclei, or by using a hydrogenation reaction to transfer magnetisation from hyperpolarised nuclei in parahydrogen. Parahydrogen constitutes one quarter of naturally occurring hydrogen at room temperature and is the fuel of the space shuttle. This proposal is concerned with a new technique that allows hyperpolarisation of a substance without the need for a chemical reaction. The proposal is specifically concerned with the optimisation of the process, in terms of the chemistry of catalysis, the range of molecules that can interact with the hyperpolarised catalysts and the physical basis of the phenomenon. The proposal seeks to create a flow cell for generic use for the continuous production of hyperpolarised substances in large quantities. It is predicted that the provision of this unprecedented new method for increasing signal strengths could have wide ranging applications within chemistry and also have important implications for methods that seek to improve MRI and therefore its power as a diagnostic tool.
People |
ORCID iD |
| S Duckett (Principal Investigator) | |
| Gary Green (Co-Investigator) |
Publications
Adams RW
(2009)
A theoretical basis for spontaneous polarization transfer in non-hydrogenative parahydrogen-induced polarization.
in The Journal of chemical physics
Aguilar JA
(2011)
Selective detection of hyperpolarized NMR signals derived from para-hydrogen using the Only Para-hydrogen SpectroscopY (OPSY) approach.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Ardenkjaer-Larsen J
(2015)
Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy
in Angewandte Chemie International Edition
Atkinson KD
(2009)
Para-hydrogen induced polarization without incorporation of para-hydrogen into the analyte.
in Inorganic chemistry
Boutain M
(2010)
A parahydrogen based NMR study of Pt catalysed alkyne hydrogenation.
in Dalton transactions (Cambridge, England : 2003)
Burns MJ
(2015)
Improving the hyperpolarization of (31)P nuclei by synthetic design.
in The journal of physical chemistry. B
Cowley M
(2011)
Iridium N-Heterocyclic Carbene Complexes as Efficient Catalysts for Magnetization Transfer from para -Hydrogen
in Journal of the American Chemical Society
Duckett SB
(2012)
Application of parahydrogen induced polarization techniques in NMR spectroscopy and imaging.
in Accounts of chemical research
| Description | Scientists at the University of York have developed new technology which could dramatically cut scanning times for important health tests and increase the accuracy of the results. They have discovered a way of making Magnetic Resonance Imaging (MRI) scanners, extensively used in hospitals, and Nuclear Magnetic Resonance (NMR) machines employed in chemistry research far more sensitive than was previously possible. Research conducted at the York NMR Centre and the York Neuroimaging Centre has uncovered/produced/developed a new technique which allows molecules to be much more easily detected in a scanner without changing their chemical structure. This is achieved by manipulating a fundamental property of atoms termed 'spin'. The key advantage over previous technologies is that this can be achieved without the use of a chemical reaction or having to cool the molecules down to very low temperatures. This will allow much easier and cheaper implementation in hospitals or in the laboratory. We have shown that the gain in sensitivity is so great that data can be acquired in seconds rather than months. This has very positive implications for faster diagnosis for patients in the future. The technique could ultimately replace current clinical imaging technologies that depend on the use of radioactive substances or heavy metals." |
| Exploitation Route | They have the potential to improve NMR or MRI |
| Sectors | Chemicals,Healthcare,Manufacturing, including Industrial Biotechology |
| URL | https://www.york.ac.uk/chym/ |
| Description | Our findings have been used by around 30 research groups worldwide. They have led to the production of a parahydrogen generator which is sold by Bruker BioSpin. Bruker have produced additional equipment which is now undergoing beta-test. |
| First Year Of Impact | 2012 |
| Sector | Chemicals,Healthcare,Manufacturing, including Industrial Biotechology |
| Impact Types | Societal,Economic |
| Description | Clinical Research Capabilities and Technologies Initiative |
| Amount | £3,105,879 (GBP) |
| Funding ID | R16249 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2015 |
| End | 06/2020 |
| Description | GlaxoSmithKline (GSK) |
| Amount | £65,000 (GBP) |
| Funding ID | STU029361 |
| Organisation | GlaxoSmithKline (GSK) |
| Sector | Private |
