BristolBridge: Bridging the Gaps between the Engineering and Physical Sciences and Antimicrobial Resistance
Lead Research Organisation:
University of Bristol
Department Name: Chemistry
Abstract
Antimicrobial (antibiotic) resistance (AMR) is a major and growing problem in many areas of medicine. AMR has been recognised as one of the most important challenges facing the UK. The availability of effective antimicrobial compounds underpins much of modern health care, making possible invasive surgical procedures and aggressive chemotherapeutic regimes that would otherwise be compromised by unacceptable risk of bacterial infection. Within this broad area, the increasing prevalence of resistant Gram-negative bacteria as causes of healthcare associated infections, the lack of new agents effective against these organisms, and the consequent requirement to stimulate antibiotic development, are all highlighted in the recent report of the UK Chief Medical Officer.
Physical scientists, engineers and mathematicians can make potentially transformative contributions to tackling AMR. Unleashing this potential requires new ways of interdisciplinary working, and bringing together researchers from these disciplines with counterparts from biology and human and animal medicine. We will achieve this by the following specific objectives:
(1) A wide range of networking activities to build new interdisciplinary research communities
(2) Pump-priming projects in, and across, three distinct strands we have identified, building on EPS research strengths, aligned with AMR strategy, to foster transformative research to combat AMR
(3) Training activities (training EPS researchers in biomedical methods and models and vice versa), to aid EPS researchers in understanding AMR and equip biomedical researchers to apply EPS methods, effectively training a new generation of researchers to tackle the problems of AMR
The University of Bristol is exceptionally well placed to build and deliver new engineering and physical science research into AMR, combining as it does international excellence across all of these fields. The University of Bristol houses world-leading research in the physical sciences, mathematics, computer science and engineering, much of which is EPSRC-funded. Bristol is also a thriving centre for basic biomedical, clinical, veterinary and community health research, with studies into AMR as a key strength. AMR is a strategic priority at the University of Bristol through our Infection and Immunity research theme and with support from the Elizabeth Blackwell Institute (EBI) for Health Research, we have already begun building connections across these interdisciplinary communities. This Bridging the Gaps project will exploit the potential opportunities that exist across a wide range of outstanding EPS researchers, including those who have never previously felt their research was relevant to AMR. By ensuring that EPS researchers are core members of interdisciplinary research activity, we will identify and seed new approaches to analyse, mitigate and ultimately overcome AMR. UoB houses world-leading research in materials science, engineering, synthetic biology, physics, maths/statistics, nanoscience and chemistry, all with significant EPSRC funding. UoB currently has the 6th largest EPSRC portfolio of any UK University, with in excess of £200M in live grants. Bristol is also a thriving centre for biomedical, clinical and community health research (within Clinical Sciences, Veterinary Sciences, Cellular and Molecular Medicine and in our NHS Trust partners, UoB has the fifth largest active portfolio of grants classified by EPSRC as relevant to the Healthcare sector, totalling approx £30M), in which studies of AMR form a key part. UoB has an outstanding track record of success in developing new interdisciplinary collaborations to address major societal challenges with the EBI, which was formed in 2012 for this express purpose. The EBI is ideally placed to help building interdisciplinary capacity in AMR, and has an existing governance mechanism for open and transparent deployment of this type of funding.
Physical scientists, engineers and mathematicians can make potentially transformative contributions to tackling AMR. Unleashing this potential requires new ways of interdisciplinary working, and bringing together researchers from these disciplines with counterparts from biology and human and animal medicine. We will achieve this by the following specific objectives:
(1) A wide range of networking activities to build new interdisciplinary research communities
(2) Pump-priming projects in, and across, three distinct strands we have identified, building on EPS research strengths, aligned with AMR strategy, to foster transformative research to combat AMR
(3) Training activities (training EPS researchers in biomedical methods and models and vice versa), to aid EPS researchers in understanding AMR and equip biomedical researchers to apply EPS methods, effectively training a new generation of researchers to tackle the problems of AMR
The University of Bristol is exceptionally well placed to build and deliver new engineering and physical science research into AMR, combining as it does international excellence across all of these fields. The University of Bristol houses world-leading research in the physical sciences, mathematics, computer science and engineering, much of which is EPSRC-funded. Bristol is also a thriving centre for basic biomedical, clinical, veterinary and community health research, with studies into AMR as a key strength. AMR is a strategic priority at the University of Bristol through our Infection and Immunity research theme and with support from the Elizabeth Blackwell Institute (EBI) for Health Research, we have already begun building connections across these interdisciplinary communities. This Bridging the Gaps project will exploit the potential opportunities that exist across a wide range of outstanding EPS researchers, including those who have never previously felt their research was relevant to AMR. By ensuring that EPS researchers are core members of interdisciplinary research activity, we will identify and seed new approaches to analyse, mitigate and ultimately overcome AMR. UoB houses world-leading research in materials science, engineering, synthetic biology, physics, maths/statistics, nanoscience and chemistry, all with significant EPSRC funding. UoB currently has the 6th largest EPSRC portfolio of any UK University, with in excess of £200M in live grants. Bristol is also a thriving centre for biomedical, clinical and community health research (within Clinical Sciences, Veterinary Sciences, Cellular and Molecular Medicine and in our NHS Trust partners, UoB has the fifth largest active portfolio of grants classified by EPSRC as relevant to the Healthcare sector, totalling approx £30M), in which studies of AMR form a key part. UoB has an outstanding track record of success in developing new interdisciplinary collaborations to address major societal challenges with the EBI, which was formed in 2012 for this express purpose. The EBI is ideally placed to help building interdisciplinary capacity in AMR, and has an existing governance mechanism for open and transparent deployment of this type of funding.
Planned Impact
Benefit of the activities on the future of collaborative research addressing AMR at the institution: UoB hosts considerable experience in the AMR field and EPS departments with huge potential for developing solutions, but the two are disconnected by structural and administrative barriers. The overriding objective of this Bridging the Gaps project is to equip engineers and physical scientists (EPS) at the University of Bristol (UoB) with the knowledge and resources necessary to make future substantive discoveries that will tackle the problem of Antimicrobial Resistance (AMR). We will use specific mechanisms to break these down and forge collaborations as described in the Pathways to Impact. By its very nature, the primary impact of this project will be an increase in collaborative research between UoB EPS and biomedical sciences academics in AMR.
Potential External Beneficiaries: Whilst the primary impact of this project will be to generate collaborations within UoB, advances in AMR research may be transformative beyond the lifetime of this project. Our proposed activities encompass novel antimicrobial discovery (research theme 1) to replenish the supply of drugs; improving antimicrobial delivery (research theme 2) to minimise systemic and environmental exposure, reduce selection for resistance and revitalise existing antibiotics; and health research and surveillance interventions (research theme 3) to reduce antibiotic prescribing and slow resistance development. These may impact upon:
The UK Population: AMR is a significant detriment to UK population health, with resulting increases in morbidity and mortality affecting tens of thousands of people each year. Advances in any of the three research areas would have significant impact on the health of the nation. AMR is also a significant veterinary issue and a threat to global food security.
The UK Health and Social Care systems: AMR cost the UK economy £1 billion per year in 1998, (House of Lords report), and £10 billion per year today (Chief Medical Officer). Greater decline in patient well being prolongs recovery, increases cost, and may result in long term complications that increase cost to outpatient, GP and social care, and potentially reduce the working lifetime of the patient. Any outcome arising from this work that reduces disease severity and time to cure, has the potential to save society money.
Industry/UK Economic Activity: AMR is a global problem. UK research council led research such as this offers potential for direct economic benefit from the research, development and sale of novel antimicrobial drugs, diagnostic tests and drug delivery systems to overseas healthcare systems. There is also potential for job creation in the UK and economic flow from the rest of the world into the UK during the R&D phase.
Increasing impact by learning from Industry: Academics can misunderstand the requirements for achieving successful therapeutic/diagnostics. Accordingly, during the project lifetime, we will use specific events as described in the Pathways to Impact to improve translation of UoB EPS research in the AMR area. This will increase the likelihood of delivering impact to external beneficiaries as set out above.
Public and Educational Engagement: AMR is primarily driven by actions of people. One way to slow the rate of AMR development is public education about the problem, its causes and potential solutions, including the value of taxpayer-funded research. Public interest in this subject, and recognition of its importance, is evidenced by the vote to set the Longitude Prize in the AMR area. Similarly, engaging with schools and young people will enhance awareness, inspire the next generation about research and possible careers in STEM, and highlight opportunities and advances in interdisciplinary research in the AMR field in particular. We see these types of engagements as important impacts and describe events and activities to deliver them.
Potential External Beneficiaries: Whilst the primary impact of this project will be to generate collaborations within UoB, advances in AMR research may be transformative beyond the lifetime of this project. Our proposed activities encompass novel antimicrobial discovery (research theme 1) to replenish the supply of drugs; improving antimicrobial delivery (research theme 2) to minimise systemic and environmental exposure, reduce selection for resistance and revitalise existing antibiotics; and health research and surveillance interventions (research theme 3) to reduce antibiotic prescribing and slow resistance development. These may impact upon:
The UK Population: AMR is a significant detriment to UK population health, with resulting increases in morbidity and mortality affecting tens of thousands of people each year. Advances in any of the three research areas would have significant impact on the health of the nation. AMR is also a significant veterinary issue and a threat to global food security.
The UK Health and Social Care systems: AMR cost the UK economy £1 billion per year in 1998, (House of Lords report), and £10 billion per year today (Chief Medical Officer). Greater decline in patient well being prolongs recovery, increases cost, and may result in long term complications that increase cost to outpatient, GP and social care, and potentially reduce the working lifetime of the patient. Any outcome arising from this work that reduces disease severity and time to cure, has the potential to save society money.
Industry/UK Economic Activity: AMR is a global problem. UK research council led research such as this offers potential for direct economic benefit from the research, development and sale of novel antimicrobial drugs, diagnostic tests and drug delivery systems to overseas healthcare systems. There is also potential for job creation in the UK and economic flow from the rest of the world into the UK during the R&D phase.
Increasing impact by learning from Industry: Academics can misunderstand the requirements for achieving successful therapeutic/diagnostics. Accordingly, during the project lifetime, we will use specific events as described in the Pathways to Impact to improve translation of UoB EPS research in the AMR area. This will increase the likelihood of delivering impact to external beneficiaries as set out above.
Public and Educational Engagement: AMR is primarily driven by actions of people. One way to slow the rate of AMR development is public education about the problem, its causes and potential solutions, including the value of taxpayer-funded research. Public interest in this subject, and recognition of its importance, is evidenced by the vote to set the Longitude Prize in the AMR area. Similarly, engaging with schools and young people will enhance awareness, inspire the next generation about research and possible careers in STEM, and highlight opportunities and advances in interdisciplinary research in the AMR field in particular. We see these types of engagements as important impacts and describe events and activities to deliver them.
