Multiscale topographical modulation of cells and bacteria for next generation orthopaedic implants.
Lead Research Organisation:
University of Glasgow
Department Name: College of Medical, Veterinary, Life Sci
Abstract
The UK has an aging population and we need to plan ahead to deal with this. Many of us will outlive the useful lives of parts of our skeleton through e.g. arthritis. Currently, e.g. hip replacements have a good survival rate between 10-15 years but then many patients require revision surgery. This is costly to the NHS and hence taxpayer, time consuming to the surgeon (it is far more complex than primary surgery) and is performed on elderly and frail patients where e.g. use of general anesthetic is a concern.
The surgeons have two major concerns regards current orthopaedic implants. Firstly, the materials used are inert. This means that the body has a low response to the materials. This is an advantage as there is no immune response (inflammation) and a disadvantage as there is no bone response. If selective bioactivity could be produced (i.e. no immune response but increased bone response) then the implant could be locked in place by growing bone and implants for life developed. This lack of bone response means that the implants are not well held and can move about during walking. This is termed micromotion. This leads to failure with time as the extent of micromotion increases. Secondly, they worry about infection control. Even after sterilisation bacteria may be present on the implant materials in low numbers or can be introduced during surgery. If the infection can take hold it has major impact on the implant lifetime and this can result in younger patients having revision surgery and that has much higher failure rates.
We have developed very small, nanoscale patterns that can be used to tune bone growth and prevent bacterial adhesion. We will thus optimise these patterns to achieve bacterial control and bone formation at appropriate points of the implant. A major advantage is that we can process these patterns in titanium, a material commonly used for orthopaedic implants due to its high strength (i.e. it can withstand the weight of the human body as we walk).
Such an approach is a step towards making implants for life and planning ahead for the aging population.
The surgeons have two major concerns regards current orthopaedic implants. Firstly, the materials used are inert. This means that the body has a low response to the materials. This is an advantage as there is no immune response (inflammation) and a disadvantage as there is no bone response. If selective bioactivity could be produced (i.e. no immune response but increased bone response) then the implant could be locked in place by growing bone and implants for life developed. This lack of bone response means that the implants are not well held and can move about during walking. This is termed micromotion. This leads to failure with time as the extent of micromotion increases. Secondly, they worry about infection control. Even after sterilisation bacteria may be present on the implant materials in low numbers or can be introduced during surgery. If the infection can take hold it has major impact on the implant lifetime and this can result in younger patients having revision surgery and that has much higher failure rates.
We have developed very small, nanoscale patterns that can be used to tune bone growth and prevent bacterial adhesion. We will thus optimise these patterns to achieve bacterial control and bone formation at appropriate points of the implant. A major advantage is that we can process these patterns in titanium, a material commonly used for orthopaedic implants due to its high strength (i.e. it can withstand the weight of the human body as we walk).
Such an approach is a step towards making implants for life and planning ahead for the aging population.
Planned Impact
Beyond academic impact, this research has clear potential benefit for clinicians, current patients and future patients in the UK and rest of the world. There is a real drive to target osteoinduction for orthopaedic implants, and our strong collaboration with clinicians and our old market survey show us that industry and surgeons are worried about osseointegration, but bacterial control is a more pressing concern.
We will continue to develop our understanding of osseointegration, but make bacterial control the major focus of this application. If this can be addressed the benefits will be:
1) Prevention of bacterial adhesion on high-risk, fluid-contacting regions of the implant, as the body would struggle to clear the bacterial cells once adhered.
2) Prevention of migration of bacteria through the metaphyseal / implant bond through increased interdigitation of bone and osteoinduction of cells with the capacity to form bone.
3) Control of slow-emerging infections in the metaphyseal and diaphyseal regions from very low numbers of bacteria present on implants prior to implantation.
4) Slowing of biofilm formation should these slow-emerging infections take hold. This would increase the lifetime of the implant.
Achieving these targets will help to achieve implants for life and at least reduce revision rates. This has clear cost and time implications for the NHS. Reduction of the prevalence of complex and risky revision surgery in elderly patients would have a clear socio-economic impact.
To help us to achieve this, we will work closely with clinicians (facilitated by Meek who will have monthly meetings with the academic team and who will recruit trainees to work alongside the project) and industry (most notably with De Puy who have agreed to regular meetings and data review (subject to confidentiality and IP protection).
We will continue to develop our understanding of osseointegration, but make bacterial control the major focus of this application. If this can be addressed the benefits will be:
1) Prevention of bacterial adhesion on high-risk, fluid-contacting regions of the implant, as the body would struggle to clear the bacterial cells once adhered.
2) Prevention of migration of bacteria through the metaphyseal / implant bond through increased interdigitation of bone and osteoinduction of cells with the capacity to form bone.
3) Control of slow-emerging infections in the metaphyseal and diaphyseal regions from very low numbers of bacteria present on implants prior to implantation.
