Multi-scale Approaches to Mechanical Contraction and Electrical Wave Conduction in A 3D Model of Human Atria during Fibrillation
Lead Research Organisation:
Lancaster University
Department Name: Engineering
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Jianqiao Ye (Principal Investigator) | |
| Yong Sheng (Co-Investigator) |
Publications
Brocklehurst P
(2017)
Electro-mechanical dynamics of spiral waves in a discrete 2D model of human atrial tissue.
in PloS one
Brocklehurst P
(2015)
A 2D Electromechanical Model of Human Atrial Tissue Using the Discrete Element Method.
in BioMed research international
Paul Brocklehurst (Author)
(2014)
ELECTROMECHANICAL MODEL OF HUMAN ATRIAL TISSUE USING THE DISCRETE ELEMENT METHOD
| Description | improved understanding of human atria during fibrillation through investigations at different scales. |
| Exploitation Route | Further research are to be proposed to move from tissues to organs, which will be evaluated by medical professionals. |
| Sectors | Digital/Communication/Information Technologies (including Software),Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | We are working with medical professionals and software company (ITASCA) to promote the use of our discrete model. ITASCA has used our case studies to demonstrate the capacities of their software. We worked with a hospital in China to use our model to simulate the contraction of blood vessels. Currently we are testing the electric-mechanical coupling algorithm with drones companies for developing sensors and monitoring systems |
| Sector | Education,Healthcare |
| Impact Types | Societal |
| Title | Research Tools |
| Description | use multiscale modelling strategy to model fibrillation of human atrium |
| Type Of Material | Model of mechanisms or symptoms - human |
| Provided To Others? | No |
| Impact | The immediate benefit will be for the rapidly growing international community of Computational Biology and Computational Materials that use reaction-diffusion PDEs and micro scale discrete elements. In general, development of stable and efficient methods for the PDE problem of electro-mechanic cardiac models with complex 3D boundaries and discrete cell arrangement is becoming ever more intensive research area for mathematicians and software developers. The ideas and practical solutions stemming from our project will be of further beneficiary to that community. The indirect benefit will be via research outputs of this project. Further long term potential beneficiaries will be outside academia, such as pharmaceutical and biomedical engineering industrials, and hence eventually patients and general public. These benefits would be through the newly developed tools and algorithms that can address more efficiently the mechanisms of cardiac arrhythmias and drug safety test. |
| Description | New collaboration (Industry) |
| Organisation | Blackpool Victoria Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | New collaboration has been established with Victoria Blackpool Hospital through this project |
| Collaborator Contribution | participate in progress meetings and provide technical advices |
| Impact | This is a multidisciplinary research requiring expertise from Cardiac electrophysiology, mathematics, material science and computational modelling. |
| Start Year | 2014 |
| Description | Research collaboration (University) -eHeart |
| Organisation | University of Manchester |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | As the PI at Lancaster contributing to the project leading by Manchester |
| Collaborator Contribution | Leading the project involving Lancaster and Leeds |
| Impact | All the publications were and will be co-authored. This is a multidisciplinary research requiring expertise from Cardiac electrophysiology, mathematics, material science and computational modelling. |
| Start Year | 2013 |
| Description | Research collaboration (industry)-eHeart |
| Organisation | ITS United Kingdom |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | PI at Lancaster on DEM modelling of human atrium |
| Collaborator Contribution | Technical support on using software and providing necessary plug-in |
| Impact | The project is multidisciplinary involving Cardiac electrophysiology , mathematics, material and computational modelling. paper have been published and we are working on new proposals. |
| Start Year | 2013 |
| Description | Engagement (e-Heart) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentations made to Medical Doctors from Regional hospital to promote the research and request inputs. |
| Year(s) Of Engagement Activity | 2013,2014 |