Underpinning Equipment for Magnetic Resonance Research
Lead Research Organisation:
University of Southampton
Department Name: Sch of Chemistry
Abstract
Nuclear Magnetic Resonance (NMR) is a technique which uses the fact that the nuclei of many atoms act as tiny radio-transmitters, emitting radio signals at precisely-defined frequencies, which can be detected by a carefully-tuned detector. In an NMR experiment, the nuclei are first magnetised by placing a sample in a strong magnetic field for some time. A sequence of radiofrequency pulses is then applied to the sample, which subsequently emits radiowaves which are detected in the radio receiver. The pattern of emitted waves provides information on the chemical composition and spatial distribution of the sample. One application of NMR is called Magnetic Resonance Imaging (MRI). This is used in hospitals to construct images of the interior of the human body, and is enormously useful for the diagnosis of diseases and injuries.
The magnetic resonance research centre of the University of Southampton is a world-leading facility for NMR and MRI research development. We are currently developing techniques which enhance NMR signals by factors of many thousands, which may lead to methods for the clinical detection and diagnosis of cancer by MRI, as well as numerous other applications in materials science, biochemistry, analytical chemistry, and quantum physics. The user group is growing rapidly in size, as is the range of research activities and collaborations. Our core research portfolio is supported by grants mostly from EPSRC, the Royal Society, and the EU Commission, with a total value in excess of £8M. These include recent awards of a £1.8M EPSRC Platform Grant and a £2.9M award from the EU Commission under the extremely competitive Future and Emerging Technologies - Open (FETopen) scheme.
This proposal seeks funding for upgrading NMR spectrometers that underpin cutting-edge research in magnetic resonance spectroscopy and imaging at the University of Southampton. Funds are requested for (i) the replacement of an ageing and obsolete 400MHz NMR console by a modern system; (ii) replacement of a second ageing 400MHz NMR console by a modern 700MHz system; (iii) provision of a workhorse 400MHz NMR console to enhance the productivity and capabilities of our homebuilt equipment which is capable of enhancing NMR signals by large factors. We will reuse our existing NMR magnets so as to keep costs down. These upgrades and replacements will being our research facility up to the international standard and significantly enhance our capability to perform, expand, and apply our cutting-edge research capabilities, in a highly cost-effective manner.
The magnetic resonance research centre of the University of Southampton is a world-leading facility for NMR and MRI research development. We are currently developing techniques which enhance NMR signals by factors of many thousands, which may lead to methods for the clinical detection and diagnosis of cancer by MRI, as well as numerous other applications in materials science, biochemistry, analytical chemistry, and quantum physics. The user group is growing rapidly in size, as is the range of research activities and collaborations. Our core research portfolio is supported by grants mostly from EPSRC, the Royal Society, and the EU Commission, with a total value in excess of £8M. These include recent awards of a £1.8M EPSRC Platform Grant and a £2.9M award from the EU Commission under the extremely competitive Future and Emerging Technologies - Open (FETopen) scheme.
This proposal seeks funding for upgrading NMR spectrometers that underpin cutting-edge research in magnetic resonance spectroscopy and imaging at the University of Southampton. Funds are requested for (i) the replacement of an ageing and obsolete 400MHz NMR console by a modern system; (ii) replacement of a second ageing 400MHz NMR console by a modern 700MHz system; (iii) provision of a workhorse 400MHz NMR console to enhance the productivity and capabilities of our homebuilt equipment which is capable of enhancing NMR signals by large factors. We will reuse our existing NMR magnets so as to keep costs down. These upgrades and replacements will being our research facility up to the international standard and significantly enhance our capability to perform, expand, and apply our cutting-edge research capabilities, in a highly cost-effective manner.
Planned Impact
Impact for the project will mainly come through the research enabled by the underpinning equipment proposed, in the following categories:
1. Knowledge: Magres@soton, in collaboration with external partners, has a strong track record of producing excellent scientific results, both on the fundamental and the applied side of research. This knowledge will mainly be spread through publications in high-impact scientific journals and conference appearances. Much of the work underpinned by the proposed equipment concerns advances in magnetic resonance methodology, which will benefit other areas of science such as biology, materials science, analytical science, and medical imaging.