Organisations
- University of Bristol (Lead Research Organisation)
- Ubon Ratchathani University (Collaboration)
- University of the West of England (Collaboration)
- UK Centre for Ecology & Hydrology (Collaboration)
- Selcia (Collaboration)
- Quaid-i-Azam University (Collaboration)
- Polytechnic University of Catalonia (Collaboration)
- University of Bristol (Collaboration)
- UNIVERSITY OF SOUTHAMPTON (Collaboration)
Publications
Espejo-Román JM
(2022)
Selective Anticancer Therapy Based on a HA-CD44 Interaction Inhibitor Loaded on Polymeric Nanoparticles.
in Pharmaceutics
Evans LE
(2019)
Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a ß-Lactamase-Activated Antibacterial Prodrug.
in Journal of medicinal chemistry
Fan Betty
(2017)
Stage IV breast cancer is increased by omitting screening mammography
in ANNALS OF SURGICAL ONCOLOGY
Felton H
(2021)
Negligible-cost microfluidic device fabrication using 3D-printed interconnecting channel scaffolds.
in PloS one
Fisher LE
(2016)
Bactericidal activity of biomimetic diamond nanocone surfaces.
in Biointerphases
Fraioli R
(2017)
Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands.
in Scientific reports
Galdadas I
(2021)
Allosteric communication in class A ß-lactamases occurs via cooperative coupling of loop dynamics.
in eLife
Ge Y
(2017)
Identification of the quinolinedione inhibitor binding site in Cdc25 phosphatase B through docking and molecular dynamics simulations.
in Journal of computer-aided molecular design
| Title | BristolBridge AMR CrossFire video series • Public engagement: consultants for Surgeon X AMR comic (http://surgeonx.co.uk/), school talks, Schools Conference on Antibiotics and Antibiotic Resistance Science and BristolBridge AMR CrossFire hosted on YouT |
| Description | BristolBridge AMR CrossFire video series • Public engagement: consultants for Surgeon X AMR comic (http://surgeonx.co.uk/), school talks, Schools Conference on Antibiotics and Antibiotic Resistance Science and BristolBridge AMR CrossFire hosted on YouTube https://www.youtube.com/channel/UCjZ6fYNvw_8Mhr4OSWCvsSw • Media engagement - TV and radio (Avison & Seddon) • Media training by BBC Radio as part of Royal Society of Chemistry funded workshop & training for Surgeon X comic (Mulholland, Hughes - 'plus' funded postdoctoral research assistant & Walker - PhD student) |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2016 |
| Impact | BristolBridge AMR CrossFire video series • Public engagement: consultants for Surgeon X AMR comic (http://surgeonx.co.uk/), school talks, Schools Conference on Antibiotics and Antibiotic Resistance Science and BristolBridge AMR CrossFire hosted on YouTube https://www.youtube.com/channel/UCjZ6fYNvw_8Mhr4OSWCvsSw • Media engagement - TV and radio (Avison & Seddon) • Media training by BBC Radio as part of Royal Society of Chemistry funded workshop & training for Surgeon X comic (Mulholland, Hughes - 'plus' funded postdoctoral research assistant & Walker - PhD student) |
| URL | http://www.bristol.ac.uk/bristolbridge/ |
| Title | Surgeon X Special 'Trial and Error' |
| Description | Surgeon X comic special edition. Written by Sara Kenney and based on a chemistry storyline developed in consultation with Prof. Adrian Mulholland, Dr Robert Hughes and PhD student Mr Paul Walker (all University of Bristol). Dr Matthew Avison (BristolBridge Co-I) is also Key Science Consultant for the Surgeon X team. |
| Type Of Art | Creative Writing |
| Year Produced | 2017 |
| Impact | This is available in print (sold in comic shops) and available online. Sara Kenney has widely exhibited Surgeon X at AMR conferences, exhibitions and many public engagement events. |
| URL | http://surgeonx.co.uk/ |
| Description | An interdisciplinary AMR research network Bristol has an active and large interdisciplinary AMR research network, initiated largely by the EPSRC-funded BristolBridge 'Bridging the Gaps between the physical sciences and engineering and AMR' network project, led by Professor Adrian Mulholland (School of Chemistry). BristolBridge was funded for two years (2015 -17) and during that time it: Built a network of over 200 researchers from 5 of our 6 faculties, two NHS trusts, the GW4 and AMR investigators in low to middle income countries (LMICs) - the latter nucleated by a week-long series of AMR workshops in our 'Bristol Tackles Global Challenges' week Funded 17 pump-priming research projects including one which led to a patent and a University of Bristol spin out company - Vitamica Ltd. Leveraged £3.8m in follow-on funds including funding from UKRI, Innovate UK and the Longitude Prize Trained engineering and physical science postdoctoral researchers and PhD students in practical microbiology techniques Funded and undertook public engagement activities including a south west Schools Conference on AMR; consultants for Sara Kenney's Surgeon X AMR comic, including the Surgeon X Special 'Trial and Error' Details of our Bridging the Gaps activities in AMR are available at: https://www.bristol.ac.uk/amr/about/bristolbridge/ Antimicrobial (antibiotic) resistance (AMR) is a major and growing problem in many areas of medicine. AMR has been recognised as one of the most important challenges facing the UK. The availability of effective antimicrobial compounds underpins much of modern health care, making possible invasive surgical procedures and aggressive chemotherapeutic regimes that would otherwise be compromised by unacceptable risk of bacterial infection. Within this broad area, the increasing prevalence of resistant Gram-negative bacteria as causes of healthcare associated infections, the lack of new agents effective against these organisms, and the consequent requirement to stimulate antibiotic development, are all highlighted in the recent report of the UK Chief Medical Officer. Physical scientists, engineers and mathematicians can make potentially transformative contributions to tackling AMR. Unleashing this potential requires new ways of interdisciplinary working, and bringing together researchers from these disciplines with counterparts from biology and human and animal medicine. We will achieve this by the following specific objectives: (1) A wide range of networking activities to build new interdisciplinary research communities (2) Pump-priming projects in, and across, three distinct strands we have identified, building on EPS research strengths, aligned with AMR strategy, to foster transformative research to combat AMR (3) Training activities (training EPS researchers in biomedical methods and models and vice versa), to aid EPS researchers in understanding AMR and equip biomedical researchers to apply EPS methods, effectively training a new generation of researchers to tackle the problems of AMR The University of Bristol is exceptionally well placed to build and deliver new engineering and physical science research into AMR, combining as it does international excellence across all of these fields. The University of Bristol houses world-leading research in the physical sciences, mathematics, computer science and engineering, much of which is EPSRC-funded. Bristol is also a thriving centre for basic biomedical, clinical, veterinary and community health research, with studies into AMR as a key strength. AMR is a strategic priority at the University of Bristol through our Infection and Immunity research theme and with support from the Elizabeth Blackwell Institute (EBI) for Health Research, we have already begun building connections across these interdisciplinary communities. This Bridging the Gaps project will exploit the potential opportunities that exist across a wide range of outstanding EPS researchers, including those who have never previously felt their research was relevant to AMR. By ensuring that EPS researchers are core members of interdisciplinary research activity, we will identify and seed new approaches to analyse, mitigate and ultimately overcome AMR. UoB houses world-leading research in materials science, engineering, synthetic biology, physics, maths/statistics, nanoscience and chemistry, all with significant EPSRC funding. UoB currently has the 6th largest EPSRC portfolio of any UK University, with in excess of £200M in live grants. Bristol is also a thriving centre for biomedical, clinical and community health research (within Clinical Sciences, Veterinary Sciences, Cellular and Molecular Medicine and in our NHS Trust partners, UoB has the fifth largest active portfolio of grants classified by EPSRC as relevant to the Healthcare sector, totalling approx £30M), in which studies of AMR form a key part. UoB has an outstanding track record of success in developing new interdisciplinary collaborations to address major societal challenges with the EBI, which was formed in 2012 for this express purpose. The EBI is ideally placed to help building interdisciplinary capacity in AMR, and has an existing governance mechanism for open and transparent deployment of this type of funding. BristolBridge: a multidisciplinary approach to tackling antimicrobial resistance. Antimicrobial resistance (AMR) is an escalating global threat. BristolBridge aims to provide exciting new research opportunities for outstanding engineering and physical sciences researchers, including those who have never previously felt their work was relevant to AMR. The antimicrobial resistance (AMR) challenge is part of a cross-Research Council initiative to encourage researchers to work collaboratively to tackle the emergence and spread of infections caused by bacteria that are resistant to treatment by current antibiotics. BristolBridge supports multiple pump-priming projects across the University to generate data for future research proposals. The University of Bristol is committed to fighting the global challenge posed by the increasing problem of antimicrobial resistance (AMR), and has received £10.25 million of research funding from the UKRI 'Tackling AMR - A Cross-Council Initiative' to find effective and sustainable solutions to this urgent problem. Antibiotics transformed healthcare in the 20th century and are still considered one of the greatest medical achievements of the era. Today, we still rely on antibiotics to treat everything from minor cuts to life-threatening bacterial infections and to prevent infection after surgery. These drugs drastically improved our quality of life and increased lifespan. In the 21st century, antibiotic overuse and misuse has led to antibiotics rapidly becoming ineffective resulting in a fall in life expectancy. Antimicrobial resistance, specifically antibacterial resistance, now poses a global threat to human life. Resistance occurs when antibiotics are rendered ineffective against the bacteria they are engineered to fight. We need urgent action to halt resistance and to accelerate new treatments for bacterial infection. The University of Bristol has a number of research projects, programmes and initiatives that are working towards understanding AMR better and finding solutions for this escalating global issue. The AMR research community at Bristol ('Bristol AMR') is a cross-faculty research network supported by the University's Elizabeth Blackwell Institute for Health Research as one of their four Research Strands, which are funded through the Wellcome Trust Institutional Strategic Support Fund (ISSF). This is further funding to which BristolBridge contributed, but as part of a Wellcome Trust ISSF Award (PI Professor Rachael Gooberman-Hill, EBI Director) apparently is not included in the ResearchFish database of awards. BristolBridge was highlighted in an Institute of Physics eBook on research collaboration |
| First Year Of Impact | 2015 |
| Sector | Agriculture, Food and Drink,Chemicals,Communities and Social Services/Policy,Creative Economy,Digital/Communication/Information Technologies (including Software),Education,Environment,Healthcare,Leisure Activities, including Sports, Recreation and Tourism,Government, Democracy and Justice,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology,Security and Diplomacy |
| Impact Types | Cultural,Societal,Economic,Policy & public services |
| Description | BNSSG CCG Diagnostics Steering Group Membership |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Contribution to new or Improved professional practice |
| Description | Research data and policy |
| Geographic Reach | National |
| Policy Influence Type | Contribution to new or improved professional practice |
| URL | https://www.chemistryworld.com/news/ukri-finds-itself-in-hot-water-too-over-researchfish-cyberbullyi... |
| Description | UKRI research data capture approaches |
| Geographic Reach | National |
| Policy Influence Type | Contribution to new or improved professional practice |
| URL | https://www.researchprofessionalnews.com/rr-news-uk-research-councils-2023-1-researchfish-tweets-aga... |
| Description | AMR Global Development Award 2017 |
| Amount | £88,000 (GBP) |
| Funding ID | MR/R014922/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2017 |
| End | 03/2018 |
| Description | BBSRC Tools and Techniques: Computational tools for enzyme engineering: bridging the gap between enzymologists and expert simulation |
| Amount | £146,027 (GBP) |
| Funding ID | BB/L018756/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2014 |
| End | 01/2016 |
| Description | BBSRC sLoLa: Innovative Routes to Monoterpene Hydrocarbons and Their High Value Derivatives |
| Amount | £3,038,984 (GBP) |
| Funding ID | BB/M000354/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2010 |
| End | 09/2019 |
| Description | Biocatalysis and Biotransformation: A 5th Theme for the National Catalysis Hub |
| Amount | £3,053,639 (GBP) |
| Funding ID | EP/M013219/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2015 |
| End | 12/2019 |
| Description | Biophysical stimulation-enhanced antimicrobial surfaces to combat implant-associated infections |
| Amount | £53,991 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2017 |
| End | 05/2018 |
| Description | BristolBridge has contributed to the University of Bristol being the UK's largest recipient of RCUK AMR cross-council funding awards both in number (7) and value (£5.268M). 6 related AMR grants awarded with BristolBridge PIs/Co-Is include MRC-led AMR. |
| Amount | £5,268,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 09/2019 |
| Description | CCPBioSim: Biomolecular Simulation at the Life Science Interface |
| Amount | £345,687 (FKP) |
| Funding ID | EP/T026308/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2020 |
| End | 10/2025 |
| Description | Canada IPAP |
| Amount | £150,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2023 |
| End | 12/2024 |
| Description | Carbapenem Antibiotic Resistance in Enterobacteriaceae: Understanding Interactions of KPC Carbapenemases with Substrates and Inhibitors |
| Amount | £668,396 (GBP) |
| Funding ID | MR/T016035/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 01/2023 |
| Description | Case-based learning on antimicrobial prescribing in farm animals for undergraduate veterinary students - Council for International Veterinary Medical Education |
| Amount | $7,700 (USD) |
| Organisation | Merck |
| Department | MSD, USA |
| Sector | Private |
| Country | United States |
| Start | 05/2023 |
| End | 04/2025 |
| Description | Confidence in Concept 'Developing a mobile device for rapid antimicrobial resistance detection in primary care' |
| Amount | £74,685 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2017 |
| End | 05/2018 |