4) Slowing of biofilm formation should these slow-emerging infections take hold. This would increase the lifetime of the implant.
Achieving these targets will help to achieve implants for life and at least reduce revision rates. This has clear cost and time implications for the NHS. Reduction of the prevalence of complex and risky revision surgery in elderly patients would have a clear socio-economic impact.
To help us to achieve this, we will work closely with clinicians (facilitated by Meek who will have monthly meetings with the academic team and who will recruit trainees to work alongside the project) and industry (most notably with De Puy who have agreed to regular meetings and data review (subject to confidentiality and IP protection).
Organisations
Publications
Reynolds PM
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Alfotawi R
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A nanostructured bacterial bioscaffold for the sustained bottom-up delivery of protein drugs.
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Wiejak J
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Genomic analysis of the role of transcription factor C/EBPd in the regulation of cell behaviour on nanometric grooves.
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Kingham E
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Nanotopographical cues augment mesenchymal differentiation of human embryonic stem cells.
in Small (Weinheim an der Bergstrasse, Germany)
Nadeem D
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Embossing of micropatterned ceramics and their cellular response.
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Dalby MJ
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Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate.
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Mashinchian O
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Cell-imprinted substrates act as an artificial niche for skin regeneration.
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Curtis AS
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in Expert review of medical devices
McNamara LE
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The use of microarrays and fluorescence in situ hybridization for the study of mechanotransduction from topography.
in Methods in cell biology
Cassidy JW
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Osteogenic lineage restriction by osteoprogenitors cultured on nanometric grooved surfaces: the role of focal adhesion maturation.
in Acta biomaterialia
Chong DS
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Luminal surface engineering, 'micro and nanopatterning': potential for self endothelialising vascular grafts?
in European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
Turner LA
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Nanotopography - potential relevance in the stem cell niche.
in Biomaterials science
Al-Fotawei R
(2014)
Radiological assessment of bioengineered bone in a muscle flap for the reconstruction of critical-size mandibular defect.
in PloS one
McMurray RJ
(2015)
Using biomaterials to study stem cell mechanotransduction, growth and differentiation.
in Journal of tissue engineering and regenerative medicine
Chong DS
(2015)
Nanotopography and plasma treatment: redesigning the surface for vascular graft endothelialisation.
in European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
Johnstone SA
(2015)
Comparison of human olfactory and skeletal MSCs using osteogenic nanotopography to demonstrate bone-specific bioactivity of the surfaces.
in Acta biomaterialia
Young PS
(2015)
Osteoclastogenesis/osteoblastogenesis using human bone marrow-derived cocultures on nanotopographical polymer surfaces.
in Nanomedicine (London, England)
Estévez M
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Adhesion and migration of cells responding to microtopography.
in Journal of biomedical materials research. Part A
Stipetic LH
(2015)
Draft Genome Sequence of Isolate Staphylococcus aureus LHSKBClinical, Isolated from an Infected Hip.
in Genome announcements
Pemberton GD
(2015)
Nanoscale stimulation of osteoblastogenesis from mesenchymal stem cells: nanotopography and nanokicking.
in Nanomedicine (London, England)
Nadeem D
(2015)
Three-dimensional CaP/gelatin lattice scaffolds with integrated osteoinductive surface topographies for bone tissue engineering.
in Biofabrication
Mashinchian O
(2015)
Regulation of stem cell fate by nanomaterial substrates.
in Nanomedicine (London, England)
Young, P.S., Greer, A.I.M., Tsimbouri, P.M., Meek, R.M.D., Gadegaard, N., And Dalby, M.J.
(2016)
Precision-Engineered Nanotopographical Surfaces to Control Osteoclast Differentiation
Tsimbouri PM
(2016)
Osteogenic and bactericidal surfaces from hydrothermal titania nanowires on titanium substrates.
in Scientific reports
Hay JJ
(2016)
Living biointerfaces based on non-pathogenic bacteria support stem cell differentiation.
in Scientific reports
Tsimbouri, P.M., Holloway, N., Fisher, L., Sjostrom, T., Nobbs, A.H., Meek, R.M.D., Su, B., And Dalby, M.J.
(2016)
Osteogenic and Bactericidal Surfaces from Hydrothermal Titania Nanowires on Titanium Substrates.