| Country | Global |
| Start | 10/2010 |
| End | 09/2013 |
| Description | GlaxoSmithKline (GSK) |
| Amount | £65,000 (GBP) |
| Organisation | GlaxoSmithKline (GSK) |
| Sector | Private |
| Country | Global |
| Start | 10/2013 |
| End | 09/2017 |
| Description | Wellcome Trust Capital Awards Scheme |
| Amount | £4,360,000 (GBP) |
| Funding ID | 092506/B/10/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2011 |
| End | 11/2016 |
| Description | Wellcome Trust Strategic Awards Scheme |
| Amount | £3,500,000 (GBP) |
| Funding ID | 098335/Z/12/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2012 |
| End | 11/2017 |
| Description | Bruker BioSpin |
| Organisation | Bruker Corporation |
| Department | Bruker BioSpin |
| Country | Germany |
| Sector | Private |
| PI Contribution | We have worked with Bruker to produce a parahydrogen generator, a device for the preparation of hyperpolarised samples and a flow probe for the detection of hyperpolarised signals |
| Collaborator Contribution | Bruker have provided access to equipment and engineering. They have provided legal support for patents |
| Impact | Bruker now sell a parahydrogen generator. A beta test version of the polariser in on test with 5 international research groups. |
| Start Year | 2009 |
| Description | Using SABRE to aid in the study of biologically relevant molecules |
| Organisation | AstraZeneca |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We have worked with AstraZeneca on the application of SABRE methods to aid in the characterisation and probing of small molecules of biological relevance |
| Collaborator Contribution | Knowledge and materials |
| Impact | Publications |
| Start Year | 2009 |
| Description | Using SABRE to aid molecular characterisation |
| Organisation | GlaxoSmithKline (GSK) |
| Country | Global |
| Sector | Private |
| PI Contribution | GlaxoSmithKline has supported two studentships to drive forward the SABRE research. They are interested in using it to probe pharamaceutical products |
| Collaborator Contribution | They provide knowledge and materials. |
| Impact | Publications |
| Start Year | 2009 |
| Description | Using parahydrogen to probe small molecules |
| Organisation | Fera Science Limited |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | We worked with FERA to develop methods to characterise trace amounts of organic materials that are relevant to food. |
| Collaborator Contribution | Knowledge and Materials |
| Impact | Publicatons |
| Start Year | 2009 |
| Title | Field cycling method for magnetic resonance |
| Description | An NMR experiment on hyperpolarizable magnetic nuclei of substrate molecules in a living human or animal body, involves polarizing the substrate molecules by non-hydrogenating para-hydrogen induced polarization (=NH-PHIP) into a singlet/pseudo singlet state in low magnetic field and injecting the substrate molecules into the living body, the body or a part thereof being previously located inside a magnet at low magnetic field. The magnet is switched on to high magnetic field, and in at least part of the substrate molecules, the singlet state/pseudo singlet state is converted into observable magnetisation. An MRI or MRS measurement is carried out with the living body or the part thereof, collecting data from the substrate molecules. The NMR experiment is well applicable on hyperpolarized nuclei within a patient, with reduced losses of magnetization due to relaxation processes. |
| IP Reference | US2014012129 |
| Protection | Patent granted |
| Year Protection Granted | 2014 |
| Licensed | Yes |
| Impact | We hope that this patent will be used by Bruker BioSpin. |
| Title | HYPERPOLARITZATION OF COMPOUNDS FOR NMR, IN PARTICULAR BY MEANS OF PHIP |
| Description | An NMR method is presented having enhanced sensitivity on a compound comprising hyperpolarizable nuclei, in particular applying enhanced PHIP. Polarization is thereby transferred from a prepared fluid, which is enriched with symmetric molecules of a particular spin state (e.g. para-hydrogen enriched), directly to the hyperpolarizable nuclei of a compound, without altering the chemical identity of the compound in this process. Spin transfer is achieved using a template having sites of ordered environment, and the fluid and the compound are brought together in the presence of the template. Polarization transfer to the hyperpolarizable nuclei of the compound is thereby easier to perform and can be applied to a broader scope of compounds. |
| IP Reference | US2010219826 |
| Protection | Patent granted |
| Year Protection Granted | 2010 |
| Licensed | Yes |
