Epigenetics: Environment, Embodiment and Equality (E4)

Lead Research Organisation: University of Bristol
Department Name: Social Medicine

Abstract

It is widely accepted that early life influences shape our development and health and behavioural outcomes across the life course. Epigenetic mechanisms are increasingly implicated in these complex interactions and provide a key to understanding (i) what aspects of our environment impact upon gene regulation, (ii) how our environment and way of living become embodied in human biology, over what timeframe and with what degree of persistence and (iii) how social and biological inequality may influence development and health.

This project builds upon a substantial foundation of epigenetic research in richly characterised longitudinal cohort studies to explore these concepts of environment, embodiment and inequality. We will utilise the Avon Longitudinal Study of Parents and Children, which currently has the most extensive collection of longitudinal epigenetic data of any birth cohort study in the world, as a platform to address these concepts and through collaboration with seven other cohorts we will extend our investigations across the entire lifecourse to understand how different social and environmental experiences in early life operate to influence epigenetic signatures and downstream outcomes. We will extend these analyses by implementing causal analysis methods, including novel applications of Mendelian randomization, to strengthen causal inference in the associations we observe. Further, we will apply social constructs/theories to elaborate these interpretations.

Analysis of the role of epigenetic processes in linking the environment with development and health across the lifecourse requires the capacity to generate, analyse and interpret complex data. The high dimensional, dynamic characteristics of epigenetic data require advanced competencies in bioinformatics and statistical methods. We have invested considerable effort in generating epigenetic data, developing and refining informatics and statistical skills over recent years and through this project propose to apply them to the questions outlined above.
The proposed work will extend current research activities, drawing together skills of social and biological scientists to apply recently developed methodologies to unresolved issues at the interface of epigenetics and social science. A major component of project activities will be the promotion of inter-disciplinary collaboration, training opportunities and widespread dissemination of both methods and scientific outputs. We will draw upon the expertise of our co-investigator team in bioinformatics, computational science, econometrics, education, epigenetics, lifecourse epidemiology, psychology, quantitative genetics, social science and statistics to execute the proposed project.

Planned Impact

The primary academic beneficiaries of this project will be social scientists and biological scientists who will gain insight into the role of the epigenome and the social environment. We aim to exploit the recent developments from established programmes of research in applied epigenetics in the medical sciences to inform advances in social science epigenetics. We will facilitate a deeper understanding of the technical, biological and bioinformatic aspects of epigenetic research for the social science community. Simultaneously the biological and biotechnological scientists involved in the programme will gain a deeper insight into social science issues and methods, in particular the theoretical constructs and statistical approaches applied in this field.

Academic benefits will be gained through scientific interaction in the execution of specific hypothesis-driven project work. Communication between social and biological domains will be facilitated by a dedicated member of the research team. Training activities will serve our multi-disciplinary team as well as a much wider audience of workshop and symposium participants. Researchers in the field of lifecourse epidemiology will benefit from a clearer understanding of the role of epigenetic mechanisms in the programming of later health and behaviours.

Many collaborators from a wide range of social and biological backgrounds have expressed their enthusiastic support for the project. Their affiliations and research interests are listed in the appended Table of Supporting Collaborators. Mutual benefit will be gained through, for example, enhancement of cohort output, discussion of theoretical frameworks and the evolution of new hypotheses.

A range of genetic and epigenetic consortia will interface with the project and will benefit from methodological developments, data harmonization and data sharing. In particular, cohorts and consortia with genetic data but without epigenetic data will have the opportunity to engage in epigenetic studies through the use of Mendelian randomization which uses genetic proxies for DNA methylation measures. This will facilitate use of data to address questions pertinent to the role of epigenetics, without the investment in DNA methylation data generation, and results from exploiting complementary data sets and collaborative working.

Academics at all career stages, from PhD students to senior academics will have the opportunity to engage with and benefit from the research proposed.