Aguayo S
(2016)
Influence of biomaterial nanotopography on the adhesive and elastic properties of Staphylococcus aureus cells
in RSC Advances
Silverwood RK
(2016)
Analysis of Osteoclastogenesis/Osteoblastogenesis on Nanotopographical Titania Surfaces.
in Advanced healthcare materials
Stipetic LH
(2016)
A novel metabolomic approach used for the comparison of Staphylococcus aureus planktonic cells and biofilm samples.
in Metabolomics : Official journal of the Metabolomic Society
Fraioli R
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Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands.
in Scientific reports
Alakpa EV
(2017)
Nacre Topography Produces Higher Crystallinity in Bone than Chemically Induced Osteogenesis.
in ACS nano
Laing S
(2017)
Correction to Thermoresponsive Polymer Micropatterns Fabricated by Dip-Pen Nanolithography for a Highly Controllable Substrate with Potential Cellular Applications.
in ACS applied materials & interfaces
Donnelly H
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Bone and cartilage differentiation of a single stem cell population driven by material interface.
in Journal of tissue engineering
Waddell SJ
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Biomimetic oyster shell-replicated topography alters the behaviour of human skeletal stem cells.
in Journal of tissue engineering
Donnelly H
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Current approaches for modulation of the nanoscale interface in the regulation of cell behavior.
in Nanomedicine : nanotechnology, biology, and medicine
Orapiriyakul W
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Antibacterial surface modification of titanium implants in orthopaedics.
in Journal of tissue engineering
Hay JJ
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Bacteria-Based Materials for Stem Cell Engineering.
in Advanced materials (Deerfield Beach, Fla.)
Damiati L
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Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants.
in Journal of tissue engineering
Huethorst E
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Mas-Moruno C
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Multifunctional Coatings and Nanotopographies: Toward Cell Instructive and Antibacterial Implants.
in Advanced healthcare materials
Huethorst E
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Customizable, engineered substrates for rapid screening of cellular cues.
in Biofabrication
Robertson SN
(2020)
Reduction of Pseudomonas aeruginosa biofilm formation through the application of nanoscale vibration.
in Journal of bioscience and bioengineering
| Description | We investigated how surfaces can be used to support normal bone growth and at the same time reduce bacterial growth. We have identified surfaces that support normal bone marrow cell growth and reduce bacterial growth by 30%. These surfaces have been generated on complex shaped, including 3D printed metals. Further, we showed that on bactericidal surfaces where MSCs could spread better and were more viable, higher bacterial kill was achieved. |
| Exploitation Route | Design of new implants or cell culture assays for understanding bacterial cell death Developing model surfaces to discover target pathways for drug development |
| Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | We have shown that bacteria as well as stem cells can be modulated by nanotopography alone. This has broad interest because of concern of surgical infection and loss of effectiveness of antibiotics. . We haver thus publicised the work in social media (especially as we publish articles) and on our website. The work has also helped us to engage industry as part of our recently awarded Centre for Doctoral Training looking at 3D tissue models for drug discovery and where there is interest in cell friendly anti-microbials. |
| Sector | Healthcare,Manufacturing, including Industrial Biotechology |
| Impact Types | Societal,Economic |
| Description | Glasgow Orthopaedic Research Initiative |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Healickick (EU grant) translational day |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Preparing surgeons for the technologies and getting advice how to best present the technologies in product form |
| Description | Organisation of industry focussed stakeholder day |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Research Together - Patient and Public Involvement and Engagement Day 2023 |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Patients have fed back very positively about the day and about what they had learnt about emerging science in the area they are interested in and also future technologies. |
| Description | 'EPSRC and SFI Centre for Doctoral Training in Engineered Tissues for Discovery, Industry and Medicine |
| Amount | £7,013,578 (GBP) |
| Funding ID | EP/S02347X/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 12/2027 |
| Description | Dr M.P. Tsimbouri was awarded a Welcome Trust Institutional Strategic Support Fund (ISSF) to studdy "Metabolite identification and targeting between normal and cancerous cells on titanium surfaces" |
| Amount | £5,000 (GBP) |
| Organisation | University of Glasgow |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 12/2019 |
| Description | Engineering growth factor microenvironments - a new therapeutic paradigm for regenerative medicine |
| Amount | £3,661,144 (GBP) |
| Funding ID | EP/P001114/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 09/2021 |
| Description | In vitro and in vivo studies of 3D orthopaedic implants with cell-instructive nanotopographies |
| Amount | £713,009 (GBP) |
| Funding ID | MR/S010343/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 05/2023 |
| Title | Antibacterial topography |
| Description | We have generated titanium topographies that can support human cell growth but that kill bacteria for use in orthopaedic implants or as a cell assay tool. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | NA |
| Title | Analysis of ostoclastogenesis / osteoblastogenesis using human bone marrow derived co-cultures on nanotopographical titania surfaces. |
| Description | |
| Type Of Material | Database/Collection of data |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Title | Materials-driven fibronectin assembly on nanoscale topography enhances mesenchymal stem cell adhesion, protecting cells from bacterial virulence factors and preventing biofilm formation |
