Regenerative Therapies and Devices
Lead Research Organisation:
University of Leeds
Department Name: Mechanical Engineering
Abstract
The Innovation and Knowledge Centre in Regenerative Therapies and Devices will provide a sustainable regional and international platform to address the creation of new technologies in Regenerative Therapies and Devices and their accelerated adoption within a complex global market place with increasing cost constraints. Therapies and devices which facilitate the regeneration of body tissues offer the potential to revolutionise healthcare and be a catalyst for economic growth, creating a new business sector within healthcare technology (Foresight Healthcare 2020). This centre is focused on emerging novel technologies in biological scaffolds, nano-biomaterials and self assembling peptides. These hybrid technologies utilise novel physical and biological functionality to enhance and accelerate the regeneration of tissues by harnessing the potential of endogenous stem cells in vivo. These novel technologies will also provide a vehicle for the delivery of exogenous stem cells to patients in the future and can be used to generate neo-tissues in vitro. The delivery of these emerging technologies to patients will be accelerated by improved diagnostics and imaging for enhanced patient targeting and by new complex simulation methodologies (patient in the lab) for improved short term predictions of the long term clinical outcomes. The life expectancy and average age of the population continues to increase as a result of advances in biomedicine and healthcare and this is generating additional social and economic burden. The Regenerative Technologies and Devices IKC will address the needs and quality of life of the ageing population, and address their expectations of an active lifestyle for fifty more years after fifty . It will specifically, but not exclusively, focus on areas of clinical need in musculoskeletal disease, dentistry, cardiovascular disease and cancer, which have been strategically prioritised by the University and the Leeds Hospitals Trust. The centre will build upon and develop substantial clinical, academic and industry partnerships. Additional new collaborative funding of over 58 million has already been confirmed to match the IKC award, and the centre has plans which have identified research and innovation funding in this area of over 100 million during the initial five year period of its activities.This rapidly growing multidisciplinary area will require innovative scientists and engineers who can cross disciplinary boundaries, work in broader systems based projects and work flexibly and collaboratively with industry and clinicians at different stages of the innovation pipeline. The centre and its partners will develop new and different approaches to innovation at an early stage of the innovation cycle, to substantially accelerate innovation, shorten the time period to clinical trials and market, and mitigate technology risks associated with this emergent sector. Collaborators in the Leeds University Business School will develop and evaluate open innovation methodologies. The University of Leeds is ideally placed to take advantage of this EPSRC call for four important reasons. First it has considerable competency in technology and science, as well as capabilities in managing collaborative innovation and entrepreneurship. Second it has the capability to both manage facilitate and create accelerated innovation in emerging healthcare technologies. Third the University already has excellent facilities and a track record (WRHIP) for innovation and is working with Yorkshire Forward to establish an Innovation Hub in Healthcare Technologies. Fourth the strategic partnership with the Clinical Trials Research Unit and the Unit of Health Economics will enable transition into NHS practice.
Organisations
- University of Leeds (Lead Research Organisation)
- Biotechnology and Biological Sciences Research Council (Co-funder)
- Innovate UK (Co-funder)
- Procter & Gamble (Collaboration)
- Simpleware Ltd (Collaboration)
- BITECIC Ltd (Collaboration)
- Biomet, Inc (Collaboration)
- RD Biomed (Collaboration)
- Leeds Teaching Hospitals NHS Trust (Collaboration)
- Isogenica (Collaboration)
- Simulation Solutions (Collaboration)
- Biocomposites (Collaboration)
- Smith and Nephew (Collaboration)
- Geistlich (Collaboration)
- Neu Biomechanics (Collaboration)
- Credentis (Collaboration)
- Corin Group PLC (Collaboration)
- Barco (Collaboration)
- Glass Technology Services (Collaboration)
- Tissue Regenix Ltd (Collaboration)
- Mathys (Collaboration)
- North American Science Associates Inc (Collaboration)
- Vascutek Ltd (Collaboration)
- Nuvasive (Collaboration)
- Surgical Innovations (Collaboration)
- NHS Blood and Transplant (NHSBT) (Collaboration)
- Euro Coatings (Collaboration)
- Neotherix Ltd (Collaboration)
- Aesculap (Collaboration)
- M Squared Lasers Ltd (Collaboration)
- JRI Orthapaedics (Collaboration)
- Avacta Group (Collaboration)
- Depuy International (Collaboration)
- Siemens AG (Collaboration)
- Invibio (Collaboration)
- Corline (Collaboration)
- Giltech (Collaboration)
- Aedstem Ltd (Collaboration)
- The Welding Institute (Project Partner)
- Medipex Ltd (Project Partner)
- Bitecic (United Kingdom) (Project Partner)
- Yorkshire Forward (Project Partner)
- Aptuscan (Project Partner)
- Simulation Solutions (United Kingdom) (Project Partner)
- DePuy Synthes (International) (Project Partner)
- IP Group (United Kingdom) (Project Partner)
Publications
Wilshaw S
(2012)
Development and Characterization of Acellular Allogeneic Arterial Matrices
in Tissue Engineering Part A
Williams S
(2013)
Comparison of ceramic-on-metal and metal-on-metal hip prostheses under adverse conditions.
in Journal of biomedical materials research. Part B, Applied biomaterials
Wang M
(2010)
A novel and non-destructive method to examine meniscus architecture using 9.4 Tesla MRI
in Osteoarthritis and Cartilage
Wang L
(2012)
The effect of cup orientation and coverage on contact mechanics and range of motion of metal-on-metal hip resurfacing arthroplasty
in Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
Vicars R
(2012)
The effect of anterior-posterior shear on the wear of CHARITÉ total disc replacement.
in Spine
Vargas-Palacios A
(2016)
Systematic Review of Retraction Devices for Laparoscopic Surgery.
in Surgical innovation
Taylor SD
(2012)
Comparison of human and animal femoral head chondral properties and geometries.
in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Tatterton M
(2012)
The use of antithrombotic therapies in reducing synthetic small-diameter vascular graft thrombosis.
in Vascular and endovascular surgery
Stapleton TW
(2011)
Investigation of the regenerative capacity of an acellular porcine medial meniscus for tissue engineering applications.
in Tissue engineering. Part A
Sood A
(2011)
Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness.