Organisations

Publications

10 25 50

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Barker ED (2019) Hidden hypotheses in 'hypothesis-free' genome-wide epigenetic associations. in Current opinion in psychology

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Cecil CAM (2018) DRD4 methylation as a potential biomarker for physical aggression: An epigenome-wide, cross-tissue investigation. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

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Chen LS (2018) Leveraging Genomic Data in Smoking Cessation Trials in the Era of Precision Medicine: Why and How. in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

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Davey Smith G (2017) On misunderstandings of individual and population risks: response to Stephen Rappaport. in International journal of epidemiology

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Karlsson Linnér R (2017) An epigenome-wide association study meta-analysis of educational attainment. in Molecular psychiatry

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Marioni RE (2019) Tracking the Epigenetic Clock Across the Human Life Course: A Meta-analysis of Longitudinal Cohort Data. in The journals of gerontology. Series A, Biological sciences and medical sciences

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McIntosh AM (2018) Do Depression and Stressful Events Cause Premature Aging? in The American journal of psychiatry

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Munafò MR (2018) Collider scope: when selection bias can substantially influence observed associations. in International journal of epidemiology

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Richmond RC (2016) Challenges and novel approaches for investigating molecular mediation. in Human molecular genetics

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Richmond RC (2018) DNA methylation as a marker for prenatal smoke exposure in adults. in International journal of epidemiology

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Roberts S (2017) DNA methylation and adolescent trajectories of psychotic symptoms in European Neuropsychopharmacology

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Saccone NL (2018) The Value of Biosamples in Smoking Cessation Trials: A Review of Genetic, Metabolomic, and Epigenetic Findings. in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

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Sharp GC (2017) Epigenetics and noncommunicable diseases. in Epigenomics

 
Description We have developed statistical methods for more robust mediation analysis when considering molecular intermediates such as DNA methylation. We have applied epidemiological methods to a variety of scenarios to understand the role of DNA methylation in pathways from social exposures and health behaviours to a range of different health-related phenotypes. Examples of studies include the use of DNA methylation as an index of alcohol use and the modelling of DNA methylation over time and how this relates to prior exposure to childhood adversity.
This award was instrumental in attracting further funding from the US NIH to investigate the role of DNA methylation in mediating the effects of racial discrimination and economic hardship with later detrimental health outcomes.
Exploitation Route The methods we have proposed are already being adopted by others.
Further funding has been awarded for collaborative work with groups (social epidemiologists) in the USA.
Sectors Education,Environment,Healthcare

URL http://www.bristol.ac.uk/integrative-epidemiology/epigenetics-social-science-network/
 
Description Findings from this project have contributed to policy briefing on the consumption of alcohol during pregnancy. They have also formed part of a range of engagement activities involving the public, with the aim of understanding research in to the use and role of molecular biomarkers in social and biological research.
Sector Environment,Healthcare
Impact Types Societal,Policy & public services

 
Description DNA methylation & adversity: pathways from exposures to health inequities
Amount $2,352,682 (USD)
Funding ID 1R01MD014304 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2021 
End 03/2023
 
Description De Pass Vice Chancellor's Fellowship - Rebecca Richmond
Amount £260,000 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 10/2022
 
Description Interpreting epigenetic signatures in studies of early life adversity (InterSTELA)
Amount £195,513 (GBP)
Funding ID ES/N000382/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 09/2015 
End 07/2018
 
Description NIH - Childhood adversity, DNA methylation and risk for depression: A longitudinal study of sensitive periods in development.
Amount $1,623,764 (USD)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 10/2017 
End 10/2019
 
Description SRNT annual meeting travel award - Rebecca Richmond
Amount $800 (USD)
Organisation Society for Research on Nicotine and Tobacco (SRNT) Europe 
Sector Academic/University
Country Mexico
Start 02/2019 
End 02/2019
 
Title EWAS Catalog 
Description A database of epigenome-wide association studies with seacrh tool 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact None as yet 
URL http://www.ewascatalog.org
 
Title Identification of differentially methylated regions 
Description This software tool improves on previous work by properly controlling false positive rates, providing support for meta-analysis and increasing statistical power 
Type Of Material Data analysis technique 
Year Produced 2019 
Provided To Others? Yes  
Impact None as yet 
 
Description Alcohol Exposure 
Organisation University of Toronto
Department Baycrest Centre for Geriatric Care
Country Canada 
Sector Academic/University 
PI Contribution Joint analysis of ALSPAC (epigenetic) data and imaging phenotypes obtained by Toronto group
Collaborator Contribution Imaging phenotypes obtained by Toronto group
Impact PhD thesis completed on the relationship between prenatal alcohol exposure, own alcohol use and neuroimaging phenotypes.
Start Year 2016
 
