Made Smarter Innovation - Digital Medicines Manufacturing Research Centre
Lead Research Organisation:
University of Strathclyde
Department Name: Inst of Pharmacy and Biomedical Sci
Abstract
Powered by data, Industrial Digital Technologies (IDTs) such as artificial intelligence and autonomous robots, can be used to improve all aspects of manufacturing and supply of products along supply chains to the customer. Many companies are embracing these technologies but uptake within the pharmaceutical sector has not been as rapid. The Medicines Made Smarter Data Centre (MMSDC) looks to address the key challenges which are slowing digitalisation, and adoption of IDTs that can transform processes to deliver medicines tailored to patient needs.
Work will be carried out across five integrated platforms designed by academic and industrial researcher teams. These are: 1) The Data Platform, 2) Autonomous MicroScale Manufacturing Platform, 3) Digital Quality Control Platform, 4) Adaptive Digital Supply Platform, and 5) The MMSDC Network & Skills Platform.
Platform 1 addresses one of the sector's core digitalisation challenges - a lack of large data sets and ways to access such data. The MMSDC data platform will store and analyse data from across the MMSDC project, making it accessible, searchable and reusable for the medicines manufacturing community. New approaches for ensuring consistently high-quality data, such as good practice guides and standards, will be developed alongside data science activities which will identify what the most important data are and how best to use them with IDTs in practice.
Platform 2 will accelerate development of medicine products and manufacturing processes by creating agile, small-scale production facilities that rapidly generate large data sets and drive research. Robotic technologies will be assembled to create a unique small-scale medicine manufacturing and testing system to select drug formulations and processes to produce stable products with the desired in-vitro performance. Integrating several IDTs will accelerate drug product manufacture, significantly reducing experiments and dramatically reducing development time, raw materials and associated costs.
Platform 3 focusses on the digitalisation of Quality Control (QC) aspects of medicines development which is important for ensuring a medicine's compliance with regulatory standards and patient safety requirements. Currently, QC checks are carried out after a process has been completed possibly spotting problems after they have occurred. This approach is inefficient, fragmented, costly (>20% of total production costs) and time consuming. The digital QC platform will research how to transform QC by utilising rich data from IDTs to confirm in real time product and process compliance.
Platform 4 will generate new understanding on future supply chain needs of medicines to support adoption of adaptive digital supply chains for patient-centric supply. IDTs make smaller scale, autonomous factory concepts viable that support more flexible and distributed manufacture and supply. Supply flexibility and agility extends to scale, product variety, and shorter lead-times (from months to days) offering a responsive patient-centric or rapid replenishment operating model. Finally, technology developments closer to the patient, such as diagnostics provide visibility on patient specific needs.
Platform 5 will establish the MMSDC Network & Skills Platform. This Network will lead engagement and collaboration across key stakeholder groups involved in medicines manufacturing and investments. The Network brings together the IDT-using community and other relevant academic and industrial groups to share developments across pharmaceuticals and broader digital manufacturing sectors ensuring cross-sector diffusion of MMSDC research. Existing strategic networks will support MMSDC and act as gateways for IDT dissemination and uptake. The lack of appropriate skills in the workforce has been highlighted as a key barrier to IDT adoption. An MMSDC priority is to identify skills needs and with partners develop and deliver training to over 100 users
Work will be carried out across five integrated platforms designed by academic and industrial researcher teams. These are: 1) The Data Platform, 2) Autonomous MicroScale Manufacturing Platform, 3) Digital Quality Control Platform, 4) Adaptive Digital Supply Platform, and 5) The MMSDC Network & Skills Platform.
Platform 1 addresses one of the sector's core digitalisation challenges - a lack of large data sets and ways to access such data. The MMSDC data platform will store and analyse data from across the MMSDC project, making it accessible, searchable and reusable for the medicines manufacturing community. New approaches for ensuring consistently high-quality data, such as good practice guides and standards, will be developed alongside data science activities which will identify what the most important data are and how best to use them with IDTs in practice.
