The Dundee Molecular Pharmacology Cooperative Group

Lead Research Organisation: University of Dundee
Department Name: Unlisted

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
 
Description Cancer chemoprevention - Dundee
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical reviews
 
Description Personalized medicine - Ninewells Hospital
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description AICR Project grant 06-015
Amount £156,000 (GBP)
Funding ID 06-015 
Organisation Association for International Cancer Research 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2006 
End 03/2009
 
Description AICR Project grant 07-0074
Amount £158,000 (GBP)
Funding ID 07-0074 
Organisation Association for International Cancer Research 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2007 
End 03/2010
 
Description CRUK Project grant C4909/A7161
Amount £240,000 (GBP)
Funding ID C4909/A7161 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2008 
End 10/2011
 
Description CRUK Project grant C4909/A9990
Amount £200,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2008 
End 04/2011
 
Title Cancer chemoprevention - Dundee 
Description A large number of assays were developed to allow measurement of mRNA levels of genes regulated by Nrf2. Also, antibodies were raised against Nrf2 target genes, and Nrf2-/- MEF cell lines were generated. 
Type Of Material Technology assay or reagent 
Provided To Others? Yes  
Impact We have been giving out reagents to researchers in the UK, Europe and USA relevant to Nrf2 since 2003. 
 
Title Clinical materials - Ninewells hospital 
Description DNA samples linked to patients 
Type Of Material Database/Collection of Data/Biological Samples 
Provided To Others? No  
Impact Substantial advances have been made in linking genetic variation to susceptibility to disease. However, such advances usually require very large patient groups to be collected and analyzed for polymorphisms, and this takes a long time. Members of the CooP group continue to be engaged in such activities. 
 
Title Transgenic mouse lines 
Description We have Nrf2-/-, Keap1-floxed and Nrf1-floxed mouse lines. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2006 
Provided To Others? Yes  
Impact At least 50 publications have arisen from the transgenic mice mentioned above. 
 
Description Patient groups - Ninewells Hospital 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact Firstly, members of the co-operative included clinically active academics who by nature of their work meet the general public on a daily basis. Secondly, blood samples were collected from volunteers from the general public who would have to be told of the purpose of the studies to gain consent. Thirdly, the majority of the work of the CooP group finished before Jan 2006.

The research of this CooP group predated the general acceptance that personalized medicine is a desirable long term objective of the NHS.
Year(s) Of Engagement Activity 2006