Description E4 Project Edinburgh and Bristol Collaboration 
Organisation University of Edinburgh
Department School of Geosciences Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution The University of Bristol team brings expertise in epigenetic epidemiology, life course epidemiology, infrastructural epidemiology, clinical epidemiology, education, public engagement, access to large data sets, training provision and hosting of visiting researchers to this collaboration.
Collaborator Contribution Dr Riccardo Marioni provides epidemiology and biostatistics expertise and access to population based cohort data and Professor Ian Deary provides cognition expertise.
Impact We have collaborated on our training programme for the project and the Edinburgh team have contributed to joint meetings. Engagement activities involved in: Statistical approaches for epigenetics workshop Bristol, Epigenetics and Social Science Network (ESSN) website, Epigenetics and Social Science Network (ESSN) Launch event in Bristol.
Start Year 2016
 
Description E4 Project UCL and Bristol Collaboration 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution The University of Bristol team brings expertise in epigenetic epidemiology, life course epidemiology, infrastructural epidemiology, clinical epidemiology, education, public engagement, access to large data sets, training provision and hosting of visiting researchers to this collaboration.
Collaborator Contribution Professor Chris Power Co-PI of the 1958 Birth Cohort provides epidemiology and punlic health expertise and access to birth cohort data. Dr Gabriella Conti provides expertise in economics within the biomedical and social sciences.
Impact The UCL team have contributed to joint meetings. Engagement activities involved in: Epigenetics and Social Science Network (ESSN) website, Epigenetics and Social Science Network (ESSN) Launch event in Bristol.
Start Year 2016
 
Description E4 Project Ulster University Collaboration 
Organisation Ulster University
Country United Kingdom 
Sector Academic/University 
PI Contribution The University of Bristol team brings expertise in epigenetic epidemiology, life course epidemiology, infrastructural epidemiology, clinical epidemiology, education, public engagement, access to large data sets, training provision and hosting of visiting researchers to this collaboration.
Collaborator Contribution Professor Colum Walsh and his team provide insight from their biopsychosocial approach investigating maternal folate status.
Impact The Ulster team have been involved in collaborative research and have visited the University of Bristol in relation to this collaborative work. Engagement activities involved in: Collaborative research visit to Bristol - Ulster University, Epigenetics and Social Science Network (ESSN) website, Epigenetics and Social Science Network (ESSN) Launch event in Bristol. 1. Irwin RE, Thursby S, Ondicova M, Pentieva K, McNulty H, Richmond RC, Caffrey A, Lees-Murdock DJ, McLaughlin M, Cassidy T, Suderman M, Relton CL, Walsh C. A randomized controlled trial of folic acid intervention in pregnancy highlights a putative methylation-regulated control element at ZFP57. Clinical Epigenetics, 2019; 11(1):31
Start Year 2016
 
Description E4 Project and Epigenetics and Social Science Network Collaboration 
Organisation University of Bristol
Department Epigenetics and Social Science Network
Country United Kingdom 
Sector Academic/University 
PI Contribution The University of Bristol team brings expertise in epigenetic epidemiology, life course epidemiology, infrastructural epidemiology, clinical epidemiology, education, public engagement, access to large data sets, training provision and hosting of visiting researchers to this collaboration.
Collaborator Contribution A collaborative network of eight projects comprising of biological and social scientists from many disciplines to facilitate collaboration and communication within the epigenetics community.
Impact The network have contributed to joint meetings and there are research collaborations within the network supported by a joint website. Engagement activities involved in: Statistical approaches for epigenetics workshop Bristol, Epigenetics and Social Science Network (ESSN) website, Epigenetics and Social Science Network (ESSN) Launch event in Bristol.
Start Year 2016
 
Description E4 and Interstela Project Collaboration 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution The University of Bristol team brings expertise in epigenetic epidemiology, life course epidemiology, infrastructural epidemiology, clinical epidemiology, education, public engagement, access to large data sets, training provision and hosting of visiting researchers to this collaboration.
Collaborator Contribution Dr Laura Howe (PI) and team collaborate on epigenetic epidemiology and the life course approach and we collaborate on our training programme.
Impact We collaborate on research and run a joint training programme. Engagement activities involved in: Statistical approaches for epigenetics workshop Bristol, Collaborative research visit to Bristol - Ulster University, Epigenetics and Social Science Network (ESSN) website, Epigenetics and Social Science Network (ESSN) Launch event in Bristol.
Start Year 2016
 