| Description | EPSRC |
| Amount | £188,950 (GBP) |
| Funding ID | E/EP/G007705/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2013 |
| End | 03/2014 |
| Description | EPSRC co-funding Innovate UK |
| Amount | £220,245 (GBP) |
| Funding ID | EP/R043361/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 02/2019 |
| Description | GW4 BioMed MRC DTP |
| Amount | £181,072 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2023 |
| End | 09/2027 |
| Description | GW4 Building Communities Programme - Generator Fund; GW4 AMR Plasmid Epidemiology and Surveillance |
| Amount | £19,991 (GBP) |
| Organisation | GW4 |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 06/2022 |
| End | 11/2022 |
| Description | GW4 Building Communities Programme - Strategic Community Development Initiative; GW4 AMR Alliance |
| Amount | £105,000 (GBP) |
| Funding ID | GW4-SCDI-003 |
| Organisation | GW4 |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2020 |
| End | 07/2023 |
| Description | In vitro and in vivo studies of 3D orthopaedic implants with cell-instructive nanotopographies |
| Amount | £699,713 (GBP) |
| Funding ID | MR/S010343/1 |
| Organisation | University of Bristol |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 05/2022 |
| Description | JPIAMR Network Call 2022 "Diagnostics and Surveillance Networks" - Tools for the Epidemiology of AMR Plasmids, One-Health Transmission and Surveillance |
| Amount | € 50,000 (EUR) |
| Funding ID | JPIAMR_NC_2022-015 |
| Organisation | JPIAMR Virtual Research Institute |
| Sector | Academic/University |
| Start | 02/2023 |
| End | 02/2024 |
| Description | One Health Drivers of Antibacterial Resistance in Thailand |
| Amount | £70,825 (GBP) |
| Funding ID | MR/R014922/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 04/2018 |
| Description | Oracle for Research Cloud Fellowship |
| Amount | $100,000 (USD) |
| Organisation | Oracle Corporation |
| Sector | Private |
| Country | United States |
| Start | 02/2023 |
| End | 12/2023 |
| Description | PREDACTED Predictive computational models for Enzyme Dynamics, Antimicrobial resistance, Catalysis and Thermoadaptation for Evolution and Desig |
| Amount | € 2,482,332 (EUR) |
| Funding ID | 101021207 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 10/2021 |
| End | 09/2026 |
| Description | Synthetic Biology Research Centre. BrisSynBio: Bristol Centre for Synthetic Biology |
| Amount | £13,528,180 (GBP) |
| Funding ID | BB/L01386X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2014 |
| End | 07/2019 |
| Description | emPOWER: in-body artificial muscles for physical augmentation, function restoration, patient empowerment and future healthcare |
| Amount | £6,142,804 (GBP) |
| Funding ID | EP/T020792/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2020 |
| End | 08/2025 |
| Description | https://gtr.ukri.org/person/2A2990B1-E1E1-4888-8848-7C256C3A3B43 |
| Amount | £20,009,000 (GBP) |
| Funding ID | https://gtr.ukri.org/person/2A2990B1-E1E1-4888-8848-7C256C3A3B43 |
| Organisation | United Kingdom Research and Innovation |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2006 |
| End | 02/2033 |
| Title | Insitute of Physics eBook on research collaboration |
| Description | BristolBridge was selected as a project to highlight in an Institute of Physics eBook on research collaboration. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | This is a transcription of the IoP interview with the research team. This should not be taken as a checked verbatim record and we accept no responsibility for the contents, and nor would IoP. Bristol Bridge 18 December 2019 18:46 What do you think made this collaboration work? • Adrian Mulholland (AM): o The 'right people' ie people that are: ? Able to speak for their discipline and are open to others ? Able to (or learned to?) translate from one discipline to another ? Open to collaboration ? Interested in developing ideas o Clear scientific area, AMR, which was recognised politically and scientifically as being really important so people cared about it; people wanted to make a difference. o Attitude of the team that managed it- people that became involved in the projects had (or adopted?) the same ethos • Matthew Avison (MA): o We had good fun and we got on well, we still do. o We didn't have too many egos in the room [AM:Just me. MA:We massage it every now and again] o When we had meetings we amicably came to decisions. o I wanted it to work because of self- interest (in AMR)- it keeps us (in AMR) all going • Annela Seddon (AS): o Within the management team- people were interested in the success of the project as a whole, rather than the individual successes that it might bring. o Leaders advocated for the project rather than themselves o People were really willing to raise up other people because that was important for them rather than it always being about them. • MA: o It wasn't about suppressing egos for the common good, the management team just didn't have that big egos anyway- and they've shown in other things that they've done that it is generally about the common good (values) o It helped that we just kind of got on with it o It might have been a bit of luck at the time but if I went back and did it again they would always be the people I would choose. • Katy Turner (KT) o Maybe the people that agreed to it maybe were willing to kind of... • MA o And that may be true, there may be an element of self-selection. • AM: o Team was deliberately not the highest profile Professor in every department, it was people who were interested in learning o AMR could be a part of advancing all of our careers o Not saintliness but an openness to learn and I knew that people were willing to learn • MA: o Apart from you (Adrian), all of us were senior lecturer at that point, we've all moved on at least one rung since then so it has helped all of our careers. • Jim Spencer(JS) o I wonder if the fact that we made it clear at the beginning that the funding was available for anyone to bid for, it wasn't, from the point of view of people from outside of the applicant team. I think we succeeded in making it clear that there was something in it for them, that the pot of money we had applied for wasn't going to be carved up between ourselves. o Any perception that we were a closed shop and I think we succeeded in making clear really early on that this something that was inclusive and that anybody could bring an idea and they had as good a chance as anybody else in Bristol and getting some money • AM: o That was important and the other thing that was important was that within the management group we had a structure that was intended to demonstrate that it was collaborative. We were divided into themes and every theme embodied bringing someone from the EPS side and someone from the biomedical side. o So every theme had joint leadership and those people that led the themes were joint leads o That embodied what we wanted to see through the project o Seed funding proposals had to be collaborative- they had to bring people together from different domains. o Strong thrust on these should be new collaborations • Rob Hughes (RH) o Something that was really obvious coming from an external perspective coming into it was how inclusive everyone was and how quickly and effectively they would wrap you in, everything you needed to know, they would get you trained in the areas that you needed, it didn't feel like there were any boundaries to where you could go, who you could go and talk to, what kind of techniques and tools you could use or learn. And that was, at that stage of career that I was, invaluable. It exposed me to a huge wealth of other things, and other fantastic people. o Initially AS was my main point of contact as I quiveringly went up and spoke to her at a conference. I saw a presentation that Annela had spoken at and I thought there was some sort of connection there, so I spoke to her and she immediately leapt on it and gave me lots of time to talk to her about it and develop the idea and then introduced me to JS and other people as well, to continue that and within a few months I found yself in a biology lab being trained how to stain bacteria, and I had never done anything like that since 6th form! o And so I was plunged into this world but there was a lot of positive and optimistic responsibility given to me and so, them trusting me that I would be able to pick it up as I went and not worrying that I was going to, not understand things straight away, just giving me the time to build those skills and knowledge was really helpful for me, not having any knowledge of that really. • AS: o I just remember a hilarious phone call from RH at about 11pm in Thailand, I sent Rob over to Thailand to collect water samples and apply all of the techniques that we were developing in the lab and to see if he could get them to work in real samples. Rob had been in the lab since 8 in the morning and it was 11 at night and you were like "I've done a thousand agar plates today" and only a few months ago you were an engineer! You've probably plated out more samples in a day than most people do in their PhD. It was brilliant! • RH: o I was on someone's grant as a PostDoc in the Engineering department. o They were very supportive, of expanding your horizons and things like that, they paused the work that I was doing at various points so that I could work on these projects. • MA: o Coming back to the point about "allowing you to..." the reason why I think we could do that we didn't feel under any pressure to make the individual projects succeed, it was about making the collaboration and the network building succeed and so the individual projects, many of them did really, really well, but actually we could be a bit risky and thats one of the benefits of this type of funding. • KT: o And it wasn't loads and loads of money. It was short, defined projects, and we spread them around and there was that feeling that- it is risky to do this, lets see what we can get out of it. • AM: o There was much less worry about the outcomes of the projects, more about getting the spending done as it was quite a short project (2 years). o You had to identify someone like Rob whose supervisor was prepared for them to move off a project or be seconded or something and didn't get a job in the meantime o So various things we could have funded didn't happen because someone moved away or something else happened o So the practicalities. • MA: o It was a flexible pot. o Claire did a huge amount of work just to make the finance work, HR, some of the contracts • AS o And getting visas sorted out • Claire Spreadbury (CS) o It's not easy to do that, across the university. • AM: o And that wasn't envisaged in the application, that came up because we got some additional GCRF funding, can you arrange visas for 20 people from Thailand! • MA: o A large part of the success of the project is that we got Claire in, we got someone who can manage multiple tasks, from organising a conference to organising a visa o They are very different skills and we were very fortunate (and thats why we're trying to keep her :-)) o If we hadn't had someone like that we may not have been successful. o CS can remember everybody's names and what everybody does, and she's like that with the students she remembers exactly what they're doing, she remembers them all and she has many skills but that's one of the important things when you are building a network, just remembering who people are is one of the most important parts of it! • CS: o You get good oversight because you've got the paperwork in front of you, its more tangible. • AM: o It's a lot of people, a huge number of people that you've dealt with. • CS: o I know a lot of people in the AMR world, now, across the country! Serendipity vs deliberate? • Bringing people together is important o E.g. Mervyn Miles meeting someone in a lunch queue at a conference that sparked a project o Making the space for luck to happen o Events are really important for that • MA: o Academics are generally quite good at bumping into each other and finding things that are interesting- reasonable common ground o But what we could do with BristolBridge is that we could put some £s in front of it and say "well there's a reason for you to actually do this", and once people saw projects funded and the university were very supportive of the project in terms of advertising its successes and seeing management attending some of our events and then the wider university sees it as a success and then they become more likely to become involved. o And its funny now like the money has kind of gone, that actually we very much worry about it kind of falling apart a little bit. • AM: o And people retreating into their silos • DH: o Now with no £ we have no avenue for it really • AS: o Its funny I had a conversation soon after we launched we did an event, a workshop, we had a series of flash talks, and a very senior academic who I won't name came over and said , "I don't know why you are bothering with these piddling little bits of money, you should just take a big tranche of money and give it to one or two people to solve the problem." o And I thought You. Don't. Get. This. Like, you don't understand the role of what we are trying to do, you don't understand the riskiness of these short term projects, you don't understand the collaboration. o Because their point of view was, "I'm the best in my field. You should give the money to me, and I will make all of this go away and it will all be fine." And I thought "but you haven't done it so far so what makes you think if we gave you the money now you would be able to, that it would be any different?" o And that attitude, kind of, I was quite taken aback by that. I wanted to say (but I couldn't, I was too scared), "look around this room, can you not see the conversations that are happening and the things that are coming out of this, do you not recognise the value in that?" And I thought well if you don't, then maybe this isn't something you should be involved in. o And that person never got involved in anything. And never turned up again, never engaged. And never applied. • AM o Its a very different sort of funding. Much of science funding is, you know, a slogging, long long process of getting funding, a lot about reputation and facing down referees and all the rest of it. This is a very, very different model of funding. o It wasn't a lottery, it was competitive. o But it was, "you've got a good idea, well, OK, we can probably give you money within a few weeks to begin with and take it from there." And lots of things came out of that. o And I think thats a model of funding that lots of universities and Research Councils could usefully use. o And then because its not really worth the mega beasts going after this, £20k, they're not interested, but for someone else, its going to change their career. • AS o That £20k could lead to a slightly bigger pot of money and then you start to look at the -O-Star project which was about £3million- something like that? • MA o The Thailand- O Dart? One? • AS o Yes that one it grew and grew and it was like a snowball • MA o It was KT doing a bit of work and people coming together and a bit of GCRF investment from the university and CS working hard and BristolBridge and it all came together and we got to that point. o And there's been other examples of success and Rob may well have got himself a lectureship anyway, but now he's got himself a lectureship with that bit of knowledge of