in Nature nanotechnology
| Title | Institute promotional video |
| Description | A 10 minute video has been professionally created to support visits to our facilities. The film showcases a range of stages in career who talk about the research challenges and outputs across the institute. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2013 |
| Impact | Increased number of people requesting visits and lab tours, increased engagement with the Medical Technologies IKC. |
| URL | https://www.youtube.com/user/MedTechLeeds/videos?view=0 |
| Description | High quality research and innovation platform £95m new research income Established academic supply chain and translational capability across 250 researchers Active collaborations and technology validation with 9 UK HEIs, 18 academic and clinical partners New Medical Technologies building and a new post of Director of Innovation in Medical Technologies Successful sustainable innovation Defined robust sustainability model Strategically identified and prioritised key market sectors that offer significant opportunity Developed a culture of innovation across academic, industry and clinical partnerships Sharing innovation good practice with 9 UK HEIs and other innovation hubs at Leeds 166 collaborative projects, 66 industry co-investors Established profile and reputation Robust brand identity and reach across the UK and beyond through targeted marketing and communications Strategic alignment with Regener8 giving access to a 240 industry members, 328 academics and 21 clinicians across UK High profile events with national partners to engage the community in issues that impact on medical and regenerative technology innovation. Significant political visits and media coverage Successful innovation and translation Established Innovation system, pipeline, stage gates and criteria for progression Defined IP portfolio and directly funded 42 Proof of Concept and 6 Co-Development projects Pipeline of 166 collaborative innovation projects with industry, of which 48 directly IKC funded Contributed to the development of 46 new products that have reached the market. Generated £57m investment in private sector partners for development of our IP/technology and a further £30m plus investment in private sector for development arising out of collaborative projects |
| Exploitation Route | The IKC has a proven system to identify larger collaborative projects with industrial partners. In these larger-scale projects the costs are split equally between ourselves and the Centre's industrial partners. Some of the larger co-development projects include: - Working with Simulation Solutions to develop an electromechanical knee simulator - A partnership with Tissue Regenix in the creation of a product for the repair of damaged or worn knees using Tissue Regenix' proprietary technology platform - Working alongside credentis ag to further develop self-assembling peptide biomimetic scaffolds for dental repair - Working with NHS Blood and Transplant to improve processes for allograft tissue banking The IKC also works with companies to support the development of technology beyond Technology Readiness Level 5 with direct, industry-funded projects that draw upon our unique capability to deliver projects demanded by industry. These are referred to as "late stage innovation" projects where a company directly accesses our expertise to support the development of their IP or to progress product development through independent, validated data from an ISO 9001 accredited and internationally-recognised laboratory The IKC leads the acceleration of new technologies and innovations to help them reach the marketplace faster. In the first three years the IKC has been involved in 136 projects that have direct industrial investment and engagement. Whilst our core capabilities in medical device research and development are in great demand, accounting for more than 70 per cent of our projects, our partners are increasingly interested in our knowledge of emerging markets, particularly in the areas of biosensors, stem cell and biological scaffold technologies. Developing relationships with centres of expertise across the UK has also been central to growth over the past year and we have seen further development of collaborative arrangements with a number of universities, including the Bristol Urological Institute, the University of Cambridge and St Andrews University. We have formed a strategic alliance with Regener8 - the partnership of academics from the eight leading research-intensive universities of the North of England (the N8 Research Partnership) - further strengthening our pool of expertise and resources and increasing our reach to more than 169 companies and more than 30 clinicians |
| Sectors | Healthcare |
| URL | http://www.medical-technologies.co.uk |
| Description | High quality research and innovation platform £95m new research income Established academic supply chain and translational capability across 250 researchers Active collaborations and technology validation with 9 UK HEIs, 18 academic and clinical partners New Medical Technologies building and a new post of Director of Innovation in Medical Technologies Successful sustainable innovation Defined robust sustainability model Strategically identified and prioritised key market sectors that offer significant opportunity Developed a culture of innovation across academic, industry and clinical partnerships Sharing innovation good practice with 9 UK HEIs and other innovation hubs at Leeds 166 collaborative projects, 66 industry co-investors Established profile and reputation Robust brand identity and reach across the UK and beyond through targeted marketing and communications Strategic alignment with Regener8 giving access to a 240 industry members, 328 academics and 21 clinicians across UK High profile events with national partners to engage the community in issues that impact on medical and regenerative technology innovation. Significant political visits and media coverage Successful innovation and translation Established Innovation system, pipeline, stage gates and criteria for progression Defined IP portfolio and directly funded 42 Proof of Concept and 6 Co-Development projects Pipeline of 166 collaborative innovation projects with industry, of which 48 directly IKC funded Contributed to the development of 46 new products that have reached the market. Generated £57m investment in private sector partners for development of our IP/technology and a further £30m plus investment in private sector for development arising out of collaborative projects |
| First Year Of Impact | 2010 |
| Sector | Healthcare |
| Impact Types | Societal,Economic |
| Description | international standards committee chair |
| Geographic Reach | Asia |
| Policy Influence Type | Membership of a guideline committee |
| Impact | international pre clinical testing standards |
| Description | Biomedical research unit |
| Amount | £6,000,000 (GBP) |
| Funding ID | Leeds musculoskeletal biomedical research unit |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2014 |
| End | 03/2017 |
| Description | CDT 2014-22 |
| Amount | £4,000,000 (GBP) |
| Funding ID | CDT TERM |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2014 |
| End | 09/2022 |
| Description | Capital equipment CDT |
| Amount | £240,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2015 |
| End | 04/2019 |
| Description | Catalyst Medical Technologies |
| Amount | £3,000,000 (GBP) |
| Organisation | Higher Education Funding Council for England |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2015 |
| End | 10/2018 |
| Description | DTP |
| Amount | £2,000,000 (GBP) |
| Funding ID | DTP |
| Organisation | DePuy Synthes |
| Sector | Private |
| Country | United States |
| Start | 01/2014 |
| End | 01/2016 |
| Description | EPSRC Healthcare Technology Challenge |
| Amount | £1,200,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2013 |
| End | 04/2016 |
| Description | EPSRC small scale equipment grant |
| Amount | £500,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2012 |
| End | 01/2013 |
| Description | European Research Council advanced award |
| Amount | £2,000,000 (GBP) |
| Funding ID | Proposal 267114 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 04/2011 |
| End | 04/2016 |
| Description | Industry Biocomposites |
| Amount | £150,000 (GBP) |
| Organisation | Biocomposites |
| Sector | Private |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 07/2016 |
| Description | Industry Invibio |
| Amount | £300,000 (GBP) |
| Organisation | Invibio |
| Sector | Private |
| Country | United Kingdom |
| Start | 10/2015 |
| End | 10/2017 |
| Description | Leeds Musculoskeletal Biomedical Research Centre |
| Amount | £6,000,000 (GBP) |
