Innovation and Knowledge Centre Regenerative Therapies and Devices Tranche 1 IKC RTD
Lead Research Organisation:
University of Leeds
Department Name: Mechanical Engineering
Abstract
The Innovation and Knowledge Centre in Regenerative Therapies and Devices will provide a sustainable platform to address the creation of new technologies in Regenerative Therapies and Devices. It will promote their accelerated adoption, with increased reliability, within a complex global marketplace with increasing cost constraints. Therapies and devices which facilitate the regeneration of body tissues offer the potential to revolutionise healthcare and be a catalyst for economic growth, creating a new business sector within healthcare technology. The IKC RTD will build upon the culture and research landscape of the University and its partners (industry, NHS and intermediaries/users) through the development of new innovation infrastructure and practices which deliver major clinical, health and industry outcomes.In the first year of operation the IKC has:1. Recruited and established a core innovation team to manage and grow the activities of the IKC.2. Established academic supply chain, new centre with 160 researchers.3. Won 50m new research income, funding over 120 research projects.4. Defined a new strategic framework for innovation.5. Established an innovation pipeline with stage gates and criteria for progression.6. Defined and developed the IP portfolio through definition of the unique capabilities.7. Established a pipeline of 63 collaborative innovation projects.8. Engaged with 26 different companies in collaborative innovation projects.9. Established a wider network of 80 plus companies.10. Contributed to nine new products that have reached the market.11. Defined a model for sustainability of IKC RTD.12. Received significant national and global recognition through political visits and extensive media coverage for research and innovation.
Planned Impact
IKC will develop and deliver innovation from fundamental research in regenerative therapies and devices and in broader aspects of medical technolgies. We are curently providing knowledge, unique capabilites and intelellctual assts to 26 companies through 63 collaborative projects, 14 of these companies are new collaborators since the stat of the IKC. Tranche one funding will allow us to substantially increase the innovation management capacity ans support, the number of proof of concept projects to advance fundamental research findings through assessed technology solutions , making them raady for product development and investment with reduced risk. Additionally IKC will support a smaller numbe rof larger scale collaborative R and D programmes. IKC will deliver highly skilled multidisciplinary scientists and engineers to industry, with enhanced innovation skills and experience in medical technology innovation. As a national centre of excelence in regenerative medicine and therapies, IKC will act as centre of excellence for both knowledge, IP, unique capabilites and intellectual assets, supplyin gindustry directly and where appropriate acting o signpost needs to other acadmeic institutions and collaborators. IKC will directly address clinical needs and provide a supportive environment for tripartite academic, clincial and industry interactions. IKC will address broader societal needs through delivery of emergent healthcare technology solutions to the ageing population and will raise the profielof successful science and innovation to society at large.
Organisations
- University of Leeds (Lead Research Organisation)
- Biotechnology and Biological Sciences Research Council (Co-funder)
- Simpleware Ltd (Collaboration)
- Neotherix Ltd (Collaboration)
- Simulation Solutions (Collaboration)
- Biocomposites (Collaboration)
- JRI Orthapaedics (Collaboration)
- Depuy International (Collaboration)
- Avacta Group (Collaboration)
- Neu Biomechanics (Collaboration)
- Credentis (Collaboration)
- Corin Group PLC (Collaboration)
- Tissue Regenix Ltd (Collaboration)
- Mathys (Collaboration)
- North American Science Associates Inc (Collaboration)
- Invibio (Collaboration)
- Vascutek Ltd (Collaboration)
- Corline (Collaboration)
- Surgical Innovations (Collaboration)
- NHS Blood and Transplant (NHSBT) (Collaboration)
- NHS Blood and Transplant (Project Partner)
- Tissue Regenix PLC (Project Partner)
- Simulation Solutions (United Kingdom) (Project Partner)
- DePuy Synthes (International) (Project Partner)
Publications
Maude S
(2013)
Biomimetic self-assembling peptides as scaffolds for soft tissue engineering.
in Nanomedicine (London, England)
Fermor HL
(2015)
Biological, biochemical and biomechanical characterisation of articular cartilage from the porcine, bovine and ovine hip and knee.
in Bio-medical materials and engineering
Behl B
(2013)
Biological effects of cobalt-chromium nanoparticles and ions on dural fibroblasts and dural epithelial cells
in Biomaterials
Papageorgiou I
(2014)
Biological Effects of Clinically Relevant CoCr Nanoparticles in the Dura Mater: An Organ Culture Study.
in Nanomaterials (Basel, Switzerland)
Ellison P
(2012)
Biological activity of polyethylene wear debris produced in the patellofemoral joint.
in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Fisher J
(2011)
Bioengineering reasons for the failure of metal-on-metal hip prostheses: an engineer's perspective.
in The Journal of bone and joint surgery. British volume
Elnikety S
(2016)
Augmentation and repair of tendons using demineralised cortical bone.
in BMC musculoskeletal disorders
Brockett C
(2011)
Assessment of Squeaking in Total Hip Replacements
in Seminars in Arthroplasty
Aldridge A
(2013)
Assay validation for the assessment of adipogenesis of multipotential stromal cells--a direct comparison of four different methods.
in Cytotherapy
Thangarajah T
(2018)
Application of a Demineralized Cortical Bone Matrix and Bone Marrow-Derived Mesenchymal Stem Cells in a Model of Chronic Rotator Cuff Degeneration.
in The American journal of sports medicine
Mengoni M
(2015)
An enhanced version of a bone-remodelling model based on the continuum damage mechanics theory.
in Computer methods in biomechanics and biomedical engineering
Ghasemi-Roudsari S
(2018)
A portable prototype magnetometer to differentiate ischemic and non-ischemic heart disease in patients with chest pain.
in PloS one
Liu F
(2011)
A new formulation for the prediction of polyethylene wear in artificial hip joints.
in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Abdelgaied A
(2017)
A comparison between electromechanical and pneumatic-controlled knee simulators for the investigation of wear of total knee replacements.
in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Fisher J
(2012)
(v) Simulation and measurement of wear in metal-on-metal bearings in vitro- understanding the reasons for increased wear.
in Orthopaedics and trauma
Jennings LM
(2012)
(iv) Enhancing the safety and reliability of joint replacement implants.
