Synthesis and Characterisation of Dual Functional Nanoparticles for Probing the Role of Reactive Oxygen Species in Cellular Function
Lead Research Organisation:
University of Nottingham
Department Name: Sch of Pharmacy
Abstract
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Organisations
Publications
Chauhan V
(2016)
Quadruple labelled dual oxygen and pH-sensitive ratiometric nanosensors
in Sensing and Bio-Sensing Research
Giuntini F
(2014)
Conjugatable water-soluble Pt(II) and Pd(II) porphyrin complexes: novel nano- and molecular probes for optical oxygen tension measurement in tissue engineering.
in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
Giuntini F
(2012)
Orthogonally bifunctionalised polyacrylamide nanoparticles: a support for the assembly of multifunctional nanodevices.
in Nanoscale
| Description | Nanoparticles capable of generating reactive oxygen species (ROS) were synthesised and delivered to mesenchymal stem cells. By modulating the amount of photo-sensitiser on the surface of the nanoparticles or the duration or power of the excitation light the amount of ROS generated could be controlled. We were able to show that different amounts of ROS induced differing cellular responses. |
| Exploitation Route | The technology developed will be useful in better understanding disease progression under conditions of oxidative stress. |
| Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | The findings have not been used as yet, other than as preliminary data to attract collaborators to investigate disease related phenomena. |
| First Year Of Impact | 2013 |
| Sector | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Societal |