| Impact | This product has been licensed to Bruker BioSpin |
| Title | NMR MEASUREMENT APPARATUS WITH FLOW-THROUGH PROBEHEAD |
| Description | The invention relates to a device (1, 21, 31, 41, 64) for the preparation and measurement of a nuclear spin reso nance (NMR) measurement sample (10), including-a flow-through NMR probehead (2), with a first tube (3) and a second tube (14) each for the supply and removal of a liquid NMR measurement sample (10),-at least one chamber (4, 22, 32) which is connected to one of the tubes (3, 14),-a sample inlet (5) for introducing the liquid measurement sample (10) into the device (1, 21, 31, 41, 64), wherein at least one chamber (4, 22, 32) has at least one connection for increasing (9, 24, 25, 42, 43, 46, 47) and releasing (8, 23, 27, 48a, 48b) the gas pressure, and in which at least one chamber (4, 22, 32) comprises means for mixing the liquid measurement sample (10) contained in the chamber (4, 22, 32) with a gas With the inventive device it is possible to reduce the measurement sample consumption when doing an NMR spectroscopic measurement on liquid measurement samples to which spin order can be catalytically transferred. |
| IP Reference | US2011285396 |
| Protection | Patent granted |
| Year Protection Granted | 2011 |
| Licensed | Yes |
| Impact | This has been licensed to Bruker BioSpin |
| Title | PULSE SEQUENCING WITH HYPERPOLARISABLE NUCLEI |
| Description | There is described a method of selective observation of non-hydrogenative para- hydrogen induced polarisation (NH-PHIP) as enhanced magnetic resonance signals which comprises separating the thermal and longitudinal spin order states. There is also described a template comprising [Ir(COD)(NHC)(Py)]+, and analogues thereof, for use in a PHIP magnetic resonance technique and a method for its preparation. |
| IP Reference | WO2010067076 |
| Protection | Patent application published |
| Year Protection Granted | 2010 |
| Licensed | Yes |
| Impact | We are working with Bruker BipSpin on the application. |
| Title | Parahydrogen Generator |
| Description | We worked with Bruker BioSpin to produce a device to make parahydrogen |
| Type Of Technology | New/Improved Technique/Technology |
| Year Produced | 2013 |
| Impact | The device is being used by a number of researchers to help support hyperpolarisation studies aligned to clinical MRI. |
| URL | http://www.bruker.com/products/mr/nmr/accessories/hyperpolarization/parahydrogen-generator/overview.... |
| Company Name | HYPERNETICS IMAGING LIMITED |
| Description | Currently company holds the patents associated with SABRE and seeks to develop their use. |
| Year Established | 2013 |
| Impact | Currently seeking investment |
| Description | 4th International Metabolic Imaging Workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A presentation on parahydrogen based methods to improve NMR and MRI |
| Year(s) Of Engagement Activity | 2016 |
| Description | 5th Australian Organometallics Meeting (Sydney) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 70 academics, postdocs and research students attended a research presentation, which sparked questions and discssion afterwards Subsequent joint ARC grant with B Messerle (Sydney) |
| Year(s) Of Engagement Activity | 2010 |
| Description | 7th Conference on Field Cycling NMR Relaxometry |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | People attended a presentation which sparked questions and discussion afterwards Other researchers now use our methods |
| Year(s) Of Engagement Activity | 2011 |
| URL | http://www.ffcrelax.com/ffcrelax/ffc2011/mainpage.php?folder=program&page=index.php |
| Description | Article in the daily mail |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Potential for hyperpolarisation to transform MRI |
| Year(s) Of Engagement Activity | 2018 |
| Description | BBC the one show |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation to celebrate the life of Sir Peter Mansfield; input into the future of MRI |
| Year(s) Of Engagement Activity | 2018 |
| Description | BioNMR workshop Weizmann Institute. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Over 50 people attended a presentation which sparked questions and discussion afterwards Over 15 research groups worldwide have adopted our methods |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.weizmann.ac.il/weizsites/bionmr/ |
| Description | CPACT Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Workshop detailing potential routes to use hyperpolarisation to aid in industrial production |
| Year(s) Of Engagement Activity | 2016 |