in Orthopaedics and trauma
| Description | High quality research and innovation platform £95m new research income Established academic supply chain and translational capability across 250 researchers Active collaborations and technology validation with 9 UK HEIs, 18 academic and clinical partners New Medical Technologies building and a new post of Director of Innovation in Medical Technologies Successful sustainable innovation Defined robust sustainability model Strategically identified and prioritised key market sectors that offer significant opportunity Developed a culture of innovation across academic, industry and clinical partnerships Sharing innovation good practice with 9 UK HEIs and other innovation hubs at Leeds 166 collaborative projects, 66 industry co-investors Established profile and reputation Robust brand identity and reach across the UK and beyond through targeted marketing and communications Strategic alignment with Regener8 giving access to a 240 industry members, 328 academics and 21 clinicians across UK High profile events with national partners to engage the community in issues that impact on medical and regenerative technology innovation. Significant political visits and media coverage Successful innovation and translation Established Innovation system, pipeline, stage gates and criteria for progression Defined IP portfolio and directly funded 42 Proof of Concept and 6 Co-Development projects Pipeline of 166 collaborative innovation projects with industry, of which 48 directly IKC funded Contributed to the development of 46 new products that have reached the market. Generated £57m investment in private sector partners for development of our IP/technology and a further £30m plus investment in private sector for development arising out of collaborative projects |
| Exploitation Route | Exploitation and commercialisation by our industry partners |
| Sectors | Healthcare |
| URL | http://www.medical-technologies.co.uk |
| Description | High quality research and innovation platform £95m new research income Established academic supply chain and translational capability across 250 researchers Active collaborations and technology validation with 9 UK HEIs, 18 academic and clinical partners New Medical Technologies building and a new post of Director of Innovation in Medical Technologies Successful sustainable innovation Defined robust sustainability model Strategically identified and prioritised key market sectors that offer significant opportunity Developed a culture of innovation across academic, industry and clinical partnerships Sharing innovation good practice with 9 UK HEIs and other innovation hubs at Leeds 166 collaborative projects, 66 industry co-investors Established profile and reputation Robust brand identity and reach across the UK and beyond through targeted marketing and communications Strategic alignment with Regener8 giving access to a 240 industry members, 328 academics and 21 clinicians across UK High profile events with national partners to engage the community in issues that impact on medical and regenerative technology innovation. Significant political visits and media coverage Successful innovation and translation Established Innovation system, pipeline, stage gates and criteria for progression Defined IP portfolio and directly funded 42 Proof of Concept and 6 Co-Development projects Pipeline of 166 collaborative innovation projects with industry, of which 48 directly IKC funded Contributed to the development of 46 new products that have reached the market. Generated £57m investment in private sector partners for development of our IP/technology and a further £30m plus investment in private sector for development arising out of collaborative projects |
| First Year Of Impact | 2011 |
| Sector | Healthcare |
| Impact Types | Societal |
| Description | international standards committee chair |
| Geographic Reach | Asia |
| Policy Influence Type | Membership of a guideline committee |
| Impact | international pre clinical testing standards |
| Description | Biocomposites |
| Amount | £200,000 (GBP) |
| Funding ID | LMJ |
| Organisation | Biocomposites |
| Sector | Private |
| Country | United Kingdom |
| Start | 01/2013 |
| End | 01/2016 |
| Description | Biomedical research unit |
| Amount | £6,000,000 (GBP) |
| Funding ID | Leeds musculoskeletal biomedical research unit |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2014 |
| End | 03/2017 |
| Description | British Heart Foundation Research Grant |
| Amount | £798,506 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | CDT 2014-22 |
| Amount | £4,000,000 (GBP) |
| Funding ID | CDT TERM |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2014 |
| End | 09/2022 |
| Description | Capital equipment CDT |
| Amount | £240,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2015 |
| End | 04/2019 |
| Description | Capital equipment hip and knee simulators |
| Amount | £920,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2015 |
| End | 04/2020 |
| Description | Catalyst Medical Technologies |
| Amount | £3,000,000 (GBP) |
| Organisation | Higher Education Funding Council for England |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2015 |
| End | 10/2018 |
| Description | China-UK Researcher Links Workshop on Healthcare Technologies (Dec 6-8th 2016). Sichuan Province, Chengdu, China. Travel fellowship - PI - (Newton Fund via Bradford Uni) |
| Amount | £1,800 (GBP) |
| Organisation | University of Bradford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 12/2016 |
| End | 12/2016 |
| Description | DTC 208-2017 |
| Amount | £7,000,000 (GBP) |
| Funding ID | DTC |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2008 |
| End | 09/2017 |
| Description | Development of Prototype Device for Minimally Invasive Delivery of Osteospheres for Treatment of Osteoporosis (MIDOs) |
| Amount | £1,100,509 (GBP) |
| Funding ID | II-C3-0714-20001 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 01/2018 |
| Description | EPSRC IAA (Impact Accelerator Account) - EP/K503800/1: Regenerating Bone Tissue in Osteoporotic Patients Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells. |
| Amount | £70,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | EPSRC IAA Feasibility Study Award (Steve Russell - Collagen wound dressing) |
| Amount | £10,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | EPSRC cartilage programme |
| Amount | £4,600,000 (GBP) |
| Funding ID | EPG01121721 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2009 |
| End | 06/2015 |
| Description | European Research Council advanced award |
| Amount | £2,000,000 (GBP) |
| Funding ID | Proposal 267114 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 04/2011 |
| End | 04/2016 |
| Description | Industry Biocomposites |
| Amount | £150,000 (GBP) |
| Organisation | Biocomposites |
| Sector | Private |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 07/2016 |
| Description | Industry Invibio |
| Amount | £300,000 (GBP) |
| Organisation | Invibio |
| Sector | Private |
| Country | United Kingdom |
| Start | 10/2015 |
| End | 10/2017 |
| Description | Mecical technologies Innovation and Knowledge Centre Phase 2 Regenerative Devices |
| Amount | £4,000,000 (GBP) |
| Funding ID | EP/N00941X/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 07/2020 |
| Description | Medcial engineering centre |
| Amount | £160,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 07/2019 |
| Description | Medical Research Council Confidence in Concept Award (Steve Russell - Collagen wound dressing) |
| Amount | £100,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Medical Technologies IKC Phase 2 Regenerative Devices |
| Amount | £3,000,000 (GBP) |
| Funding ID | EP/N00941X/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 06/2020 |
| Description | Medical engineering centre |
| Amount | £4,200,000 (GBP) |
| Funding ID | WELMEC |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2014 |
| End | 09/2015 |
| Description | NHSBT |
| Amount | £200,000 (GBP) |
| Funding ID | EI |