| Organisation | University of Leicester |
| Department | NIHR Biomedical Research Centre |
| Sector | Hospitals |
| Country | United Kingdom |
| Start | 04/2017 |
| End | 03/2022 |
| Description | Mecical technologies Innovation and Knowledge Centre Phase 2 Regenerative Devices |
| Amount | £4,000,000 (GBP) |
| Funding ID | EP/N00941X/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 07/2020 |
| Description | Medcial engineering centre |
| Amount | £160,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 07/2019 |
| Description | Medical Technologies IKC Phase 2 Regenerative Devices |
| Amount | £3,000,000 (GBP) |
| Funding ID | EP/N00941X/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 06/2020 |
| Description | Medical engineering centre |
| Amount | £4,200,000 (GBP) |
| Funding ID | WELMEC |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2014 |
| End | 09/2015 |
| Description | Optimising knee therapies |
| Amount | £4,000,000 (GBP) |
| Funding ID | EP/P001076/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2021 |
| Description | senior investigator |
| Amount | £100,000 (GBP) |
| Funding ID | LMBRU |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2014 |
| End | 04/2015 |
| Title | Hip Joint simulator |
| Description | In vitro simulator for artificial hip joints |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | Method commercialised by Simulation Solutions |
| Title | Knee joint simulator |
| Description | artificial knee joint simulator |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | Simulator and simulation method commercialised by simulation solution |
| Title | Microbial biofilm model for testing of antimicrobials to prevent oral disease |
| Description | Assay developed that assess the ability of an anti-microbial to control the microbial load on a 5 species biofilm model - this model is being developed further by changing the balance of the pathogens to develop models that are specific to particular oral diseases - i.e. caries The assay developed is specific to the human oral environment The assay has provided robust information with regard to how different peptide materials deliver different anti- microbials. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | This has contributed to the delivery of a proof of concept projects in collaboration with industry partner - Credentis |
| Title | Natural knee simulator |
| Description | Simulation system for natural knee |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | Simulator commercially available, Simulation Solutions |
| Title | natural hip simulator |
| Description | Simulation system for natural hip |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | System commercially availa le from Simulation Solutions |
| Title | spine simulator |
| Description | Spinal disc simulator |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2012 |
| Provided To Others? | Yes |
| Impact | Commercialised by Simulation solutions |
| Title | Biomechanical and biotribological simulation model natural hip |
| Description | Biomechanical and biotribological model of natural hip |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | used in follow on research |
| Title | Biomechanical model of functional spinal unit |
| Description | model of functional spinal unit |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | used in follow on research |
| Title | Biotribological model naturala knee |
| Description | Biotribological model natural knee |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | Used in follow on research on regenerative devices |
| Title | wear simulation model artificial hip |
| Description | wear simulation model artificial hip |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2010 |
| Provided To Others? | Yes |
| Impact | applied in industry contract research |
| Title | wear simulation model artificial knee |
| Description | wear simulation model artificial knee |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2012 |
| Provided To Others? | Yes |
| Impact | used in industry contract research |
| Description | Aedstem |
| Organisation | Aedstem Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Diagnostic test for prancreatic islet transplantation |
| Start Year | 2011 |
| Description | Aesculap |
| Organisation | Aesculap |
| Country | Germany |
| Sector | Private |
| PI Contribution | LifeLongJoints - Silicon Nitride Coatings |
| Start Year | 2013 |
| Description | Avacta |
| Organisation | Avacta Group |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Electronic Biomarker Detection (eTect); Use of spectroscopy for non-invasive phenotyping of stem cells; Use of di-electrophoresis for minimally manipulated stem cell enrichment. |
| Start Year | 2010 |
| Description | Barco |
| Organisation | Barco |
| Country | Belgium |
| Sector | Private |
| PI Contribution | Leeds Virtual Microscope (LVM) - High Speed Digital Examination of clinical histological samples |
| Start Year | 2011 |
| Description | Biocomposites Ltd |
| Organisation | Biocomposites |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Calcium Phosphate Bone Void Filler - A Pin-on-Plate Study; Calcium Sulphate Bone Void Filler Comparison - A Pin-on-Plate Study |
| Collaborator Contribution | participate in research and publication |
| Impact | Publication |
| Start Year | 2014 |
| Description | Biomet |
| Organisation | Biomet, Inc |
| Department | Biomet UK |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Evaluate biomechanics and tribology of new ankle implant. |
| Start Year | 2011 |
| Description | Corin |
| Organisation | Corin Group PLC |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Metal on metal hip wear |
| Collaborator Contribution | materials |
| Impact | multidiciplinary |
| Start Year | 2009 |
| Description | Corline |
| Organisation | Corline |
| Country | Sweden |
| Sector | Private |
| PI Contribution | Heparin coated acellular vascular grafts |
| Start Year | 2011 |
| Description | Credentis |
| Organisation | Credentis |
| Country | Switzerland |
| Sector | Private |
| PI Contribution | Use of Self assembling peptide(SAP) technology for hard tissue engineering (dental applications) |
| Collaborator Contribution | materilas |
| Impact | Ip piublications |
| Start Year | 2014 |
| Description | DePuy |
| Organisation | Depuy International |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Thirty-three projects. |
| Collaborator Contribution | funds , materilas staff |
| Impact | publications |
| Start Year | 2013 |
| Description | Euro Coatings |
| Organisation | Euro Coatings |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Evaluation of coating wear |
| Start Year | 2010 |
| Description | Geistlich |
| Organisation | Geistlich |
| Country | Switzerland |
| Sector | Private |
| PI Contribution | Use of self assembling peptides in hard tissue engineering (bone) |
| Description | Giltech Ltd |
| Organisation | Giltech |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Collaboration partner on the "Restoration of lost enamel using engineered acid-resistant and photosensitive minerals and eyesafe pulsed lasers" project |
| Start Year | 2011 |
| Description | Glass Technology Services Ltd |
| Organisation | Glass Technology Services |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Collaboration partner on the "Restoration of lost enamel using engineered acid-resistant and photosensitive minerals and eyesafe pulsed lasers" project. |
| Start Year | 2011 |
| Description | Invibio |
| Organisation | Invibio |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Four projects: PEEK low con knees; Investigation of biocompatibilty of PEEK wear debris; Investigation of PEEK as cervical disc bearing material; Low Cost Polymer Knee |
| Start Year | 2010 |
| Description | Isogenica |
| Organisation | Isogenica |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Combining Novel Invitro display technology with antibody mimetics screening |
| Start Year | 2011 |
| Description | JRI |
| Organisation | JRI Orthapaedics |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Ceramic composite hip wear |
| Start Year | 2009 |
| Description | LMBRU LTHT |
| Organisation | Leeds Teaching Hospitals NHS Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | patient specific and population based simulation an d modelling publications and outputs |
| Collaborator Contribution | clinical imaging patient data retrieval bank patient participation |
| Impact | publications simulation methods new standards joint grant applications |
| Start Year | 2015 |
| Description | M Squared Lasers Ltd |
| Organisation | M Squared Lasers Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Collaboration partner on the "Restoration of lost enamel using engineered acid-resistant and photosensitive minerals and eyesafe pulsed lasers" project |