Platform 2 will accelerate development of medicine products and manufacturing processes by creating agile, small-scale production facilities that rapidly generate large data sets and drive research. Robotic technologies will be assembled to create a unique small-scale medicine manufacturing and testing system to select drug formulations and processes to produce stable products with the desired in-vitro performance. Integrating several IDTs will accelerate drug product manufacture, significantly reducing experiments and dramatically reducing development time, raw materials and associated costs.
Platform 3 focusses on the digitalisation of Quality Control (QC) aspects of medicines development which is important for ensuring a medicine's compliance with regulatory standards and patient safety requirements. Currently, QC checks are carried out after a process has been completed possibly spotting problems after they have occurred. This approach is inefficient, fragmented, costly (>20% of total production costs) and time consuming. The digital QC platform will research how to transform QC by utilising rich data from IDTs to confirm in real time product and process compliance.
Platform 4 will generate new understanding on future supply chain needs of medicines to support adoption of adaptive digital supply chains for patient-centric supply. IDTs make smaller scale, autonomous factory concepts viable that support more flexible and distributed manufacture and supply. Supply flexibility and agility extends to scale, product variety, and shorter lead-times (from months to days) offering a responsive patient-centric or rapid replenishment operating model. Finally, technology developments closer to the patient, such as diagnostics provide visibility on patient specific needs.
Platform 5 will establish the MMSDC Network & Skills Platform. This Network will lead engagement and collaboration across key stakeholder groups involved in medicines manufacturing and investments. The Network brings together the IDT-using community and other relevant academic and industrial groups to share developments across pharmaceuticals and broader digital manufacturing sectors ensuring cross-sector diffusion of MMSDC research. Existing strategic networks will support MMSDC and act as gateways for IDT dissemination and uptake. The lack of appropriate skills in the workforce has been highlighted as a key barrier to IDT adoption. An MMSDC priority is to identify skills needs and with partners develop and deliver training to over 100 users
Organisations
- University of Strathclyde (Lead Research Organisation)
- Centre for Process Innovation (CPI) (Collaboration)
- LOUGHBOROUGH UNIVERSITY (Collaboration)
- Altair Engineering (United Kingdom) (Collaboration)
- NVIDIA (Collaboration)
- Chiesi (Collaboration)
- KUKA Robotics (Collaboration)
- Siemens (United Kingdom) (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- Cancer Research UK (Collaboration)
- Applied Materials (Collaboration)
- Eli Lilly & Company Ltd (Collaboration)
- BDD Pharma Ltd (Collaboration)
- National Physical Laboratory (Collaboration)
- UCB SA (Collaboration)
- Medicines and Healthcare Regulatory Agency (Collaboration)
- Smith and Nephew (Collaboration)
- Malvern Panalytical (Collaboration)
- Roche Pharmaceuticals (Collaboration)
- Cambridge Crystallographic Data Centre (Collaboration, Project Partner)
- GlaxoSmithKline (GSK) (Collaboration)
- UNIVERSITY OF NOTTINGHAM (Collaboration)
- Henry Royce Institute (Collaboration, Project Partner)
- Takeda Pharmaceutical Company (Collaboration)
- UNIVERSITY OF STRATHCLYDE (Collaboration)
- Innovate UK (Collaboration)
- AstraZeneca (United Kingdom) (Collaboration, Project Partner)
- MG2 S.r.l. (Project Partner)
- Centre for Process Innovation (Project Partner)
- Calderdale & Huddersfield NHS Foun Trust (Project Partner)
- NVIDIA Limited (UK) (Project Partner)
- Connected Everything Network+ (II) (Project Partner)
- EPSRC Future Manufact Hub Target Health (Project Partner)
- Altair Engineering (United Kingdom) (Project Partner)
- Perceptive Engineering (United Kingdom) (Project Partner)
- TÜV SÜD (United Kingdom) (Project Partner)
- Dietrich Engineering Consultants S.A. (Project Partner)
- Fette Compacting (Project Partner)
- MEDELPHARM (Project Partner)
- Knowledge Transfer Network KTN (Project Partner)
- Process Systems Enterprise (United Kingdom) (Project Partner)
- CPACT (Project Partner)
- Blaze Metrics, LLC. (Project Partner)
- KUKA (United Kingdom) (Project Partner)
- GSK (UK) (Project Partner)
- Malvern Panalytical Ltd (Project Partner)
- National Physical Laboratory (Project Partner)
- Chiesi Pharmaceuticals (Project Partner)
- UCB Pharma (Belgium) (Project Partner)
- Bio-Images Drug Delivery (United Kingdom) (Project Partner)
- Smith & Nephew plc (UK) (Project Partner)
Publications
Wilkinson M
(2023)
Predicting pharmaceutical powder flow from microscopy images using deep learning
in Digital Discovery
Poole A
(2021)
A Novel Complete-Surface-Finding Algorithm for Online Surface Scanning with Limited View Sensors.