| Organisation | NHS Blood and Transplant (NHSBT) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2014 |
| End | 01/2017 |
| Description | NIHR Invention for Innovation (i4i) Programme (Pete Culmer IAP) |
| Amount | £445,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | NIHR related (II-C3-0714-20001 - Development of Prototype Device for minimally invasive delivery of osteospheres for Treatment of Osteoporosis |
| Amount | £1,200,000 (GBP) |
| Funding ID | II-C3-0714-20001 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2015 |
| End | 01/2018 |
| Description | ORUK studentship: Influencing Stem Cells down an Osteogenic Lineage via Release of Therapeutic Ions from Resorbable Porous Calcium Phosphate Microspheres |
| Amount | £74,000 (GBP) |
| Organisation | Orthopaedic Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Tissue regenix |
| Amount | £60,000 (GBP) |
| Funding ID | EI |
| Organisation | Tissue Regenix Ltd |
| Sector | Private |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 01/2018 |
| Description | invibio |
| Amount | £400,000 (GBP) |
| Funding ID | LMJ |
| Organisation | Invibio |
| Sector | Private |
| Country | United Kingdom |
| Start | 01/2014 |
| End | 12/2016 |
| Description | mathys |
| Amount | £400,000 (GBP) |
| Funding ID | LMJ |
| Organisation | Mathys |
| Sector | Private |
| Country | Switzerland |
| Start | 01/2014 |
| End | 01/2016 |
| Description | senior investigator |
| Amount | £100,000 (GBP) |
| Funding ID | LMBRU |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2014 |
| End | 04/2015 |
| Title | Hip Joint simulator |
| Description | In vitro simulator for artificial hip joints |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | Method commercialised by Simulation Solutions |
| Title | Knee joint simulator |
| Description | artificial knee joint simulator |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | Simulator and simulation method commercialised by simulation solution |
| Title | Natural knee simulator |
| Description | Simulation system for natural knee |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | Simulator commercially available, Simulation Solutions |
| Title | POC015 Methods for histological staining of sheep tissue |
| Description | This relates to new methods, specifically a whole battery of methods to stain sheep tissue were developed that were not available previously. |
| Type Of Material | Biological samples |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | New methods developed; whole battery of methods to stain sheep tissue were developed that were not available previously. These methods have been made available to the wider team and subsequent research projects. |
| Title | natural hip simulator |
| Description | Simulation system for natural hip |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | System commercially availa le from Simulation Solutions |
| Title | spine simulator |
| Description | Spinal disc simulator |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2012 |
| Provided To Others? | Yes |
| Impact | Commercialised by Simulation solutions |
| Title | Biomechanical and biotribological simulation model natural hip |
| Description | Biomechanical and biotribological model of natural hip |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | used in follow on research |
| Title | Biomechanical model of functional spinal unit |
| Description | model of functional spinal unit |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | used in follow on research |
| Title | Biotribological model naturala knee |
| Description | Biotribological model natural knee |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | Used in follow on research on regenerative devices |
| Title | Data associated with "Third body wear of UHMWPE-on-PEEK-OPTIMA™" |
| Description | The dataset contains material to supplement the paper "Third body wear of UHMWPE-on-PEEK-OPTIMA™" including: measurements of the surface topography of PEEK and cobalt chrome plates following third body damage simulation with particles of PMMA cement and wear factors of UHMWPE against PEEK and cobalt chrome plates damaged both with cement particles and scratched with a diamond stylus. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | http://archive.researchdata.leeds.ac.uk/658/ |
| Title | wear simulation model artificial hip |
| Description | wear simulation model artificial hip |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2010 |
| Provided To Others? | Yes |
| Impact | applied in industry contract research |
| Title | wear simulation model artificial knee |
| Description | wear simulation model artificial knee |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2012 |
| Provided To Others? | Yes |
| Impact | used in industry contract research |
| Description | Avacta |
| Organisation | Avacta Group |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Electronic Biomarker Detection (eTect); Use of spectroscopy for non-invasive phenotyping of stem cells; Use of di-electrophoresis for minimally manipulated stem cell enrichment. |
| Start Year | 2010 |
| Description | Biocomposites Ltd |
| Organisation | Biocomposites |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Calcium Phosphate Bone Void Filler - A Pin-on-Plate Study; Calcium Sulphate Bone Void Filler Comparison - A Pin-on-Plate Study |
| Collaborator Contribution | participate in research and publication |
| Impact | Publication |
| Start Year | 2014 |
| Description | Corin |
| Organisation | Corin Group PLC |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Metal on metal hip wear |
| Collaborator Contribution | materials |
| Impact | multidiciplinary |
| Start Year | 2009 |
| Description | Corline |
| Organisation | Corline |
| Country | Sweden |
| Sector | Private |
| PI Contribution | Heparin coated acellular vascular grafts |
| Start Year | 2011 |
| Description | Credentis |
| Organisation | Credentis |
| Country | Switzerland |
| Sector | Private |
| PI Contribution | Use of Self assembling peptide(SAP) technology for hard tissue engineering (dental applications) |
| Collaborator Contribution | materilas |
| Impact | Ip piublications |
| Start Year | 2014 |
| Description | DePuy |
| Organisation | Depuy International |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Thirty-three projects. |
| Collaborator Contribution | funds , materilas staff |
| Impact | publications |
| Start Year | 2013 |
| Description | Depuy International Ltd |
| Organisation | Depuy International |
| Country | United Kingdom |
| Sector | Private |
| Start Year | 2003 |
| Description | Invibio |
| Organisation | Invibio |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Four projects: PEEK low con knees; Investigation of biocompatibilty of PEEK wear debris; Investigation of PEEK as cervical disc bearing material; Low Cost Polymer Knee |
| Start Year | 2010 |
| Description | JRI |
| Organisation | JRI Orthapaedics |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Ceramic composite hip wear |
| Start Year | 2009 |
| Description | Mathys Medical |
| Organisation | Mathys |
| Country | Switzerland |
| Sector | Private |
| PI Contribution | Four projects including: Evaluation of potential ceramic matrix hips Ceramic matrix composite hip Wear of Experimental Ceramics in Total Hip Replacement - A Hip Joint Simulator Study (Mathys IV) Wear of Experimental Ceramics in Total Hip Replacement - A Hip Joint Simulator Study (Mathys V) |
| Collaborator Contribution | materials , research methods , analysis |
| Impact | papres |
| Start Year | 2013 |
| Description | NAMSA |
| Organisation | North American Science Associates Inc |
| Country | United States |
| Sector | Private |
| PI Contribution | In vivo testing of dCell bone to detremine osseointegration and biocompatibility |
| Collaborator Contribution | undertaking research work |
| Impact | pubication |
| Start Year | 2015 |
| Description | NHS NBTS |
| Organisation | NHS Blood and Transplant (NHSBT) |
