Diagnosis and treatment in primary care of young children with symptoms of respiratory infection

Lead Research Organisation: University of Oxford
Department Name: Population Health

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Bettiol S (2010) Symptomatic treatment of the cough in whooping cough. in The Cochrane database of systematic reviews

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Brogan PA (2004) Endothelial and platelet microparticles in vasculitis of the young. in Arthritis and rheumatism

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Haj-Hassan TA (2011) Which early 'red flag' symptoms identify children with meningococcal disease in primary care? in The British journal of general practice : the journal of the Royal College of General Practitioners

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Jefferson T (2012) Vaccines for preventing influenza in healthy children. in The Cochrane database of systematic reviews

 
Description JVCI
Geographic Reach UK 
Policy Influence Type Participation in advisory committee
Impact Issue of national guidance on vaccine policy
 
Description NICE
Geographic Reach UK 
Policy Influence Type Participation in advisory committee
Impact Issue of national guidance on management of feverish children
 
Description SACAR paediatric sub-group
Geographic Reach Europe 
Policy Influence Type Participation in advisory committee
Impact Influenced national guidance on antibiotic use
 
Description NIHR HTA
Amount £1,496,480 (GBP)
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 10/2007 
End 09/2012
 
Description NIHR HTA
Amount £200,264 (GBP)
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 10/2006 
End 09/2010
 
Description NIHR NSPCR
Amount £3,000,000 (GBP)
Organisation National Institute for Health Research 
Department School for Primary Care Research
Sector Academic/University
Country United Kingdom
Start 10/2006 
End 09/2011
 
Description NIHR Programme Grant
Amount £700,695 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 10/2008 
End 09/2011
 
Title Pertussis oral fluid assay 
Description IgG-capture ELISA capable of detecting anti-PT IgG in oral fluid 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Assay can be used for national monitoring; research on pertussis infection much easier as blood tests no longer required 
 
Description HPA 
Organisation Public Health England
Department Centre of Infectious Disease Surveillance and Control
Country United Kingdom 
Sector Public 
PI Contribution Co-development of oral fluid assay for pertussis. Oxford group contributed serum and oral fluid sample to HPA to allow development of method.
Collaborator Contribution Development of oral fluid assay for pertussis antibodies has allowed easier diagnosis of pertussis and directly contributed to current research carried out by the group for which this method is used.
Impact Development of oral fluid assay for pertussis; ongoing collaboration with further studies on pertussis (University of Oxford PI Dr A Harnden)
 
Description WOXCIS 
Organisation University Hospitals Coventry and Warwickshire NHS Trust
Department Paediatrics University Hospitals Coventry and Warwickshire
Country United Kingdom 
Sector Public 
PI Contribution Funding, research expertise and training, research methods
Collaborator Contribution Joint research on measurement of vital signs in children attending hospital A and E and paediatric assessment unit.
Impact See publications
 
Title oximetric measurement of breathing rate 
Description development of signal processing technology to determine the breathing rate using pulse oximetry to allow rapid and easy assessment of vital signs in primary and emergency care triage 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Refinement. Clinical
Year Development Stage Completed 2010
Development Status Under active development/distribution
Impact Phase 1 studies are complete; stage 2 starting in 2010. 
 
Description NHS Gp updates 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Attendance by all clinical team members at various NHS GP update meetings to advise on management of children with supected infection

None
Year(s) Of Engagement Activity 2006,2007,2008,2009
 
Description evidence to JVCI 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Primary Audience Policymakers/parliamentarians
Results and Impact Anthony Harnden provided evidence to JVCI, particularly wrt to pertuissis and influenza

JVCI recommendation to amend pertussis vaccine policy
Year(s) Of Engagement Activity 2007,2008,2009
 
Description evidence to NICE 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Primary Audience Policymakers/parliamentarians
Results and Impact Matthew Thompson provided expert advice

NICE guideline on Feverish Illness in Children
Year(s) Of Engagement Activity 2006,2007
 
Description evidence to RCGP 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Data presented to expert group on early diagnosis of serious infection

ongoing activity
Year(s) Of Engagement Activity 2007,2008
 
Description evidence to SACAR 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Primary Audience Policymakers/parliamentarians
Results and Impact David Mant orovided evidence to the paediatric sub-group of SACAR

Report and recommendations of the paediatric-subgroup of SACAR
Year(s) Of Engagement Activity 2006,2007