in Sensors (Basel, Switzerland)
Joglekar N
(2022)
Configuration of digital and physical infrastructure platforms: Private and public perspectives
in Production and Operations Management
Bouchkira I
(2022)
32nd European Symposium on Computer Aided Process Engineering
Anandan P
(2022)
32nd European Symposium on Computer Aided Process Engineering
| Title | Digital Medicines Manufacturing (DM²) |
| Description | An overview of the DM2 centre |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| Impact | Increased the awareness regarding the DM2 project |
| URL | https://www.youtube.com/watch?v=0vNqEm4aAp0 |
| Description | Membership of the Skills subgroup of Medicines Manufacturing Industry Partnership (MMIP) |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | MMIP has identified six objectives for medicines manufacturing skills in the UK: 1: Promote the Medicines Manufacturing Industry and careers within it 2: Create apprenticeships standards to enable companies to use the Apprenticeship Levy 3: Share and promote good practice for training and skills development 4: Address the low level of practical skills in graduates and other new-starters 5: Address the issues arising from there being relatively small national cohorts for education and training in a number of critical skills areas 6: As part of the ATMP Taskforce recommendations, deliver an End to End Talent Management Plan for the sector and establish a Skills and Training Academy for the UK |
| URL | https://www.abpi.org.uk/r-d-manufacturing/medicines-manufacturing-industry-partnership-mmip/ |
| Description | CCDC Engagement Grant Programme |
| Amount | £1,500 (GBP) |
| Organisation | Cambridge Crystallographic Data Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2023 |
| End | 07/2023 |
| Description | Dialling up performance for on demand manufacturing |
| Amount | £5,865,535 (GBP) |
| Funding ID | EP/W017032/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 09/2027 |
| Description | Project partnership with Altair |
| Organisation | Altair Engineering Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The research team is working with Altair to achieve the project outcomes. |
| Collaborator Contribution | Altair is working with the research team providing technical expertise and access to software to deliver towards the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with Applied Materials (Perceptive Engineering) |
| Organisation | Applied Materials |
| Country | United States |
| Sector | Private |
| PI Contribution | The research team is working with Applied Materials to achieve the project outcomes. |
| Collaborator Contribution | Applied Materials is working with the research team providing technical expertise and access to software to deliver towards the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with AstraZeneca |
| Organisation | AstraZeneca |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The research team is working with AstraZeneca to achieve the project outcomes. |
| Collaborator Contribution | AstraZeneca is working with the research team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with BDD Pharma |
| Organisation | BDD Pharma Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The research team is working with BDD Pharma to achieve the project outcomes. |
| Collaborator Contribution | BDD Pharma is working with the research team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with Cambridge Crystallographic Data Centre (CCDC) |
| Organisation | Cambridge Crystallographic Data Centre |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The research team is working with CCDC to achieve the project outcomes. |
| Collaborator Contribution | CCDC is working with the research team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with Cancer Research UK |
| Organisation | Cancer Research UK |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | The research team is working with Cancer Research UK to achieve the project outcomes. |
| Collaborator Contribution | Cancer Research UK is working with the research team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with Chiesi |
| Organisation | Chiesi |
| Country | Italy |
| Sector | Private |
| PI Contribution | The research team is working with Chiesi to achieve the project outcomes. |
| Collaborator Contribution | Chiesi is working with the research team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with Eli Lilly & Company |
| Organisation | Eli Lilly & Company Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The DM2 team is working with Eli Lilly & Company to achieve the project outcomes. |
| Collaborator Contribution | Eli Lilly & Company is working with the DM2 team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2022 |
| Description | Project partnership with GlaxoSmithKline (GSK) |
| Organisation | GlaxoSmithKline (GSK) |
| Country | Global |
| Sector | Private |
| PI Contribution | The research team is working with GSK to achieve the project outcomes. |
| Collaborator Contribution | GSK is working with the research team and assisting/contributing to the project outcomes. Also, GSK is working with the DM2 platform 4 to contribute with a case study. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with Henry Royce Institute |
| Organisation | Henry Royce Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The DM2 team is working with Henry Royce Institute to achieve the project outcomes. |
