The role of phosphorylation in neurofilament function and dysfunction.
Lead Research Organisation:
King's College London
Department Name: Unlisted
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Brownlees J
(2002)
Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport.
in Human molecular genetics
Utton MA
(2002)
The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons.
in The Journal of neuroscience : the official journal of the Society for Neuroscience
Lau KF
(2002)
Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.
in Molecular and cellular neurosciences
Ackerley S
(2003)
Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments.
in The Journal of cell biology
Lee JH
(2003)
The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice.
in The Journal of biological chemistry
Standen CL
(2003)
The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).
in Molecular and cellular neurosciences
Kesavapany S
(2003)
Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase.
in The Journal of neuroscience : the official journal of the Society for Neuroscience
Al-Chalabi A
(2003)
Neurofilaments and neurological disease.
in BioEssays : news and reviews in molecular, cellular and developmental biology
Lee CW
(2003)
Glycogen synthase kinase-3 beta-mediated tau phosphorylation in cultured cell lines.
in Neuroreport
Turner MR
(2004)
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.
in Neurobiology of disease
| Description | Axonal transport, protein trafficking and Alzheimerâ??s disease |
| Amount | £74,142 (GBP) |
| Funding ID | ART-PhD2006-2 |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2006 |
| End | 10/2009 |
| Description | CS -Wellcome Trust/MRC neurodegenerative diseases strategic award |
| Amount | £7,372,440 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2010 |
| End | 01/2015 |
| Description | MRC Programme Grant |
| Amount | £1,246,890 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2006 |
| End | 08/2014 |
| Description | Protein kinase-N (PKN) signalling and neurodegeneration in ALS. |
| Amount | £63,021 (GBP) |
| Organisation | Motor Neurone Disease Association (MND) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2004 |
| End | 09/2007 |
| Description | cdk5 signalling and disruption to the Golgi apparatus in amyotrophic lateral sclerosis |
| Amount | £73,868 (GBP) |
| Organisation | Motor Neurone Disease Association (MND) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2005 |
| End | 09/2009 |