Complement as a mediator of chronic injury in renal transplantation

Lead Research Organisation: King's College London
Department Name: Immunology Infection and Inflam Diseases

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50
publication icon
Asgari E (2010) Complement in organ transplantation. in Current opinion in organ transplantation

publication icon
Brown KM (2006) Influence of donor C3 allotype on late renal-transplantation outcome. in The New England journal of medicine

publication icon
Farrar CA (2006) Local extravascular pool of C3 is a determinant of postischemic acute renal failure. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology

publication icon
Farrar CA (2013) The innate immune system and transplantation. in Cold Spring Harbor perspectives in medicine

 
Description Technology Strategy Board Assessor Briefing for Healthcare
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description British Transplant Society Fellowship Award
Amount £40,000 (GBP)
Organisation British Transplantation Society (BTS) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2008 
End 10/2009
 
Description Guy's & St Thomas' Charity Fellowship
Amount £203,000 (GBP)
Organisation Guy’s & St Thomas’ Charity 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description MRC Centre Grant
Amount £2,700,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2007 
End 09/2012
 
Description MRC PhD Studentship
Amount £50,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2007 
End 09/2010
 
Description MRC Project Grant
Amount £520,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 12/2007 
End 12/2010
 
Description MRC Project Grant
Amount £600,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2008 
End 09/2011
 
Description NIHR Biomedical Center Grant
Amount £5,369,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Comprehensive Biomedical Research Centre, Guy's and St Thomas
Sector Public
Country United Kingdom
Start 04/2007 
End 03/2012
 
Description NIHR Senior Investigator award
Amount £40,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 05/2008 
End 04/2012
 
Description Opsona - pre clinical studies
Amount £220,000 (GBP)
Organisation Opsona Therapeutics 
Sector Private
Country Ireland
Start 06/2009 
End 09/2010
 
Description Wellcome Trust Equipment Grant
Amount £977,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2007 
End 08/2010
 
Description Wellcome Trust Project Grant
Amount £222,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2006 
End 01/2009
 
Title Complement imaging technology 
Description Cloning of complement receptor 2 and modification to develop a new imaging tool for detection of complement activation by external body imaging. 
Type Of Material Technology assay or reagent 
Year Produced 2015 
Provided To Others? No  
Impact Being developed for clinical investigation 
 
Description AdProTec, UK 
Organisation AdProTec
Country United Kingdom 
Sector Private 
PI Contribution 1.Established the rationale of membrane targetting approach to prevent complement injury in donor kidney organs. 2. Enabled pre clinical study in prevention of reperfusion damage. 3. Enabled and led clinical (phase IIa) study to determine safety and feasibility of treating donor organs prior to transplantation.
Collaborator Contribution The company provided chemicals and consumables for this study
Impact Publications - Pubmed references 14507653 and 16510763 Joint patent application (Case 40336). This is now wholly owned by King's College London. Led to development of PhD project successfully awarded in 2006. Keynote symposium presentations including Presidents Lecture, Transplantation Society for Australia and New Zealand 2007.
 
Description Alexion Pharmaceuticals 
Organisation Alexion Pharmaceuticals
Country United States 
Sector Private 
PI Contribution We collaborated on an investigator led pre clinical study to determine the impact of complement inhibitor (anti-C5) on reperfusion injury in native and transplant kidneys.
Collaborator Contribution Alexion Pharmaveuticals provided Chemicals, Consumables and animals to this study
Impact The therapeutic antibody failed to penetrate into transplanted kidney and therefore helped to define types of injury that would not amenable to this particular therapeutic strategy.
 
Description BBC Radio 4 Interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Prof Steven Sacks describes his work on finding an easier way to get the body to accept a new organ on BBC Radio 4.

Publicity for the work of the MRC Centre for Transplantation.
Year(s) Of Engagement Activity 2008
 
Description Kidney Patients Association Board Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Participants in your research and patient groups
Results and Impact Summary of translational research including progress with complement inhibitors and potential therapeutics.

Ongoing funding notably £750K contribution to the MRC Centre for Transplantation.
Year(s) Of Engagement Activity 2007
 
Description Kidney Patients' Association Open Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Participants in your research and patient groups
Results and Impact Laboratory visit and talk concerning ongoing research.

Articles in National KPA newsletter.
Year(s) Of Engagement Activity 2009
 
Description Session Organiser for BSI 2013 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact None as yet - Meeting occurring 2-5 December 2013
Year(s) Of Engagement Activity 2013
URL http://www.bsicongress.com/