| Description | Data package for publication |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Better understanding of how cells and bacteria can interface with novel orthopaedic biomaterials |
| URL | http://researchdata.gla.ac.uk/id/eprint/1051 |
| Title | Osteogenic and bactericidal surfaces from hydrothermal titania nanowires on titanium substrates |
| Description | |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Description | COllaboration with Atelerix |
| Organisation | Atelerix |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Thi sis a joint PhD project in which we are designing in vitro stem cell niches |
| Collaborator Contribution | Provision and tailoring of hydrogel materials |
| Impact | Early collaboration |
| Start Year | 2021 |
| Description | Collaboration with Bone Cancer Research Trust |
| Organisation | Bone Cancer Research Trust |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | We are developing models of sarcoma that are useful for bone cancer research |
| Collaborator Contribution | They are supporting us with training placements, access to patients and advice. |
| Impact | Development of better tissue models and enhanced training. |
| Start Year | 2020 |
| Description | Souhtampton Collaboration |
| Organisation | University of Southampton |
| Department | Bone and Joint Research Group |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This is a long term collaboration where cells, materials and expertise are shared to drive research |
| Collaborator Contribution | This is a long term collaboration where cells, materials and expertise are shared to drive research |
| Impact | A large number of papers, grants and IP. |
| Description | Surgical collaboration |
| Organisation | NHS Greater Glasgow and Clyde (NHSGGC) |
| Department | Surgery Glasgow and Clyde |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | We are working hard to establish clinical collaborations and to improve orthopaedic/bone related materials to make better implants. |
| Collaborator Contribution | Bone marrow for isolation of stem cells/ expertise and perspective. |
| Impact | We have formed the Glasgow Orthopaedic Research Initiative to bring clinicians and basic scientists together for lab projects and for meetings. We host many clinical trainees in the lab and together have applied for, and secured, funds from CSO, BBSRC, MRC and EPSRC. |
| Start Year | 2009 |
| Description | Surgical collaboration |
| Organisation | NHS Greater Glasgow and Clyde (NHSGGC) |
| Department | Surgery Glasgow and Clyde |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | We are working hard to establish clinical collaborations and to improve orthopaedic/bone related materials to make better implants. |
| Collaborator Contribution | Bone marrow for isolation of stem cells/ expertise and perspective. |
| Impact | We have formed the Glasgow Orthopaedic Research Initiative to bring clinicians and basic scientists together for lab projects and for meetings. We host many clinical trainees in the lab and together have applied for, and secured, funds from CSO, BBSRC, MRC and EPSRC. |
| Start Year | 2009 |
| Description | Surgical collaboration |
| Organisation | NHS Greater Glasgow and Clyde (NHSGGC) |
| Department | Surgery Glasgow and Clyde |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | We are working hard to establish clinical collaborations and to improve orthopaedic/bone related materials to make better implants. |
| Collaborator Contribution | Bone marrow for isolation of stem cells/ expertise and perspective. |
| Impact | We have formed the Glasgow Orthopaedic Research Initiative to bring clinicians and basic scientists together for lab projects and for meetings. We host many clinical trainees in the lab and together have applied for, and secured, funds from CSO, BBSRC, MRC and EPSRC. |
| Start Year | 2009 |
| Description | Surgical collaboration |
| Organisation | NHS Greater Glasgow and Clyde (NHSGGC) |
| Department | Surgery Glasgow and Clyde |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | We are working hard to establish clinical collaborations and to improve orthopaedic/bone related materials to make better implants. |
| Collaborator Contribution | Bone marrow for isolation of stem cells/ expertise and perspective. |
| Impact | We have formed the Glasgow Orthopaedic Research Initiative to bring clinicians and basic scientists together for lab projects and for meetings. We host many clinical trainees in the lab and together have applied for, and secured, funds from CSO, BBSRC, MRC and EPSRC. |
| Start Year | 2009 |
| Description | Surgical collaboration |
| Organisation | Royal Hospital for Children |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | We are working hard to establish clinical collaborations and to improve orthopaedic/bone related materials to make better implants. |
| Collaborator Contribution | Bone marrow for isolation of stem cells/ expertise and perspective. |
| Impact | We have formed the Glasgow Orthopaedic Research Initiative to bring clinicians and basic scientists together for lab projects and for meetings. We host many clinical trainees in the lab and together have applied for, and secured, funds from CSO, BBSRC, MRC and EPSRC. |
| Start Year | 2009 |
| Description | Surgical collaboration |
| Organisation | Royal Hospital for Children |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | We are working hard to establish clinical collaborations and to improve orthopaedic/bone related materials to make better implants. |
| Collaborator Contribution | Bone marrow for isolation of stem cells/ expertise and perspective. |
| Impact | We have formed the Glasgow Orthopaedic Research Initiative to bring clinicians and basic scientists together for lab projects and for meetings. We host many clinical trainees in the lab and together have applied for, and secured, funds from CSO, BBSRC, MRC and EPSRC. |
| Start Year | 2009 |
| Description | Surgical collaboration with Mr Peter Young |
| Organisation | NHS Greater Glasgow and Clyde (NHSGGC) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Work on orthopaedic biomaterials |
| Collaborator Contribution | Provision of bone marrow for cell isolation |