Description E4 project and KCL Collaboration 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution The E4 team at the University of Bristol team brings expertise in epigenetic epidemiology, life course epidemiology, infrastructural epidemiology, clinical epidemiology, education, public engagement, access to large data sets, training provision and hosting of visiting researchers to this collaboration.
Collaborator Contribution Dr Jordana Bell provides expertise in epigenetics and is Principal Investigator on study using Twin data. Dr Helen Fisher provides expertise in social genetics and developmental psychiatry.
Impact Dr Jordana Bell and Dr Helen Fisher have contributed to meetings related to the project. Engagement activities involved in: Statistical approaches for epigenetics workshop Bristol, Epigenetics and Social Science Network (ESSN) website, Epigenetics and Social Science Network (ESSN) Launch event in Bristol.
Start Year 2016
 
Description E4 project and Nancy Krieger collaboration 
Organisation Harvard University
Country United States 
Sector Academic/University 
PI Contribution The E4 team at the University of Bristol team brings expertise in epigenetic epidemiology, life course epidemiology, infrastructural epidemiology, clinical epidemiology, education, public engagement, access to large data sets, training provision and hosting of visiting researchers to this collaboration.
Collaborator Contribution Nancy Krieger provides expertise in social inequalities in health.
Impact Attended Harvard University meeting in December 2016 on causal inference. Sought funding for additional work to investigate the relationship between social adversity, DNA methylation and health disadvantage. NIH R01 awarded in 2019 and is now a separate collaboration.
Start Year 2016
 
Description ESRC Biomarker Data Project Fellowship in Understanding Society - R Richmond 
Organisation University of Essex
Department Institute for Social and Economic Research, Essex
Country United Kingdom 
Sector Academic/University 
PI Contribution Data analysis of Understanding Society data.
Collaborator Contribution Data provision for Understanding Society and mentorship.
Impact Rebecca Richmond was awarded an ESRC fellowship.
Start Year 2018
 
Description GenR-ADHD 
Organisation Erasmus MC
Country Netherlands 
Sector Academic/University 
PI Contribution Joint analysis of ALSPAC and GenR epigenetic data
Collaborator Contribution Joint analysis of ALSPAC and GenR epigenetic data
Impact Association between DNA methylation and ADHD symptoms from birth to school age: A prospective meta-analysis Alexander Neumann, Esther Walton, Silvia Alemany, Charlotte Cecil, Juan Ramon González, Dereje Demissie Jima, Jari Lahti, Samuli T. Tuominen, Edward D. Barker, Elisabeth Binder, Doretta Caramaschi, Ángel Carracedo, Darina Czamara, Jorunn Evandt, Janine F. Felix, Bernard F. Fuemmeler, Kristine B. Gutzkow, Cathrine Hoyo, Jordi Julvez, Eero Kajantie, Hannele Laivuori, Rachel Maguire, Léa Maitre, Susan K. Murphy, Mario Murcia, Pia M. Villa, Gemma Sharp, Jordi Sunyer, Katri Raikkönen, Marian Bakermans-Kranenburg, Marinus van IJzendoorn, Mònica Guxens, Caroline L Relton, Henning Tiemeier doi: https://doi.org/10.1101/806844 Under review at Molecular Psychiatry
Start Year 2016
 
Description HUNT collaboration - R Richmond 
Organisation Norwegian University of Science and Technology (NTNU)
Country Norway 
Sector Academic/University 
PI Contribution Rebecca Richmond developed an analysis plan for running parallel analysis in UK Biobank and HUNT.
Collaborator Contribution Developed an analysis plan for running parallel analysis in UK Biobank and HUNT.
Impact 1. Sun YG, Richmond RC, Chen Y, Mai X. Mixed evidence for the relationship between periodontitis and Alzheimer's disease: A bidirectional Mendelian randomization study. PLOS ONE, 2020; 15(1): e0228206
Start Year 2017
 