| Collaborator Contribution | Henry Royce Institute is working with the DM2 team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with KUKA Robotics UK Ltd. |
| Organisation | KUKA Robotics |
| Department | KUKA Robotics UK Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The research team is working with KUKA Robotics to achieve the project outcomes. |
| Collaborator Contribution | KUKA Robotics is working with the research team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with Knowledge Transfer Network (KTN) |
| Organisation | Knowledge Transfer Network |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | The DM2 team is working with KTN to achieve the project outcomes. |
| Collaborator Contribution | KTN is working with the DM2 team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with Loughborough University |
| Organisation | Loughborough University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Platform 3 of the DM2 project is led by Dr Brahim Benyahia, Loughborough University |
| Collaborator Contribution | Platform 3 of the DM2 project is led by Dr Brahim Benyahia, Loughborough University |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with Malvern Panalytical |
| Organisation | Malvern Panalytical |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The research team is working with Malvern Panalytical to achieve the project outcomes. |
| Collaborator Contribution | Malvern Panalytical is working with the research team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with Medicines and Healthcare Regulatory Agency (MHRA) |
| Organisation | Medicines and Healthcare Regulatory Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | The DM2 team is working with MHRA to achieve the project outcomes. |
| Collaborator Contribution | MHRA is working with the DM2 team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with NVIDIA |
| Organisation | NVIDIA |
| Country | Global |
| Sector | Private |
| PI Contribution | The research team is working with NVIDIA to achieve the project outcomes. |
| Collaborator Contribution | NVIDIA is working with the research team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with National Physical Laboratory (NPL) |
| Organisation | National Physical Laboratory |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The research team is working with NPL to achieve the project outcomes. |
| Collaborator Contribution | NPL is working with the research team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with Process Systems Enterprise Limited (PSE)-Siemens |
| Organisation | Siemens Process Systems Engineering Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The research team is working with PSE to achieve the project outcomes. |
| Collaborator Contribution | PSE is working with the research team providing technical expertise and access to software to deliver towards the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with Roche |
| Organisation | Roche Pharmaceuticals |
| Country | Global |
| Sector | Private |
| PI Contribution | The DM2 team is working with Roche to achieve the project outcomes. |
| Collaborator Contribution | Roche is working with the DM2 team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2022 |
| Description | Project partnership with Smith and Nephew (S&N) |
| Organisation | Smith and Nephew |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The research team is working with S&N to achieve the project outcomes. |
| Collaborator Contribution | S&N is working with the research team and assisting/contributing to the project outcomes. Also, S&N is working with the DM2 platform 4 to contribute with a case study. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with Takeda |
| Organisation | Takeda Pharmaceutical Company |
| Country | Japan |
| Sector | Private |
| PI Contribution | The DM2 team is working with Takeda to achieve the project outcomes. |
| Collaborator Contribution | Takeda is working with the DM2 team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2022 |
| Description | Project partnership with UCB Pharma |
| Organisation | UCB SA |
| Country | Belgium |
| Sector | Private |
| PI Contribution | The research team is working with UCB to achieve the project outcomes. |
| Collaborator Contribution | UCB is working with the research team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with University of Cambridge |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Platform 4 of the DM2 project is led by Dr Jagjit Singh Srai, University of Cambridge |
| Collaborator Contribution | Platform 4 of the DM2 project is led by Dr Jagjit Singh Srai, University of Cambridge |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with the Centre for Process Innovation (CPI) |
| Organisation | Centre for Process Innovation (CPI) |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The research team is working with CPI to achieve the project outcomes. |
| Collaborator Contribution | CPI is working with the research team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with the University of Nottingham (Connected Everything) |
| Organisation | University of Nottingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The DM2 team is working with Connected Everything to achieve the project outcomes. |