| Impact | THis has allowed us to establish osteoblast/osteoclast co-culture models |
| Start Year | 2018 |
| Description | surgical collaboration |
| Organisation | Glasgow Royal Infirmary |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | We are further interested in assessing the suitability of our identified candidate titanium surfaces in bone cancers. Hence we are collaborating with clinicians to provide us with bone cancer samples. |
| Collaborator Contribution | Clinical expertise and provision of samples. |
| Impact | too early to say |
| Start Year | 2013 |
| Description | surgical collaboration |
| Organisation | NHS Greater Glasgow and Clyde (NHSGGC) |
| Department | Bio Repository |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | We are further interested in assessing the suitability of our identified candidate titanium surfaces in bone cancers. Hence we are collaborating with clinicians to provide us with bone cancer samples. |
| Collaborator Contribution | Clinical expertise and provision of samples. |
| Impact | too early to say |
| Start Year | 2013 |
| Description | 29th Annual Meeting of the European Society for Biomaterials, 9-13 September 2018, Maastricht, the Netherlands |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ms Laila Damiati attended the 29th Annual Meeting of the European Society for Biomaterials, 9-13 September 2018, Maastricht, the Netherlands and had an Oral presentation. |
| Year(s) Of Engagement Activity | 2018 |
| Description | ARCADIA public engagement |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | ARCADIA was a festival of public events that celebrated the public opening for the ARC building form 15 to 23 September 2022. The general aims were collaboration between university and non academic groups. I covered mixed disciplines form arts to social, physical and life sciences, engaging with marginalised groups. The event attracted public visitors of all ages throughout the two weeks and everyone provided good comments and they would like to be able to experience an event like that in the future. 75 free events for all ages were held day and night in the ARC, from schools workshops to cinema screenings, exhibitions, comedy, gaming, talks and even an outdoor ceilidh with dancing dinosaurs. Over 63% of events involved working in partnership with non-academic groups. It attracted over 7,000 people to engage with the activities. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.gla.ac.uk/myglasgow/news/newsarchive/2022/8november2022/headline_893700_en.html |
| Description | ARCADIA public engagement |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | ARCadia, was a festival of public events that celebrated the public opening of the ARC from 16-30 September 2022 that attracted almost 7000 people. The general aims were: Collaboration between the university and non-academic groups A mix of disciplines, from the arts to social, physical and life sciences Engaging traditionally marginalised groups, or groups who experience barriers to accessing the university Engaging communities local to the ARC (postcodes G11, G3, G12) 75 free events for all ages were held day and night in the ARC, from schools workshops to cinema screenings, exhibitions, comedy, gaming, talks and even an outdoor ceilidh with dancing dinosaurs. Over 63% of events involved working in partnership with non-academic groups. An astonishing number of people helped organise and run ARCadia events (and our group CeMi was central in this) , including 326 UofG colleagues, 147 students, 239 partner staff, 30 volunteers and for student interns. The event attracted public visitor of all ages throughout the 2 weeks and everyone provided good comments and they would like to be able to experience an event like that in the future. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.gla.ac.uk/myglasgow/news/newsarchive/2022/8november2022/headline_893700_en.html |
| Description | BORS |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | We organised the British Orthopedic Society annual conference in Glasgow. The conference sparked discussion after every talk and new collaborations were initiated between research and clinical groups. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Biomaterials seminar |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Ms Laila Damiati gave a talk at the local Biomaterials seminar session on 15/05/2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | CCE-GLORI (Glasgow) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | workshop facilitator |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr MP Tsimbouri, organised the local CCE-GLORI half day conference twice a year where there were presentations and discussions about collaborative projects between clinicians and scientists. More clinicians interested in research leading to future funding |
| Year(s) Of Engagement Activity | 2014,2015,2016 |
| Description | Cell block science |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Presented at prisoner outreach day at HMP Shotts |
| Year(s) Of Engagement Activity | 2019 |
| Description | Centre for Cellular Microenvironment (CeMi) Seminar |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Rosalia Cuahtecontzi Delint presented data and project progression related to her project in In-vitro Studies of Orthopaedic Implants with Cell Instructive Nanotopographies. These presentations are done quarterly. After the talks there are questions regarding the methods of experiments and suggestions for future work. |
| Year(s) Of Engagement Activity | 2021,2022,2023 |
| Description | Centre for Doctoral Training Retreat |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Retreat to The Burn for formal PGR student training in entrepreneurship |
| Year(s) Of Engagement Activity | 2021 |
| Description | Centre for the Cellular Microenvironment symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | We organised an open symposium with expert speakers from the UK, EU and US - and from academic and industry |
| Year(s) Of Engagement Activity | 2019 |
| Description | Centre for the Cellular Microenvironment GLORI mini symposium 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | We organised an open symposium with expert speakers from the UK, EU and US - and from academic and industry |
| Year(s) Of Engagement Activity | 2019,2020,2021 |