Description Longitudinal_epi_GenR - E Walton 
Organisation Erasmus MC
Country Netherlands 
Sector Academic/University 
PI Contribution joint analysis of ALSPAC and GenR epigenetic data
Collaborator Contribution joint analysis of ALSPAC and GenR epigenetic data
Impact 188. Walton E, Relton CL, Caramaschi D. Using openly accessible resources to strengthen causal inference in epigenetic epidemiology of neurodevelopment and mental health. Genes 2019 Mar 1;10(3). pii: E193. doi: 10.3390/genes10030193. PMID:308903164. Additional publications in preparation
Start Year 2016
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Center for Environmental Research and Children's Health
Department The CHAMACOS Study
Country United States 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Columbia Center for Children's Environmental Health
Country United States 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation European Association for Research on Learning and Instruction (EARLI)
Country Belgium 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation European Huntington's Disease Network (Euro-HD)
Country Germany 
Sector Charity/Non Profit 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU)
Department International Climate Initiative (ICI)
Country Germany 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Finnish Birth Cohort
Country Finland 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation GECKO Drenthe Birth Cohort
Country Netherlands 
Sector Hospitals 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation GenExp
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation GenR
Country United States 
Sector Charity/Non Profit 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Glyndwr University
Country United Kingdom 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Government of Canada
Department Aboriginal Affairs and Northern Development
Country Canada 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation ITS United Kingdom
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Inmarsat
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation MTT Ltd Machine Tools Technologies
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation National Heart, Lung, and Blood Institute (NHLBI)
Country United States 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation National Institute of Environmental Health Sciences
Department Norway Facial Clefts Study (NCL)
Country United States 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation National Institute of Standards & Technology (NIST)
Country United States 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation New Hampshire Birth Cohort Study
Country United States 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation PRISMA ONG
Country Peru 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Progressive Energy Ltd
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Project Viva
Country United States 
Sector Charity/Non Profit 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Rhode Island Child Health Study
Sector Charity/Non Profit 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Rutherford Appleton Laboratory
Department Space Science and Technology Department
Country United Kingdom 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation University of Bristol
Department Avon Longitudinal Study of Parents and Children (ALSPAC)
Country United Kingdom 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation University of Cambridge
Department PomBase
Country United Kingdom 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation University of Western Australia
Department Raine Medical Research Foundation
Country Australia 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation VCE Mobile & Personal Comm Ltd
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. Multiple additional published outputs have arisen, with more in preparation.
Start Year 2014
 
Description University of Memphis 
Organisation University of Memphis
Country United States 
Sector Academic/University 
PI Contribution Collaborations with two groups concerned with molecular changes during puberty and their relation to asthma risk. My team has contributed to study design, data provision, data analysis and drafting of manuscripts.
Collaborator Contribution Study design, data generation, writing of manuscripts, provision of funding.
Impact Publications jointly co-authored by multi-disciplinary team including clinicians, statisticians and epigeneticists.
Start Year 2015
 
Description BBC Radio 4 interview - Caroline Relton 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Caroline Relton was interviewed on BBC radio 4 show 'Start the week' on Monday 13th November 2017. Professor Relton discusses her research into how stress and other environmental factors can be passed down through generations, affecting our genetic make-up. This interview rasied the profile of Professor Relton and her research.
Year(s) Of Engagement Activity 2017
URL http://www.bbc.co.uk/programmes/b09drjb7
 
Description CAPICE workshop session: "Introduction to EWAS" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact I presented a workshop session on preparing and analysing genome-wide DNA methylation datasets for associations with phenotypes and exposures. The audience included postgraduate students and postdoctoral researchers attending the 2-day "CAPICE workshop on Mendelian Randomization and Epigenetics".
Year(s) Of Engagement Activity 2019
URL https://www.capice-project.eu/
 
Description Citizen Science Project - R.Richmond 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Rebecca Richmond has been involved in a Citizen Science project taking place as part of the SPHERE initiative which has involved engaging and working with members of the project as part of a participant-led research project around sleep.
Year(s) Of Engagement Activity 2018
 
Description Collaborative research visit to Bristol - Ulster University 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Three members from Ulster University (Professor Colum Walsh, Rachelle Irwin and Sarah-Jayne Mackin) visited our research unit in Bristol for a collaborative research visit. We all presented our work and looked for synergy within the projects in order for us to share research strategies for the future.
Year(s) Of Engagement Activity 2016
 
Description DATA MINE: interactive festival science installation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Hundreds of attendees at the Green Man music festival attended our "DATA MINE , an interactive art installation inspired by genetic epidemiology." The goal of the installation was to spread awareness of and interest in the process of scientific research, the structure of the human genome and how genes control biological phenotypes. While attendees of all ages were welcome to (and did!) participate, the installation was focussed at children and their parents. Discussion between researchers and attendees was sparked and many reported increased interest and knowledge of our research area .
Year(s) Of Engagement Activity 2016
 