| Collaborator Contribution | Connected Everything is working with the DM2 team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | Project partnership with the University of Strathclyde Centre for Process Analytics and Control Technology (CPACT) |
| Organisation | University of Strathclyde |
| Department | Centre for Process Analytics & Control Technology (CPACT) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The research team is working with CPACT to achieve the project outcomes. |
| Collaborator Contribution | CPACT is working with the research team and assisting/contributing to the project outcomes. |
| Impact | Made Smarter Innovation - Digital Medicines Manufacturing Research Centre |
| Start Year | 2021 |
| Description | SEARCH |
| Organisation | University of Strathclyde |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | New technology transfer to industry and academic partners |
| Collaborator Contribution | New applications e.g. in pharmaceutical manufacture, welding & joining, cladding |
| Impact | New project partnerships with end users - technology demonstrators |
| Start Year | 2021 |
| Description | Attending a workshop on Machine Learning/Artificial Intelligence Workshop, Uni. of Strathclyde, Aug. 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Machine Learning/Artificial Intelligence Workshop, Uni. of Strathclyde, Aug. 2022, Glasgow, UK |
| Year(s) Of Engagement Activity | 2022 |
| Description | DM2 researchers training at MG2, June 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Two researchers from the DM2 recieved training on FlexaLab capsule filling machine at MG2, June 2022, Bologna, Italy. |
| Year(s) Of Engagement Activity | 2022 |
| Description | DM2 researchers training by Altair, Nov-Dec 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Training on Discrete Element Modelling using EDEM by Altair, Nov-Dec 2022, UK |
| Year(s) Of Engagement Activity | 2022 |
| Description | DM2 researchers training by Siemens, during CMAC summer school programme, June 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Training on gproms by Siemens in CMAC summer school programme, June 2022, Crieff, UK |
| Year(s) Of Engagement Activity | 2022 |
| Description | Doors Open Glasgow 2022 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | CMAC are participated in the #Glasgow Doors Open Days Festival (https://glasgowdoorsopendays.org.uk) Saturday 17th September 2022 (10am-4pm) at the Technology & Innovation Centre (TIC), University of Strathclyde. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://glasgowdoorsopendays.org.uk/building-no-booking/technology-innovation-centre-tic-university-... |
| Description | EPSRC 's Executive Chair, Lynn Gladden visit & blog mention |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | In a new blog post, the EPSRC 's Executive Chair, Lynn Gladden, reflects on her university visits, including a visit to CMAC at University of Strathclyde. It was a pleasure to host Lynn as part of this tour, showcasing our facilities and discussing how CMAC can work with UKRI to 'transform tomorrow together'. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://bit.ly/3Du7kgM |
| Description | Exhibited at the Digital Manufacturing Week, November 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Exhibited at the Digital Manufacturing Week. This event was brimming with expert content, and provided valuable peer to peer interaction and the best solutions available. It attracted over 6,000 manufacturers, industry leaders and technology solution providers. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://digital-manufacturing-week.com/ |
| Description | Hosted visitors from Bristol Myers Squibb & Malvern Panalytical |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | CMAC were delighted to host visitors from Bristol Myers Squibb & Malvern Panalytical @newsfrom_MP 17th Aug 2022. Mike Tobyn (Senior Scientific Director at Bristol-Myers Squibb) gave an engaging seminar to the CMAC community titled Small Particles and Big Data. |
| Year(s) Of Engagement Activity | 2022 |
| Description | New CMAC Industry Board Chair - Dr Ivan Marziano |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | CMAC announced the new chair of the CMAC Industry Board by press release on the CMAC website and Twitter. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://cmac.ac.uk/news-database/a-new-chapter-for-cmacs-industry-board |
| Description | Official launch of the DM2 at the CMAC Open Days, May 2022 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | The DM2 was officially launched at CMAC Open days. The event included exhibition of the DM2 platforms, partners, panel discussion, and keynote presentations. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://cmac.ac.uk/events-database/cmac-open-day-2022-hub-and-articular-showcase |
| Description | Organised a CMAC PhD Training Week Coding and ML Course, Sep. 2022/Mar. 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | CMAC PhD Training Week Coding and ML Course, Sep. 2022/Mar. 2023 |
| Year(s) Of Engagement Activity | 2022,2023 |
| URL | https://github.com/bionictoucan/cmac_coding_ml |
| Description | Organised a workshop on version control on GitLab, Jan 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Version control on GitLab, Jan 2023, Glasgow, UK |
| Year(s) Of Engagement Activity | 2023 |