AMR, that bit of knowledge of microbiology and now going forward in his career he's going to be always thinking "oh, maybe there's something we can do in that area" that is as much, as far as I'm concerned (given he's got another 50 years before he is allowed to retire), that's a really good outcome just a much as a £3million grant. • LO o Importance of intangible- this is the effect that this project has had on me, and this is what I have been able to do. Social value of the collaboration. • DH o About 3 different pump priming projects working with 3 different people who were some involved with the initial Bristol Bridge- some have come on board, some have dropped away a bit, you know. o The initial project was I went to one of the initial world cafe events and I sat down on a table on my own saying I'd like to talk about Gonhorrea and I thought that I would spend the afternoon and I would have a nice day out and I'd have a cup of tea and a bun and that would be me! But actually lots of people were interested and I met lots of people with really cool technologies that you think , wow, I wonder how I could use that and so I had a sort of half idea in mind but it really consolidated and I think there were twelve people on the initial application. o And we got really nice principle data that enabled more funding elsewhere and thats led to confidence in concept award ultimately from MRC, which is now moving forward which is really good. o Different members of the team have come and gone as its gone on. o KT is the only other person at the university who loves Gonhorrea as much as I do... o We've got now a joint PhD student, co-funded by GSK vaccines and maybe more to come. Building quite a nice nucleus around Gonhorrea expertise in Bristol. o With Charlotte (Birmingham) and the company we've got one of the prototype microscopes now that we're going to apply that technology to the problem so again that's an ongoing, and I'm a molecular microbiologist but its been re-engineered (and thats the extent of my knowledge still about engineering!) but to make a heater stage so thats lots of cross disciplinary stuff happening o And we're working with synthetic chemists as part of the CiC award, so there's still lots of clusters and Shaun, who I met through Merv(yn Miles) - a physicist, we've now got a PhD student on atomic force microscopy as well looking at the surface of bacteria and these are all direct results of a cup of tea and a bun and a chat. • CS o Scones, actually, a cream tea. • AM o We spent quite a lot of time choosing the catering actually • CS o It is important- you want to run a good event so people want to come to the next one • DH o Compared to other events, and I've been to a few different things, over the years, because I've been in Bristol quite a while, and what struck me are, what Adrian said, not only the people, first and foremost, but also the set-up in terms of the space, and the tangible hook that there might be some money that you could apply for, but with so many meetings you sit there and there is talk after talk after talk and they overrun and then you get coffee and then you get "we're only going to have 10 minutes for coffee" and then its back into more talks and then everyone goes away. o Having the space to sit with people from other disciplines and be creative, was what led to that initial application. • AM o We had never done World Cafes before, but we'd defined them in the proposal, we'd said, we'll do that. o I'd never run a world cafe and you do, you have to be quite strict with people to let them be free form in their thinking and by giving short talks, it meant moving people around tables, it meant telling people you can't sit next to your friend from your own department you need to sit next to someone else. Anf that took a bit of prodding but it was worth it. • CS o It was quite nice the way we had a GP and a secondary care physician and a vet lay out the probl |
| Title | A Multiscale Workflow for Modelling Ligand Complexes of Zinc Metalloproteins |
| Description | Representative MD trajectories, topologies and input files for the protein:ligand complexes presented in the paper Yang et al. J Chem. Inf. Model. 2021. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Zinc metalloproteins are ubiquitous, with protein zinc centers of structural and functional importance, involved in interactions with ligands and substrates and often of pharmacological interest. Biomolecular simulations are increasingly prominent in investigations of protein structure, dynamics, ligand interactions, and catalysis, but zinc poses a particular challenge, in part because of its versatile, flexible coordination. A computational workflow generating reliable models of ligand complexes of biological zinc centers would find broad application. Here, we evaluate the ability of alternative treatments, using (nonbonded) molecular mechanics (MM) and quantum mechanics/molecular mechanics (QM/MM) at semiempirical (DFTB3) and density functional theory (DFT) levels of theory, to describe the zinc centers of ligand complexes of six metalloenzyme systems differing in coordination geometries, zinc stoichiometries (mono- and dinuclear), and the nature of interacting groups (specifically the presence of zinc-sulfur interactions). MM molecular dynamics (MD) simulations can overfavor octahedral geometries, introducing additional water molecules to the zinc coordination shell, but this can be rectified by subsequent semiempirical (DFTB3) QM/MM MD simulations. B3LYP/MM geometry optimization further improved the accuracy of the description of coordination distances, with the overall effectiveness of the approach depending upon factors, including the presence of zinc-sulfur interactions that are less well described by semiempirical methods. We describe a workflow comprising QM/MM MD using DFTB3 followed by QM/MM geometry optimization using DFT (e.g., B3LYP) that well describes our set of zinc metalloenzyme complexes and is likely to be suitable for creating accurate models of zinc protein complexes when structural information is more limited. |
| URL | https://data.bris.ac.uk/data/dataset/10p78zgsappbz226bzrdagabq9/ |
| Title | Crystallography and QM/MM Simulations Identify Preferential Binding of Hydrolyzed Carbapenem and Penem Antibiotics to the L1 Metallo-beta-lactamase in the Imine Form |
| Description | MD trajectories, topologies, parameters and input files for the data presented in the paper Twidale et al. J Chem. Inf. Model. 2021. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Widespread bacterial resistance to carbapenem antibiotics is an increasing global health concern. Resistance has emerged due to carbapenem-hydrolyzing enzymes, including metallo-ß-lactamases (MßLs), but despite their prevalence and clinical importance, MßL mechanisms are still not fully understood. Carbapenem hydrolysis by MßLs can yield alternative product tautomers with the potential to access different binding modes. Here, we show that a combined approach employing crystallography and quantum mechanics/molecular mechanics (QM/MM) simulations allow tautomer assignment in MßL:hydrolyzed antibiotic complexes. Molecular simulations also examine (meta)stable species of alternative protonation and tautomeric states, providing mechanistic insights into ß-lactam hydrolysis. We report the crystal structure of the hydrolyzed carbapenem ertapenem bound to the L1 MßL from Stenotrophomonas maltophilia and model alternative tautomeric and protonation states of both hydrolyzed ertapenem and faropenem (a related penem antibiotic), which display different binding modes with L1. We show how the structures of both complexed ß-lactams are best described as the (2S)-imine tautomer with the carboxylate formed after ß-lactam ring cleavage deprotonated. Simulations show that enamine tautomer complexes are significantly less stable (e.g., showing partial loss of interactions with the L1 binuclear zinc center) and not consistent with experimental data. Strong interactions of Tyr32 and one zinc ion (Zn1) with ertapenem prevent a C6 group rotation, explaining the different binding modes of the two ß-lactams. Our findings establish the relative stability of different hydrolyzed (carba)penem forms in the L1 active site and identify interactions important to stable complex formation, information that should assist inhibitor design for this important antibiotic resistance determinant. |
| URL | https://data.bris.ac.uk/data/dataset/13pu85dfaobij2rumzql5buyy2/ |
| Title | E Coli Oxidative Stress |
| Description | Data for "Oxidative Stress Contributes to Bacterial Airborne Loss of Viability" published in Microbiology Spectrum. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| URL | https://data.bris.ac.uk/data/dataset/1u96yv19o3ojh2ow3zpttwp3e4/ |
| Title | Individual-based gonorrhoea transmission model |
| Description | This repository contains the following MATLAB files, which define and simulate an individual-based dynamic transmission model of gonorrhoea infection and treatment in MSM. The model incorporates ciprofloxacin-sensitive and resistant strains, a time-dependent sexual contact network, and allows a flexible choice of complex (individual-based) treatment, testing and tracing options, including strain-sensitive diagnostic tests with variable time delays. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Title | Negligible-cost microfluidic device fabrication using 3D-printed interconnecting channel scaffolds |
| Description | Data supporting the journal paper - Negligible-cost microfluidic device fabrication using 3D-printed interconnecting channel scaffolds - published in PLOS ONE. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://data.bris.ac.uk/data/dataset/34ac9q8m7ulgl2msiaiyfbv3zu/ |
| Description | A sustained delivery chlorhexidine gel (Barbour/van Duijenvelt/Spencer) |
| Organisation | Quaid-i-Azam University |
| Country | Pakistan |
| Sector | Academic/University |
| PI Contribution | Barbour (PI) - intellectual input, project design and expertise in antimicrobial biomaterials and oral nanoscience. |
| Collaborator Contribution | Expertise from a physical chemist (specialising in soft condensed matter) to help develop a sustained release antimicrobial gel formulation. Expertise from a microbiologist and training of the research assistant undertaking the project in microbiological techniques |
| Impact | Project funded by BristolBridge. New research collaboration: Dr Rabaab Zahra at Quaid-i-Azam University in Pakistan. Follow-on funding via Elizabeth Blackwell Institute/Wellcome Trust Translational Acceleration and Knowledge Transfer (TRACK) award in July 2016 to further the initial work funded by BristolBridge. "A novel, emulsion gel formulation of sustained release chlorhexidine to prevent umbilical cord infection and improve outcomes for neonates in developing countries". Follow-on funding by EPSRC GCRF Institutional Sponsorship "Saving neonates' lives by preventing umbilical cord infection: Cheap and effective spray delivery of sustained efficacy chlorhexidine" Barbour (PI), van Duijneveldt (Co-I) and Spencer (Co-I) (BristolBridge Co-I) Related iCASE BBSRC SWBio DTP studentship that evolved after conversation between Barbour and Barrett (Veterinary Sciences) at the BristolBridge AMR World Cafe in January 2016. "A novel, sustained efficacy, biocide-based treatment for bacterial foot disease in ruminants". Supervisor, David Barrett, Co-supervisor Jim Spencer (BristolBridge Co-I); industry supervisor Michele Barbour; CASE partner. Pertinax Pharma Ltd. This is a multi-disciplinary collaboration involving biomaterials, oral nanoscience, chemistry and microbiology. |
| Start Year | 2015 |
| Description | A sustained delivery chlorhexidine gel (Barbour/van Duijenvelt/Spencer) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Barbour (PI) - intellectual input, project design and expertise in antimicrobial biomaterials and oral nanoscience. |
| Collaborator Contribution | Expertise from a physical chemist (specialising in soft condensed matter) to help develop a sustained release antimicrobial gel formulation. Expertise from a microbiologist and training of the research assistant undertaking the project in microbiological techniques |
| Impact | Project funded by BristolBridge. New research collaboration: Dr Rabaab Zahra at Quaid-i-Azam University in Pakistan. Follow-on funding via Elizabeth Blackwell Institute/Wellcome Trust Translational Acceleration and Knowledge Transfer (TRACK) award in July 2016 to further the initial work funded by BristolBridge. "A novel, emulsion gel formulation of sustained release chlorhexidine to prevent umbilical cord infection and improve outcomes for neonates in developing countries". Follow-on funding by EPSRC GCRF Institutional Sponsorship "Saving neonates' lives by preventing umbilical cord infection: Cheap and effective spray delivery of sustained efficacy chlorhexidine" Barbour (PI), van Duijneveldt (Co-I) and Spencer (Co-I) (BristolBridge Co-I) Related iCASE BBSRC SWBio DTP studentship that evolved after conversation between Barbour and Barrett (Veterinary Sciences) at the BristolBridge AMR World Cafe in January 2016. "A novel, sustained efficacy, biocide-based treatment for bacterial foot disease in ruminants". Supervisor, David Barrett, Co-supervisor Jim Spencer (BristolBridge Co-I); industry supervisor Michele Barbour; CASE partner. Pertinax Pharma Ltd. This is a multi-disciplinary collaboration involving biomaterials, oral nanoscience, chemistry and microbiology. |
| Start Year | 2015 |
| Description | A systems-based platform for the production of novel antibiotics |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | BristolBridge funded this pump-priming project |
| Collaborator Contribution | Expertise and intellectual input |
| Impact | Outcome: A PhD student is taking this project forward. Multidisciplinary collaboration: Microbiology, chemistry, biochemistry, computer science |
| Start Year | 2016 |
| Description | Assay Development for Bacterial Phosphoethanolamine Transferases that Confer Resistance to Last Resort Antibiotics |
| Organisation | University of Bristol |
| Department | School of Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Pump-priming project funded by BristolBridge. Intellectual input by the research team. |
| Collaborator Contribution | Intellectual input and expertise. Access to equipment and facilities. |
| Impact | This is a multi-disciplinary project involving synthetic chemistry and microbiology |
| Start Year | 2017 |
| Description | Biomimetic antimicrobial surfaces to combat antimicrobial resistant infection (Su/Nobbs/Briscoe/May) |
| Organisation | University of Bristol |
| Department | School of Oral & Dental Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Su (PI) Intellectual input, project design and expertise in biomaterials engineering. |
| Collaborator Contribution | The collaborators are providing expertise in chemistry and oral microbiology. |
| Impact | Project funded by BristolBridge. Invitation to speak at workshop on Bio-inspired antimicrobial surfaces for medical implants at Sheffield University (EPSRC-funded Sheffield Antimicrobial Resistance Network) 6th April 2016. New research collaboration with University of Southampton (stem cells for nanospikes) Meetings with Renishaw plc to develop a new collaboration on surface nanoengineering of 3D printed titanium scaffolds/devices. MRC Theme 2 Innovation Grant (awarded to Prof. Su in Oct 2015) has taken the BristolBridge funded project further (same Research Associate) A multi-disciplinary collaboration comprising biomaterials engineering, chemistry and oral microbiology . |