Description Education in our genes 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This one day workshop was aimed at both social and biomedical scientists to present current developments around the application of genetic and epigenetic data in relation the educational attainment and related characteristics
Year(s) Of Engagement Activity 2017
 
Description Embracing epigenetics in epidemiological studies 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact A webinar covering various approaches to study design and data analysis in epigenetic epidemiology. The webinar sought to communicate areas of expertise and consolidate future collaborative activity with the Million Veterans Programme (Boston, USA).
Year(s) Of Engagement Activity 2019
 
Description Epigenetic Clock Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A one day workshop was held to present and discuss approaches to research using the epigenetic clock as a biomarker of biological age.
Year(s) Of Engagement Activity 2017
 
Description Epigenetics and Social Science Network (ESSN) Launch event in Bristol 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This event was to launch the ESRC and BBSRC Epigenetics Initiative, which has subsequently became known as the Epigenetics and Social Science Network (ESSN). Approximately 54 people attended the launch event, including academics in a variety of fields, as well as ESRC and BBSRC representatives in order to share information about the 8 projects which make up the network. All eight research projects were presented, and discussion followed regarding how the ESRC and BBSRC epigenetics community might provide mutual support including through data sharing, a shared calendar of events, resource sharing, networking opportunities for early career researchers and effective communication within the group. Following the event research collaborations have been established and a network website has been produced which allows the group to have a central method of communication.
Year(s) Of Engagement Activity 2015
URL http://www.bristol.ac.uk/integrative-epidemiology/epigenetics-social-science-network/news/2016/epige...
 
Description Epigenetics and Social Science Network (ESSN) website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact We have designed and established a website for the epigenetics community within the Epigenetics and Social Science Network (ESSN) as a means of communication between researchers within the network, as well as providing insight into our work to other users and the general public. The website reaches over 100 unique users per month and provides an overview of each of the eight projects/networks within the ESSN. It also provides a means to communicate research outputs, publicise events related to the network, job opportunities linked to the network and post news stories of relevance. The website has provided a central means of communication within the network and all eight projects have contributed to it.
Year(s) Of Engagement Activity 2016
URL http://www.bristol.ac.uk/essn
 
Description Epigenetics in Neuroscience and Psychiatry 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact An invited talk at a one day workshop
Year(s) Of Engagement Activity 2019
 
Description Epigenetics: Environment, Embodiment and Equality seminar Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Rebecca Richmond from the E4 project team gave a seminar for the Unit of Biocultural Variation and Obesity at the University of Oxford. The seminar sparked a lot of discussion as the researchers in this group were predominantly anthropologists rather than biologists so they knew relatively little beforehand about the intricacies of measuring epigenetic changes in large studies and the types of quantitative methods being applied. Collaborations are being developed with the seminar organiser and other attendees and the presentation allowed them to gain more of an insight into the type of research undertaken.
Year(s) Of Engagement Activity 2016
URL http://user37685.vs.easily.co.uk/wp/?page_id=223
 
Description From genes to genomes in middle years biology (Neil Ingram) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Dr Neil Ingram spoke at the Association of Science Education conference at the University of Reading in a talk entitled 'From genes to genomes in middle years biology'. His talked was to approximately 35 school science teachers and educators. Plans are being made for a future event to further develop the interest of schools in the study of epigenetics.
Year(s) Of Engagement Activity 2017
URL http://bristol.ac.uk/integrative-epidemiology/epigenetics-social-science-network/news/2017/from-gene...
 
Description Greenman - R.Richmond 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Rebecca Richmond helped to organize and implement several public engagement activities in the "Einstein's Garden" of the Green Man Festival in 2018. More than 500 people attended.
Year(s) Of Engagement Activity 2018
 
Description Invited speaker at IGMM (Edinburgh) - C Relton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Caroline Relton (PI for ICEP) was invited to give a presentation at the Institute of Genomic and Molecular Medicine at the University of Edinburgh. Professor Relton's talk was entitled Using genotype as a causal anchor in epigenetic studies. The presentation raised the profile of Professor Relton and her research.
Year(s) Of Engagement Activity 2017
 
Description Invited speaker at Rank Prize Funds Symposium - C Relton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Caroline Relton (PI of ICEP) was an invited speaker at the Rank Prize Funds Symposium on Maternal and Paternal Intergenerational Programming Effects in Cumbria. Professor Relton gave a talk entitled Parental influences on the epigenome: Evidence from human cohort studies. The presentation raised the profile of Professor Relton and her research.
Year(s) Of Engagement Activity 2017
 