2. Society and Economy: The research underpinned has significant commercial relevance. Hyperpolarised NMR is targeted as a commercial opportunity by several companies, some of them headquartered in the UK. Integration of microfluidic technology with high-resolution NMR spectroscopy, another priority at Magres@soton, could find important applications in the life sciences and in healthcare, with corresponding commercial opportunities. Several collaboration projects underpinned by the proposed equipment immediately target commercially important systems, such as petrochemical catalysts, drug candidates, and novel materials.
3. People: Magnetic resonance is an advanced and complex analytical tool. Its application in science, medicine, and engineering requires highly trained specialists, who have direct experience in working with current hardware. The proposed equipment will be operated by postdoctoral research fellows, postgraduate students, and undergraduate project students, who will be fully trained in its use. This conveys a directly marketable skill, the value of which will be considerably enhanced by the proposed equipment. On the one hand, it will provide access to contemporary kit, which is more job-relevant than working with obsolescent hardware, and it will significantly increase throughput, making space for a corresponding increase in student populations.
4. Public Outreach: The magnetic resonance systems feature prominently in various public outreach programmes at the University, Faculty, and School level. For example, we annually host a number of secondary school students in the "Chemistry Work Shadow" programme, where they get direct exposure to advanced NMR systems.
1. Knowledge: Magres@soton, in collaboration with external partners, has a strong track record of producing excellent scientific results, both on the fundamental and the applied side of research. This knowledge will mainly be spread through publications in high-impact scientific journals and conference appearances. Much of the work underpinned by the proposed equipment concerns advances in magnetic resonance methodology, which will benefit other areas of science such as biology, materials science, analytical science, and medical imaging.
2. Society and Economy: The research underpinned has significant commercial relevance. Hyperpolarised NMR is targeted as a commercial opportunity by several companies, some of them headquartered in the UK. Integration of microfluidic technology with high-resolution NMR spectroscopy, another priority at Magres@soton, could find important applications in the life sciences and in healthcare, with corresponding commercial opportunities. Several collaboration projects underpinned by the proposed equipment immediately target commercially important systems, such as petrochemical catalysts, drug candidates, and novel materials.
3. People: Magnetic resonance is an advanced and complex analytical tool. Its application in science, medicine, and engineering requires highly trained specialists, who have direct experience in working with current hardware. The proposed equipment will be operated by postdoctoral research fellows, postgraduate students, and undergraduate project students, who will be fully trained in its use. This conveys a directly marketable skill, the value of which will be considerably enhanced by the proposed equipment. On the one hand, it will provide access to contemporary kit, which is more job-relevant than working with obsolescent hardware, and it will significantly increase throughput, making space for a corresponding increase in student populations.
4. Public Outreach: The magnetic resonance systems feature prominently in various public outreach programmes at the University, Faculty, and School level. For example, we annually host a number of secondary school students in the "Chemistry Work Shadow" programme, where they get direct exposure to advanced NMR systems.
Organisations
- University of Southampton (Lead Research Organisation)
- University of Stuttgart (Collaboration)
- Columbia University (Collaboration)
- University of Paderborn (Collaboration)
- University of Kyoto (Collaboration)
- DIAMOND LIGHT SOURCE (Collaboration)
- École Normale Supérieure, Paris (Collaboration)
- Helmholtz Association of German Research Centres (Collaboration)
- Cambridge Cancer Centre (Collaboration)
- Max Planck Society (Collaboration)
- University of California, Berkeley (Collaboration)
- University of Pennsylvania (Collaboration)
- National Institute of Chemical Physics and Biophysics (Collaboration)
- New York University (Collaboration)
- Institut Laue–Langevin (Collaboration)
- Jianghan University (Collaboration)
- National institute of Chemical Physics, Tallinn (Collaboration)
- Jagiellonian University (Collaboration)
- University of Copenhagen (Collaboration)
- UNIVERSITY OF NOTTINGHAM (Collaboration)
- Lancaster University (Collaboration)
- Italian Institute of Technology (Istituto Italiano di Tecnologia IIT) (Collaboration)
- Russian Academy of Sciences (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- Technical University of Denmark (Collaboration)
- Johannes Gutenberg University of Mainz (Collaboration)
- Swiss Federal Institute of Technology in Lausanne (EPFL) (Collaboration)
- University of Turin (Collaboration)
- Technical University of Darmstadt (Collaboration)
- University of Osnabrück (Collaboration)
- Moscow Institute of Physics and Technology (Collaboration)
- Brown University (Collaboration)
- École normale supérieure de Lyon (ENS Lyon) (Collaboration)
- Science and Technologies Facilities Council (STFC) (Collaboration)
- Claude Bernard University Lyon 1 (UCBL) (Collaboration)
- University of Lille (Collaboration)
- University of Ulm (Collaboration)
- Technical University Kaiserslautern (Collaboration)
- UNIVERSITY OF YORK (Collaboration)
- Institute of Electronics Microelectronics and Nanotechnology (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
Publications
Utz Marcel
(2018)
Integration of nuclear magnetic resonance spectroscopy with microfluidic devices: Materials and other challenges
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Biskupek J
(2020)
Bond Dissociation and Reactivity of HF and H2O in a Nano Test Tube.