| Start Year | 2016 |
| Description | Biomimetic antimicrobial surfaces to combat antimicrobial resistant infection (Su/Nobbs/Briscoe/May) |
| Organisation | University of Southampton |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Su (PI) Intellectual input, project design and expertise in biomaterials engineering. |
| Collaborator Contribution | The collaborators are providing expertise in chemistry and oral microbiology. |
| Impact | Project funded by BristolBridge. Invitation to speak at workshop on Bio-inspired antimicrobial surfaces for medical implants at Sheffield University (EPSRC-funded Sheffield Antimicrobial Resistance Network) 6th April 2016. New research collaboration with University of Southampton (stem cells for nanospikes) Meetings with Renishaw plc to develop a new collaboration on surface nanoengineering of 3D printed titanium scaffolds/devices. MRC Theme 2 Innovation Grant (awarded to Prof. Su in Oct 2015) has taken the BristolBridge funded project further (same Research Associate) A multi-disciplinary collaboration comprising biomaterials engineering, chemistry and oral microbiology . |
| Start Year | 2016 |
| Description | Developing novel biocompatible and antimicrobial coatings for orthopaedic implants (Tarlton/Scott/Cogan) |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Tarlton (PI); Intellectual input, design of project, expertise in matrix biology and regenerative medicine |
| Collaborator Contribution | The collaborator in Physics is helping to develop a novel photocatalytic titanium dioxide (TiO2) based antimicrobial surface for use in orthopaedic implants |
| Impact | Project funded by BristolBridge. No outputs or outcomes yet. This is a multi-disciplinary collaboration involving regenerative medicine, matrix biology and physics. |
| Start Year | 2016 |
| Description | Developing strategies to minimize AMR in territorial wildlife population |
| Organisation | University of Bristol |
| Department | Faculty of Engineering |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project funded by BristolBridge. |
| Collaborator Contribution | Intellectual input and expertise. |
| Impact | This is a multidisciplinary project involving applied mathematics and biology. A paper has been submitted for publication. |
| Start Year | 2017 |
| Description | Early phase development of a primary care device to detect rapidly antibiotic resistance in common bacteria |
| Organisation | University of Bristol |
| Department | School of Biological Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | BristolBridge 'Bridging the Gaps between the Engineering and Physical Sciences' funded this pump-priming project |
| Collaborator Contribution | Antognozzi (PI) project design, physics expertise Avison (BristolBridge Co-I and Impact Lead) has contributed his microbiology expertise to this project |
| Impact | Follow on funding via EPSRC Institutional Sponsorship 2016, August 2016 (Validation of a primary care device to rapidly detect antimicrobial drug resistance in common bacteria" Antognozzi (Physics), Avison (Cellular & Molecular Medicine), Baxter (South Gloucestershire & North Somerset Clinical Commissioning Groups and Social & Community Medicine) and Redmond (National Institute for Health Research Collaborations for Leadership in Applied Health Research and Care West [NIHR CLAHRC West] & Social and Community Medicine). University Research Committee Interdisciplinary Research Internship 2016 to Kloucek MSci 2nd year Physics undergraduate. Supervisor Antognozzi, Co-supervisor Avison Follow on funding: Innovation-to-Commercialisation (ICURe) award from the SETsquared Partnership, March 2017 to validate primary care device in the marketplace. Longitude Prize Development Award, August 2017. Innovate UK funding, January 2018. Multidisciplinary collaboration: Physics, microbiology, social science. |
| Start Year | 2016 |
| Description | Electrostatic capture of bacteria (Schwarzacher/Carreira/Spencer) |
| Organisation | University of Bristol |
| Department | School of Physics |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Schwarzacher/Carreira PI's; Intellectual input, planning and designing project |
| Collaborator Contribution | Spencer Co-I; Supervision of microbiological work |
| Impact | Project application to BristolBridge (approved for funding) Multi-disciplinary collaboration involving physics and microbiology |
| Start Year | 2016 |
| Description | Identifying and Characterising Inhibitors of Essential Enzymes as Routes to New Anti-Tuberculosis Therapies |
| Organisation | Ubon Ratchathani University |
| Country | Thailand |
| Sector | Academic/University |
| PI Contribution | Funded by BristolBridge, Intellectual input and expertise. Training of visiting research staff and access to equipment and facilties. |
| Collaborator Contribution | Intellectual input and expertise. |
| Impact | This is a multi-disciplinary collaboration involving computational chemistry. biochemistry and microbiology. A grant application has been submitted to the MRC. |
| Start Year | 2017 |
| Description | Investigating AMR gene transfer in the aerosol phase |
| Organisation | UK Centre for Ecology & Hydrology |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | The research team provided intellectual input, expertise and access to equipment and facilties |
| Collaborator Contribution | The partner provided Intellectual input and expertise. |
| Impact | This collaboration is multi-disciplinary and involves the disciplines of aerosol science/chemistry and microbiology |
| Start Year | 2017 |
| Description | Mathematical modelling of the impact of novel AMR diagnostics for Neisseria gonorrhoeae |
| Organisation | University of Bristol |
| Department | School of Clinical Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Funded by EPSRC GCRF Institutional Sponsorship award to BristolBridge Turner (BristolBridge Co-I) project design, intellectual input, statistical and economic modelling expertise Homer (BristolBridge Co-), mathematics, data science expertise |
| Collaborator Contribution | Hill (Co-I) Microbiology expertise Christensen (Co-I) economic modelling expertise |
| Impact | Multidisciplinary project: mathematics, data science, computer science, modelling, social medicine |
| Start Year | 2016 |
| Description | Novel methods for visualising bacteria (GersenAvison) |
| Organisation | University of Bristol |
| Department | School of Cellular and Molecular Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Gersen (PI); Intellectual input, project design and expertise in imaging |
| Collaborator Contribution | Avison (Co-I); Microbiology expertise and training of postdoctoral research assistant (a physical scientist) in microbiological techniques. |
| Impact | Short project application submitted to BristolBridge (approved for funding) Multidisciplinary collaboration; physics and microbiology |
| Start Year | 2016 |
| Description | Novel ways of improving antibiotic delivery to promote the direct killing of Neisseria gonorrhoeae |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | BristolBridge funded the project Turner (BristolBridge Co-I) contributed expertise on sexually transmitted infectious diseases and intellectual input to the design of project and potential for impact |
| Collaborator Contribution | Hill (PI) Project design, intellectual input, microbiology expertise Crosby (Co-I) chemistry expertise |
| Impact | Part-funded by EPSRC GCRF Institutional Sponsorship awarded to BristolBridge resulting in project extension EPSRC Bristol Centre for Functional Nanomaterials CDT full-time PhD student researching related aspects of this project. Patent under discussion Multidisciplinary: Microbiology, Chemistry, Physics |
| Start Year | 2016 |
| Description | Phage based sensitization to fluoroquinolone antibiotics (Avison/Dillingham) |
| Organisation | University of Bristol |
| Department | School of Cellular and Molecular Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Intellectual input and microbiological expertise |
| Collaborator Contribution | Intellectual input and biochemical expertise. |
| Impact | Funding application made to the BBSRC/EPSRC-funded Bristol Synthetic Biology Research Centre (pending) A multi-disciplinary collaboration involving biochemistry and microbiology |
| Start Year | 2016 |
| Description | Rapid identification of urinary tract infection bacteria and their antibiotic susceptibility using volatile profile sensing technology |
| Organisation | University of the West of England |
| Department | Faculty of Health and Applied Science |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The research team provided microbiological expertise, training of staff and access to facilities. |
| Collaborator Contribution | The partners provided intellectual input and expertise on volatile metabolite profiling. |
| Impact | The collaboration is multi-disciplinary and involves the disciplines of Chemistry and Microbiology |
| Start Year | 2017 |
| Description | Selcia collaboration (Spencer/Mulholland) |
| Organisation | Selcia |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Hosted meetings to build a collaboration. Agreement to look at Selcia material in vitro and in silico at the University of Bristol (pending material transfer agreement MTA) |
| Collaborator Contribution | Selcia to provide materials (once MTA is approved) |
| Impact | Muiti-disciplinary collaboration involving drug discovery, microbiology, chemistry and computer modelling |
| Start Year | 2016 |
| Description | Selcia collaboration (Spencer/Mulholland) |
| Organisation | University of Bristol |
| Department | School of Cellular and Molecular Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Hosted meetings to build a collaboration. Agreement to look at Selcia material in vitro and in silico at the University of Bristol (pending material transfer agreement MTA) |
| Collaborator Contribution | Selcia to provide materials (once MTA is approved) |
| Impact | Muiti-disciplinary collaboration involving drug discovery, microbiology, chemistry and computer modelling |
| Start Year | 2016 |
| Description | Towards devices for detecting antimicrobial resistance in resource-poor settings; on-chip magnetic separation, concentration and detection of bacteria |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Funded by EPSRC GCRF Insitutional Sponsorship funds awarded to BristolBridge Seddon (BristolBridge Co-I) - project design, intellectual input, physics/diagnostics expertise Spencer (BristolBridge Co-I) - microbiology and diagnostics expertise |
| Collaborator Contribution | Hughes (Co-I) design, engineering and fabrication of devices |
| Impact | New LIMC collaboration with Professor Skorn Mongkolsuk (Chulabhorn Research Institute, Bangkok, Thailand New LIMC collaboration with Dr Cecelia Mbae, Kenya Medical Research Institute, Nairobi Multidisciplinary project involving physics, mechanical engineering and clinical microbiology |
| Start Year | 2016 |
| Description | cell-instructive surfaces |
| Organisation | Polytechnic University of Catalonia |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Nanostructured surfaces: generation and characterisation |
| Collaborator Contribution | Functionalisation of nano-surfaces with cell-binding ligands to improve cell attachment while preventing bacterial growth |
| Impact | A joint publication in Scientific Reports. One more in preparation. |
| Start Year | 2017 |
| Title | APPARATUS FOR AND METHOD OF PROCESSING BIOLOGICAL SAMPLES |
| Description | The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing. Other embodiments include automated systems, automated devices, automated cartridges and automated methods for separation, preparation and purification of nucleic acids, such as DNA or RNA or fragments thereof, including plasmid DNA, genomic DNA, bacterial DNA, viral DNA and any other DNA, and for automated systems, automated devices, automated cartridges and automated methods for processing, separation and purification of proteins, peptides and the like. |
| IP Reference | US2018111121 |
| Protection | Patent application published |
| Year Protection Granted | 2018 |
| Licensed | Yes |
| Impact | the patent has been instrumental for the incorporation of the spin out company Vitamica Ltd |
| Title | METHOD AND APPARATUS FOR BACTERIAL ANALYSIS |
| Description | An apparatus (10) comprising: a light source (12); to cast light toward a substrate (20) defining a bacteria binding volume to create an evanescent field (22), the bacteria binding volume being within the evanescent field; a detector (32, 34) arranged to receive light from the bacteria binding volume and output data (36, 37); and a processor (38) arranged to determine vibration of bacteria (26) within the bacteria binding volume in three-dimensions from the data. |
| IP Reference | WO2019025771 |
| Protection | Patent application published |
| Year Protection Granted | 2019 |
| Licensed | Yes |
| Impact | The patent has being instrumental for the incorporation of the spin out company Vitamica Ltd. |
| Title | METHOD FOR DETECTION OF INTESTINAL, AND BLOOD-BRAIN BARRIER PERMEABILITY AND TESTING MATERIALS THERETO |
| Description | METHOD FOR DETECTION OF INTESTINAL, AND BLOOD-BRAIN BARRIER PERMEABILITY AND TESTING MATERIALS THERETO Methods, assays, and apparatus are disclosed for testing of antigens associated with intestinal and/or blood-brain barrier permeability. For example, blood, saliva or other bodily fluid can be tested for binding (1) to a bacterial toxin (preferably a lipopolysaccharide), and (2) binding to tissue antigens selected from at least one of (a) a gut-related antigen and (b) a blood brain barrier-related antigen. Analysis of test results can be used to assist in detecting and diagnosing diseases associated with leaky gut syndrome (whether due to paracellular or transcellular pathways, and whether due to bacterial toxins or some other cause) and/or to diseases associated with excessive blood brain barrier permeability, which are contemplated herein to include both neuroinflammation and/or neuroautoimmunity conditions, and especially amyotrophic lateral sclerosis, Parkinsons disease, multiple sclerosis, Alzheimer's, or peripheral neuropathy, and major depression. |
| IP Reference | AU2016259430 |
| Protection | Patent application published |
| Year Protection Granted | 2016 |
| Licensed | Yes |
| Impact | the patent has been instrumental for the incorporation of the spin out company Vitamica Ltd |
| Company Name | Vitamica Ltd |