| Department | National Blood Service |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | 8 projects in collaboration with NHS NBTS Acellular bone ligament graft (Human) Acellular bone meniscus bone graft (Human) Acellular OC graft (Human) Allo vascular graft Allo heart valve Biocompatibility of acellular allogeanic dermis Acellular allogeneic aorta Development of dCELL bone-patella-bone allograft for anterior cruciate ligament replacement |
| Collaborator Contribution | funds time |
| Impact | multidiciplinary |
| Start Year | 2010 |
| Description | National Blood Service |
| Organisation | NHS Blood and Transplant (NHSBT) |
| Department | National Blood Service |
| Country | United Kingdom |
| Sector | Public |
| Start Year | 2003 |
| Description | Neotherix |
| Organisation | Neotherix Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Repair of oral and peridontal defects using regenerative and antibacterial strategies delivered by a novel tissue scaffold vehicle Polymeric scaffolds functionalised for periodontal repair |
| Collaborator Contribution | materials |
| Impact | multidisciplinary |
| Start Year | 2015 |
| Description | Neu Biomechanics, BiteCiC |
| Organisation | Neu Biomechanics |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Evaluation of coating wear |
| Start Year | 2010 |
| Description | Simpleware |
| Organisation | Simpleware Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Development of finite element simulation tools to capture patient variation for the analysis of orthopaedic devices across a patient cohort |
| Collaborator Contribution | software |
| Impact | papers |
| Start Year | 2014 |
| Description | Simulation Solutions |
| Organisation | Simulation Solutions |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | 10 projects in collaboration with Simulation Solutions: High flex knee simulator Natural knee simulator Natural hip simulator Natural spine simulator Natural joint friction simulator knee joint simulator SOP for hip simulator SOP for knee simulator Natural Knee Simulation System Electro mechanical hip simulator method SOP and training |
| Collaborator Contribution | equipment development |
| Impact | publications |
| Start Year | 2014 |
| Description | Surgical Innovations |
| Organisation | Surgical Innovations |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | A total of 4 collaborations with Surgical Innovations A new Arthroscopic Port for use in Arthroscopic Surgery applications Arthroscopic Port Environment Test Cell Design improvements to existing laparoscopy scissors Intra-Abdominal Platform (IAP) development |
| Start Year | 2010 |
| Description | Tissue Regenix |
| Organisation | Tissue Regenix Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | A total of 12 projects collaborating with Tissue Regenix Acellular ligament graft (Animal) Acellular bone meniscus bone graft (Animal) Acellular OC graft (Animal) Xeno vascular patch Xeno heart valve Decellularised bladder Decellularised meniscus (see also 12b) Acellular porcine flexor tendon graft Development of the dCELL Partial Meniscus In vivo testing of dCell bone to determine osseointegration and biocompatibility In vivo evaluation of decellularised porcine pulmonary roots. Long Term Evaluation of an Acellular Bovine Arterial Graft in an Ovine Arteriovenous Access Model |
| Start Year | 2009 |
| Description | Vascutec |
| Organisation | Vascutek Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Heart valve conduit |
| Start Year | 2010 |
| Title | ACELLULAR VASCULAR PRODUCTS |
| Description | A product comprising a natural acellular xenogenic vascular tissue matrix having at least an80% reduction in DNA content as compared to an untreated control vascular tissue matrix and being antigenically inert by being substantially free of epitopes capable of reacting with pre-formed human antibodies and also without having the ability to substantially activate complement. The invention also includes methods of preparing such products and uses of the products especially in bypass surgery. |
| IP Reference | WO2012042250 |
| Protection | Patent application published |
| Year Protection Granted | 2012 |
| Licensed | Yes |
| Impact | This IP has been assigned to Tissue Regenix (AIM listed Leeds spin out company), which is developing a portfolio of products based on this IP as well as three other patents we have assigned. Products such as a vascular patch for peripheral vascular reconstruction (clinical trial in 2009). |
| Title | COMBINATION OF MATERIAL FOR JOINT PROSTHESIS |
| Description | An orthopaedic joint prosthesis comprises first and second articulating components having respective bearing surfaces in contact with one another. The material of the first bearing surface (14) comprises a metallic material and the material of the second bearing surface (6) comprises a ceramic material. The hardness of the metallic material is at least about 2500 MPa, and the hardness of the ceramic material is greater than that of the metallic material by at least about 4000 MPa. |
| IP Reference | WO0117464 |
| Protection | Patent granted |
| Year Protection Granted | 2001 |
| Licensed | Yes |
| Impact | Clinical trials started 2006. Now marketed world wide. FDA IDE study underway in USA. A revenue sharing arrangement is in place between us and DePuy International. |
| Title | COMPOSITE BONE IMPLANTS |
| Description | The invention provides natural multi-composite bone implants such as bone-connective tissue-bone and osteochondral implants for the replacement and/or repair of, for example and in particular a damaged or defective bone-meniscus-bone joint or a bone-patella tendon-bone joint or osteochondral lesions, methods of preparing the composites and uses thereof. The invention also provides natural or native composite bone-connective tissue- bone and osteochondral matrices or scaffolds that are substantially decellularised for subsequent transplantation/implantation. |
| IP Reference | WO2014037713 |
| Protection | Patent application published |
| Year Protection Granted | 2014 |
| Licensed | No |
| Impact | Proof of concept phase in large animal model completed for bone-tendon-bone, discussions ongoing with a company on development re licensing |
| Title | Composition |
| Description | The present invention relates to a photosensitive composition comprising synthetic nanocrystalline hydroxyapatite or a synthetic precursor thereof doped with a rare earth ion, the use of the composition in restorative or cosmetic dentistry, a process for preparing the composition and a method of generating an image of an exposed dentinal surface of a tooth. |
| IP Reference | WO2012046082 |
| Protection | Patent application published |
| Year Protection Granted | 2012 |
| Licensed | Yes |
| Impact | This IP is supporting three projects: an EPSRC Health Technology Challenge project, an Innovate UK project, and a European funded Marie-Curie award with industrial partners which aims to produce commercial products. IPGroup and commercialisation team scoping out POC in vivo trial to evaluate the technology with the possibility of forming a spin-out company, two other patents would also be bought into this project. |
| Title | DECELLULARISATION OF MATRICES |
| Description | A method of preparing matrices or tissue engineered biomaterials for implantation, and in particular to a method of improving decellularisation of matrices or tissue engineered biomaterials prior to implantation. The method employs a single anionic detergent in combination with protease inhibitors. |
| IP Reference | WO02096476 |
| Protection | Patent granted |
| Year Protection Granted | 2002 |
| Licensed | Yes |
| Impact | A portfolio of products is in development for different clinical needs. A spin-out company has been formed (Tissue Regenix) which has a licence of this and three other patents. Also, this IP has been licensed to NHS Blood and Transplant, Tissue Services, for allografts in the NHS in the UK. |
| Title | Decellularised human livers |
| Description | The process could be applied to human donor organs thus increasing the number of such organs available for transplantation. This IP has not been patented and may still be confidential. |