| Start Year | 2011 |
| Description | Mathys Medical |
| Organisation | Mathys |
| Country | Switzerland |
| Sector | Private |
| PI Contribution | Four projects including: Evaluation of potential ceramic matrix hips Ceramic matrix composite hip Wear of Experimental Ceramics in Total Hip Replacement - A Hip Joint Simulator Study (Mathys IV) Wear of Experimental Ceramics in Total Hip Replacement - A Hip Joint Simulator Study (Mathys V) |
| Collaborator Contribution | materials , research methods , analysis |
| Impact | papres |
| Start Year | 2013 |
| Description | NAMSA |
| Organisation | North American Science Associates Inc |
| Country | United States |
| Sector | Private |
| PI Contribution | In vivo testing of dCell bone to detremine osseointegration and biocompatibility |
| Collaborator Contribution | undertaking research work |
| Impact | pubication |
| Start Year | 2015 |
| Description | NHS NBTS |
| Organisation | NHS Blood and Transplant (NHSBT) |
| Department | National Blood Service |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | 8 projects in collaboration with NHS NBTS Acellular bone ligament graft (Human) Acellular bone meniscus bone graft (Human) Acellular OC graft (Human) Allo vascular graft Allo heart valve Biocompatibility of acellular allogeanic dermis Acellular allogeneic aorta Development of dCELL bone-patella-bone allograft for anterior cruciate ligament replacement |
| Collaborator Contribution | funds time |
| Impact | multidiciplinary |
| Start Year | 2010 |
| Description | NHSBT |
| Organisation | NHS Blood and Transplant (NHSBT) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Provision of expertise in tissue decellularisation technology Provision of expertise in tissue characterisation methods |
| Collaborator Contribution | Provision of consented human donor tissues for research and analysis purposes |
| Impact | Publications Wilshaw SP Rooney P. Berry H. Kearney JN. Homer-Vanniasinkam S. Fisher J. Ingham E. Development and Characterisation of acellular allogeneic arterial matrices. Tissue Engineering Part A. 18; 471-483 (2012). Michalopoulos E. Knight RL. Korossis S. Kearney JN. Fisher J. Ingham E. Development of methods for studying the differentiation of human mesenchymal stem cells under cyclic compressive strain. Tissue Engineering Part C Methods. 18; 252-262 (2012) Hogg, P., Rooney, P., Ingham, E., Kearney, JN. Development of a decellularised dermis. Cell & Tissue Banking [Epub 2012] 14(3):465-474 September 2013 Huang, Q., Ingham, E., Rooney, P., Kearney, JN. Production of sterilised decellularisaed tendon allograft for clinical use. Cell Tissue Bank Feb 14, 645-54 (2013). Paniagua Gutierrez, JR., Wilcox-Berry, H Korossis, SA., Mirsadraee, S., Veiga Lopes, S., da Costa, F., Kearney, J., Watterson., K., Fisher, J., Ingham, E. Regenerative potential of low concentration SDS decellularised porcine aortic valved conduits in vivo. Tissue Engineering Part A. 21; 332-342 (2015) Hogg, P., Rooney, P., Leow-Dyke, S., Ingham, E., Kearney, JN. Development of a terminally sterilised decellularised dermis. Cell & Tissue Banking 16; 351-359 (2015). |
| Description | Neotherix |
| Organisation | Neotherix Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Repair of oral and peridontal defects using regenerative and antibacterial strategies delivered by a novel tissue scaffold vehicle Polymeric scaffolds functionalised for periodontal repair |
| Collaborator Contribution | materials |
| Impact | multidisciplinary |
| Start Year | 2015 |
| Description | Neu Biomechanics, BiteCiC |
| Organisation | Neu Biomechanics |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Evaluation of coating wear |
| Start Year | 2010 |
| Description | Nuvasive |
| Organisation | Nuvasive |
| Country | United States |
| Sector | Private |
| PI Contribution | Cellular Characterisation of Osteocel Plus |
| Collaborator Contribution | materials |
| Impact | multidisciplinary engineering medicne |
| Start Year | 2013 |
| Description | Proctor and Gamble |
| Organisation | Procter & Gamble |
| Country | United States |
| Sector | Private |
| PI Contribution | Electronic Biomarker Detection (eTect) |
| Start Year | 2010 |
| Description | RD Biomed |
| Organisation | RD Biomed |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Use of a novel therapeutic device for treatment of periodontal disease Penetration of a new market (dental) for an existing diagnostic device |
| Start Year | 2010 |
| Description | Siemens |
| Organisation | Siemens AG |
| Country | Germany |
| Sector | Private |
| PI Contribution | Novel Metal Suppression MRI Biomarkers for Joint Prosthesis |
| Collaborator Contribution | software |
| Impact | publications |
| Start Year | 2013 |
| Description | Simpleware |
| Organisation | Simpleware Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Development of finite element simulation tools to capture patient variation for the analysis of orthopaedic devices across a patient cohort |
| Collaborator Contribution | software |
| Impact | papers |
| Start Year | 2014 |
| Description | Simulation Solutions |
| Organisation | Simulation Solutions |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | 10 projects in collaboration with Simulation Solutions: High flex knee simulator Natural knee simulator Natural hip simulator Natural spine simulator Natural joint friction simulator knee joint simulator SOP for hip simulator SOP for knee simulator Natural Knee Simulation System Electro mechanical hip simulator method SOP and training |
| Collaborator Contribution | equipment development |
| Impact | publications |
| Start Year | 2014 |
| Description | Smith & Nephew, BiteCiC |
| Organisation | BITECIC Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Evaluate fixation of OC plug |
| Start Year | 2010 |
| Description | Smith & Nephew, BiteCiC |
| Organisation | Smith and Nephew |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Evaluate fixation of OC plug |
| Start Year | 2010 |
| Description | Surgical Innovations |
| Organisation | Surgical Innovations |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | A total of 4 collaborations with Surgical Innovations A new Arthroscopic Port for use in Arthroscopic Surgery applications Arthroscopic Port Environment Test Cell Design improvements to existing laparoscopy scissors Intra-Abdominal Platform (IAP) development |
| Start Year | 2010 |
| Description | TRG |
| Organisation | Tissue Regenix Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Provision of expertise in tissue decellularisation Provision of expertise in tissue characterisation methods |
| Collaborator Contribution | Provision of manufactured products Provision of insight into manufacturing, regulation and marketing of medical devices |
| Impact | Publications Wilshaw SP Rooney P. Berry H. Kearney JN. Homer-Vanniasinkam S. Fisher J. Ingham E. Development and Characterisation of acellular allogeneic arterial matrices. Tissue Engineering Part A. 18; 471-483 (2012). Owen, K., Wilshaw, SP., Homer-Vanniasinkam, S., Bojar, RE., Berry, H. & Ingham, E. Assessment of the antimicrobial activity of acellular vascular grafts. European Journal of Endovascular Surgery. 43; 573-581 (2012). Paniagua Gutierrez, JR., Wilcox-Berry, H Korossis, SA., Mirsadraee, S., Veiga Lopes, S., da Costa, F., Kearney, J., Watterson., K., Fisher, J., Ingham, E. Regenerative potential of low concentration SDS decellularised porcine aortic valved conduits in vivo. Tissue Engineering Part A. 21; 332-342 (2015) Abdelgaied, A., Stanley, M., Galfe, M., Berry, H., Ingham, E., Fisher, J. Comparison of the biomechanical tensile and compressive properties of decellularised and natural porcine meniscus. J. Biomechanics. 48; 1389-1396 (2015). |
| Start Year | 2006 |
| Description | Tissue Regenix |
| Organisation | Tissue Regenix Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | A total of 12 projects collaborating with Tissue Regenix Acellular ligament graft (Animal) Acellular bone meniscus bone graft (Animal) Acellular OC graft (Animal) Xeno vascular patch Xeno heart valve Decellularised bladder Decellularised meniscus (see also 12b) Acellular porcine flexor tendon graft Development of the dCELL Partial Meniscus In vivo testing of dCell bone to determine osseointegration and biocompatibility In vivo evaluation of decellularised porcine pulmonary roots. Long Term Evaluation of an Acellular Bovine Arterial Graft in an Ovine Arteriovenous Access Model |
| Start Year | 2009 |
| Description | Vascutec |
| Organisation | Vascutek Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Heart valve conduit |
| Start Year | 2010 |
| Title | ACELLULAR VASCULAR PRODUCTS |