| Description | Vitamica is developing a novel diagnostic technology to test pathogenic bacteria for susceptibility to antibiotics within one hour. The need for more targeted and appropriate use of existing antibiotics grows daily, and healthcare professionals must have the diagnostic tools to support decisions on which antibiotic to use. Rapid antimicrobial susceptibility testing (AST) of patient samples would inform doctors which antibiotics will be effective and to which the bacteria show resistance. Crucially, the test results would be available in time for the first antibiotics to be prescribed, rather than 48 hours later as is typical for current testing methods. Rapid AST enables the timely prescription of appropriate antibiotics leading to better patient outcomes as patients receive effective antibiotics sooner, and also reducing healthcare costs due to faster recovery times and a lower incidence of complications. Importantly, the prescription of more targeted and appropriate antibiotics enabled by rapid AST also reduces the spread of antimicrobial resistance. Current susceptibility testing methods typically take 36-48 hours because they rely on detecting growth of the organism as a phenotypic signal that the bacteria are alive (or not) after treatment with antibiotics. In order to develop rapid susceptibility testing methods, approaches that do not rely on detecting growth of the organism are needed. Vitamica is developing a rapid AST based on a novel technology that detects tiny fluctuations within the individual bacteria, indicating in a few seconds whether the cells are alive or not. This technology will allow us to test pathogenic bacteria for susceptibility to antibiotics within one hour, transforming the way clinicians make decisions on antibiotic choice for the benefit of patients now and in the future. Rapid AST is based on a recently developed imaging technique - Sub-cellular Fluctuation Imaging (SCFI) - that directly detects nanoscale fluctuations that are present in bacteria when they are alive. These fluctuations are too small to be seen using an optical microscope, but the unique optical set up of SCFI allows us to directly image them in real time. Using this technology Vitamica can detect the effects of antibiotics as soon as they have acted on the bacteria - leading to a very rapid susceptibility test. |
| Year Established | 2018 |
| Impact | One full time equivalent scientific post |
| Website | http://www.bristol.ac.uk/amr/research/development-of-novel-resistance-diagnostics/rapid-amr-detector... |
| Company Name | VITAMICA LIMITED |
| Description | Vitamica was established in early 2018 as a spin-out company from the University of Bristol. Taking optical technology from the School of Physics, the new company is beginning its journey towards commercialisation of a rapid and novel diagnostic method that has high potential for use in antimicrobial susceptibility testing. With a growing IP portfolio and an active approach to identifying opportunities in healthcare, veterinary and pharma sectors, Vitamica fully intends to make its mark as another successful company to originate from the University of Bristol. |
| Year Established | 2018 |
| Impact | The company is working on the development of a rapid AMR diagnostic device that could be used in healthcare, veterinary and pharma sectors. |
| Website | https://www.vitamica.co.uk |
| Description | (Bruce and Reyher) Food Industry Initiative on Antimicrobials R&D group, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Attending meeting |
| Year(s) Of Engagement Activity | 2019 |
| Description | (Reyher and Buller) Fieldwork, presentations and meetings in Bangkok, Thailand |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | Presentation of DIAL research and engagement with academic and research community through MRC funded OH-DART project |
| Year(s) Of Engagement Activity | 2018 |
| Description | (Reyher) DARC, Stonleigh |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Attendance at Meeting as member of DIAL project (and other projects) |
| Year(s) Of Engagement Activity | 2018 |
| Description | (Reyher) Food Industry Initiative on Antimicrobials R&D group, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Presentation of DIAL project and other engaged AMR research |
| Year(s) Of Engagement Activity | 2018 |
| Description | (Reyher) RSM AMR Meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Attendance and presentation of DIAL project and related research |
| Year(s) Of Engagement Activity | 2018 |
| Description | (Reyher) RUMA, Stoneleigh |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Attended meeting as member of DIAL team (and other research teams) |
| Year(s) Of Engagement Activity | 2018 |
| Description | (Reyher) SEFARI AMR conference, Glasgow |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presentation as a member of DIAL Research team (and other teams) |
| Year(s) Of Engagement Activity | 2018 |
| Description | (Reyher) UK AMR Strategy Stakeholder Forum, Surrey |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Attended as member of Forum and as member of DIAL research team (and other research teams) |
| Year(s) Of Engagement Activity | 2018 |
| Description | (Reyher) UK-Israel AMR workshop, Birmingham |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attended meeting as member of DIAL research team (and others) |
| Year(s) Of Engagement Activity | 2018 |
| Description | AMR Force (Reyher) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Exploration of collaboration opportunities with VMD, Langford |
| Year(s) Of Engagement Activity | 2019,2020 |
| Description | AMR talk at Monkton Coombe School |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Matthew Avison visited Monkton Coombe School to give a talk on AMR entitled 'Superbugs: Is Resistance Futile?' Pupils came up with imaginative questions and the school reported increased interest in the subject within the school population. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Access to Bristol schools event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | About 50 motivated college students came to Bristol from the region to get a taster for microbiology. Matthew gave a talked entitled Superbugs: Is Resistance Futile? Some students reported it had given them an interest in going into the field of microbiology. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Agriculture and Horticulture Development Board Mastitis Control Plan Management Group meeting (Reyher) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Mastitis Control Plan Management Group Committee meeting in Wells |
| Year(s) Of Engagement Activity | 2019 |
| Description | Agriculture and Horticulture Development Board eMedicines Hub Data Task & Finish Group |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Working group to discuss principles for data sharing to be applied across the national eMedicines Hub for ruminants - shared expertise from results of AMU and AMR research |
| Year(s) Of Engagement Activity | 2022,2023 |
| Description | American and Canadian High School visit to UoB |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Pupils from American and Canadian High Schools attended a day at UoB. Matthew gave a talk entitled Superbugs: Is Resistance Futile? Pupils had many challenging questions and some said afterwards that they had no idea you could select for an antibiotic resistance gene by using another antimicrobial like ammonium compounds. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Antibiotics Unearthed, A school visit and workshop exploring the potential for new soil microbes as producers of antibiotic substances. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | a workshop sponsored by the Microbiology Society, culturing soil bacteria and investigating them to see if any were making antibiotic substances. This event was aimed at Y13 students as St Marys School, Calne, Wilts, taking A-level Biology. It demonstrated good microbiological practice, techniques such as serial dilution, bioassays and the like. The activity is ongoing and will likely be repeated. A presentation was included about the challenges of how to combat AMR, and led top lively debate, particularly from some student s interested in pursuing careers in medicine. |
| Year(s) Of Engagement Activity | 2017 |
| Description | BBC Bristol Interview regarding One Health antimicrobial resistance |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview on BBC Bristol discussing usage of antimicrobials in animals and the food supply |
| Year(s) Of Engagement Activity | 2022 |
| Description | BBC Radio Bristol Interview |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Matthew Avison had 30 minute interview with Steve Yabsley on BBC Radio Bristol about AMR research project. Stimulated discussion via phone in comment from members of the public |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bbc.co.uk/programmes/p04dxl57 |
| Description | Biofilm Create! Competition 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A competition organised by the National Biofilm Innovation Centre funded by the UKRI (BBSRC). |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.biofilms.ac.uk/biofilm-create-competition-2022-winners/ |
| Description | BridgeBridge AMR Schools Outreach Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | 160 students from the region came to a cross-faculty schools conference recently for post-16 biology and chemistry students held within the School of Chemistry to examine why AMR is an escalating global threat. Matthew opened the conference and gave a talk entitled 'Superbugs: Is Resistance Futile?' |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bristol.ac.uk/news/2016/december/schools-conference-amr.html |
| Description | Bristol AMR/Colston Research Symposium. The Antibiotic Age: The End or a New Beginning? |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Gave a speech entitled: 'Antibiotics Anonymous - Antimicrobial stewardship and voluntary reduction across the UK livestock sectors' and networked with conference attendees |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.bristol.ac.uk/amr/events/2019/colston-research-society-symposium.html |
| Description | Bristol Grammar School |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Matthew Avison gave a talk entitled 'Superbugs: Is Resistance Futile?' to Bristol Grammar Senior School pupils. Pupils gave feedback such as "I used to think antibiotics were normal when you have a bad cold but I now know it's more likely to be a virus so will only use them if I have to." |
| Year(s) Of Engagement Activity | 2017 |
| Description | Bristol Health Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Matthew gave a talk to over 100 members of the general public during a session called Bristol Love Bugs. His talk was about the Impact of Antibiotic Use on the Microbiome. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bristolhealthpartners.org.uk/events/view/2016/10/22/bristol-loves-bugs-the-human-microbio... |
| Description | Bristol One Health Society - One Health AMR Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Presentation about AMR research to UK vet students |
| Year(s) Of Engagement Activity | 2023 |
| Description | Bristol Post newspaper article (Dr Matthew Avison) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Matthew Avison was interviewed by the Bristol Post on his antibiotic resistance research and an article published (print and on line version) |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bristolpost.co.uk/Bristol-professor-s-UK-trial-antibiotic/story-28687151-detail/story.htm... |
| Description | Bristol Vet School visit day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Discussed AMR research and importance to society |
| Year(s) Of Engagement Activity | 2022 |
| Description | Bristol, North Somerset, South Gloucestershire CCG, One Health AMR meeting (Reyher) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Meeting of the Bristol, North Somerset, South Gloucestershire Clincial Commissioning Group One Health AMR meeting at Bristol Royal Infirmary |
| Year(s) Of Engagement Activity | 2019 |
| Description | BristolBridge Press release |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press release/news story ("BristolBridge: a multidisciplinary approach to tackling antimicrobial resistance") on the BristolBridge grant award. This raised the profile of BristolBridge which helped to engage interdisciplinary research interest across the campus, research institutes and local NHS Trusts. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.bristol.ac.uk/news/2015/april/bristolbridge.html |
| Description | BristolBridge Schools Conference on Antibiotics and Antibiotic Resistance Science |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | 160 students and 15 teachers from nine schools across the south west attended lectures, hands-on displays and discovery-led demonstrations. The students were invited to comment about what they had learned in the lectures and whether it had changed their attitude to antibiotics and AMR. The views received included: "I realise now how much we need/should reduce the use of antibiotics";"I never realised how close and urgent this whole issue is"; "Antibiotics need to be used less in farming". After hearing about, and exploring the ways in which the physical sciences, engineering and mathematics research at the University of Bristol is helping to tackle the global problem of AMR, it was very encouraging that one student commented "Not as hopeless as I thought. Excited by the new technology that can help!" The University's press release can also be read here: http://www.bristol.ac.uk/news/2016/december/schools-conference-amr.html |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bristol.ac.uk/bristolbridge/news/schools-conference-on-antibiotics-and-antibiotic-resista... |
| Description | British Society for Antimicrobial Chemotherapy Antibiotic Resistance and Mechanisms meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation about AMR research and outcomes |
| Year(s) Of Engagement Activity | 2022 |
| Description | CHAWG AMU Steering group (Reyher) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Cattle Health and Welfare Group, Antimicrobial Use Group steering group committee meeting in London |
| Year(s) Of Engagement Activity | 2019 |
| Description | Capacity Building Workshop for FARMS-SAFE research group |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | The Capacity Building Workshop was held at the Faculty of Veterinary Medicine of University of La Plata from 3rd to 7th February 2020. The workshop was facilitated by the UK & Argentine PIs and CoIs to learn more about farm systems and the data that exists in Argentina, especially in La Plata and Cordoba. By adopting a participatory approach SOPs were designed for data and sample collection for: i) drafting a national survey & tools for WS1 and WS2, ii) AMU and AMR for WS3, iv) AMR and AM/chemical contamination for WS4 and v) developing a risk-based approach to targeting AMR for WS5. National Autorities from SENASA, academics and postgraduate students from UNLP and Rio Cuarto as well as the team from UoB participated in the meeting. During the workshop farm visits were organised for both the UK and Argentine colleagues to interview and participatorily observe and analyse the different farming practices among dairy and pig farms around La Plata. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Cattle Antibiotic Guardian Group |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Quarterly meetings advising the industry about AMU and AMR, discussing outcomes and plans for national policy |
| Year(s) Of Engagement Activity | 2022 |
| Description | Cattle Antibiotic Guardian Group |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Industry-led group discussing antibiotic stewardship in cattle |
| Year(s) Of Engagement Activity | 2022 |