| IP Reference | |
| Protection | Copyrighted (e.g. software) |
| Year Protection Granted | 2014 |
| Licensed | No |
| Impact | Too early for notable impacts. |
| Title | IMPROVEMENTS RELATING TO DECELLULARISATION OF TISSUE MATRICES FOR BLADDER IMPLANTATION |
| Description | The invention provides an improved method of producing a natural, acellular matrix scaffold for subsequent use in tissue-engineered replacement of tissues such as the bladder. Decellularisation is carried out on an expanded or distended bladder and the product retains the strength and compliance of natural material. The invention also provides use of the matrix scaffolds as wound healing material and to investigate tissue structure and function in vitro. |
| IP Reference | WO2007110634 |
| Protection | Patent granted |
| Year Protection Granted | 2007 |
| Licensed | Yes |
| Impact | This IP has supported a spin-out (Tissue Regenix) and its development of products. It is one of the four patents licensed to Tissue Regenix to date. |
| Title | MAGNETOMETER FOR MEDICAL USE |
| Description | A medical magnetometer (10) comprising one or more induction coils (2) for detecting a time varying magnetic field of a region of a subject's body, such as the heart. Each coil has a maximum outer diameter of 4 to 7 cm, and a configuration such that the ratio of the coil's length to its outer diameter is at least 0.5, and the ratio of the coil's inner diameter to its outer diameter is 0.5 or less. Each induction coil (2) is coupled to a respective detection circuit comprising a low impedance pre-ampiifier (3), a low pass filter (5), a notch filter (6) to remove line noise, and an averaging element (7). Each detection circuit produces an output signal (9) for use to analyse the time varying magnetic field of the region of the subject's body. |
| IP Reference | WO2014006387 |
| Protection | Patent application published |
| Year Protection Granted | 2014 |
| Licensed | Yes |
| Impact | IP is currently licensed to a Leeds spin-out (Creavo Medical Technologies Ltd, previously known as Quantum Imaging Ltd). Primary focus at present is the development of cardiac focussed devices, such as the VitalScan machine to support rule out triaging of patients presenting with chest pain in an emergency room setting. |
| Title | METHOD AND APPARATUS FOR MANIPULATING PARTICLES |
| Description | A method and apparatus for manipulating polarizable dielectric particles. The method includes positioning a liquid containing the particles above a surface of a piezoelectric material (2). The method also includes inducing a shear-horizontal surface acoustic wave in the piezoelectric material (2), thereby to form a time-varying non-uniform evanescent electric field extending into the liquid. The method further includes using the time-varying non-uniform evanescent electric field to apply a force to at least some of the particles (50, 52) by dielectrophoresis. |
| IP Reference | WO2015022481 |
| Protection | Patent application published |
| Year Protection Granted | 2015 |
| Licensed | Yes |
| Impact | Spin out of company based on this technology called Relitect. |
| Title | METHODS AND DEVICES FOR DETECTING STRUCTURAL CHANGES IN A MOLECULE MEASURING ELECTROCHEMICAL IMPEDANCE |
| Description | The invention relates to a method of detecting a structural change in a molecule, said molecule being attached to a surface, said surface being electrically conductive, wherein the phase of the electrochemical impedance at said surface is monitored, and wherein a change in the phase in the electrochemical impedance at said surface indicates a change in the structure of said molecule. The invention further relates to methods for making arrays having molecules such as, polypeptides attached to electrically conductive surfaces such as electrodes, and to arrays. |
| IP Reference | WO2008032066 |
| Protection | Patent application published |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | This IP should support a spin-out company (Phase DX) in the near future. |
| Title | Method and apparatus for manipulating particles (DEP-SAW) |
| Description | This invention relates to a method and apparatus for manipulating particles. The patent has not been published yet so may still be confidential. |
| IP Reference | |
| Protection | Copyrighted (e.g. software) |
| Year Protection Granted | 2013 |
| Licensed | No |
| Impact | The manipulation of particles finds application in a wide range of fields, many of which are medical in nature. |
| Title | NETWORKS |
| Description | There is described a material comprising ribbons, fibrils or fibres characterised in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a beta-sheet tape-like substructure. |
| IP Reference | WO2004007532 |
| Protection | Patent granted |
| Year Protection Granted | 2004 |
| Licensed | Yes |
| Impact | A spin-out company (Credentis AG). |
| Title | ORTHOPAEDIC MEDICAL DEVICE |
| Description | This present invention provides an orthopaedic medical device, in particular an arthroscopic aid, for stimulating the release of cells and/or encouraging migration of cells to a surgical site or an injury site. The invention includes methods of increasing a cell population at a surgical site or injury, a method of improving surgical outcome of synovial joint procedures and methods of delivering intra-operative minimally manipulated cells to a synovial joint. |
| IP Reference | US2018161022 |
| Protection | Patent application published |
| Year Protection Granted | 2018 |
| Licensed | Yes |
| Impact | Xiros have an exclusive license to use and sell, in all species but University still are able to use technology for research and teaching. |
| Title | On-chip spectroscopy system |
| Description | This IP has not been patented and may still be confidential. |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | No notable impacts as yet. |
| Title | Orthopaedic medical device |
| Description | A UK priority patent filing has been made but not yet published. The invention relates to an orthopaedic medical device, in particular an arthroscopic aid, for stimulating the release of cells and/or encouraging migration of cells to a surgical site. |
| IP Reference | |
| Protection | Copyrighted (e.g. software) |
| Year Protection Granted | 2014 |
| Licensed | No |
| Impact | A first in man clinical trial is being planned. |
| Title | POROUS AND NON-POROUS BODIES |
| Description | A method of manufacture of a powder comprising, or consisting essentially of, microspheres, the method comprising: providing a feed powder; and applying at least one spheroidisation flame to the powder. The powder may be suitable for use in medical and/or non-medical applications. |
| IP Reference | WO2016027110 |
| Protection | Patent granted |
| Year Protection Granted | 2016 |
| Licensed | Yes |
| Impact | Unknown as yet (12/03/2019) |
| Title | PREPARATION OF TISSUE FOR MENISCAL IMPLANTATION |
| Description | The present invention relates to a method of preparing a tissue matrix and its subsequent use in the replacement and/or repair of a damaged or defective meniscus. The invention also provides meniscal tissue that is substantially decellularised. |
| IP Reference | WO2008059244 |
| Protection | Patent granted |
| Year Protection Granted | 2008 |
| Licensed | Yes |
| Impact | This IP has supported a spin-out (Tissue Regenix) and its development of products. It is one of the four patents licensed to Tissue Regenix. |
| Title | Regional anaesthetic delivery system |
| Description | Unpatented know-how on a regional anaesthetic delivery system. |
| IP Reference | |
| Protection | Copyrighted (e.g. software) |
| Year Protection Granted | 2013 |
| Licensed | No |
| Impact | Confidentiality agreements in place with various potential partners but no notable impacts yet. |
| Title | SCAFFOLD PROTEINS DERIVED FROM PLANT CYSTATINS |
