the functional integration of elementary calcium signals in an excitable secretory cell
Lead Research Organisation:
Newcastle University
Department Name: Inst for Cell and Molecular Biosciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Tim Cheek (Principal Investigator) |
Publications
Brown AM
(2005)
Mechanistic and functional changes in Ca2+ entry after retinoic acid-induced differentiation of neuroblastoma cells.
in The Biochemical journal
Riddoch FC
(2007)
Changes in functional properties of the caffeine-sensitive Ca2+ store during differentiation of human SH-SY5Y neuroblastoma cells.
in Cell calcium
Riddoch FC
(2005)
Release and sequestration of Ca2+ by a caffeine- and ryanodine-sensitive store in a sub-population of human SH-SY5Y neuroblastoma cells.
in Cell calcium
| Description | BBSRC Quota DTG Studentship |
| Amount | £70,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2007 |
| End | 09/2011 |
| Description | MRC PhD Studentship |
| Amount | £35,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2008 |
| End | 09/2013 |
| Description | MRC Research Grant |
| Amount | £400,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2007 |
| End | 08/2010 |
| Description | PhD studentship/Randerson Foundation |
| Amount | £80,000 (GBP) |
| Organisation | Newcastle University |
| Department | Randerson Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2011 |
| End | 09/2015 |
| Description | metal binding |
| Organisation | Newcastle University |
| Department | Institute for Cell and Molecular Biosciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Experimental technique (confocal microscopy) and intellectual input. |
| Collaborator Contribution | Expertise in metal chelation and bacterial biochemistry |
| Impact | PMID: 18948958 |
| Start Year | 2007 |
| Description | patch-clamp |
| Organisation | University of Washington |
| Department | Department of Pharmacology |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Expertise in calcium signalling in electrically excitable cells and training of staff |
| Collaborator Contribution | provision of technical expertise and equipment |
| Impact | PMID: 16806464 |
| Description | retinoids |
| Organisation | Newcastle University |
| Department | Northern Institute for Cancer Research Newcastle |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in calcium signalling mechanisms in neuronal cells and confocal microscopy |
| Collaborator Contribution | Expertise in retinoid-induced differentiation of cells |
| Impact | Several publications, notably PMID 16914200. See also entry for G0000190 PhD studentship funded |
| Description | retinoids |
| Organisation | Newcastle University |
| Department | Northern Institute for Cancer Research Newcastle |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in calcium signalling in neuronal cells |
| Collaborator Contribution | Expertise in retinoid-induced differentiation of cells |
| Impact | PMID:15673285 PMID:16095688 PMID:16914200 PhD studentship funded |
| Description | ryanodine |
| Organisation | University of Oxford |
| Department | Department of Physiology, Anatomy and Genetics |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in mammalian ryanodine receptor signalling mechanisms |
| Collaborator Contribution | MRC Functional Genomics Unit: Expertise in insect signalling mechanisms |
| Impact | PMID: 18696132 |
| Start Year | 2007 |
| Description | urology |
| Organisation | Beatson Institute for Cancer Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | measurements of changes in concentration of intracellular Ca2+ |
| Collaborator Contribution | increased understanding of mechanisms of smooth muscle cell differentiation |
| Impact | PMID: 20546875 multi-disciplinary: molecular and cellular techniques |
| Start Year | 2006 |
| Description | Institute booklet |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Institute research booklet, aimed at the public Unknown |
| Year(s) Of Engagement Activity | 2007,2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018,2019 |
| Description | School Open Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Public Open Days - c5 per year. for prospective undergraduate and postgraduate students, and their parents. Increase in number of 'Unconditional/Conditional Firm' UCAS applicants to School (Department). Info: Board of Studies, School of Biomedical Sciences |
| Year(s) Of Engagement Activity | 2007,2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018,2019,2020 |
| Description | School children - Sunderland |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Field questions on email from primary school children in Sunderland who wanted to talk to a 'real scientist'. The children were very pleased. |
| Year(s) Of Engagement Activity | 2007,2008,2009 |
| Description | School pupils - work experience |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | School pupils work in the lab during vacation for work experience (ongoing dates) increase in requests for information on career pathways to become a researcher |
| Year(s) Of Engagement Activity | 2009,2010,2011,2012,2013,2014,2015,2016 |
| Description | Website - public |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | General University website Unkown |
| Year(s) Of Engagement Activity | 2008,2009,2010,2011,2012,2013,2014,2015,2016 |
| Description | Website - specialised |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Personal and Institute websites Contact from prospective PhD students and post-doctoral researchers |
| Year(s) Of Engagement Activity | 2007,2008,2009,2010,2011,2012,2013,2014,2015,2016 |