in ACS nano
Barker SJ
(2022)
Direct Production of a Hyperpolarized Metabolite on a Microfluidic Chip.
in Analytical chemistry
Eills J
(2021)
Singulett-Kontrast-Magnetresonanztomographie: Freisetzung der Hyperpolarisation durch den Metabolismus**
in Angewandte Chemie
Bloodworth S
(2019)
First Synthesis and Characterization of CH 4 @C 60
in Angewandte Chemie
Hoffman G
(2021)
A Solid-State Intramolecular Wittig Reaction Enables Efficient Synthesis of Endofullerenes Including Ne@C 60 , 3 He@C 60 , and HD@C 60
in Angewandte Chemie
Hoffman G
(2021)
A Solid-State Intramolecular Wittig Reaction Enables Efficient Synthesis of Endofullerenes Including Ne@C60 , 3 He@C60 , and HD@C60.
in Angewandte Chemie (International ed. in English)
Eills J
(2021)
Singlet-Contrast Magnetic Resonance Imaging: Unlocking Hyperpolarization with Metabolism*.
in Angewandte Chemie (International ed. in English)
Bloodworth S
(2019)
First Synthesis and Characterization of CH4 @C60.
in Angewandte Chemie (International ed. in English)
Roy SS
(2022)
Tuning of pH enables carbon-13 hyperpolarization of oxalates by SABRE.
in Chemical communications (Cambridge, England)
| Description | The equipment is now in place and fully operational. The key findings are documented in the papers that have been published over the past year, and this level of output is projected to continue over the coming several years. The equipment is well utilised. |
| Exploitation Route | The outputs of this work are important for the development of Nuclear Magnetic Resonance as a technique. This has wide applicability across a number of sectors. |
| Sectors | Chemicals,Energy,Environment,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| URL | https://www.southampton.ac.uk/chemistry/about/staff/mhl.page |
| Description | The NMR equipment purchased in this award is now fully operational. It has already been instrumental in enabling a consortium (ZULF), a Marie Curie ITN, with academic and non academic partners. |
| First Year Of Impact | 2019 |
| Sector | Aerospace, Defence and Marine,Chemicals,Energy,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Societal,Economic |
| Description | EPSRC Platform Grant |
| Amount | £1,784,689 (GBP) |
| Funding ID | EP/P009980/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 02/2022 |
| Description | European Research Council Advanced Grant |
| Amount | € 2,762,223 (EUR) |
| Funding ID | 786707 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 10/2018 |
| End | 09/2023 |
| Description | Marie Sklodowska-Curie Innovative Training Networks |
| Amount | € 2,794,786 (EUR) |
| Funding ID | 766402 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 02/2018 |
| End | 01/2022 |
| Description | Underpinning Equipment |
| Amount | £1,999,999 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2017 |
| End | 03/2018 |
| Title | SpinDynamica software |
| Description | SpinDynamica software is a Mathematica-based system for analyzing, understanding, and simulating nuclear spin dynamics, with applications to NMR and MRI. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Widespread use in the NMR community |
| URL | http://www.spindynamica.soton.ac.uk/ |
| Description | Endofullerene collaboration |
| Organisation | Brown University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | NMR and theory |
| Collaborator Contribution | Synthesis, physical techniques, and theory |
| Impact | Too complex to report here. |
| Start Year | 2006 |
| Description | Endofullerene collaboration |
| Organisation | Columbia University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | NMR and theory |
| Collaborator Contribution | Synthesis, physical techniques, and theory |
| Impact | Too complex to report here. |
| Start Year | 2006 |
| Description | Endofullerene collaboration |
| Organisation | Diamond Light Source |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | NMR and theory |
| Collaborator Contribution | Synthesis, physical techniques, and theory |
| Impact | Too complex to report here. |
| Start Year | 2006 |
| Description | Endofullerene collaboration |
| Organisation | Helmholtz Association of German Research Centres |
| Department | Helmholtz Institute Mainz |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | NMR and theory |
| Collaborator Contribution | Synthesis, physical techniques, and theory |
| Impact | Too complex to report here. |
| Start Year | 2006 |
| Description | Endofullerene collaboration |
| Organisation | Institut Laue–Langevin |
| Country | France |
| Sector | Academic/University |
