Towards disease diagnosis through spectrochemical imaging of tissue architecture.
Lead Research Organisation:
Lancaster University
Department Name: Physics
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Ahlstrom S
(2014)
A Quasiparticle Detector for Imaging Quantum Turbulence in Superfluid $$^3$$ 3 He-B
in Journal of Low Temperature Physics
Nazarenko M
(2017)
A simplified model to estimate thermal resistance between carbon nanotube and sample in scanning thermal microscopy
in Journal of Physics D: Applied Physics
Trabelsi AB
(2014)
Charged nano-domes and bubbles in epitaxial graphene.
in Nanotechnology
Robinson B
(2019)
Correlation of shear forces and heat conductance in nanoscale junctions
in Physical Review B
Harzheim A
(2020)
Direct mapping of local Seebeck coefficient in 2D material nanostructures via scanning thermal gate microscopy
in 2D Materials
Kay ND
(2014)
Electromechanical sensing of substrate charge hidden under atomic 2D crystals.
in Nano letters
Gehring P
(2017)
Field-Effect Control of Graphene-Fullerene Thermoelectric Nanodevices.
in Nano letters
Robinson BJ
(2017)
Formation of Two-Dimensional Micelles on Graphene: Multi-Scale Theoretical and Experimental Study.
in ACS nano
Robson AJ
(2013)
High-accuracy analysis of nanoscale semiconductor layers using beam-exit ar-ion polishing and scanning probe microscopy.
in ACS applied materials & interfaces
Spiece J
(2018)
Improving accuracy of nanothermal measurements via spatially distributed scanning thermal microscope probes
in Journal of Applied Physics
Tovee PD
(2013)
Mapping nanoscale thermal transfer in-liquid environment-immersion scanning thermal microscopy.
in Nanotechnology
Vyas V
(2019)
Micro-Acoustic-Trap (µAT) for microparticle assembly in 3D.
in Ultrasonics sonochemistry
Bosse J
(2013)
Multidimensional SPM applied for nanoscale conductance mapping
in Journal of Materials Research
Guthrie A
(2019)
Multimode probing of superfluid 4He by tuning forks
in Applied Physics Letters
Bosse J
(2014)
Nanomechanical morphology of amorphous, transition, and crystalline domains in phase change memory thin films
in Applied Surface Science
Robinson BJ
(2013)
Nanoscale interfacial interactions of graphene with polar and nonpolar liquids.
in Langmuir : the ACS journal of surfaces and colloids
Rivas M
(2015)
Nanoscale mapping of in situ actuating microelectromechanical systems with AFM
in Journal of Materials Research
El Sachat A
(2019)
Nanoscale Mapping of Thermal and Mechanical Properties of Bare and Metal-Covered Self-Assembled Block Copolymer Thin Films
in ACS Applied Polymer Materials
Tovee PD
(2014)
Nanoscale resolution scanning thermal microscopy using carbon nanotube tipped thermal probes.
in Physical chemistry chemical physics : PCCP
Evangeli C
(2019)
Nanoscale Thermal Transport in 2D Nanostructures from Cryogenic to Room Temperature
in Advanced Electronic Materials
Bosse J
(2014)
Nanothermal characterization of amorphous and crystalline phases in chalcogenide thin films with scanning thermal microscopy
in Journal of Applied Physics
Pozo-Zamudio O
(2015)
Photoluminescence of two-dimensional GaTe and GaSe films
in 2D Materials
Bosse J
(2014)
Physical mechanisms of megahertz vibrations and nonlinear detection in ultrasonic force and related microscopies
in Journal of Applied Physics
Robinson BJ
(2014)
Probing nanoscale graphene-liquid interfacial interactions via ultrasonic force spectroscopy.
in Nanoscale
Kolosov O
(2017)
Quantum effects: Heat flow in atomic bottlenecks.