| Description | The present invention relates to scaffold proteins derived from plant cystatins and to nucleic acids encoding them. The scaffolds are highly stable and have the ability to display peptides. The scaffolds are particularly well suited for constructing libraries, e.g. in phage display or related systems. The invention also related to various uses of the scaffolds, including in therapy, diagnosis, environmental and security monitoring, synthetic biology and research, and to cells and cell cultures expressing the scaffold proteins. |
| IP Reference | WO2014125290 |
| Protection | Patent application published |
| Year Protection Granted | 2014 |
| Licensed | Yes |
| Impact | This IP was exclusively licensed to Avacta Life Sciences Ltd in the field of life sciences research reagents and diagnostics. Avacta pay royalties based on the University providing a screening service to Avacta and also for catalogue sales. |
| Title | SURGICAL RETRACTION DEVICE AND PROCEDURE |
| Description | The present invention provides a retraction device comprising, a shaft, a plurality of arms supported by the shaft, the arms being configured to be moveable between a first orientation in which the device assumes an insertion profile for passage of the device through a surgical incision, and a second orientation in which the device assumes a retraction profile. At least one of the plurality of the arms is adapted to be adjustable between a first length and a second length. |
| IP Reference | WO2017134415 |
| Protection | Patent application published |
| Year Protection Granted | 2017 |
| Licensed | No |
| Impact | Two companies are potentially interested in using this IP. |
| Title | SURGICAL RETRACTION DEVICE AND PROCEDURE |
| Description | The present invention provides a retraction device comprising, a shaft, a plurality of arms supported by the shaft, the arms being configured to be moveable between a first orientation in which the device assumes an insertion profile for passage of the device through a surgical incision, and a second orientation in which the device assumes a retraction profile. At least one of the plurality of the arms is adapted to be adjustable between a first length and a second length. |
| IP Reference | WO2017134415 |
| Protection | Patent application published |
| Year Protection Granted | 2017 |
| Licensed | No |
| Impact | None yet, commercial device undergoing prototyping. Patent arose based on refinements made during i4i project, continuing work performed during IKC POC project. |
| Title | Tissue sensors for medical diagnosis |
| Description | Optical sensors for the diagnosis of a range of medical conditions. |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2012 |
| Licensed | No |
| Impact | A licence, with revenue sharing provisions, with another University. |
| Title | ULTRASONIC MODIFICATION OF SOFT TISSUE MATRICES |
| Description | The present invention provides a method of, and apparatus for, utilising ultrasonic energy so as to mechanically disrupt the collagenous architecture of biological matrices in a controlled manner so that the tissue can be rapidly recellularised in continuous form. The present invention also provides for the production of tissue matrices with improved recellularisation properties, cell stratification or patterning. |
| IP Reference | WO2004103461 |
| Protection | Patent granted |
| Year Protection Granted | 2004 |
| Licensed | Yes |
| Impact | This IP is used in various of our Proof of Concept projects. It has also supported a spin-out company, and a portfolio of products is under development by them. |
| Title | VIRTUAL MICROSCOPY |
| Description | Computer implemented methods and data processing apparatus are described for displaying virtual slide images. Images of a plurality of slides are automatically displayed in a first region of a display device at a first magnification. The slides comprise all the slides including material from a same specimen. An image of at least one of the slides is displayed in a second region at a second magnification greater than the first magnification. At least the image displayed in the second region is changed responsive to receiving user input. Methods for automatically determining a slide layout pattern and methods for virtually melding glass slide images into a single image are also described. |
| IP Reference | US2012320094 |
| Protection | Patent application published |
| Year Protection Granted | 2012 |
| Licensed | No |
| Impact | IP portfolio assigned to Roche (Ventana Medical Systems) as part of asset sale of technology, deal completed July 2015. EP and GB patents still pending. US patent granted. |
| Title | Visual parameter optimisation software |
| Description | Software and an algorithm for use with image analysis/process engineering. |
| IP Reference | |
| Protection | Copyrighted (e.g. software) |
| Year Protection Granted | 2013 |
| Licensed | No |
| Impact | This software was developed for the optimization of image processing algorithms. Today, this is done in a time-consuming way that relies on trial-and-error. Our software enables users to make better choices of parameter values, to do so faster, and to better understand the influence of the parameters on image processing. The software is applicable to image processing, in general, although our research has focussed on applications in biomedical research. |
| Title | Arthroscopic device for stimulating synovial mesenchymal stem cells in the knee |
| Description | The arthroscopic device is currently (as of Jan 2017) in a small scale clinical evaluation study at Leeds Teaching Hospitals funded through NIHR funded Leeds Musculoskeletal Biomedical Research Unit, led and managed by Prof Dennis McGonagle, Dr Tom Baboolal with Consultant Mr Owen Wall. |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Early clinical assessment |
| Year Development Stage Completed | 2017 |
| Development Status | Actively seeking support |
| Impact | IKC funded Proof of Concept (POC) Project supported early development of the new medical device. This supported device design and testing, prototype manufacture and subsequent manufacture of devices for use in the clinical evaluation. The POC also supported generation of data used in patent filing. |
| Title | ISO accredited simulation test laboratory |
| Description | ISO accredited simulation test laboratory for pre clinical testing and trials widely used by customers around globe |
| Type | Support Tool - For Medical Intervention |
| Current Stage Of Development | Wide-scale adoption |
| Year Development Stage Completed | 2013 |
| Development Status | Under active development/distribution |
| Impact | uptake by wide range of companies |
| Title | acellular bone |
| Description | under development and in in vivo trials |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Refinement. Non-clinical |
| Year Development Stage Completed | 2014 |
| Development Status | Under active development/distribution |
| Impact | under development and in animal trials |
| Title | acellular bone cartilage osteochondral graft |
| Description | under development |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2014 |
| Development Status | Under active development/distribution |
| Impact | under developemnt |
| Title | acellular bone cartilage osteochondral graft |
| Description | under development NHSBT |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2015 |
| Development Status | Under active development/distribution |
| Impact | under development |
| Title | acellular bone patellar bone graft |
| Description | under development by NHSBT |
| Type | Therapeutic Intervention - Surgery |
| Current Stage Of Development | Refinement. Non-clinical |
| Year Development Stage Completed | 2014 |
| Development Status | Under active development/distribution |
| Impact | under development by NHSBT |
| Title | acellular dcell vascular patch |
| Description | licensed to and commercialised by Tissue Regenix |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Small-scale adoption |
| Year Development Stage Completed | 2010 |
| Development Status | Under active development/distribution |
| Clinical Trial? | Yes |
| Impact | First dcell clinical product |