| PI Contribution | NMR and theory |
| Collaborator Contribution | Synthesis, physical techniques, and theory |
| Impact | Too complex to report here. |
| Start Year | 2006 |
| Description | Endofullerene collaboration |
| Organisation | Jianghan University |
| Country | China |
| Sector | Academic/University |
| PI Contribution | NMR and theory |
| Collaborator Contribution | Synthesis, physical techniques, and theory |
| Impact | Too complex to report here. |
| Start Year | 2006 |
| Description | Endofullerene collaboration |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NMR and theory |
| Collaborator Contribution | Synthesis, physical techniques, and theory |
| Impact | Too complex to report here. |
| Start Year | 2006 |
| Description | Endofullerene collaboration |
| Organisation | Lancaster University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NMR and theory |
| Collaborator Contribution | Synthesis, physical techniques, and theory |
| Impact | Too complex to report here. |
| Start Year | 2006 |
| Description | Endofullerene collaboration |
| Organisation | Max Planck Society |
| Department | Fritz Haber Institute |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | NMR and theory |
| Collaborator Contribution | Synthesis, physical techniques, and theory |
| Impact | Too complex to report here. |
| Start Year | 2006 |
| Description | Endofullerene collaboration |
| Organisation | Moscow Institute of Physics and Technology |
| Country | Russian Federation |
| Sector | Academic/University |
| PI Contribution | NMR and theory |
| Collaborator Contribution | Synthesis, physical techniques, and theory |
| Impact | Too complex to report here. |
| Start Year | 2006 |
| Description | Endofullerene collaboration |
| Organisation | National institute of Chemical Physics, Tallinn |
| Country | Estonia |
| Sector | Academic/University |
| PI Contribution | NMR and theory |
| Collaborator Contribution | Synthesis, physical techniques, and theory |
| Impact | Too complex to report here. |
| Start Year | 2006 |
| Description | Endofullerene collaboration |
| Organisation | University of Kyoto |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | NMR and theory |
| Collaborator Contribution | Synthesis, physical techniques, and theory |
| Impact | Too complex to report here. |
| Start Year | 2006 |
| Description | Endofullerene collaboration |
| Organisation | University of Lille |
| Country | France |
| Sector | Academic/University |
| PI Contribution | NMR and theory |
| Collaborator Contribution | Synthesis, physical techniques, and theory |
| Impact | Too complex to report here. |
| Start Year | 2006 |
| Description | Endofullerene collaboration |
| Organisation | University of Nottingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NMR and theory |
| Collaborator Contribution | Synthesis, physical techniques, and theory |
| Impact | Too complex to report here. |
| Start Year | 2006 |
| Description | Endofullerene collaboration |
| Organisation | University of Osnabrück |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | NMR and theory |
| Collaborator Contribution | Synthesis, physical techniques, and theory |
| Impact | Too complex to report here. |
| Start Year | 2006 |
| Description | Endofullerene collaboration |
| Organisation | University of Paderborn |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | NMR and theory |
| Collaborator Contribution | Synthesis, physical techniques, and theory |
| Impact | Too complex to report here. |
| Start Year | 2006 |
| Description | Endofullerene collaboration |
| Organisation | University of Stuttgart |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | NMR and theory |
| Collaborator Contribution | Synthesis, physical techniques, and theory |
| Impact | Too complex to report here. |
| Start Year | 2006 |
| Description | Endofullerene consortium starting 2015 |
| Organisation | Institut Laue–Langevin |
| Country | France |
| Sector | Academic/University |
| PI Contribution | NMR & theory |
| Collaborator Contribution | multidisciplinary research and measurements |
| Impact | Numerous outputs. See linked grants. Multidisciplinary: chemistry, physics |
| Start Year | 2015 |
| Description | Endofullerene consortium starting 2015 |
| Organisation | Institute of Electronics Microelectronics and Nanotechnology |
| Country | France |
| Sector | Academic/University |
| PI Contribution | NMR & theory |
| Collaborator Contribution | multidisciplinary research and measurements |
| Impact | Numerous outputs. See linked grants. Multidisciplinary: chemistry, physics |