| Description | A product comprising a natural acellular xenogenic vascular tissue matrix having at least an80% reduction in DNA content as compared to an untreated control vascular tissue matrix and being antigenically inert by being substantially free of epitopes capable of reacting with pre-formed human antibodies and also without having the ability to substantially activate complement. The invention also includes methods of preparing such products and uses of the products especially in bypass surgery. |
| IP Reference | WO2012042250 |
| Protection | Patent application published |
| Year Protection Granted | 2012 |
| Licensed | Yes |
| Impact | This IP has been assigned to Tissue Regenix (AIM listed Leeds spin out company), which is developing a portfolio of products based on this IP as well as three other patents we have assigned. Products such as a vascular patch for peripheral vascular reconstruction (clinical trial in 2009). |
| Title | COMBINATION OF MATERIAL FOR JOINT PROSTHESIS |
| Description | An orthopaedic joint prosthesis comprises first and second articulating components having respective bearing surfaces in contact with one another. The material of the first bearing surface (14) comprises a metallic material and the material of the second bearing surface (6) comprises a ceramic material. The hardness of the metallic material is at least about 2500 MPa, and the hardness of the ceramic material is greater than that of the metallic material by at least about 4000 MPa. |
| IP Reference | WO0117464 |
| Protection | Patent granted |
| Year Protection Granted | 2001 |
| Licensed | Yes |
| Impact | Clinical trials started 2006. Now marketed world wide. FDA IDE study underway in USA. A revenue sharing arrangement is in place between us and DePuy International. |
| Title | COMPOSITE BONE IMPLANTS |
| Description | The invention provides natural multi-composite bone implants such as bone-connective tissue-bone and osteochondral implants for the replacement and/or repair of, for example and in particular a damaged or defective bone-meniscus-bone joint or a bone-patella tendon-bone joint or osteochondral lesions, methods of preparing the composites and uses thereof. The invention also provides natural or native composite bone-connective tissue- bone and osteochondral matrices or scaffolds that are substantially decellularised for subsequent transplantation/implantation. |
| IP Reference | WO2014037713 |
| Protection | Patent application published |
| Year Protection Granted | 2014 |
| Licensed | No |
| Impact | Proof of concept phase in large animal model completed for bone-tendon-bone, discussions ongoing with a company on development re licensing |
| Title | Composition |
| Description | The present invention relates to a photosensitive composition comprising synthetic nanocrystalline hydroxyapatite or a synthetic precursor thereof doped with a rare earth ion, the use of the composition in restorative or cosmetic dentistry, a process for preparing the composition and a method of generating an image of an exposed dentinal surface of a tooth. |
| IP Reference | WO2012046082 |
| Protection | Patent application published |
| Year Protection Granted | 2012 |
| Licensed | Yes |
| Impact | This IP is supporting three projects: an EPSRC Health Technology Challenge project, an Innovate UK project, and a European funded Marie-Curie award with industrial partners which aims to produce commercial products. IPGroup and commercialisation team scoping out POC in vivo trial to evaluate the technology with the possibility of forming a spin-out company, two other patents would also be bought into this project. |
| Title | DECELLULARISATION OF MATRICES |
| Description | A method of preparing matrices or tissue engineered biomaterials for implantation, and in particular to a method of improving decellularisation of matrices or tissue engineered biomaterials prior to implantation. The method employs a single anionic detergent in combination with protease inhibitors. |
| IP Reference | WO02096476 |
| Protection | Patent granted |
| Year Protection Granted | 2002 |
| Licensed | Yes |
| Impact | A portfolio of products is in development for different clinical needs. A spin-out company has been formed (Tissue Regenix) which has a licence of this and three other patents. Also, this IP has been licensed to NHS Blood and Transplant, Tissue Services, for allografts in the NHS in the UK. |
| Title | Decellularised human livers |
| Description | The process could be applied to human donor organs thus increasing the number of such organs available for transplantation. This IP has not been patented and may still be confidential. |
| IP Reference | |
| Protection | Copyrighted (e.g. software) |
| Year Protection Granted | 2014 |
| Licensed | No |
| Impact | Too early for notable impacts. |
| Title | IMPROVEMENTS RELATING TO DECELLULARISATION OF TISSUE MATRICES FOR BLADDER IMPLANTATION |
| Description | The invention provides an improved method of producing a natural, acellular matrix scaffold for subsequent use in tissue-engineered replacement of tissues such as the bladder. Decellularisation is carried out on an expanded or distended bladder and the product retains the strength and compliance of natural material. The invention also provides use of the matrix scaffolds as wound healing material and to investigate tissue structure and function in vitro. |
| IP Reference | WO2007110634 |
| Protection | Patent granted |
| Year Protection Granted | 2007 |
| Licensed | Yes |
| Impact | This IP has supported a spin-out (Tissue Regenix) and its development of products. It is one of the four patents licensed to Tissue Regenix to date. |
| Title | MAGNETOMETER FOR MEDICAL USE |
| Description | A medical magnetometer (10) comprising one or more induction coils (2) for detecting a time varying magnetic field of a region of a subject's body, such as the heart. Each coil has a maximum outer diameter of 4 to 7 cm, and a configuration such that the ratio of the coil's length to its outer diameter is at least 0.5, and the ratio of the coil's inner diameter to its outer diameter is 0.5 or less. Each induction coil (2) is coupled to a respective detection circuit comprising a low impedance pre-ampiifier (3), a low pass filter (5), a notch filter (6) to remove line noise, and an averaging element (7). Each detection circuit produces an output signal (9) for use to analyse the time varying magnetic field of the region of the subject's body. |
| IP Reference | WO2014006387 |
| Protection | Patent application published |
| Year Protection Granted | 2014 |
| Licensed | Yes |
| Impact | IP is currently licensed to a Leeds spin-out (Creavo Medical Technologies Ltd, previously known as Quantum Imaging Ltd). Primary focus at present is the development of cardiac focussed devices, such as the VitalScan machine to support rule out triaging of patients presenting with chest pain in an emergency room setting. |
| Title | METHODS AND DEVICES FOR DETECTING STRUCTURAL CHANGES IN A MOLECULE MEASURING ELECTROCHEMICAL IMPEDANCE |
| Description | The invention relates to a method of detecting a structural change in a molecule, said molecule being attached to a surface, said surface being electrically conductive, wherein the phase of the electrochemical impedance at said surface is monitored, and wherein a change in the phase in the electrochemical impedance at said surface indicates a change in the structure of said molecule. The invention further relates to methods for making arrays having molecules such as, polypeptides attached to electrically conductive surfaces such as electrodes, and to arrays. |
| IP Reference | WO2008032066 |
| Protection | Patent application published |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | This IP should support a spin-out company (Phase DX) in the near future. |
| Title | Method and apparatus for manipulating particles (DEP-SAW) |
| Description | This invention relates to a method and apparatus for manipulating particles. The patent has not been published yet so may still be confidential. |
| IP Reference | |
| Protection | Copyrighted (e.g. software) |
| Year Protection Granted | 2013 |
| Licensed | No |
| Impact | The manipulation of particles finds application in a wide range of fields, many of which are medical in nature. |
| Title | NETWORKS |
| Description | There is described a material comprising ribbons, fibrils or fibres characterised in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a beta-sheet tape-like substructure. |
| IP Reference | WO2004007532 |
| Protection | Patent granted |
| Year Protection Granted | 2004 |
| Licensed | Yes |
| Impact | A spin-out company (Credentis AG). |
| Title | On-chip spectroscopy system |