| Description | Dalton Discussion Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | A research talk on the use of parahydrogen enhanced NMR methods for cataysis |
| Year(s) Of Engagement Activity | 2016 |
| Description | Domino Printing Inks Visit |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | A presentation was given on the potential of SABRE as a tool to aid in the analysis of printing ink solutions |
| Year(s) Of Engagement Activity | 2017 |
| Description | Euromar, Florence, Italy. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Over 100 people attended a presentation which sparked questions and discussion afterwards Over 15 research groups worldwide have adopted our methods |
| Year(s) Of Engagement Activity | 2010 |
| URL | http://www.euromar.org/about.html |
| Description | Experimental Nuclear Magnetic Resonance Conference (ENC), Daytona Beach USA. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Over 100 people attended a presentation which sparked questions and discussion afterwards Over 15 research groups worldwide have adopted our methods |
| Year(s) Of Engagement Activity | 2010 |
| URL | http://www.enc-conference.org/ |
| Description | German-UK MR Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited key-note talk at international meeting. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.chemie.tu-darmstadt.de/gdch-fgmr2015/fgmr_2015/index.en.jsp |
| Description | Gordon Conference, In Vivo Magnetic Resonance |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Over 100 people attended a presentation which sparked questions and discussion afterwards Over 15 research groups worldwide have adopted our methods |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.grc.org/programs.aspx?year=2014&program=invivo |
| Description | Huddersfield Hyperpolarisation Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Series of presentations detailing aspects of hyperpolarisation |
| Year(s) Of Engagement Activity | 2016 |
| Description | Imaging in 2020 VII, Bridging Molecular Imaging and Therapy, Jackson Hole USA. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | people attended a presentation which sparked questions and discussion afterwards 15 research groups worldwide have adopted our methods |
| Year(s) Of Engagement Activity | 2011 |
| Description | Intermediary Metabolism in Cancer meeting, Dallas USA. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Over 100 people attended a presentation which sparked questions and discussion afterwards Over 15 research groups worldwide have adopted our methods. This includes groups at Johns Hopkins, UT Southwestern Medical Centre, and the University Medical Center Freiburg |
| Year(s) Of Engagement Activity | 2010 |
| URL | http://www.utsouthwestern.edu/edumedia/edufiles/departments_centers/airc/annual-symposium-202010.pdf |
| Description | Invited Speaker, Euromar, Dublin, Eire. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Over 100 people attended a presentation which sparked questions and discussion afterwards Over 15 research groups worldwide have adopted our methods |
| Year(s) Of Engagement Activity | 2012 |
| Description | Local Workshop for EUROPOL (ITN) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | A workshop on hyperpolarisation methods based on parahydrogen. |
| Year(s) Of Engagement Activity | 2016 |
| Description | MRC Hyperpolarised MRI workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Workshop to consider progress in hyperpolarisation that will lead to clinical use |
| Year(s) Of Engagement Activity | 2015 |
| Description | NMR discussion group meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Local organiser and speaker at a meeting focussed on low field NMR |
| Year(s) Of Engagement Activity | 2016 |
| Description | New national centre to transform medical imaging |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Detail new funding stream A new £6.8 million research centre based across two Yorkshire universities will aim to transform diagnosis and treatment of patients suffering from cancer, heart disease and musculoskeletal diseases with the help of new medical imaging facilities to be created at Leeds Teaching Hospitals and the University of York. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.york.ac.uk/news-and-events/news/2014/medical-imaging-centre/ |