| URL | https://clinicaltrials.gov/show/NCT00958230 |
| Title | acellular dcell dermis |
| Description | commercialised by Tissue regenix from 2014 |
| Type | Therapeutic Intervention - Medical Devices |
| Year Development Stage Completed | 2014 |
| Development Status | Under active development/distribution |
| Impact | sold and distributed in USA |
| Title | acellular dermis |
| Description | supplied as clinical product by NHSBT |
| Type | Therapeutic Intervention - Surgery |
| Current Stage Of Development | Small-scale adoption |
| Year Development Stage Completed | 2014 |
| Development Status | Under active development/distribution |
| Impact | supplied by NHSBT, improved wound healing in chronic leg ulcers |
| Title | acellular heart valve |
| Description | clinical application through human tissue bank |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Small-scale adoption |
| Year Development Stage Completed | 2010 |
| Development Status | Under active development/distribution |
| Impact | proof of clinical use acellular technology |
| Title | acellular vascular graft |
| Description | under development by NHSBT and Tissue Regenix |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Refinement. Non-clinical |
| Year Development Stage Completed | 2014 |
| Development Status | Under active development/distribution |
| Impact | Under development by NHSBT an dTissue Regenix |
| Title | all polymer knee |
| Description | collaborative development with Invibio |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2015 |
| Development Status | Under active development/distribution |
| Impact | collaborative development with Invibio |
| Title | ceramic on ceramic hip |
| Description | Mathys |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Market authorisation |
| Year Development Stage Completed | 2012 |
| Development Status | Under active development/distribution |
| Impact | successfully adopted an d commercilised |
| Title | ceramic on ceramic and ceramic on metal hip |
| Description | commercialised by DePuy and by Mathys |
| Type | Therapeutic Intervention - Medical Devices |
| Year Development Stage Completed | 2015 |
| Development Status | Under active development/distribution |
| Impact | successfully adopted an d commercilised |
| Title | dcell ligament |
| Description | Under commercial development by tissue Regenix, progressing to CE mark and product launch |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Refinement. Non-clinical |
| Year Development Stage Completed | 2014 |
| Development Status | Under active development/distribution |
| Clinical Trial? | Yes |
| Impact | under commercial development by Tissue Regenix in clinical trial started 2015 proceeding to Ce mark and product launch 2017 |
| URL | https://clinicaltrials.gov/show/NCT02540811 |
| Title | dcell meniscus |
| Description | Developed by tissue Regenix In clinical trial started 2015 |
| Type | Therapeutic Intervention - Medical Devices |
| Current Stage Of Development | Late clinical evaluation |
| Year Development Stage Completed | 2014 |
| Development Status | Under active development/distribution |
| Clinical Trial? | Yes |
| Impact | first in man clinical trial started 2015 |
| URL | https://clinicaltrials.gov/show/NCT02270905 |
| Title | ankle joint simulator |
| Description | ankle joint simulator |
| Type Of Technology | Physical Model/Kit |
| Year Produced | 2015 |
| Impact | support product development |
| Title | finite element simulation tools to capture patient variation for the analysis of orthopaedic devices across a patient cohort |
| Description | This project has been led by Dr Ruth Wilcox in partnership with Simpleware Limited. The development of the software add-on has been completed and the final validations with the Leeds data set-set are coming to an end. It is anticipated that a technology demonstrator project will now be undertaken with a company that can demonstrate the utility of the software for evaluating spinal implants. The commercial team is now engaged and discussions with Simpleware around a possible license deal are on-going. It is envisaged that as part of this license deal Simpleware will engage Leeds expertise as part of their offer to companies. In addition Leeds personnel will retain the right to undertake consultancy in their own capacity. |
| Type Of Technology | Software |
| Year Produced | 2013 |
| Impact | further research |
| Title | hip joint simulator |
| Description | hip joint simulator |
| Type Of Technology | Physical Model/Kit |
| Year Produced | 2012 |
| Impact | commercial product Simulation solutions |
| Title | knee joint simulator |
| Description | knee joint simulator |
| Type Of Technology | Physical Model/Kit |
| Year Produced | 2013 |
| Impact | Commercial product simulation solutions |
| Title | natural hip simulator |
| Description | natural hip simulator |
| Type Of Technology | Physical Model/Kit |
| Year Produced | 2014 |
| Impact | commercial product simulation solutions |
| Title | natural knee simulator |
| Description | natural knee simulator |
| Type Of Technology | Physical Model/Kit |
| Year Produced | 2013 |
| Impact | commercialised by simulation solutions |
| Title | spinal disc simulator |
| Description | spinal disc simulator |
| Type Of Technology | Physical Model/Kit |
| Year Produced | 2010 |
| Impact | commercial product simulation solutions |
| Company Name | Creavo Medical Technologies Ltd (formerly Quantum Imaging) |
| Description | Creavo Medical Technologies Ltd is a UK-based, privately held medical device company engaged in the development of innovative imaging technologies. The company was formed to commercialise sensor technology developed by Professor Ben Varcoe, Chair of Quantum Information Science at Leeds University and has facilities in Leeds and in Warwickshire UK. The first application of this technology will be to aid the rapid triage and identification of patients presenting to Emergency Departments with chest pain, but who ultimately have no cardiac related diagnosis. Identifying these patients early enables them to leave expensive cardiac diagnostic pathways so releasing resources to focus on other acute patients. Creavo Medical Technologies has an experienced management team, with a mix of fundamental research, medical device commercialisation, manufacturing and global regulatory and clinical strategy. |
| Year Established | 2014 |
| Impact | A new cardiac scanning device that could save the NHS £200 million a year is being trialled at four of the UK's largest emergency departments (Bristol, Nottingham, Leicester and Sheffield). The British-made Vitalscan device, which has been developed by Creavo Medical Technologies and could revolutionise the way patients with chest pain are managed in emergency departments, works by conducting a non-invasive three to five-minute scan at a patient's bedside to rule out significant cardiac conditions, such as heart attacks. Data from the York Health Economics Consortium shows that 1.3 million A&E admissions in 2014/15 were due to chest pain. Of these, 63% ultimately had no cardiac-related condition but, the majority would still have gone through the same costly cardiac triage process of someone having a heart attack. Vitalscan has the potential to identify a significant proportion of these patients which would radically change the management of chest pain patients entering emergency departments. Conservative estimates indicate that the device could save the NHS £200 million a year, the equivalent of £3.85 million a week and £382 a minute, easing pressure on bed space in A&E departments and reducing patient anxiety by getting patients to the correct treatment more quickly. Steve Parker, CEO Creavo Medical Technologies says: "Cardiac-related chest pain is one of the biggest issues facing emergency departments in the western world due to the economic burden it places on healthcare services and the disruption it causes to inpatient care. "The triage process for someone entering an emergency department with chest pain can take anywhere from six to 24 hours which places a huge amount of strain on resources. "Early results from smaller sets of clinical trials indicate that Vitalscan can quickly identify and rule out significant ischemic heart disease so it prevents patients who aren't suffering from a cardiac-related condition from having to go through the lengthy, costly chest pain triage process, easing the burden on emergency departments at a time when they are facing unprecedented pressures." Creavo Medical Technologies was established to commercialise the work undertaken by Professor Ben Varcoe at the University of Leeds to develop Vitalscan, a portable, passive magnetocardiography device that measures the electromagnetic fluctuations of the heart, while maintaining the accuracy and efficacy of older SQUID devices. The start of clinical trials at Sheffield Teaching Hospitals NHS Foundation Trust, University Hospitals of Leicester NHS Trust, North Bristol NHS Trust and Nottingham University Hospitals NHS Trust marks the largest ever clinical trial of a magnetocardiography device. This will be followed by a second stage starting at three centres in the United States at Mayo Clinic Rochester, Cincinnati and Baylor Texas. |