| Start Year | 2015 |
| Description | Endofullerene consortium starting 2015 |
| Organisation | Jagiellonian University |
| Department | Jagiellonian University Medical College |
| Country | Poland |
| Sector | Academic/University |
| PI Contribution | NMR & theory |
| Collaborator Contribution | multidisciplinary research and measurements |
| Impact | Numerous outputs. See linked grants. Multidisciplinary: chemistry, physics |
| Start Year | 2015 |
| Description | Endofullerene consortium starting 2015 |
| Organisation | Johannes Gutenberg University of Mainz |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | NMR & theory |
| Collaborator Contribution | multidisciplinary research and measurements |
| Impact | Numerous outputs. See linked grants. Multidisciplinary: chemistry, physics |
| Start Year | 2015 |
| Description | Endofullerene consortium starting 2015 |
| Organisation | National institute of Chemical Physics, Tallinn |
| Country | Estonia |
| Sector | Academic/University |
| PI Contribution | NMR & theory |
| Collaborator Contribution | multidisciplinary research and measurements |
| Impact | Numerous outputs. See linked grants. Multidisciplinary: chemistry, physics |
| Start Year | 2015 |
| Description | Endofullerene consortium starting 2015 |
| Organisation | University of Nottingham |
| Department | School of Psychology Nottingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NMR & theory |
| Collaborator Contribution | multidisciplinary research and measurements |
| Impact | Numerous outputs. See linked grants. Multidisciplinary: chemistry, physics |
| Start Year | 2015 |
| Description | Endofullerenes as laser materials |
| Organisation | Institute of Electronics Microelectronics and Nanotechnology |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Materials, theory, concepts |
| Collaborator Contribution | Experiments, concepts, materials |
| Impact | none yet |
| Start Year | 2019 |
| Description | Field-cycling investigations of long-lived nuclear spin states |
| Organisation | New York University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Samples, ideas, spin dynamical expertise |
| Collaborator Contribution | Equipment, personnel, spin dynamical expertise |
| Impact | Publications listed under grants |
| Start Year | 2018 |
| Description | Field-cycling investigations of long-lived nuclear spin states |
| Organisation | Russian Academy of Sciences |
| Department | International Tomography Center |
| Country | Russian Federation |
| Sector | Public |
| PI Contribution | Samples, ideas, spin dynamical expertise |
| Collaborator Contribution | Equipment, personnel, spin dynamical expertise |
| Impact | Publications listed under grants |
| Start Year | 2018 |
| Description | Hyperpolarization collaboration |
| Organisation | Cambridge Cancer Centre |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NMR techniques, materials, theory, simulations |
| Collaborator Contribution | MRI techniques, materials, methodology |
| Impact | Too complex to report here. |
| Start Year | 2010 |
| Description | Hyperpolarization collaboration |
| Organisation | Swiss Federal Institute of Technology in Lausanne (EPFL) |
| Country | Switzerland |
| Sector | Public |
| PI Contribution | NMR techniques, materials, theory, simulations |
| Collaborator Contribution | MRI techniques, materials, methodology |
| Impact | Too complex to report here. |
| Start Year | 2010 |
| Description | Hyperpolarization collaboration |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | NMR techniques, materials, theory, simulations |
| Collaborator Contribution | MRI techniques, materials, methodology |
| Impact | Too complex to report here. |
| Start Year | 2010 |
| Description | Hyperpolarization collaboration |
| Organisation | University of Pennsylvania |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | NMR techniques, materials, theory, simulations |
| Collaborator Contribution | MRI techniques, materials, methodology |
| Impact | Too complex to report here. |
| Start Year | 2010 |
| Description | Hyperpolarization collaboration |
| Organisation | École normale supérieure de Lyon (ENS Lyon) |
| Country | France |
| Sector | Academic/University |
| PI Contribution | NMR techniques, materials, theory, simulations |
| Collaborator Contribution | MRI techniques, materials, methodology |
| Impact | Too complex to report here. |
| Start Year | 2010 |
| Description | Hyperpolarized 3He NMR |
| Organisation | Jagiellonian University |
| Country | Poland |