| Description | Cattle Health and Welfare AMU Steering Group (Reyher) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | committee meeting of the steering group on Cattle Health and Welfare at Stoneleigh |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cattle Health and Welfare Group AMR Steering Group, UK |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Online meetings held on 4/28/2021 and 7/16/2020 to discuss antimicrobial use and measurement in the cattle sectors - metrics for antimicrobial use have been developed and uptaken across the UK cattle industries |
| Year(s) Of Engagement Activity | 2020,2021 |
| Description | Cheltenham Ladies' College - talk on AMR |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Matthew Avison gave a talk called "Superbugs: Is Resistance Futile?" to 90 students at Cheltenham Ladies College. This talk provoked questions and debate about AMR and Matthew was also approached by students afterwards with further queries. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Clare Phythian (Reyher) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Collaboration with Clare Phythian, visiting researcher from Norwegian University of Life Sciences |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.nmbu.no/emp/clare.phythian |
| Description | Clevedon School Be Inspired Careers Talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Discussed career as a vet researcher and research results to inspire students |
| Year(s) Of Engagement Activity | 2023 |
| Description | Collaboration between Veterinary Schools Council AMR group and Food Industry Initiative on Antimicrobials |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Collaboration to discuss best ways to report and compare antimicrobial usage data in food-producing animals |
| Year(s) Of Engagement Activity | 2021,2022 |
| Description | Collaborative meeting with Rothamsted Research |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | North Wyke Farm Platform researchers visiting Langford as a collaborative meeting with Rothamsted Research; talked about potential collaborations and updated on work |
| Year(s) Of Engagement Activity | 2019 |
| Description | Dairy Health Management Continuing Education Programme |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | invited headline presenter as an expert on AMR at Canada's premier training programme for diary veterinarians |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://guelphdhmcp.ca/ |
| Description | Discuss AMR research with VMD/Welsh Government |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Discussion of AMR research, potential questions and opportunities |
| Year(s) Of Engagement Activity | 2022 |
| Description | Engagement with Food Industry Initiative on Antimicrobials regarding AMU reporting (through Vet Schools Council AMR subgroup) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Discussions and preparation of a white paper regarding AMU reporting and data management best practice for industry |
| Year(s) Of Engagement Activity | 2022,2023 |
| Description | Engagement with Welsh Lamb and Beef Producers and VetIMPRESS regarding AMU recording and analysis |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Engaged with companies performing AMU analysis for UK livestock to share knowledge gained through research |
| Year(s) Of Engagement Activity | 2021,2022,2023 |
| Description | European Antibiotic Awareness Day Event, Veterinary School, Bristol (Dr Matthew Avison) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk on 'What you really need to know about antibiotic prescribing' to professional practitioners, policy makers and undergraduate and postgraduate students in clinical and veterinary medicine as part of Antibiotic Awareness Week. Feedback received that people's views changed on antibiotic prescribing as a result. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.bristol.ac.uk/infection-immunity/seminars/2015/world-antimicrobial-awareness-week.html |
| Description | FUTURES festival on 30th Sep 2022 held in SS Great Britain, Bristol |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Outreach event to showcase researches in the University |
| Year(s) Of Engagement Activity | 2023 |
| Description | Feature article on AMR on the Times Higher Education |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Article showcasing the research work at the University of Bristol, where researchers from numerous disciplines are working together to understand and control AMR in an effort to save lives at home and abroad. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.timeshighereducation.com/hub/university-bristol/p/taking-fight-superbugs |
| Description | Filton College |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Matthew gave a talk entitled 'Superbugs: Is Resistance Futile?'. Response was good and some students asked about careers in microbiology. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Food Industry Initiative on Antimicrobials Research & Development Committee + Data Committee - Quarterly Meeting (Reyher) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Quarterly committee meeting of the Food Industry Initiative on Antimicrobials Research & Development Committee + Data Committee |
| Year(s) Of Engagement Activity | 2019 |
| Description | Gave talk at Sidmouth Science Festival 2016 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | About 100 members of the general public attended my talk, "Superbugs: Is Resistance Futile?". Feedback included surprise at "cross resistance caused by biocides," that "antibiotics occur in soils" and "how long E.coli can live in the body". The audience reported changed views such as "I used to think basically that the more antibiotics you used, the healthier and better prepared you were. Now I'll be more cautious." |
| Year(s) Of Engagement Activity | 2016 |
| Description | Gloucestershire Antimicrobial Stewardship Group, UK |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Working with medical and dental practitioners in a One Health context to better understand antimicrobial stewardship and resistance; Online meeting of shared working held on 18/06/2020. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Gloucestershire One Health AMR group (Reyher) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prepared communication plan for Gloucestershire on One Health AMR |
| Year(s) Of Engagement Activity | 2019 |
| Description | Grant Launch Workshop - UK & Argentina AMR in the environment |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | The Grant Launch Workshop was organised by BBSRC & CONICET. Five projects funded through DoHSC/UKAid (along with BBSRC & NERC) in the UK and CONICET in Argentina presented their workpackages in order to create a collective proposal to develop a Pan-Program Intregration Project (PPIP) and policy translation activities within the Argentine context. A draft PPIP document was gathered from the workshop aiming to: - Aim 1 Combine expertise and data from all five project teams to provide consistency to (i) the co-design of policy with agricultural livestock sectors (ii) the measurement of antimicriobial use (AMU) and resistance (AMR), and (iii) knowledge exchange messages across all the livestock species and production systems encompassed by the program. - Aim 2 "A whole that is greater than the sum of its parts" - to generate research outcomes at the level of the program that would not be possible for any one project alone through combining effort and new work in specifically defined areas. The aims will be addressed through four work packages. UoB through the FARMS-SAFE project leads Work Package 1 (WP1) - Harmonising antimicrobial use and data collection. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://bbsrc.ukri.org/news/events/2018/1806-argentina-antimicrobial-resistance/ |
| Description | Highlight notice on Diamond Light Source website |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I worked with the Diamond Light Source press office to coordinate a press release related to our study of MCR-1 mediated resistance and to produce a highlight notice to feature on their website |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.diamond.ac.uk/Science/Research/Highlights/2017/MX-resistance.html |
| Description | Host Head of Population Health and Head of Research, Ontario Veterinary College, Guelph University, Ontario, Canada |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discuss AMR research and possible overlaps in collaborations |
| Year(s) Of Engagement Activity | 2019 |
| Description | IDF Conference Keynote Speech (Reyher) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Keynote speech by Kristen Reyher on AMR to the International Diary Federation Mastitis Conference 2019 - Social sciences and antimicrobial usage session, title "Antibiotic Anonymous - Playing Our Part in Reducing Antibiotic Usage" |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.idfmastitis2019.com/keynote-speakers.html |
| Description | Inaugural lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Inaugural lecture celebrating my body of research work, results and impact - conducted in a blended fashion with in-person and Zoom attendance internationally |
| Year(s) Of Engagement Activity | 2022 |
| Description | International Antibiotic Usage Forum |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Collaborative catch-up with AMR groups around the world - collaborations and contributions to practice |
| Year(s) Of Engagement Activity | 2021 |
| Description | International Antibiotic Usage Forum (Reyher) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Collaborative catch-up with AMR groups around the world - collaborations and contributions to practice |
| Year(s) Of Engagement Activity | 2019 |
| Description | Interview for BBC Points West |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Discussed AMR research at the Bristol Veterinary School on 14th November 2019. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Interview with FAIRR re: AMR in livestock |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview on 25/09/20 - informed evidence gathering for use in advising a global network of investors - fed into international webinar regarding antimicrobial stewardship by companies |
| Year(s) Of Engagement Activity | 2020 |
| Description | Invited Talk , Advanced Powder Materials Online Forum |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | An online event organised by the Central South University of China |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited lecture, London Interdisciplinary Biosciences Consortium, UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | PhD students based in BBSRC DTP in London Interdisciplinary Biosciences Consortium attended this lecture. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Invited talk in a workshop by The Sheffield Antimicrobial Resistance Network (SHAMROK). |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk in a workshop by The Sheffield Antimicrobial Resistance Network (SHAMROK). |
| Year(s) Of Engagement Activity | 2016 |
| Description | Invited talk in a workshop organised by the Institute for Molecular Science and Engineering (IMSE) at Imperial College London |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Audience from a number of different department at Imperial, including Materials, Medicine, Mathematics, Life Sciences, Chemical Engineering, Chemistry, and the Imperial NHS Trust attended. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited talk in an international conference of Advanced Materials organised by Newcastle University |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | International audience mostly from Europe attended this conference |
| Year(s) Of Engagement Activity | 2016 |
| Description | Keynote presentation at 'A Celebration of One Health: Collaborative Cultures' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Collaborative Cultures explores the impact of a One Health approach. Working, learning and sharing best-practice across disciplines. In September 2019 ACTAsia launched its Institute of Caring for Life Academic Research & Education (iCARE) at Oxford University, at a meeting called 'Health & Well-being: Science and Humanity are One'. As a follow-up to this event and to discuss the progress made, we are holding a webinar on One Health Day, 3 Nov 2020. Fast-forward to this webinar, we will celebrate a One Health interdisciplinary approach to the challenges faced for humans, animals and the environment. The discussions are especially poignant in 2020 as many academics and professionals are shifting their thinking to incorporate all three areas into their research and solutions to ensure maximum impact. The Webinar will close with a Charter for Collaborative Cultures being drawn up for iCARE projects. Speakers: Dr. Laura Kahn, Professor Terence Ryan, Professor Adam Hart, Dr. Kristen Rehyer, Sarah Gould and Dr Helen Winter. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://onehealthplatform.com/content/celebration-one-health-collaborative-cultures |
| Description | Launch of GW4 AMR Alliance |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | Launch of interdisciplinary research alliance on AMR - sharing of information regarding ongoing research, results and impact |
| Year(s) Of Engagement Activity | 2021 |
| Description | Lecture to vet students - Bristol University |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Training of practitioners and professionals: Lecture on "Big ideas in veterinary medicine: AMR" to veterinary students |
| Year(s) Of Engagement Activity | 2019,2021 |
| Description | MOOC, Creating course on antimicrobial stewardship for vets (Reyher) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion about AMR Massive Open Online Course phone meeting re training of practitioners and professionals |
| Year(s) Of Engagement Activity | 2019 |
| Description | Magazine article (Nonesuch biannual magazine) |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | BristolBridge lead PI (Professor Adrian Mulholland) and Co-I's (Dr Matthew Avison and Dr Michele Barbour) were interviewed for an article written by Catherine Treble on "Buying time: the fight against antibiotic resistance". The magazine is sent to University alumni and supporters around the world and resulted in shared information from an Italian resident about the research being undertaken by a team member. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://bristol.ac.uk/alumni/news/2015/antibiotic-resistance.html |
| Description | Massive open online course - contribution |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Massive Open Online Course on Antimicrobial Stewardship for Veterinarians - Kristen Reyher contributed to a conversation about antimicrobial stewardship that forms part of this course which has so far reached and changed the views and behaviours over 4000 learners from more than 120 countries. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.futurelearn.com/courses/antimicrobial-stewardship-in-veterinary-practice |
| Description | Medical Research Foundation AMR PhD student cohort meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Gave a talk at the training day for PhD students - discussed my background and journey in research and AMR research at Bristol - 15th November 2020. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Meeting with National Milk Labs (Reyher) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Collaboration with FarmAssist, thinking about AMU metrics. Meeting in Langford |
| Year(s) Of Engagement Activity | 2019 |