| Description | Conference Oral Presentation - World Biomaterials Congress 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ms Laila Damiati delivered an Oral presentation "2D and 3D titanium nanoscale topographies that lower Pseudomonas aeruginosa adhesion, reduce the effects of quorum signalling molecules on MSCs and enhance MSC differentiation to bone". |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://wbc2020.org/ |
| Description | Conference attendance-RSC Biomaterials Chemistry Annual Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ms Laila Damiati delivered an oral presentation at the RSC Biomaterials Chemistry Annual Conference, Liverpool, UK. "Role of nanotopography and bioactive coated 2D/ 3D titanium lattices on mesenchymal stem cells and Pseudomonas aeruginosa behaviour" There was discussion and chance of networking post presentation. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Conference attendance: TERMIS EU 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ms Laila Damiati delivered an oral presentation at the TERMIS EU 2019, Rhodes, Greece. "Engineered bioactive coatings for 2D/3D titanium implants to enhance osteogenesis and reduce biofilm formation" The conference was very interesting and conversation with other scientists led to new ideas. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Conference organisation CCE-GLORI 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | The local CCE-GLORI workshop is organised by Dr Monica P. Tsimbouri every year. It is a workshop where postgraduate students present their work to their peers and supervisors and discussion then follows the talks. This is highly beneficial to students and promotes collaboration. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Conference organisation-GLORI2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Monica P. Tsimbouri organises GLORI bi-annually. This conference encourages collaboration between the basic sciences, applied sciences, engineering and clinic. This has the aim of bringing the latest ideas in basic materials research into use to deliver the next-generation of orthopaedic care. It combines expertise from orthopaedic surgeons, plastic surgeons, biologists, engineers and chemists. The conference is free for attendance and involves oral and poster presentations from professionals, scientists, clinicians and postgraduate students. It is always well attended. It is sponsored by industry who are also involved in the conference. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Conference presentation |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Biology of Regenerative Medicine, Wellcome Genome Campus, Hinxton, Cambridge, UK- 2017 (Poster + 3 minuets talk presentation By Laila Damiati). |
| Year(s) Of Engagement Activity | 2017 |
| Description | Conference presentation |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | 17 th Annual Meeting of the TCES and the BATB Pre-Conference Training, University of Manchester, Manchester, UK- 2017 (Poster presented by Laila Damiati). |
| Year(s) Of Engagement Activity | 2017 |
| Description | Conference presentation |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | 10 th Annual UK MSC Meeting. Held at the University of York, York, UK- 2016. Attended by Laila Damiati |
| Year(s) Of Engagement Activity | 2016 |
| Description | Conference talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation by Dr PM Tsimbouri about osteogenic and Bactericidal effects of Ti nanowires. |
| Year(s) Of Engagement Activity | 2016 |
| Description | DTC |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr MP Tsimbouri. Talk sparked questions and discussion The DTC students were interested in doing a project on the subject covered |
| Year(s) Of Engagement Activity | 2010,2011,2012,2013 |
| Description | Dr Monica Tsimbouri, Change Champion helping to organise and interface with academics regarding the Advanced Research Centre at UofG |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | In the role of a Change Champion deputy my role was to assist in the organisation and planning of the building of a new centre for advanced research within Glasgow university. This centre consists of a large inter disciplinary cohort, to encourage collaboration, and would therefore require a wide degree of specialisations. At these events i was required to interface with companies, academics and univeristy professionals to exchange information and then disseminate this to my own colleagues. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Dr PM Tsimbouri Tissue and Cell Engineering Society Conference, 2-4 July 2018, Keele University, Keele, Staffordshire, UK. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr PM Tsimbouri attended the Tissue and Cell Engineering Society Conference, 2-4 July 2018, Keele University, Keele, Staffordshire, UK and had a Poster presentation |
| Year(s) Of Engagement Activity | 2017,2018 |
| Description | Dr Tsimbouri; SULSA's Antimicrobial Resistance Conference, Technology & Innovation Centre, Glasgow, UK- April 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr P.M Tsimbouri presented a poster at the SULSA's Antimicrobial Resistance Conference, Technology & Innovation Centre, Glasgow, UK- April 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | European Society for Biomaterials Keynote (Dalby) Talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote conference talk |
| Year(s) Of Engagement Activity | 2021 |
| Description | GLORI (Glasgow) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | workshop facilitator |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | GLORI was founded by Prof Dalby and Mr Meek with the aim to bring together Scientists and Clinicians and stimulate collaborations with great success so far. Dr MP Tsimbouri and Peter Young (Orthopedic registrar) are now taking the responsibility of organising the event this year at a larger scale, with poster and paper presentations. The event has been successful so far with a number of clinicians engaging in a science project and related funding was awarded to support 3 projects. |
| Year(s) Of Engagement Activity | 2009,2010,2011,2012,2013,2014,2015,2016 |