| Description | This IP has not been patented and may still be confidential. |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No notable impacts as yet. |
| Title | Orthopaedic medical device |
| Description | A UK priority patent filing has been made but not yet published. The invention relates to an orthopaedic medical device, in particular an arthroscopic aid, for stimulating the release of cells and/or encouraging migration of cells to a surgical site. |
| IP Reference | |
| Protection | Copyrighted (e.g. software) |
| Year Protection Granted | 2014 |
| Licensed | No |
| Impact | A first in man clinical trial is being planned. |
| Title | PREPARATION OF TISSUE FOR MENISCAL IMPLANTATION |
| Description | The present invention relates to a method of preparing a tissue matrix and its subsequent use in the replacement and/or repair of a damaged or defective meniscus. The invention also provides meniscal tissue that is substantially decellularised. |
| IP Reference | WO2008059244 |
| Protection | Patent granted |
| Year Protection Granted | 2008 |
| Licensed | Yes |
| Impact | This IP has supported a spin-out (Tissue Regenix) and its development of products. It is one of the four patents licensed to Tissue Regenix. |
| Title | Regional anaesthetic delivery system |
| Description | Unpatented know-how on a regional anaesthetic delivery system. |
| IP Reference | |
| Protection | Copyrighted (e.g. software) |
| Year Protection Granted | 2013 |
| Licensed | No |
| Impact | Confidentiality agreements in place with various potential partners but no notable impacts yet. |
| Title | SCAFFOLD PROTEINS DERIVED FROM PLANT CYSTATINS |
| Description | The present invention relates to scaffold proteins derived from plant cystatins and to nucleic acids encoding them. The scaffolds are highly stable and have the ability to display peptides. The scaffolds are particularly well suited for constructing libraries, e.g. in phage display or related systems. The invention also related to various uses of the scaffolds, including in therapy, diagnosis, environmental and security monitoring, synthetic biology and research, and to cells and cell cultures expressing the scaffold proteins. |
| IP Reference | WO2014125290 |
| Protection | Patent application published |
| Year Protection Granted | 2014 |
| Licensed | Yes |
| Impact | This IP was exclusively licensed to Avacta Life Sciences Ltd in the field of life sciences research reagents and diagnostics. Avacta pay royalties based on the University providing a screening service to Avacta and also for catalogue sales. |
| Title | SURGICAL RETRACTION DEVICE AND PROCEDURE |
| Description | The present invention provides a retraction device comprising, a shaft, a plurality of arms supported by the shaft, the arms being configured to be moveable between a first orientation in which the device assumes an insertion profile for passage of the device through a surgical incision, and a second orientation in which the device assumes a retraction profile. At least one of the plurality of the arms is adapted to be adjustable between a first length and a second length. |
| IP Reference | WO2017134415 |
| Protection | Patent application published |
| Year Protection Granted | 2017 |
| Licensed | No |
| Impact | Two companies are potentially interested in using this IP. |
| Title | Tissue sensors for medical diagnosis |
| Description | Optical sensors for the diagnosis of a range of medical conditions. |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2012 |
| Licensed | No |
| Impact | A licence, with revenue sharing provisions, with another University. |
| Title | ULTRASONIC MODIFICATION OF SOFT TISSUE MATRICES |
| Description | The present invention provides a method of, and apparatus for, utilising ultrasonic energy so as to mechanically disrupt the collagenous architecture of biological matrices in a controlled manner so that the tissue can be rapidly recellularised in continuous form. The present invention also provides for the production of tissue matrices with improved recellularisation properties, cell stratification or patterning. |
| IP Reference | WO2004103461 |
| Protection | Patent granted |
| Year Protection Granted | 2004 |
| Licensed | Yes |
| Impact | This IP is used in various of our Proof of Concept projects. It has also supported a spin-out company, and a portfolio of products is under development by them. |
| Title | VIRTUAL MICROSCOPY |
| Description | Computer implemented methods and data processing apparatus are described for displaying virtual slide images. Images of a plurality of slides are automatically displayed in a first region of a display device at a first magnification. The slides comprise all the slides including material from a same specimen. An image of at least one of the slides is displayed in a second region at a second magnification greater than the first magnification. At least the image displayed in the second region is changed responsive to receiving user input. Methods for automatically determining a slide layout pattern and methods for virtually melding glass slide images into a single image are also described. |
| IP Reference | US2012320094 |
| Protection | Patent application published |
| Year Protection Granted | 2012 |
| Licensed | No |
| Impact | IP portfolio assigned to Roche (Ventana Medical Systems) as part of asset sale of technology, deal completed July 2015. EP and GB patents still pending. US patent granted. |
| Title | Visual parameter optimisation software |
| Description | Software and an algorithm for use with image analysis/process engineering. |
| IP Reference | |
| Protection | Copyrighted (e.g. software) |
| Year Protection Granted | 2013 |
| Licensed | No |
| Impact | This software was developed for the optimization of image processing algorithms. Today, this is done in a time-consuming way that relies on trial-and-error. Our software enables users to make better choices of parameter values, to do so faster, and to better understand the influence of the parameters on image processing. The software is applicable to image processing, in general, although our research has focussed on applications in biomedical research. |
| Title | Antimicrobial self-assembling peptide for treatment of periodontitis |
| Description | Work carried out to date aims to demonstrate the efficacy of drug delivery via a biomimetic regenerative scaffold. Preliminary data suggests that the scaffold is able to deliver an antimicrobial in a controlled manner, work is ongoing to assess if this delivery method is viable in order to control the microbial load of a established biofilm. With this test data (and depending on results) we intend on taking this through to a clinical trial. This work has further demonstrated efficacy of drug delivery via a biomimetic regenerative scaffold. Our industrial partners have used this information and have been developing novel Encapsulating moieties to try to incorporate into the peptide scaffold. It is intended to gain funding form our partners to test this in the model developed. We still intend (on completion of this work) on taking this device into clinical trials |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Refinement. Non-clinical |
| Year Development Stage Completed | 2019 |
| Development Status | Under active development/distribution |
| Impact | The device will allow general dentists to manage periodontal disease without the need to refer patients to a clinical specialist |
| Title | Arthroscopic device for stimulating synovial mesenchymal stem cells in the knee |
| Description | The arthroscopic device is currently (as of Jan 2017) in a small scale clinical evaluation study at Leeds Teaching Hospitals funded through NIHR funded Leeds Musculoskeletal Biomedical Research Unit, led and managed by Prof Dennis McGonagle, Dr Tom Baboolal with Consultant Mr Owen Wall. |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Early clinical assessment |
| Year Development Stage Completed | 2017 |
| Development Status | Actively seeking support |
| Impact | IKC funded Proof of Concept (POC) Project supported early development of the new medical device. This supported device design and testing, prototype manufacture and subsequent manufacture of devices for use in the clinical evaluation. The POC also supported generation of data used in patent filing. |
| Title | Decelularised dermis |
| Description | Decellularised dermal allograft developed by University of Leeds in collaboration with NHS Blood & Transplant Tissue Services now subject to independent randomised interventional treatment study in patients with diabetic foot ulcers |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Early clinical assessment |
| Year Development Stage Completed | 2015 |
| Development Status | Under active development/distribution |