Description MRC Talks Podcast - C Relton 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Professor Caroline Relton's career story featured as an episode on the Medical Research Council's 2019 'career inspirations' podcast series: "Career inspiration: Caroline Relton, population health scientist". This podcast raised the profile of Professor Relton and her research.
Year(s) Of Engagement Activity 2016,2019
URL https://soundcloud.com/the_mrc/career-inspirations-caroline-relton
 
Description New Horizons in Genomics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited talk at a symposium.
Year(s) Of Engagement Activity 2019
 
Description Poster presentation Epigenomics of Common Diseases Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Matthew Suderman from the E4 project team presented a poster entitled 'DNA methylation proxy for exposure and outcome prediction' at the Epigenomics of Common Diseases conference in Cambridge to an audience of academics and post doctoral researchers. In relation to the poster presentation, there was discussion about how to solve some of the challenges related to prediction.

Authors:
Matthew Suderman, Gemma Sharp, Leanne Küpers, Fahimeh Falahi, Janine Felix, Harold Snieder, Ellen A. Nohr, Thorkild I. A. Sørensen, Caroline Relton, George Davey Smith.

Abstract:
Many environmental exposures particularly in early development are known to influence later health outcomes. Unfortunately records of exposure tend to be based on self-report long after the exposure has occurred and therefore lack precision and objectivity. A possible solution is to infer exposure from stable, accessible biomarkers. DNA methylation measured in peripheral tissues is a promising candidate because it is commonly measured in many human cohort studies and is known to retain associations with certain exposures for many years. As a proof of principle, we created proxies for prenatal tobacco exposure (PTE) using cord blood DNA methylation levels. We then asked how well the proxies correlate with PTE and well-known outcomes of PTE. We were indeed able to derive accurate DNA methylation proxies for PTE and showed that accuracy could be improved by including certain data preprocessing steps as well as including association effect information from large meta-analyses of PTE in DNA methylation. Our proxies also related to known PTE outcomes similarly to PTE but did identify cases of collider bias introduced by certain data preprocessing steps. In future we will further investigate approaches for improving proxy accuracy and preventing collider bias.
Year(s) Of Engagement Activity 2016
URL http://bristol.ac.uk/integrative-epidemiology/epigenetics-social-science-network/news/2016/-dna-meth...
 
Description Presentation at Kings College London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Caroline Relton (PI of ICEP) was an invited speaker at the Epigenetics & Social Science Network Meeting at Kings College London. Professor Relton gave a talk entitled E4: Epigenetics, Environment, Embodiment, Equality. The presentation raised the profile of Professor Relton and her research.
Year(s) Of Engagement Activity 2017
 
Description Presentation at NTNU (Trondheim) - C Relton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Caroline Relton (PI of ICEP) was an invited speaker at the Studying Genomic Variation in Populations conference at the KG Jebsen Center for Genetic Epidemiology, NTNU in Trondheim. Professor Relton gave a talk entitled Epigenetics and non-communicable diseases. The presentation raised the profile of Professor Relton and her research.
Year(s) Of Engagement Activity 2017
 
Description Presentation at Nutrition Symposium, Erasmus - C Relton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Caroline Relton was invited to present at Nutrition Symposium, Erasmus Medical Center in June 2018. Prof Relton presented: Causal analysis in epigenetic epidemiology. The talk prompted the following exchange of letters: http://advances.sciencemag.org/content/4/1/eaao4364/tab-e-letters. The talk also raised the profile of Prof Relton and her research.
Year(s) Of Engagement Activity 2018
URL http://advances.sciencemag.org/content/4/1/eaao4364/tab-e-letters
 
Description Presentation at UCLA - R Richmond 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Dr Rebecca Richmond was invited to give a talk at the Department of Human Genetics Seminar Series, UCLA in Los Angeles, USA in September 2019. The presentation was entitled: Investigating the mediating role of molecular mechanisms in common complex disease using epidemiological tools. This talk raised the profile of Dr Richmond and her research.
Year(s) Of Engagement Activity 2019
 