| Description | GLORI conference organisation |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Planning and Organisation of Dr Monica P Tsimbouri the scientific mentor of the Glasgow Orthopaedic Research Initiative (GLORI). GLORI has been established to encourage collaboration between the basic sciences, applied sciences, engineering and clinic. This has the aim of bringing the latest ideas in basic materials research into use to deliver the next-generation of orthopaedic care. It combines expertise from orthopaedic surgeons, biologists, engineers and chemists not only from Glasgow and Strathclyde Universities but the rest of Scotland too and also with the view to expand to the rest of the UK. |
| Year(s) Of Engagement Activity | 2018 |
| Description | GLaMOR 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | paper presentation |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | talk sparked questions and discussion afterwards After the talk,new Orthopedic registrars joined the group for research |
| Year(s) Of Engagement Activity | 2014 |
| Description | Glasgow Crucible |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr P. Tsimbouri was selected to attend the Glasgow Crucible, a highly prestigious networking workshop organised by the GU in attempt to promote interdisciplinary collaborations. A potential collaboration arose from this event. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Glasgow Science Festival: Regenerate |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The Glasgow Science Festival runs for a few weeks and we did a full day focusing on Stem Cell activities, talking to the general public (mainly children). The aim was teach them how stem cells differentiate. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Group meetings |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Rosalia Cuahtecontzi Delint presented progress and results from the project In-vitro Studies of Orthopaedic Implants with Cell Instructive Nanotopographies. this presentation lead to discussion within the group for further experiments and techniques that could be used to gather data. |
| Year(s) Of Engagement Activity | 2021,2022,2023 |
| Description | Healickick (EU grant) translation day |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion between academics and surgeons around technologies we have developed. |
| Year(s) Of Engagement Activity | 2021 |
| Description | International Conference presentation |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was a poster presentation entitled: "Bifunctional Ti nanotopography with osteogenic potential and anti-microbial actions" by Dr Monica Tsimbouri on 02 July - 07 July 2017 - Hotel Eden Roc, Sant Feliu de Guixols, Catalonia, Spain which trigered a lot of interest and discussion. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://mimeresearch.com/biointerfaces2017/ |
| Description | Invited talk at BCRT Scotland day May 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was an invited talk for Dr Monica P. Tsimbouri by BCRT in Perth May 16th 2017. The presentation was intended for clinical partitioners as well as patients and carers affected by bone cancers. There was a lot of interest and discussions after the talk and Dr Tsimbouri was asked to give a further presenation in the future. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.bcrt.org.uk/news/2017/may/our-first-scottish-patient-and-carer-day |
| Description | Invited talk at British Orthopaedic Research Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussed research training of junior surgeons |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited talk at Monklands Hospital, Glasgow |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr P.M. Tsimbouri was invited by a Clinical colleague to give a talk at the Monklands Hospital. Clinical staff from different backgrounds but especially immunology and microbiology were particularly interested in our work. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Keynote talk (Dalby) at Tissue Engineerign and Regenerative medicien International Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote talk at a major conference |
| Year(s) Of Engagement Activity | 2021 |
| Description | Laila Damiati GLORI 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ms Laila Damiati presented a poster at the GLORI 2018 meeting |
| Year(s) Of Engagement Activity | 2018 |
| Description | Local Talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Year 1 Project Talk by Laila Damiati, University of Glasgow. March 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | MRC catch up with collaborators at University of Bristol |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | This meeting is done quarterly with collaborators from the University of Bristol. We discuss and compare results from the titanium surfaces created and how bacterial and mammalian cells respond to them. Rosalia Cuahtecontzi Delint presents data regarding the project in In-vitro Studies of Orthopaedic Implants with Cell Instructive Nanotopographies. The outcomes of the meeting are future experiments to better the project and to solve any other controls for experiments. |
| Year(s) Of Engagement Activity | 2021,2022,2023 |
| Description | Media interest BBC (nanokicking) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Talk sparked public interest Many interested enquirers. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Media interest BBC (orthopaedic materials) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Sparked public interest Enquieries from the public |
| Year(s) Of Engagement Activity | 2013 |
| Description | Media interest BBC (stem cell growth) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Talk sparked public interest Enquieries from the public |
| Year(s) Of Engagement Activity | 2011 |
| Description | Ms Laila Damiati SULSA 2018 conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ms L. Damiati attended the SULSA's Antimicrobial Resistance Conference, Technology & Innovation Centre, Glasgow, UK- April 2018 and had a poster presentation |
| Year(s) Of Engagement Activity | 2018 |
| Description | Ms Laila Damiati Tissue and Cell Engineering Society Conference, 2-4 July 2018, Keele University, Keele, Staffordshire, UK (Turbo talk + Poster). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ms Laila Damiati attended the Tissue and Cell Engineering Society Conference, 2-4 July 2018, Keele University, Keele, Staffordshire, UK where she was asked to give a Turbo talk and a Poster presentation. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Nanotoxicology Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk for the Naotoxicology Society |