| Clinical Trial? | Yes |
| Impact | Too early to describe impacts |
| URL | http://www.isrctn.com/ISRCTN64926597 |
| Title | ISO accredited simulation test laboratory |
| Description | ISO accredited simulation test laboratory for pre clinical testing and trials widely used by customers around globe |
| Type | Support Tool - For Medical Intervention |
| Current Stage Of Development | Wide-scale adoption |
| Year Development Stage Completed | 2013 |
| Development Status | Under active development/distribution |
| Impact | uptake by wide range of companies |
| Title | acellular bone |
| Description | under development and in in vivo trials |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Refinement. Non-clinical |
| Year Development Stage Completed | 2014 |
| Development Status | Under active development/distribution |
| Impact | under development and in animal trials |
| Title | acellular bone cartilage osteochondral graft |
| Description | under development |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2014 |
| Development Status | Under active development/distribution |
| Impact | under developemnt |
| Title | acellular bone cartilage osteochondral graft |
| Description | under development NHSBT |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2015 |
| Development Status | Under active development/distribution |
| Impact | under development |
| Title | acellular bone patellar bone graft |
| Description | under development by NHSBT |
| Type | Therapeutic Intervention - Surgery |
| Current Stage Of Development | Refinement. Non-clinical |
| Year Development Stage Completed | 2014 |
| Development Status | Under active development/distribution |
| Impact | under development by NHSBT |
| Title | acellular dcell vascular patch |
| Description | licensed to and commercialised by Tissue Regenix |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Small-scale adoption |
| Year Development Stage Completed | 2010 |
| Development Status | Under active development/distribution |
| Clinical Trial? | Yes |
| Impact | First dcell clinical product |
| URL | https://clinicaltrials.gov/show/NCT00958230 |
| Title | acellular dcell dermis |
| Description | commercialised by Tissue regenix from 2014 |
| Type | Therapeutic Intervention - Medical Devices |
| Year Development Stage Completed | 2014 |
| Development Status | Under active development/distribution |
| Impact | sold and distributed in USA |
| Title | acellular dermis |
| Description | supplied as clinical product by NHSBT |
| Type | Therapeutic Intervention - Surgery |
| Current Stage Of Development | Small-scale adoption |
| Year Development Stage Completed | 2014 |
| Development Status | Under active development/distribution |
| Impact | supplied by NHSBT, improved wound healing in chronic leg ulcers |
| Title | acellular heart valve |
| Description | clinical application through human tissue bank |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Small-scale adoption |
| Year Development Stage Completed | 2010 |
| Development Status | Under active development/distribution |
| Impact | proof of clinical use acellular technology |
| Title | acellular vascular graft |
| Description | under development by NHSBT and Tissue Regenix |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Refinement. Non-clinical |
| Year Development Stage Completed | 2014 |
| Development Status | Under active development/distribution |
| Impact | Under development by NHSBT an dTissue Regenix |
| Title | all polymer knee |
| Description | collaborative development with Invibio |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2015 |
| Development Status | Under active development/distribution |
| Impact | collaborative development with Invibio |
| Title | ceramic on ceramic hip |
| Description | Mathys |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Market authorisation |
| Year Development Stage Completed | 2012 |
| Development Status | Under active development/distribution |
| Impact | successfully adopted an d commercilised |
| Title | ceramic on ceramic and ceramic on metal hip |
| Description | commercialised by DePuy and by Mathys |
| Type | Therapeutic Intervention - Medical Devices |
| Year Development Stage Completed | 2015 |
| Development Status | Under active development/distribution |
| Impact | successfully adopted an d commercilised |
| Title | dcell ligament |
| Description | Under commercial development by tissue Regenix, progressing to CE mark and product launch |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Refinement. Non-clinical |
| Year Development Stage Completed | 2014 |
| Development Status | Under active development/distribution |
| Clinical Trial? | Yes |
| Impact | under commercial development by Tissue Regenix in clinical trial started 2015 proceeding to Ce mark and product launch 2017 |
| URL | https://clinicaltrials.gov/show/NCT02540811 |
| Title | dcell meniscus |
| Description | Developed by tissue Regenix In clinical trial started 2015 |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Late clinical evaluation |
| Year Development Stage Completed | 2014 |
| Development Status | Under active development/distribution |
| Clinical Trial? | Yes |
| Impact | first in man clinical trial started 2015 |
| URL | https://clinicaltrials.gov/show/NCT02270905 |
| Title | finite element simulation tools to capture patient variation for the analysis of orthopaedic devices across a patient cohort |
| Description | This project has been led by Dr Ruth Wilcox in partnership with Simpleware Limited. The development of the software add-on has been completed and the final validations with the Leeds data set-set are coming to an end. It is anticipated that a technology demonstrator project will now be undertaken with a company that can demonstrate the utility of the software for evaluating spinal implants. The commercial team is now engaged and discussions with Simpleware around a possible license deal are on-going. It is envisaged that as part of this license deal Simpleware will engage Leeds expertise as part of their offer to companies. In addition Leeds personnel will retain the right to undertake consultancy in their own capacity. |
| Type Of Technology | Software |
| Year Produced | 2013 |
| Impact | further research |
| Title | hip joint simulator |
| Description | hip joint simulator |
| Type Of Technology | Physical Model/Kit |
| Year Produced | 2012 |
| Impact | commercial product Simulation solutions |
| Title | knee joint simulator |
| Description | knee joint simulator |
| Type Of Technology | Physical Model/Kit |
| Year Produced | 2013 |
| Impact | Commercial product simulation solutions |
| Title | natural hip simulator |
| Description | natural hip simulator |
| Type Of Technology | Physical Model/Kit |
| Year Produced | 2014 |
| Impact | commercial product simulation solutions |
| Title | natural knee simulator |
| Description | natural knee simulator |
| Type Of Technology | Physical Model/Kit |
| Year Produced | 2013 |
| Impact | commercialised by simulation solutions |
| Title | spinal disc simulator |
| Description | spinal disc simulator |
| Type Of Technology | Physical Model/Kit |
| Year Produced | 2010 |
| Impact | commercial product simulation solutions |
| Company Name | Creavo Medical Technologies Ltd (formerly Quantum Imaging) |
| Description | Creavo Medical Technologies Ltd is a UK-based, privately held medical device company engaged in the development of innovative imaging technologies. The company was formed to commercialise sensor technology developed by Professor Ben Varcoe, Chair of Quantum Information Science at Leeds University and has facilities in Leeds and in Warwickshire UK. The first application of this technology will be to aid the rapid triage and identification of patients presenting to Emergency Departments with chest pain, but who ultimately have no cardiac related diagnosis. Identifying these patients early enables them to leave expensive cardiac diagnostic pathways so releasing resources to focus on other acute patients. Creavo Medical Technologies has an experienced management team, with a mix of fundamental research, medical device commercialisation, manufacturing and global regulatory and clinical strategy. |
| Year Established | 2014 |