| Description | Organised a workshop that focused on PharmaMV training, Jan 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | This workshop focused on providing a suitable training by Applied Materials experts on PharmaMV. DM2 and CMAC researchers have attended the training. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Organised the DM2 Data Platform workshop, Nov 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | This workshop was organised by the DM2 team to discuss the best ways to share and extract data related to medicines manufacturing. Different companies like CCDC and NVIDIA have attended. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Organising a webinar with Malvern Panalytical (From Particles to Drug Product Performance and Stability), March 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | About The Event How a pharmaceutical tablet disintegrates and dissolves when it comes in contact with a physiological fluid is crucial for the performance of the medicine. Critical performance characteristics are controlled by the chemical and physical properties of the drug substance and excipients paired with the manufacturing processes used to transform the powder into a compact. The microstructure created during manufacturing in combination with the wetting, swelling and dissolution properties of the raw materials are decisive for reliable drug release. Recently it has also become increasingly clearer that physical characteristics of pharmaceutical tablets change during storage, which in turn affect the performance when the medicine reaches the patient. In this webinar, we will discuss the interplay between particle properties, formulation, microstructure and stability-related performance changes. We will demonstrate the integrated use of advanced measurement techniques with multi-scale modelling approaches to gain insights into the relationship between particle characteristics, compact microstructure, storage conditions and the disintegration and dissolution performance of tablets. The new insights gained about the relationship between the raw material attributes, manufacturing process and drug product performance will allow us to move away from a laborious and lengthy empirical, trial and error, development to a digitally driven design process, where the tablet disintegrates and releases the drug substance in a reproducible and predictable manner. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://events.malvernpanalytical.com/W230321-DrugPerformance?_gl=1*jz6rit*_ga*MTYyNzg5ODI5OS4xNjc2N... |
| Description | Organising a webinar with Malvern Panalytical (Time to go digital: digitalization and AI in pharmaceutical R&D), Feb 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | About The Event CMAC's Digital Medicines Manufacturing research center (DM2) is a 3.5-year program co-funded by the Made Smarter Innovation at UK Research and Innovation. DM2 has ambitions to transform medicines development and manufacturing productivity, and drive a more patient-centric supply model, through digitalization. As a developer of laboratory technology, we at Malvern Panalytical see the value of digital transformation in materials science. Much of the data that is generated from our instrumentation does not end its journey in the lab. Rather, it is combined and harmonized with data from diverse sources to solve ever more complex challenges. For this reason, we join Prof. Blair Johnston in the DM2 center to learn and contribute to the integration of data pipelines and data science to improve medicines development. In this webinar, we will discuss the benefits to be gained from digitalization and the adoption of industrial digital technologies from a pharmaceutical perspective. We will also provide insights into the challenges of "going digital" and provide some examples of useful solutions and how we are implementing them across the DM2 Centre. These include technologies such as AI, digital twins, knowledge engineering as well as some practical solutions for bringing all staff within an organization along on the digital transformation journey. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://events.malvernpanalytical.com/W230228-DigitalManufacturing?_gl=1*uquwf0*_ga*MTYyNzg5ODI5OS4x... |
| Description | Participated at Glasgow Explorathon event, Nov. 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Engaged with kids and families to explain the exciting research conducted at the DM2, such as medicines manufacturing and digitalisation, using simple experiments like marshmallow crystal builder, beat the machine game, and polymorphs of chocolate. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.explorathon.co.uk/ |
| Description | Participated at Knowledge Graph Forum by OnoText, Sep 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A 4-day hybrid event with a strong focus on industry applications presented by leading practitioners: Sep 26: Technology Ecosystem (virtually) Sep 27: Manufacturing, Aerospace, AECO (virtually) Sep 28: Life Sciences & Healthcare (live in Basel and virtually) Sep 29: Financial Services & Publishing (live in NYC and virtually) |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.ontotext.com/company/event/knowlege-graph-forum-2022/ |
| Description | Participated at MACH, April 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | The DM2 engagement manager, Scott Hone, participated at MACH 2022, which is the national exhibition for inspiring, innovating and connecting engineering-based manufacturing. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.machexhibition.com/ |