in Nature nanotechnology
Gregori M
(2017)
Retro-inverso peptide inhibitor nanoparticles as potent inhibitors of aggregation of the Alzheimer's Aß peptide.
in Nanomedicine : nanotechnology, biology, and medicine
Timofeeva M
(2016)
Scanning thermal microscopy with heat conductive nanowire probes.
in Ultramicroscopy
Anyebe E
(2014)
Self-catalysed growth of InAs nanowires on bare Si substrates by droplet epitaxy Self-catalysed growth of InAs nanowires on bare Si substrates by droplet epitaxy
in physica status solidi (RRL) - Rapid Research Letters
Robinson B
(2015)
Structural, optical and electrostatic properties of single and few-layers MoS 2 : effect of substrate
in 2D Materials
Dinelli F
(2017)
Subsurface imaging of two-dimensional materials at the nanoscale.
in Nanotechnology
Mazzocco R
(2015)
Surface and interfacial interactions of multilayer graphitic structures with local environment
in Thin Solid Films
Stone R
(2013)
Tungstate sharpening: a versatile method for extending the profile of ultra sharp tungsten probes.
in The Review of scientific instruments
Tinker-Mill C
(2014)
Ultrasonic force microscopy for nanomechanical characterization of early and late-stage amyloid-ß peptide aggregation.
in Scientific reports
Afouxenidis D
(2015)
ZnO-based thin film transistors employing aluminum titanate gate dielectrics deposited by spray pyrolysis at ambient air.
in ACS applied materials & interfaces
Mayes J
(2014)
ß-Amyloid Fibrils in Alzheimer Disease Are Not Inert When Bound to Copper Ions but Can Degrade Hydrogen Peroxide and Generate Reactive Oxygen Species
in Journal of Biological Chemistry
| Description | It may become possible to detect early stages of Alzheimer decease using nanoscale probing of the small samples from the person body, using scanning probe microscopy methods combined with the spectroscopic identification of the toxic amyloid peptides. Also, it was found that even at advanced stages of the assembly of these peptides creating fibres and plaques in teh brain, significant proportion of small and presumed most toxic monomers still present, leading a way for designing new drugs against Alzheimer decease. New medicines based on the retro-inverso peptides loaded in the liposomes are been developed. Using combination of QCL and SPM shown the significant benefit for identification of biomaterials. |
| Exploitation Route | This creates a new platform for fighting Alzheimer decease and can be exploited by other groups worldwide. A new EPSRC project FLUENCE using FELIX FEL have been established for bioapplications of new method. Further an approach used by this now is the core of the new awarded UKRI project EP/V00767X/1 High performance Wide spectral range Nanoprobe (HiWiN) for mapping spectrocopical properties on mid IR and THz radiation region to create at multi-user EPSRC facility for chemical, physical and biomedical studies using FELIX FEL in Nijmegen Netherland. |
| Sectors | Chemicals,Communities and Social Services/Policy,Digital/Communication/Information Technologies (including Software),Electronics,Energy,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| URL | https://academicminute.org/2014/08/kolosov/ |
| Description | Some of the medicines for Alzheimer decease developed over the grant methodology are being tested medically for the efficacy. Industrial application of new methods have been implemented by Anasys Instruments. The company Anasys Instruments was bought by Bruker - one of the largest international players in scientific and medical instrumentation. |
| First Year Of Impact | 2018 |
| Sector | Communities and Social Services/Policy,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Societal,Economic |
| Description | 3D mapping of energy materials |
| Amount | £6,000 (GBP) |
| Funding ID | DST/NBHF/2020/1 |
| Organisation | Lancaster University |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2021 |
| End | 01/2022 |
| Description | FP7 QUANTIHEAT |
| Amount | € 586,000 (EUR) |
| Funding ID | 604668 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 12/2013 |
| End | 11/2017 |
| Description | High performance Wide spectral range Nanoprobe (HiWiN) |
| Amount | £745,943 (GBP) |
| Funding ID | EP/V00767X/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2020 |
| End | 01/2023 |
| Description | NEXGENNA, Faraday Institution |
