The role of phosphorylation in neurofilament function and dysfunction.
Lead Research Organisation:
King's College London
Department Name: Unlisted
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Mitchell JC
(2009)
X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.
in Human molecular genetics
Panzeri C
(2006)
The first ALS2 missense mutation associated with JPLS reveals new aspects of alsin biological function.
in Brain : a journal of neurology
Perkinton MS
(2004)
The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.
in The Journal of biological chemistry
Rogelj B
(2006)
The X11/Mint family of adaptor proteins.
in Brain research reviews
Saha AR
(2004)
Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons.
in Journal of cell science
Sreedharan J
(2008)
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis.
in Science (New York, N.Y.)
Standen CL
(2003)
The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).
in Molecular and cellular neurosciences
Stevenson A
(2009)
Riluzole protects against glutamate-induced slowing of neurofilament axonal transport.
in Neuroscience letters
Tudor EL
(2005)
ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.
in The Journal of biological chemistry
Turner MR
(2004)
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.
in Neurobiology of disease
| Description | Axonal transport, protein trafficking and Alzheimerâ??s disease |
| Amount | £74,142 (GBP) |
| Funding ID | ART-PhD2006-2 |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2006 |
| End | 10/2009 |
| Description | CS -Wellcome Trust/MRC neurodegenerative diseases strategic award |
| Amount | £7,372,440 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2010 |
| End | 01/2015 |
| Description | MRC Programme Grant |
| Amount | £1,246,890 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2006 |
| End | 08/2014 |
| Description | Protein kinase-N (PKN) signalling and neurodegeneration in ALS. |
| Amount | £63,021 (GBP) |
| Organisation | Motor Neurone Disease Association (MND) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2004 |
| End | 09/2007 |
| Description | cdk5 signalling and disruption to the Golgi apparatus in amyotrophic lateral sclerosis |
| Amount | £73,868 (GBP) |
| Organisation | Motor Neurone Disease Association (MND) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2005 |
| End | 09/2009 |