| Description | Meeting with representatives of the Welsh Government |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Phone meeting with Welsh Government to discuss about AMR |
| Year(s) Of Engagement Activity | 2019 |
| Description | Meetings with National Milk Laboratories, UK |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Discuss and decide upon FarmAssist software features rolled out to the cattle industries - currently ~35% of the dairy sector has access to this software with >1300 farms from >180 veterinary practices actively using the software to benchmark antimicrobial use. Meetings held on 21/7/2021, 4/22/2021, 5/18/2020 and 6/24/2020. |
| Year(s) Of Engagement Activity | 2020,2021 |
| URL | https://www.nationalmilklaboratories.co.uk/vets/farm-assist |
| Description | Monkton Combe School Talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Talk on AMR and research being done to combat it to A-level students |
| Year(s) Of Engagement Activity | 2022 |
| Description | National Biofilms Innovation Centre (NBIC) All Research Partner meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Researchers and industrial partners to exchange information of their research under the NBIC memberships |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.biofilms.ac.uk/ |
| Description | PATH-SAFE Steering Group |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Engagement with Food Standards Agency research project destined to influence UK-level AMR surveillance |
| Year(s) Of Engagement Activity | 2022 |
| Description | Phone talk with Channel 4 Dispatches, UK |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Phone conversation with reporter about AMR in the environment - not featured in programme |
| Year(s) Of Engagement Activity | 2020 |
| Description | Poster presentation, Infection and Immunity Research Network Early Career Researchers' event, University of Bristol, 1st Feb 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Annual event organised by the University, esp. for ECRs |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster presentation, The 8th Thesinge Biofilm Conference, May 23-24, 2022, The Netherlands |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | An international conference held biennially with about 200-300 participants from academia and industries. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://biofilm-thesinge.com/index.php |
| Description | Presentation to Chief Scientific Advisor Chris Whitty |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Professor Chris Whitty, Chief Scientific Advisor for the Department of Health visited University of Bristol to hear of our work and latest findings. Matthew Avison and Ashley Bryce gave presentations, and Professor Whitty sent feedback later in the week saying he'd taken our findings on board and had found the visit useful. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation to Wellcome Trust |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | 25th March, 2022 - Discussed AMR research with potential charity funders |
| Year(s) Of Engagement Activity | 2022 |
| Description | Public Open Day at the University of Bristol (Dr Matthew Avison) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Members of the general public attended a University of Bristol open day and heard a public engagement talk on 'Antibiotic resistance: We are all in it together'. Feedback since has shown that people changed the way they thought about antibiotics and the problem of antibiotic resistance. |
| Year(s) Of Engagement Activity | 2015 |
| Description | RCVS Veterinary Antibiotic Champions initiative |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Engaging with industry and charity stakeholders to offer antimicrobial stewardship to veterinary surgeons across the UK. Stakeholder meeting 26/2/21. |
| Year(s) Of Engagement Activity | 2021 |
| Description | RSC Poster 2023 - Twitter Conference |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | An online conference organised by the RSC. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.rsc.org/our-events/rsc-poster/ |
| Description | RUMA Independent Scientific Group committee meeting (Reyher) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Responsible Use of medicines in Agriculture Alliance (RUMA) scientific group meeting in London |
| Year(s) Of Engagement Activity | 2019 |
| Description | Recorded podcast about responsible use of antimicrobials and alternatives |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Discussed AMR and alternatives in order to inform a global network of investors |
| Year(s) Of Engagement Activity | 2021 |
| Description | Research Talk: Chulabhorn Research Institute, Thailand |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I gave a talk to staff and students of Chulabhorn Research Institute, Thailand as part of my collaboration/network building activities visiting Thailand in January 2017. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Research meeting with representative from Boehringer Ingelheim |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Research meeting with representative from Boehringer Ingelheim to discuss AMR topics |
| Year(s) Of Engagement Activity | 2019 |
| Description | Responsible Use of Medicines in Agriculture Alliance (RUMA) Independent Scientific Group meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | RUMA Independent Scientific Group - providing scientific evidence to this industry body made up of stakeholders from across the animal health spheres - regular meetings and e-mail advice |
| Year(s) Of Engagement Activity | 2020,2021,2022,2023 |
| Description | Responsible Use of Medicines in Agriculture Alliance (RUMA) meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | RUMA Cattle Antibiotic Use Targets meeting on 01/09/20 - engaged with industry to encourage reduction of antimicrobials in the cattle sectors |
| Year(s) Of Engagement Activity | 2020 |
| Description | Responsible use of medicines in Agriculture Alliance (RUMA) Targets Task Force |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave an invited talk to challenge livestock industries in AM stewardship targets in Stoneleigh on 10th September 2019 |
| Year(s) Of Engagement Activity | 2019 |
| Description | Royal Society of Biology meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited by the Royal Society of Biology to talk about AMR research, specifically transmission of AMR - overview of talk will be loaded on their blog |
| Year(s) Of Engagement Activity | 2019 |
| Description | School visit to Clifton College, Bristol (Dr Matthew Avison) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Outreach presentation to pupils and teachers on antibiotic resistance "We are all in it together" |
| Year(s) Of Engagement Activity | 2015 |
| Description | School visit to King Edward VI High School, Birmingham (Dr Matthew Avison) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Outreach presentation to pupils and teachers on antibiotic resistance "We are all in it together" |
| Year(s) Of Engagement Activity | 2015 |
| Description | School visit to St. Joseph's International Institution, Singapore (Dr Matthew Avison) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Talk to international school pupils on antibiotic resistance on "We're all in this together". |
| Year(s) Of Engagement Activity | 2016 |
| Description | School visit to Tanglin Trust School, Singapore (Dr Matthew Avison) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Presentation to approximately 100 international school pupils on antibiotic resistance on "We're all in this together" |
| Year(s) Of Engagement Activity | 2016 |
| Description | School visit to Taylors College, Kuala Lumpur, Malaysia (Dr Matthew Avison) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Talk to up to 100 international school pupils on antibiotic resistance on "We're all in this together". |
| Year(s) Of Engagement Activity | 2016 |
| Description | School visit to United World College, Dover Campus, Singapore (Dr Matthew Avison) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Talk to international school pupils and teachers on antibiotic resistance "We're all in it together" |
| Year(s) Of Engagement Activity | 2016 |
| Description | Sheldon School - AMR talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Matthew Avison gave a talk entitled 'Superbugs: Is Resistance Futile?' to 80 secondary school pupils. Students asked questions about antibiotics and resistant bacteria and the school sent good feedback about the talk. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Speak with BBC Radio4 Costing the Earth |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Phone interview with the BBC Radio4 to discuss AMR research - background information to be used in radio presentation |
| Year(s) Of Engagement Activity | 2020 |
| Description | Speak with Channel 4 Dispatches |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Phone interview with Channel 4 Dispatches to inform a documentary about food safety |
| Year(s) Of Engagement Activity | 2020 |
| Description | St Lawrence School talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Matthew gave a talk entitled 'Superbugs: Is Resistance Futile?' There were many interesting questions from pupils and teachers reported the kids felt they had learnt a lot. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Surgeon X Comic |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Matthew Avison was asked to advise and contribute to the Surgeon X comic (Wellcome Trust Funded), which imagines a world beyond the antibiotic age, which was published via Wowbagger Productions. The comic is sold in print form and via an app. There has been significant international impact. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://surgeonx.co.uk/our-team/ |
| Description | Swindon College AMR talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Matthew Avison gave a talk entitled 'Superbugs: Is Resistance Futile?' This was to inspire a new generation of microbiologists and raise awareness of AMR. Students fed back change in perceptions and increased interest in microbiology. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Symposium talk: do beta lactams have a future (Oxford University) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at a symposium (Nov 2nd 2016) organised to mark the award of an American Chemical Society Citation for Chemical Breakthrough to the University of Oxford for the development of penicillin. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Talk at Warwick SWON Alliance Industry day. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Talk at the SWAN industry day to industry and academic representatives. Significant interest generated in methods for determining antibiotic action via proteomics |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www2.warwick.ac.uk/fac/cross_fac/wamic/swon/industry/ |
| Description | Talk to Queen's University Belfast Vet School |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Research talk about Functional genomic dissection of complex antibacterial resistance mechanisms, considering implications for rapid diagnosis of resistance |
| Year(s) Of Engagement Activity | 2021 |
| Description | Telephone interview: The Atlantic magazine |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I gave a telephone interview to a journalist from this publication, which resulted in a published article highlighting our research. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.theatlantic.com/health/archive/2017/01/colistin-resistance-spread/512705/ |
| Description | Training talk at South West Regional Microbiology Registrar Training Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a talk about how to predict AMR from whole genome sequence, and the implications of this on diagnostic microbiology. Audience were registrars and consultants within South West hospitals. |
| Year(s) Of Engagement Activity | 2021 |
| Description | University of Bristol Open Day Talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Talk on AMR and research activities to combat AMR |
| Year(s) Of Engagement Activity | 2022 |
| Description | Vet Schools Council AMR subgroup |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Discuss incorporating AMR research into UK/Ireland/Netherlands veterinary curricula |
| Year(s) Of Engagement Activity | 2022 |
| Description | Veterinary Schools Council AMR (Reyher) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | phone meeting |
| Year(s) Of Engagement Activity | 2019 |
| Description | Veterinary Schools Council, AMR (Reyher) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Phone meeting with committee |
| Year(s) Of Engagement Activity | 2019 |
| Description | Visit to Clarence House to talk with potential charitable donors |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | Spoke with HRH The Duchess of Cornwall and other charitable donors about AMR research |
| Year(s) Of Engagement Activity | 2022 |
| Description | Webinar training Welsh farm vets on antimicrobial stewardship, UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Arwain Vet Cymru Webinar for veterinary practitioners on 14/10/20 - inspired veterinarians to design antimicrobial stewardship interventions in their veterinary practices |
| Year(s) Of Engagement Activity | 2020 |
| Description | Welsh Animal and Environment AMR Delivery Group Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Discussing One Health AMR work |
| Year(s) Of Engagement Activity | 2021 |
| Description | Winterbourne International Academy - school talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Parents and pupils of Winterbourne Academy attended their Festival of Science lectures, one of which was a talk by Matthew entitled "No more drugs for superbugs" |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.myyate.co.uk/yate/e/18972/festival-of-science-lectures |
| Description | invited talk, Naresuan University, Phitsanulok, Thailand |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I presented our work on MCR-1 to staff and students of Naresuan University as part of my visit to Thailand to build collaborations and research networks. |
| Year(s) Of Engagement Activity | 2017 |
| Description | presented display at National Fungus Day event at FeedBristol, Sept 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | National Fungus Day is facilitated by the Bristish Mycological Society. We had a locally organized day as part of this national event. It was based at Feed Bristol which is an independent farming/gardening cooperative and was open to the public. It was advertised via a number of supporting organisations including various local conservation groups such as Avon Wildlife Trust. I presented display material relating to approaches for the discovery of useful antibiotics and other pharmaceuticals from fungi. The event was attended by more than 300 visitors of all ages, and I was kept busy all day with conversations about the beneficial uses of fungi and why their conservation might be important as it allows their exploitation in the future for useful products. It also severed as a useful platform to talk about antibiotics and the ongoing concerns about their use and many useful conversations were had discussing various aspect of this, including dealing with some major misunderstandings about their use in farming.. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.avonwildlifetrust.org.uk/events/2018/10/06/uk-fungus-day?instance=0 |