| Sector | Academic/University |
| PI Contribution | samples, background knowledge, ideas |
| Collaborator Contribution | 3He NMR and MRI |
| Impact | none yet |
| Start Year | 2018 |
| Description | Hyperpolarized fumarate |
| Organisation | Helmholtz Association of German Research Centres |
| Department | Helmholtz Institute Mainz |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | NMR expertise |
| Collaborator Contribution | NMR expertise |
| Impact | see publication list |
| Start Year | 2019 |
| Description | Hyperpolarized fumarate |
| Organisation | Johannes Gutenberg University of Mainz |
| Department | Mainz Microtron MAMI |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | NMR expertise |
| Collaborator Contribution | NMR expertise |
| Impact | see publication list |
| Start Year | 2019 |
| Description | Hyperpolarized fumarate |
| Organisation | Technical University Kaiserslautern |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | NMR expertise |
| Collaborator Contribution | NMR expertise |
| Impact | see publication list |
| Start Year | 2019 |
| Description | Hyperpolarized fumarate |
| Organisation | Technical University of Darmstadt |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | NMR expertise |
| Collaborator Contribution | NMR expertise |
| Impact | see publication list |
| Start Year | 2019 |
| Description | Hyperpolarized fumarate |
| Organisation | University of California, Berkeley |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | NMR expertise |
| Collaborator Contribution | NMR expertise |
| Impact | see publication list |
| Start Year | 2019 |
| Description | Hyperpolarized fumarate |
| Organisation | University of Turin |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | NMR expertise |
| Collaborator Contribution | NMR expertise |
| Impact | see publication list |
| Start Year | 2019 |
| Description | Infrared and THz spectroscopy of endofullerenes |
| Organisation | Institute of Electronics Microelectronics and Nanotechnology |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Provision of samples, theory, numerical simulations |
| Collaborator Contribution | Terahertz and infrared spectroscopy, and their interpretation |
| Impact | Numerous outputs listed under associated grants in ResearchFish |
| Start Year | 2015 |
| Description | Infrared and THz spectroscopy of endofullerenes |
| Organisation | Max Planck Society |
| Department | Fritz Haber Institute |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Provision of samples, theory, numerical simulations |
| Collaborator Contribution | Terahertz and infrared spectroscopy, and their interpretation |
| Impact | Numerous outputs listed under associated grants in ResearchFish |
| Start Year | 2015 |
| Description | Infrared and THz spectroscopy of endofullerenes |
| Organisation | National Institute of Chemical Physics and Biophysics |
| Country | Estonia |
| Sector | Academic/University |
| PI Contribution | Provision of samples, theory, numerical simulations |
| Collaborator Contribution | Terahertz and infrared spectroscopy, and their interpretation |
| Impact | Numerous outputs listed under associated grants in ResearchFish |
| Start Year | 2015 |
| Description | Neutron scattering of endofullerenes |
| Organisation | Institut Laue–Langevin |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Provision of samples, concepts, and theoretical expertise |
| Collaborator Contribution | PhD studentship; instrument time; expert help; accommodation and substistence |
| Impact | Numerous publications; listed under associated grants in` ResearchFish. |
| Start Year | 2015 |
| Description | Neutron scattering of endofullerenes |
| Organisation | Science and Technologies Facilities Council (STFC) |
| Department | ISIS Neutron and Muon Source |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of samples, concepts, and theoretical expertise |
| Collaborator Contribution | PhD studentship; instrument time; expert help; accommodation and substistence |
| Impact | Numerous publications; listed under associated grants in` ResearchFish. |
| Start Year | 2015 |
| Description | Theory and investigations of nuclear spin isomer conversion (especially in water) |
| Organisation | National institute of Chemical Physics, Tallinn |
| Country | Estonia |
| Sector | Academic/University |
| PI Contribution | Experimental results, theory |
| Collaborator Contribution | Theory, interpretation |
| Impact | none yet |
| Start Year | 2019 |
| Description | Theory and investigations of nuclear spin isomer conversion (especially in water) |
