Quantum Cascade amplifiers for high power Terahertz time domain spectrometry
Lead Research Organisation:
University of Cambridge
Department Name: Physics
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Yassin S
(2015)
The Disintegration Process in Microcrystalline Cellulose Based Tablets, Part 1: Influence of Temperature, Porosity and Superdisintegrants.
in Journal of pharmaceutical sciences
Sibik J
(2016)
Direct measurement of molecular mobility and crystallisation of amorphous pharmaceuticals using terahertz spectroscopy.
in Advanced drug delivery reviews
Sibik J
(2014)
Thermal Decoupling of Molecular-Relaxation Processes from the Vibrational Density of States at Terahertz Frequencies in Supercooled Hydrogen-Bonded Liquids.
in The journal of physical chemistry letters
Sibik J
(2015)
Predicting Crystallization of Amorphous Drugs with Terahertz Spectroscopy.
in Molecular pharmaceutics
Sibik J
(2015)
Terahertz response of organic amorphous systems: experimental concerns and perspectives
in Philosophical Magazine
Ruggiero MT
(2016)
Measuring the Elasticity of Poly-l-Proline Helices with Terahertz Spectroscopy.
in Angewandte Chemie (International ed. in English)
Ruggiero MT
(2017)
Quantification of cation-anion interactions in crystalline monopotassium and monosodium glutamate salts.
in Physical chemistry chemical physics : PCCP
Ruggiero MT
(2016)
Examination of l-Glutamic Acid Polymorphs by Solid-State Density Functional Theory and Terahertz Spectroscopy.
in The journal of physical chemistry. A
Ruggiero M
(2016)
Measuring the Elasticity of Poly- l -Proline Helices with Terahertz Spectroscopy
in Angewandte Chemie
Ren Y
(2014)
Single mode terahertz quantum cascade amplifier
in Applied Physics Letters
| Description | Thz quantum cascade lasers have been developed along with other devices such as THz modulators and quantum cascade amplifiers. |
| Exploitation Route | In academic and industrial research |
| Sectors | Aerospace, Defence and Marine,Agriculture, Food and Drink,Digital/Communication/Information Technologies (including Software),Pharmaceuticals and Medical Biotechnology |
| Description | In the development and applications of quantum cascade lasers at THz frequencies. The development of active THz optical components such as modulators. |
| Impact Types | Economic |
| Title | Research data supporting "Examination of L-Glutamic Acid Polymorphs by Solid-State Density Functional Theory and Terahertz Spectroscopy" |
| Description | Experimental crystallographic information files (.CIF), Experimental terahertz absorption spectra, theoretical absorption spectra, Gibbs free energy curves. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Title | Research data supporting "Terahertz response of organic amorphous systems: experimental concerns and perspectives" |
| Description | Terahertz spectra for several amorphous materials over a range of temperatures, from below to above the glass transition: Figure 2 (fig2_data.csv): Absorption coefficient and refractive index of polyvinylpyrrolidone/vinyl acetate at 1 THz prepared as tablet and thin film from melt. Figure 5 (fig5_data.csv): Terahertz absorption of amorphous sorbitol, trehalose and BSA between 80 - 340 K at 0.8 THz. Figure 6 (fig6_data_THz-TDS.csv): Dielectric losses of amorphous sorbitol observed by terahertz spectroscopy. Figure 6 (fig6_data_synchrotron.csv): Dielectric losses of amorphous sorbitol observed at Diamond synchrotron facility. Figure 7a (fig7a_data.csv): Rescaled absorption coefficient of amorphous sorbitol between 80 - 420 K measured by terahertz spectroscopy Figure 7b (fig7b_data.csv): Refractive index of amorphous sorbitol between 80-420 K measured by terahertz spectroscopy. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| URL | https://www.repository.cam.ac.uk/handle/1810/252491 |
| Description | BMS |
| Organisation | Bristol-Myers Squibb |
| Country | United States |
| Sector | Private |
| PI Contribution | Measurement of model drug compounds for stability prediction |
| Collaborator Contribution | Advice through regular teleconferences Supply of sample polymer material Complementary characterisation data |
| Impact | The discussions with BMS have been extremely helpful for our team to learn the important parameters when characterising materials in an industrial context; this will help with subsequent impact when translating the measurement technique into industrial applications. |
| Start Year | 2014 |
| Description | Copenhagen (collaboration with TR) |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Measurement of amorphous drug material using THz-TDS |
| Collaborator Contribution | Complementary characterisation using thermal analysis methods (DSC, TGA, etc.) Sample preparation by scary drying |
| Impact | A number of joint international conference presentations have resulted (4 posters and 2 talks) |
| Start Year | 2013 |
| Description | MedImmune (funding of 9 month PDRA) |
| Organisation | AstraZeneca |
| Department | MedImmune |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We have investigated the applicability of terahertz spectroscopy to accurately determine the collapse temperature in freeze-dried product. |
| Collaborator Contribution | MedImmune provided funding for a 9 month postdoc extension for JS. They supplied materials and training and we were able to use their facilities. |
| Impact | Ongoing, one conference presentation (invited talk for JS) at the 40th IRMMW-THz conference in Hong Kong in August 2015. |
| Start Year | 2015 |
| Description | Physics at work |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Physics at work takes place every year at the Cavendish Laboratory. A total of 2000 school students visit to listern to talks and demonstrations. My research group gives around 20 presentations to 25 students each year about semiconductor physics. Heightened interest in science and particular physics amongst local school students. Physics undergraduates are currently at record numbers in Cambridge. |
| Year(s) Of Engagement Activity | Pre-2006,2006,2007,2008,2009,2010,2011,2012,2013,2014 |
| URL | http://www-outreach.phy.cam.ac.uk/physics_at_work/ |