| Description | New scanning technology aims to achieve quicker diagnosis of disease |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | New scanning technology aims to achieve quicker diagnosis of disease. Groundbreaking research taking place at the University of York could lead to Alzheimer's disease being diagnosed in minutes using a simple brain scan. Scientists are working on new technology that could revolutionise the way in which Magnetic Resonance Imaging (MRI) scans are used to view the molecular events behind diseases like Alzheimer's, without invasive procedure, by increasing the sensitivity of an average hospital scanner by 200,000 times. The technology underpinning this project, SABRE (Signal Amplification by Reversible Exchange), has received a £3.6m Strategic Award from the Wellcome Trust to fund a team of seven post-doctoral researchers from this month. on-going |
| Year(s) Of Engagement Activity | 2012 |
| URL | http://www.york.ac.uk/chym/news/2012/scanning/ |
| Description | Opening National Centre of Hyperpolarised MRI |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Scientific talk on developments in SABRE hyperpolarisation. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Progress With Parahydrogen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk to Pfizer |
| Year(s) Of Engagement Activity | 2018 |
| Description | Rank Prize Symposium |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I contributed to a workshop aimed at driving forward change in chemical detection Over 15 research groups worldwide have adopted our methods |
| Year(s) Of Engagement Activity | 2011 |
| URL | http://www.rankprize.org/index.php/symposia/general |
| Description | Seminar Programme |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Series of seminars in Strasbourg related to hyperpolarisation |
| Year(s) Of Engagement Activity | 2018 |
| Description | Series of talks based on award of RSC Tilden Prize |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Three talks were given to illustrate future opportunities for MRI and NMR based on our scientific developments at Aston, Durham and Southampton |
| Year(s) Of Engagement Activity | 2019 |
| Description | Talk Cambridge Synthesis and Applications of Labelled Compounds |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk within international meeting |
| Year(s) Of Engagement Activity | 2016 |
| Description | Talk Hyperpolarisation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk as part of a prize symposium |
| Year(s) Of Engagement Activity | 2016 |
| Description | Talk on progress with parahydrogen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | talk with scientists at AstraZeneca |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk on progress with parahydrogen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk with GSK |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk, ISMAR, Rio de Janerio, Brazil |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | people attended a presentation which sparked questions and discussion afterwards Over 15 research groups worldwide have adopted our methods |
| Year(s) Of Engagement Activity | 2013 |
| Description | Using SABRE to improve NMR and MRI |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk given in Paris |
| Year(s) Of Engagement Activity | 2016 |
| Description | Wellcome Trust Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | To inform on progress towards the clinical uptake of SABRE |
| Year(s) Of Engagement Activity | 2016 |
| Description | Wellcome Trust, Next Generation Brain Imaging Technologies, London, UK. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | people attended a presentation which sparked questions and discussion afterwards Funding awarded to take methods forward. |
| Year(s) Of Engagement Activity | 2011 |
| Description | York Hyperpolarisation Symposium (2 Day) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Series of 20 talks over 2 days |
| Year(s) Of Engagement Activity | 2016 |
| Description | iMR CDT Research Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at CDT workshop to inform on hyperpolarisation with parahydrogen |
| Year(s) Of Engagement Activity | 2015 |
| URL | https://www2.warwick.ac.uk/fac/sci/physics/research/condensedmatt/imr_cdt/news_events/ |
| Description | press release |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A press release written to share a research success Over 30 reports in the national and international media picked up this press release. Interviews resulted on local radio. |
| Year(s) Of Engagement Activity | 2009 |
| URL | http://www.york.ac.uk/news-and-events/news/2009/medical-diagnosis/ |
| Description | press release |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Information shared with public Research progresses towards clinical use |
| Year(s) Of Engagement Activity | 2010 |
| URL | http://www.york.ac.uk/news-and-events/news/2010/research/hyperpolarisation/ |