| Website | http://creavomedtech.com/ |
| Company Name | Tissue Regenix |
| Description | Developemnt and manufacture of Regenerative Biological Scaffolds for tissue repair in vascular, cardiovascular and musculoskeletal systems |
| Year Established | 2007 |
| Impact | aim listed d raised £0m investment value £150m 4 clinical products |
| Company Name | Relitect Ltd |
| Description | Relitect Ltd are developing a novel technology for the detection of binding events, which can be used for the analysis of proteins, small molecules and nucleic acids. The Relitect proprietary technology enables highly sensitive detection of biomarkers or other analytes in a label free multiplexed format, using small sample volumes. Relitect's approach has potential for utilisation across the clinical diagnostics and life sciences industries. |
| Year Established | 2014 |
| Impact | March 2015 - Relitect secured a £750K tranched investment from IP Group Plc and Scottish Enterprise's investment arm, the Scottish Investment Bank to develop its novel high sensitivity diagnostic/science technology. 20th April 2015 - Relitect moves to new laboratory facilities at Biocity Scotland -www.biocity.co.uk/biocity/scotland |
| Website | http://www.relitect.com/ |
| Description | Bone paste could provide treatment for osteoporosis |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online article in Orthopaedic Product News profiling the research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.opnews.com/2015/02/osteoporosis/9449 |
| Description | Funding for Injectable Stem-Cell Carrying Microspheres |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://scienmag.com/1-2-million-for-injectable-stem-cell-carrying-microspheres-to-regenerate-bones/ |
| Description | Funding for injectable stem-cell carrying microspheres |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://phys.org/wire-news/230900690/12-million-for-injectable-stem-cell-carrying-microspheres-to-re... |
| Description | Funding for injectable stem-cell carrying microspheres |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.m3medical.com/news/blog/2016/07/26/microsphere-plan-for-bone-care/ |
| Description | Funding for injectable stem-cell carrying microspheres |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Blog about general bone research, highlighting IKC POC025 as a case study |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.frogheart.ca/?p=21311 |
| Description | Funding for injectable stem-cell carrying microspheres |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://abccontentboard.com/breakthrough-stem-call-jab-could-save-millions-from-osteoporosis-bone-fra... |
| Description | Funding for injectable stem-cell carrying microspheres |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://microscopy83.rssing.com/chan-6837248/latest.php |
| Description | Funding for injectable stem-cell carrying microspheres |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.englemed.co.uk/16/16jul261_osteoporosis_treatment.php |
| Description | Funding for injectable stem-cell carrying microspheres |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.hcplive.com/medical-news/injection-for-injectable-research-midos-project-receives-grant-f... |
| Description | Funding for injectable stem-cell carrying microspheres |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.myscience.org/wire/1_2m_for_injectable_stem_cell_carrying_microspheres_to_regenerate_bon... |
| Description | Funding for injectable stem-cell carrying microspheres |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.eurekalert.org/pub_releases/2016-07/uon-fi072516.php |
| Description | Funding for injectable stem-cell carrying microspheres |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://medicalphysicsweb.org/cws/article/newsfeed/65702 |
| Description | Funding for injectable stem-cell carrying microspheres |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.m3medical.com/news/blog/2016/07/26/microsphere-plan-for-bone-care/ |
| Description | Funding for injectable stem-cell carrying microspheres |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://healthmedicinet.com/i/1-2-million-for-injectable-stem-cell-carrying-microspheres-to-regenerat... |
| Description | Microspheres as a Treatment for Weak Bones |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Blog about the use of microspheres, highlighting IKC POC025 as a case study |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://blog.spotchemi.com/microspheres-as-a-treatment-for-weak-bones/ |
| Description | National newspaper article - Liquid bone jab may prevent breaks in elderly |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Article in Sunday Times profiling the research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells. |
| Year(s) Of Engagement Activity | 2014 |
| URL | https://www.thetimes.co.uk/article/liquid-bone-jab-may-prevent-breaks-in-elderly-nntb3hgc7mg |
| Description | National newspaper article: Stem Cell Jab hope to Prevent bone fractures. |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Article in Sunday Express profiling the research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.express.co.uk/life-style/health/694981/osteoporosis-bone-fracture-stem-cell-injection-tr... |
| Description | New grant for injectable stem-cell carrying microspheres |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.nanowerk.com/nanotechnology-news/newsid=44022.php |
| Description | Online article - Injectable-stem-cell-carrying-microspheres-to-regenerate-bones |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online article profiling research and technology of IKC POC025 - Manufacturing Bone Tissue Using Resorbable Porous Calcium Phosphate Microspheres Loaded with Autologous Stem Cells, and a funding grant from NIHR. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.odtmag.com/contents/view_breaking-news/2016-07-25/injectable-stem-cell-carrying-microsph... |
| Description | Press release - funding for injectable stem cell-carrying microspheres |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | NIHR article detailing a funding award for the technology |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.nihr.ac.uk/newsroom/nihr-i4i-challenge-award-for-preventative-osteoporosis-treatment/3796 |
| Description | Press release - funding for injectable stem cell-carrying microspheres |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Article detailing NIHR funding for the technology. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.nottingham.ac.uk/news/pressreleases/2016/july/1.2m-for-injectable-stem-cell-carrying-mic... |
| Description | Regen - Regener8 Annual Newsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Glossy review of annual activity of the Regener8 programme. Review sponsored by the MTIKC |
| Year(s) Of Engagement Activity | 2014,2015,2016 |