| Organisation | Russian Academy of Sciences |
| Country | Russian Federation |
| Sector | Public |
| PI Contribution | Experimental results, theory |
| Collaborator Contribution | Theory, interpretation |
| Impact | none yet |
| Start Year | 2019 |
| Description | ZULF consortium |
| Organisation | Claude Bernard University Lyon 1 (UCBL) |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Theory, simulations, NMR methodology |
| Collaborator Contribution | Collaborative research |
| Impact | publication DOIs: 10.1016/j.jmr.2019.106645 10.1039/C8CC06636A 10.1063/1.5089486 |
| Start Year | 2017 |
| Description | ZULF consortium |
| Organisation | Italian Institute of Technology (Istituto Italiano di Tecnologia IIT) |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | Theory, simulations, NMR methodology |
| Collaborator Contribution | Collaborative research |
| Impact | publication DOIs: 10.1016/j.jmr.2019.106645 10.1039/C8CC06636A 10.1063/1.5089486 |
| Start Year | 2017 |
| Description | ZULF consortium |
| Organisation | Jagiellonian University |
| Country | Poland |
| Sector | Academic/University |
| PI Contribution | Theory, simulations, NMR methodology |
| Collaborator Contribution | Collaborative research |
| Impact | publication DOIs: 10.1016/j.jmr.2019.106645 10.1039/C8CC06636A 10.1063/1.5089486 |
| Start Year | 2017 |
| Description | ZULF consortium |
| Organisation | Johannes Gutenberg University of Mainz |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Theory, simulations, NMR methodology |
| Collaborator Contribution | Collaborative research |
| Impact | publication DOIs: 10.1016/j.jmr.2019.106645 10.1039/C8CC06636A 10.1063/1.5089486 |
| Start Year | 2017 |
| Description | ZULF consortium |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Theory, simulations, NMR methodology |
| Collaborator Contribution | Collaborative research |
| Impact | publication DOIs: 10.1016/j.jmr.2019.106645 10.1039/C8CC06636A 10.1063/1.5089486 |
| Start Year | 2017 |
| Description | ZULF consortium |
| Organisation | University of Turin |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | Theory, simulations, NMR methodology |
| Collaborator Contribution | Collaborative research |
| Impact | publication DOIs: 10.1016/j.jmr.2019.106645 10.1039/C8CC06636A 10.1063/1.5089486 |
| Start Year | 2017 |
| Description | ZULF consortium |
| Organisation | University of Ulm |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Theory, simulations, NMR methodology |
| Collaborator Contribution | Collaborative research |
| Impact | publication DOIs: 10.1016/j.jmr.2019.106645 10.1039/C8CC06636A 10.1063/1.5089486 |
| Start Year | 2017 |
| Description | ZULF consortium |
| Organisation | University of York |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Theory, simulations, NMR methodology |
| Collaborator Contribution | Collaborative research |
| Impact | publication DOIs: 10.1016/j.jmr.2019.106645 10.1039/C8CC06636A 10.1063/1.5089486 |
| Start Year | 2017 |
| Description | dDNP collaboration |
| Organisation | Technical University of Denmark |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | NMR methodology, theory and experiments. |
| Collaborator Contribution | NMR methodology, theory and experiments. |
| Impact | see grant entries. |
| Start Year | 2016 |
| Description | dDNP collaboration |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NMR methodology, theory and experiments. |
| Collaborator Contribution | NMR methodology, theory and experiments. |
| Impact | see grant entries. |
| Start Year | 2016 |
| Description | dDNP collaboration |
| Organisation | École Normale Supérieure, Paris |
| Country | France |
| Sector | Academic/University |
| PI Contribution | NMR methodology, theory and experiments. |
| Collaborator Contribution | NMR methodology, theory and experiments. |
| Impact | see grant entries. |
| Start Year | 2016 |
| Description | dDNP collaboration |
| Organisation | École normale supérieure de Lyon (ENS Lyon) |
| Country | France |
| Sector | Academic/University |
| PI Contribution | NMR methodology, theory and experiments. |
| Collaborator Contribution | NMR methodology, theory and experiments. |
| Impact | see grant entries. |
| Start Year | 2016 |
| Title | SpinDynamica |
| Description | Large set of Mathematica packages for analyzing, simulating, and understanding NMR experiments. |
| Type Of Technology | Software |
| Year Produced | 2017 |
| Impact | widely used in NMR community |
| URL | http://www.spindynamica.soton.ac.uk |