Description Presentation at Ulster University - R Richmond 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Dr Rebecca Richmond was invited to give a talk at the Epigenetics in Health and Wellbeing Workshop at Ulster University, Northern Ireland in April 2019. The presentation was entitled: Epigenetics and Lifecourse Epidemiology. This talk raised the profile of Dr Richmond and her research.
Year(s) Of Engagement Activity 2019
 
Description Presentation at University of Edinburgh - R Richmond 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Dr Rebecca Richmond was invited to give a talk at the Division of Psychiatry Seminar Series, University of Edinburgh in August 2019. The presentation was entitled: Smoking, DNA methylation and lung function: A Mendelian randomization analysis to investigate causal relationships. This talk raised the profile of Dr Richmond and her research.
Year(s) Of Engagement Activity 2019
 
Description Presentations at MR Conference (Bristol) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The 3rd International Mendelian Randomization Conference in Bristol was organised by Professor George Davey Smith and he gave a talk entitled: Does MR have any place in the Social Sciences. Caroline Relton (PI of ICEP) was an invited speaker and gave a talk entitled: Mendelian randomisation for molecular mediation. Paul Brennan (Co-I of ICEP) was an invited speaker and gave a talk entitled: Elucidating the role of BMI and diabetes in cancer using an MR approach. Robert Carreras-Torres (ICEP Researcher) was an invited speaker and gave a talk entitled: Solving complex relationships between metabolic parameters and cancer risk: from Mendelian randomization to matrix analysis. Various other ICEP members attended the event and were involved by chairing sessions and presenting posters. This raised the profile of ICEP related research.
Year(s) Of Engagement Activity 2017
URL https://www.mendelianrandomization.org.uk/programme/
 
Description Richard Doll Seminar in Public Health & Epidemiology, (University of Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact A formal seminar. Additional collaborative activity arose following the visit.
Year(s) Of Engagement Activity 2019
 
Description Society for Epidemiological Research Annual Meeting workshop: An introduction to predicting exposures and outcomes using omic biomarkers 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Our workshop provided a primer on the essential considerations and evaluation procedures required when developing predictors of health-related exposures and outcomes using omic datasets. We offered context on how such predictors have been developed in the past, as well as common pitfalls. We introduced how several machine learning techniques can be harnessed to design generalizable and interpretable predictors.
Year(s) Of Engagement Activity 2019
URL https://epiresearch.org/annual-meeting/2019-meeting/
 
Description Statistical approaches for epigenetics workshop Bristol 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact 31 academics from across the UK attended this event. There were 5 talks, each followed by discussion: Methods for multiple imputation of missing data in epigenetic datasets (Professor Kate Tilling)
Principal Component Informed Dimensionality Reduction Approach for 450K Mehtylation data (Tom Richardson)
Modelling epigenetic change (Dr Andrew Simpkin and Dr Riccardo Marioni)
Enrichment Analysis in Epigenome Wide Association Studies (Dr Benjamin Lehne)
Prediction modelling using epigenetic data (Dr Matthew Suderman and Ryan Langdon). There followed an interactive quick fire 3 minute discussion point session where all academics were able to discuss and share their ideas and expertise and make plans for the future.
Year(s) Of Engagement Activity 2016
URL http://bristol.ac.uk/integrative-epidemiology/epigenetics-social-science-network/news/2016/statistic...
 
Description Statistics in Epigenetics Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A one day workshop was held to describe and discuss recent key statistical advances for analysing DNA methylation data funded by an MRC grant. A keynote lecture was also given on the 'Estimation of a significance threshold for epigenome-wide association studies'. Over 60 post-grad students, fellow researchers, and health professionals attended this free workshop.
Year(s) Of Engagement Activity 2018
URL https://www.eventbrite.co.uk/e/epigenetics-statistics-workshop-tickets-49889050493
 
Description Three minute video production for YouTube - Epigenetics 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Production on a three minute primer video where Caroline Relton gives a brief overview of Epigenetics, placed on YouTube.
Year(s) Of Engagement Activity 2017
URL https://www.youtube.com/watch?time_continue=1&v=6CaQlUpvy5U
 
Description Visit to Barshi, India - C Relton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Professors Caroline Relton and George Davey Smith went to Barshi, India in May 2018. They visited the India Study for Health of Adults (Barshi Cohort Study) in action and the TATA Memorial Centre. Their trip included presenting to villages who were cohort participants and visiting the field site of the Barshi cohort. Future collaborations between Bristol and the TATA team were discussed.
Year(s) Of Engagement Activity 2018