| Year(s) Of Engagement Activity | 2016 |
| Description | Nuffield Research Placement |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Offered a summer research project for two S5 school pupils. Nuffield Research Placements are funded by the Nuffield Foundation and delivered by STEM Learning. They are engaging, hands-on research projects, where students can contribute towards the work of a host organisation. They are a fantastic opportunity for students to apply skills and knowledge learned at school and work alongside researchers and industry professionals. The final presentation was online where students presented a poster on their project which could be attended by the public. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.nuffieldfoundation.org/students-teachers/nuffield-research-placements |
| Description | Oral presentation-GLORI2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ms Laila Damiati delivered an oral presentation with the title: "Biofunctional and Antibacterial Titanium Nanotopography for Orthopaedic Implants". |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://glasgow.thecemi.org/2020/03/13/glori-2020-symposium/ |
| Description | Poster presentation-Euro Biofilm 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ms Laila Damiati presented poster at the Euro Biofilm 2019, Glasgow, UK. "Pseudomonas aeruginosa quorum-sensing signal molecules interfere with human mesenchymal stem cells on bioactive coated 2D/3D titanium implants" |
| Year(s) Of Engagement Activity | 2019 |
| Description | Poster presentation: 30th annual conference of the European society of biomaterials |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ms Laila Damiati presentated a poster at the 30th annual conference of the European society of biomaterials, Dresden, Germany. "Bioengineered nontopographical coating to drive osteointegration and reduce implant infection" A lot of interest was expressed. |
| Year(s) Of Engagement Activity | 2019 |
| Description | RSC Biomaterials Chemistry Annual Conference 2019, 9-11 January 2019, Liverpool, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ms Laila Damiati attaended the RSC Biomaterials Chemistry Annual Conference 2019, 9-11 January 2019, Liverpool, UK and had an Oral presentation. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Royal Society of Chemistry Biomaterials Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Conference presentation |
| Year(s) Of Engagement Activity | 2017 |
| Description | School outreach |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Dr Monica P Tsimbouri, organised a talk and workshop on Bone cells, Bones and implants for ages P5-P7 primary school. Stimulated the pupils to thinks about their body and the exiting science behind it. The children had the chance to look down a microscope and later make bone cells and bones. During and after the workshop there was a lot of discussion. The school requested Dr Tsimbouri to visit he school again next year. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Scottish Metabolomics Network |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk |
| Year(s) Of Engagement Activity | 2016 |
| Description | TCES 2010 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | paper presentation |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Monica P Tsimbouri. exiting discussion after talk Interested parties continued discussion |
| Year(s) Of Engagement Activity | 2010 |
| Description | TCES 2012 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | paper presentation |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr P Tsimbouri. talk sparked questions and discussion afterwards Engagement with company Reps and received very good discount on equipment. |
| Year(s) Of Engagement Activity | 2012 |
| Description | TCES 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | poster presentation |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | questions and discussion followed presentation collaborative paper discussion |
| Year(s) Of Engagement Activity | 2014 |
| Description | TERMIS EU 2011 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | paper presentation |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Monica P Tsimbouri. Talk sparked questions and discussion afterwards There was further discussion during a later session about my talk |
| Year(s) Of Engagement Activity | 2011 |
| Description | Talk in Portugal |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk for Dalby at University of Aviero |
| Year(s) Of Engagement Activity | 2022 |
| Description | UKSB |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | paper presentation |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr M. P. Tsimbouri. Interesting discussion following presentation Discussion lead to problem solving for a fellow scientist |
| Year(s) Of Engagement Activity | 2010 |
| Description | YRD2014 Research day (Glasgow) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | poster presentation |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | presentation created interest in the project and a poster prize award to Dr M.P. Tsimbouri Interest from medical staff to undertake research experience in our lab |
| Year(s) Of Engagement Activity | 2014 |
| Description | school workshop: Bones and bone cells, 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Dr P.M. Tsimbouri has organised a full day workshop for P5,P6 and P7 school pupils at the Milngavie primary school. The workshop involves presentation slides and Q/A session with the children about the skeleton, bones and bone cells. This followed by hands on experience looking at fixed cells using bright field microscopes. The children were given colour-in pages and also word searches to take home. |
| Year(s) Of Engagement Activity | 2015,2017 |
| Description | seminar talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr P.M. Tsimbouri presented an update of her work on osteogenic and bactericidal properties of Titanium nanosurfaces at the local Biomaterials seminars series. The talk sparked questions and discussion. |
| Year(s) Of Engagement Activity | 2016 |