Enzyme-responsive Microgels
Lead Research Organisation:
University of Strathclyde
Department Name: Pure and Applied Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Rein Ulijn (Principal Investigator) |
Publications
McCann J
(2014)
Effects of crosslinker on the morphology and properties of microgels containing N-vinylformamide, glycidylmethacrylate and vinylamine.
in Journal of colloid and interface science
Kalafatovic D
(2015)
MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin.
in Biomaterials science
Kalafatovic D
(2016)
MMP-9 triggered self-assembly of doxorubicin nanofiber depots halts tumor growth
in Biomaterials
Thaiboonrod S
(2013)
Poly(vinylamine) microgels: pH-responsive particles with high primary amine contents
in Soft Matter
| Description | - developed a range of new micro gels with amine functionality. - developed enzyme responsive peptide particles for controlled release |
| Exploitation Route | The enzyme-responsive systems were developed further as potential anti-cancer therapeutics. These were tested in vitro and in vivo at the Beatson Institute in Glasgow. |
| Sectors | Healthcare |
| Description | Beatson |
| Organisation | Beatson Institute for Cancer Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaborated with Dr Kurt Anderson to test peptide nano structures as therapeutic delivery systems. |
| Collaborator Contribution | In vivo and in vitro testing of peptide nano structures as therapeutic delivery systems in breast cancer models. |
| Impact | publication in Biomaterials Science. Further publication under review (March 2016) |
| Start Year | 2013 |
| Description | Joint research with University of Manchester |
| Organisation | University of Manchester |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | University of Strathclyde researchers worked on this project with researchers from University of Manchester |
| Start Year | 2011 |