EPRSC Resource Only Strategic Equipment: the Warwick Analytical Science Centre

Lead Research Organisation: University of Warwick
Department Name: Physics

Abstract

Access to analytical instrumentation lies at the heart of scientific progress; from the earliest days, with the availability of the first Dutch microscopes in the early 17th century, to the cutting edge of most advanced fields of contemporary science. The vast majority of advances and breakthroughs in knowledge are linked to the invention or improvement of analytical equipment and their availability both enables and sustains modern science and technology. Thus, it would not be possible to imagine chemistry without nuclear magnetic resonance spectroscopy, molecular biology without electron microscopy, or material science without X-ray diffraction.

The University of Warwick is one of the foremost centres for analytical science in the UK, with an internationally leading analytical equipment infrastructure underpinning an unrivalled spectrum of research areas, from functional materials (catalysts, polymers, composites, battery electrodes, photovoltaics, steels, nanoparticles, diamond and quantum materials) to biomedical research (pharmaceuticals, novel antimicrobials, detection of infectious agents, biologic cryopreservation, drug delivery, metabolism and ageing, and bacterial antibiotic resistance).

Warwick's philosophy in managing this unique set of facilities has been characterised by the drive to maximise its access for all researchers from undergraduate students to Professors, a commitment that is grounded in the University's Research Strategy. This has been achieved by organising the most advanced, state-of-the-art equipment into a range of university-wide Research Technology Platforms (RTPs) and interdepartmental facilities available to both internal and external users. This unique model brings together experts and instrument developers with frequent or occasional end-users and has been the origin of a large number of highly successful collaborative research initiatives across the Departments of Chemistry, Engineering, Life Sciences and Physics, and with a number of other UK universities and industrial partners.

This proposal is aimed at sustaining and expanding the access to Warwick's analytical equipment infrastructure, with a particular focus towards supporting research and postgraduate training and, concurrently, expanding multi-disciplinary collaboration and end-user engagement. This will be achieved by investing in research technical professionals (RTProfs), who are integral to deriving optimum benefit from the existing substantial infrastructure investment. Their presence will represent an essential asset for the effective and consistent training, at the highest standards, of PhD students in the Midlands and across the UK and will provide them with over 480 days of seed-corn use of the analytical science instrumentation at Warwick. The RTProfs will also be responsible for showcasing the availability of funding for PhD students and for disseminating analytical science best practice, through the organisation of national analytical science meetings that will involve UK universities, learned societies, and industry.

This investment has an overarching vision to substantially promote analytical sciences to the UK, with Warwick playing a key role nationally as hub of excellence and a beacon for its development and practice.

Publications

10 25 50

 
Description Increasing the recognition of the key role of research technical professionals (RTProfs) that support analytical science, building on 2 well attended (in-person and hybrid) conferences in 2022.
Use of Warwick analytical science instrumentation via the seedcorn access scheme via UK PhD students in a wide range of applications.
Exploitation Route Continuing to work with UKRI and other UK Universities to increase the profile and career progression opportunities for RTProfs
Sectors Agriculture, Food and Drink,Chemicals,Construction,Energy,Environment,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

 
Title Supplementary information files for Crosslinked p(MMA) particles by RAFT emulsion polymerisation: tuning size and stability 
Description Supplementary information files for article Crosslinked p(MMA) particles by RAFT emulsion polymerisation: tuning size and stability The controlled synthesis of amphiphilic di-block copolymers allows a large array of nanostructures to be created, including block copolymer particles, which have proved valuable for biomedical applications. Despite progress in targeting specific block copolymer architectures, control over the size and stability of spherical particles is less well explored. Here, we report the use of RAFT emulsion polymerisation to synthesise a library of p(MMA) particles, crosslinked with ethylene glycol dimethacrylate and stabilised by brush-like poly(ethylene glycol)-based polymers. We successfully synthesised a range of block copolymer particles, offering stability up to p(MMA)1000, with DLS reporting stable particle diameters of 33-176 nm and PDI < 0.2. DLS and AFM studies showed a general increase in particle diameter with increasing amounts of p(MMA). The use of a PEG methacrylate monomer with a methyl ether end group resulted in more well defined and stable particles than those with hydroxyl end groups. The copolymerisation of a suitably functionalized Gd(III) complex into the shell of the spherical p(MMA) particles resulted in Gd-loaded particles that were investigated in detail by 1H NMR relaxometry, demonstrating that the Gd complex was successfully incorporated into the particles. This study will inform the synthesis of core-shell particles with optimised stability and targeted sizes, and show a simple method to incorporate a molecular sensor, generating a macromolecular imaging agent. 
Type Of Material Database/Collection of data 
Year Produced 2022 
Provided To Others? Yes  
URL https://repository.lboro.ac.uk/articles/dataset/Supplementary_information_files_for_Crosslinked_p_MM...
 
Title Supplementary information files for Crosslinked p(MMA) particles by RAFT emulsion polymerisation: tuning size and stability 
Description Supplementary information files for article Crosslinked p(MMA) particles by RAFT emulsion polymerisation: tuning size and stability The controlled synthesis of amphiphilic di-block copolymers allows a large array of nanostructures to be created, including block copolymer particles, which have proved valuable for biomedical applications. Despite progress in targeting specific block copolymer architectures, control over the size and stability of spherical particles is less well explored. Here, we report the use of RAFT emulsion polymerisation to synthesise a library of p(MMA) particles, crosslinked with ethylene glycol dimethacrylate and stabilised by brush-like poly(ethylene glycol)-based polymers. We successfully synthesised a range of block copolymer particles, offering stability up to p(MMA)1000, with DLS reporting stable particle diameters of 33-176 nm and PDI < 0.2. DLS and AFM studies showed a general increase in particle diameter with increasing amounts of p(MMA). The use of a PEG methacrylate monomer with a methyl ether end group resulted in more well defined and stable particles than those with hydroxyl end groups. The copolymerisation of a suitably functionalized Gd(III) complex into the shell of the spherical p(MMA) particles resulted in Gd-loaded particles that were investigated in detail by 1H NMR relaxometry, demonstrating that the Gd complex was successfully incorporated into the particles. This study will inform the synthesis of core-shell particles with optimised stability and targeted sizes, and show a simple method to incorporate a molecular sensor, generating a macromolecular imaging agent. 
Type Of Material Database/Collection of data 
Year Produced 2022 
Provided To Others? Yes  
URL https://repository.lboro.ac.uk/articles/dataset/Supplementary_information_files_for_Crosslinked_p_MM...