| Description | Participation at InterAct Annual Conference, October 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The InterAct Network is a £4.4 million, Made Smarter Innovation funded, Economic and Social Research Council-led network that aims to bring together economic and social scientists, UK manufacturers, and digital technology providers to address the human issues resulting from the diffusion of new technologies in industry. The events aim are as follow: Gain actionable human insights into the future manufacturing environment. Network and build relationships with cross-sector experts interested in creating a positive, forward-thinking vision for UK industry. Build your narrative development skills to enhance the reach of you messaging in the digital environment. Take part in a collaborative workshop on the theme 'How do we create the digital manufacturing futures we want to see, together'. Engage with a panel of highly regarded speakers from the world of manufacturing, policy, and academia for an interactive Q&A session. Learn more about the InterAct Network, our future development and funding opportunities. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.madesmarter.uk/events/interact-annual-conference/ |
| Description | Participation at PharmaTech Integrates, September 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Participation in the conference and visited the MMIC facility. Also, CMAC, who are based within the Technology and Innovation Centre, offered a tour of their world-class facilities. This provided an opportunity to meet with key researchers and to see the innovative technologies that are being developed, including the robotics they have integrated into the Digital CMC and data-factory stream. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.lifescienceintegrates.com/agenda/pharmatech-integrates-2022/ |
| Description | Queen's Anniversary Prize |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | CMAC were honoured to be part of the University of Strathclyde's team that received the Queen's Anniversary Prize for Higher and Further Education at St James's Palace on 23rd Feb 2022 for our excellence in Advanced Manufacturing. The university and CMAC have posted this on their websites. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://cmac.squarespace.com/news-database/qap |
| Description | Represented the DM2 in Robotics Industry Fair, Jan 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | A networking event for senior industry members with students at the University of Strathclyde to attend and showcase a more authentic manufacturing industry rather than a traditional careers fair. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.strathunion.com/events/6868/4083/ |
| Description | Scotland House Office Opens |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | CMAC are take up residence at Scotland House, London, UK on 29/04/2022. We're delighted to introduce the new CMAC Central London Office. Press release on website. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://cmac.ac.uk/news-database/cmac-london-office |
| Description | Scottish Secretary of State visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Policymakers/politicians |
| Results and Impact | CMAC were happy to show Scottish Secretary of State, Lord Offord of Garvel, around our world-leading facilities at the end of July 2022 as part of his broader visit to University of Strathclyde. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Visit by MP Carol Monaghan |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Policymakers/politicians |
| Results and Impact | CMAC hosted MP Carol Monaghan on 5th October 2022 (@CMonaghanSNP) and showcased all the innovative medicines manufacturing research being carried out by CMAC here in Glasgow. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Visit by Parliamentary Under Secretary of State (Minister for Small Business, Consumers and Labour Markets) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Policymakers/politicians |
| Results and Impact | 17/02/2022: CMAC host UK were thrilled to host Parliamentary Under Secretary of State (Minister for Small Business, Consumers and Labour Markets), @scullyp this week and provide a tour of our facilities highlighting #CMACs vision to transform #medicines development, manufacture and supply. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Visit by UK Science and Technology Select Committee |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Policymakers/politicians |
| Results and Impact | 11/02/2022: CMAC were delighted to host the UK Science and Technology Select Committee this week! We were excited to provide its members with a guided tour of our #facilities and show how #CMAC are helping tackle major UK and global challenges in #medicinesmanufacturing. #researchexcellence |
| Year(s) Of Engagement Activity | 2022 |
| Description | Webinar on the #FutureOfWork in Medicines #Manufacturing |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | @ESRC @InterActNetw0rk collaborated with CMAC to host a webinar on the #FutureOfWork in Medicines #Manufacturing, Thursday 12 January, 2023. Traget audience members: people manager or workplace stakeholder in the sector. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://linkedin.com/pulse/digital-medicines-manufacturing-future-work-webinar-lindsay-mcipd-/ |