| Amount | £11,000,000 (GBP) |
| Funding ID | NEXGENNA |
| Organisation | Lancaster University |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 12/2019 |
| End | 04/2024 |
| Description | Paul Instrument Fund |
| Amount | £100,000 (GBP) |
| Organisation | The Royal Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2017 |
| End | 11/2019 |
| Title | Novel methodology for nanoscale characterisation |
| Description | Novel platform for the measurements and characterisation of materials and devices with ~ 10-50 nm spatial resolution using a diamond based ultra-broadband tool. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | IP created and being discussed with the potential users. |
| URL | https://hiwin-felix.org/ |
| Description | UCONN-ULANC collaboration |
| Organisation | University of Connecticut |
| Department | Institute of Materials Science |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Multiple new research direction were explored with 3 publications in the main Physics and materials science journals resulting from it and two more in the preparation. |
| Collaborator Contribution | Provided financial support for travel to the UCONN, access to equipment on the order of $400,000, with technical support on-site. |
| Impact | Publications:Nanothermal characterization of amorphous and crystalline phases in chalcogenide thin films with scanning thermal microscopy Bosse, J., Timofeeva, M., Tovee, P., Robinson, B., Huey, B. & Kolosov, O. 7/10/2014 In : Journal of Applied Physics. 116, 13, 8 p., 134904 Research output: Contribution to journal > Journal article Nanomechanical morphology of amorphous, transition, and crystalline domains in phase change memory thin films Bosse, J., Grishin, I., Huey, B. & Kolosov, O. 30/09/2014 In : Applied Surface Science. 314, p. 151-157 7 p. Research output: Contribution to journal > Journal article Nanoscale mapping of in situ actuating microelectromechanical systems with AFM Rivas, M., Vyas, V., Carter, A., Veronick, J., Khan, Y., Kolosov, O. V., Polcawich, R. G. & Huey, B. D. 14/02/2015 In : Journal of Materials Research. 30, 3, p. 429-441 13 p. Research output: Contribution to journal > Journal article |
| Start Year | 2014 |
| Title | METHOD AND APPARATUS FOR ION BEAM POLISHING |
| Description | A method for forming a polished facet between an edge and a face of a sample, involves removing a first portion of the sample by directing an ion beam onto the edge adjacent the first portion along an ion beam axis to leave the polished facet. The ion beam axis lies on an ion beam plane oriented at a glancing incident angle, preferably from 1° to 30°, to a sample plane defined by and parallel to the first face. The ion beam is directed to flow from the edge towards the first face. Also disclosed is a sample preparation apparatus comprising a chamber adapted for evacuation with a sample holder adapted to hold a sample comprising a first face bounded by an edge, and an ion gun arranged to direct an ion beam along an ion beam axis towards the sample. The sample holder is configurable to position the sample relative to the ion beam such that a first portion of the sample is removable by the ion beam to leave a polished facet between the edge and the first face of said sample. The sample holder is configured to hold the sample whereby the ion beam axis lies on an ion beam plane oriented at an incident angle from 1° to 30° to a sample plane defined by and parallel to the first face of the sample. |
| IP Reference | WO2011101613 |
| Protection | Patent granted |
| Year Protection Granted | 2011 |
| Licensed | Commercial In Confidence |
| Impact | The invention allowed to establish a new business for theLancaster University spin-off Lancaster Materials Analysis and research collaboration with several industrial partners in UK, EU and USA. |
| Company Name | Lancaster Materials Analysis |
| Description | Services to the industry and implementation of IP based on Lancaster patent US9082587 |
| Year Established | 2014 |
| Impact | Demonstrated potential for replacing TEM and SEM methods by less expensive in the characterization of semiconductor and optoelectronic structures |
| Website | http://www.lancaster.ac.uk/news/articles/2014/novel-materials-analysis-technique-promises-to-reduce-... |