| Impact | A new cardiac scanning device that could save the NHS £200 million a year is being trialled at four of the UK's largest emergency departments (Bristol, Nottingham, Leicester and Sheffield). The British-made Vitalscan device, which has been developed by Creavo Medical Technologies and could revolutionise the way patients with chest pain are managed in emergency departments, works by conducting a non-invasive three to five-minute scan at a patient's bedside to rule out significant cardiac conditions, such as heart attacks. Data from the York Health Economics Consortium shows that 1.3 million A&E admissions in 2014/15 were due to chest pain. Of these, 63% ultimately had no cardiac-related condition but, the majority would still have gone through the same costly cardiac triage process of someone having a heart attack. Vitalscan has the potential to identify a significant proportion of these patients which would radically change the management of chest pain patients entering emergency departments. Conservative estimates indicate that the device could save the NHS £200 million a year, the equivalent of £3.85 million a week and £382 a minute, easing pressure on bed space in A&E departments and reducing patient anxiety by getting patients to the correct treatment more quickly. Steve Parker, CEO Creavo Medical Technologies says: "Cardiac-related chest pain is one of the biggest issues facing emergency departments in the western world due to the economic burden it places on healthcare services and the disruption it causes to inpatient care. "The triage process for someone entering an emergency department with chest pain can take anywhere from six to 24 hours which places a huge amount of strain on resources. "Early results from smaller sets of clinical trials indicate that Vitalscan can quickly identify and rule out significant ischemic heart disease so it prevents patients who aren't suffering from a cardiac-related condition from having to go through the lengthy, costly chest pain triage process, easing the burden on emergency departments at a time when they are facing unprecedented pressures." Creavo Medical Technologies was established to commercialise the work undertaken by Professor Ben Varcoe at the University of Leeds to develop Vitalscan, a portable, passive magnetocardiography device that measures the electromagnetic fluctuations of the heart, while maintaining the accuracy and efficacy of older SQUID devices. The start of clinical trials at Sheffield Teaching Hospitals NHS Foundation Trust, University Hospitals of Leicester NHS Trust, North Bristol NHS Trust and Nottingham University Hospitals NHS Trust marks the largest ever clinical trial of a magnetocardiography device. This will be followed by a second stage starting at three centres in the United States at Mayo Clinic Rochester, Cincinnati and Baylor Texas. |
| Website | http://creavomedtech.com/ |
| Company Name | Tissue Regenix |
| Description | Developemnt and manufacture of Regenerative Biological Scaffolds for tissue repair in vascular, cardiovascular and musculoskeletal systems |
| Year Established | 2007 |
| Impact | aim listed d raised £0m investment value £150m 4 clinical products |
| Company Name | Relitect Ltd |
| Description | Relitect Ltd are developing a novel technology for the detection of binding events, which can be used for the analysis of proteins, small molecules and nucleic acids. The Relitect proprietary technology enables highly sensitive detection of biomarkers or other analytes in a label free multiplexed format, using small sample volumes. Relitect's approach has potential for utilisation across the clinical diagnostics and life sciences industries. |
| Year Established | 2014 |
| Impact | March 2015 - Relitect secured a £750K tranched investment from IP Group Plc and Scottish Enterprise's investment arm, the Scottish Investment Bank to develop its novel high sensitivity diagnostic/science technology. 20th April 2015 - Relitect moves to new laboratory facilities at Biocity Scotland -www.biocity.co.uk/biocity/scotland |
| Website | http://www.relitect.com/ |
| Description | Bridging the gap in translating regenerative therapies |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | An article on the POC funding available to the N8 universities to progress projects with significant commercial potential. Proof of Concept projects were funded. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Could Regenerative Medicine help heal UK economy? |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | BBC Online featured the story on Eileen Ingham's spin out company, Tissue Regenix: The regenerative medicine industry has "huge potential" to boost the UK economy, the managing director of Tissue Regenix has said. Antony Odell told the BBC's Hugh Pym that the research expertise of the UK has "enormous" potential to create jobs and revenue. Initiated interest in the University of Leeds and the Medical Technologies IKC |
| Year(s) Of Engagement Activity | 2012 |
| Description | Healthcare Innovation Expo, ExCel London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Europe's largest, most exciting healthcare innovation event 13th & 14th March 2013. The IKC hosted an exhibition stand at the event to connect to potential clinical partners. Initiated new contacts and potential collaborations. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Innovate 13, Business Design Centre, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The UK's leading multi-sector innovation & trade event for business. The IKC exhibited at this event. Initiated new contacts and potential new collaborations |
| Year(s) Of Engagement Activity | 2013 |
| Description | Interviews on academic/industry collaboration |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | A series of video interviews were created with representatives from partner companies and funders that raises the profile of the benefits of industry/academia collaboration. Initiated interest in the University of Leeds and the Medical Technologies IKC |
| Year(s) Of Engagement Activity | 2012 |
| Description | Professor John Fisher appointed to Board of Marketing Leeds |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Deputy Vice-Chancellor and IKC Academic Director, Professor John Fisher, has been appointed as a non-executive director of Marketing Leeds. In a major move to refocus and provide strategic leadership to Marketing Leeds as it moves forward with a broader role to attract inward investment and tourism, it has announced the appointment of nine Non-Executive Directors. The Board will oversee a series of programmes and initiatives as Marketing Leeds widens its focus to drive economic growth in the city and ensure Leeds achieves its ambition to be the best city in the UK. Professor John Fisher will represent the University and its key capabilities of innovation and collaboration with industry, aligning well with the Medical Technologies IKC mission to bring together businesses and our world-class experts to accelerate the commercial development of new products and services. The new Board members commenced their role with immediate effect. . Awarding Body - Leeds and Partners, Name of Scheme - Non-executive Board of Directors Initiated interest in the University of Leeds and the Medical Technologies IKC |
| Year(s) Of Engagement Activity | 2012 |
| Description | Regen Med Nears the Market |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Article published by Genetic Engineering and Biotechnology news about the IKC and Regener8. Increased number of people visiting website. |
| Year(s) Of Engagement Activity | 2012 |
| Description | United States link up could pay off for medical park plans - Yorkshire Post |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The work led by Ceri Williams of the IKC is included in this write up in the Yorkshire Post around inward investment to Leeds from the USA. Initiated interest in the Medical Technologies IKC |
| Year(s) Of Engagement Activity | 2013 |
| Description | University Spin-outs - Yorkshire Post |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | An article on the regions most successful university spin-outs featuring Tissue Regenix. Initiated interest in the University of Leeds and Medical Technologies IKC |
| Year(s) Of Engagement Activity | 2013 |
| Description | University helps improve medical devices - Yorkshire Post |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Story on the output of project POC018 - Electromechanical hip simulator method SOP (standard operating procedure) and training. The story covered how the research and project is helping improve safety in medical devices in China. Initiated new contacts and interest in the Medical Technologies IKC |
| Year(s) Of Engagement Activity | 2013 |
| Description | Who wants to live forever? |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | ITV Tonight Programme, aired 7:30pm, Thursday 5 July 2012. A look at how thousands are now celebrating their one hundredth birthday. John Fisher and Eileen Ingham present their research around "50 Active years after 50" as part of the programme. Initiated interest in the University of Leeds and the Medical Technologies IKC |
| Year(s) Of Engagement Activity | 2012 |