Dissection of pathways involved in polyglutamine disease pathogenesis- identification and analyses of modifier genes

Lead Research Organisation: University of Cambridge
Department Name: Unlisted

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Berger Z (2006) Rapamycin alleviates toxicity of different aggregate-prone proteins. in Human molecular genetics

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Ravikumar B (2006) Rapamycin pre-treatment protects against apoptosis. in Human molecular genetics

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Ravikumar B (2006) Role of autophagy in the clearance of mutant huntingtin: a step towards therapy? in Molecular aspects of medicine

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Sarkar S (2005) Lithium induces autophagy by inhibiting inositol monophosphatase. in The Journal of cell biology

 
Description MRC Programme Grant
Amount £2,968,260 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2007 
End 12/2011
 
Description Testing rapamycin analogues in neurodegenerative diseases 
Organisation Pfizer Ltd
Department Wyeth Pharmaceuticals
Country United States 
Sector Private 
PI Contribution We are testing rapamycin analogogues for therapeutic efficacy in mouse models of different neurodegenrative diseases
Collaborator Contribution Collaboration
Impact Berger, B Ravikumar, FM. Menzies, L Garcia Oroz, BR Underwood, MN Pangalos, I Schmitt, U Wullner, BO Evert, CJ O'Kane, and DC Rubinsztein (2006). Rapamycin alleviates toxicity of different aggregate-prone proteins. Human Molecular Genetics 15:433-442
 
Title Methods and Means for Treating Protein Conformational Disorders. 
Description Use of autophagy upregulation for treating neurodegenerative diseases 
IP Reference US2007155771 
Protection Patent granted
Year Protection Granted 2007
Licensed No
Impact USA patent
 
Title Use of autophagy inducing drugs for neurodegenerative diseases 
Description Use of autophagy inducing drugs for neurodegenerative diseases 
Type Therapeutic Intervention - Drug
Current Stage Of Development Initial development
Year Development Stage Completed 2009
Development Status Under active development/distribution
Impact Currently we are providing proof to expand the use of this strategy beyong Huntington disease 
 
Description School visit - Cambridge 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact talk to school class

good feedback from students
Year(s) Of Engagement Activity 2006
 
Description Talks at international conferences 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact India-EMBO Autophagy Symposium (Bubaneswar 2017), Autophagy as a Common Pathway in Diseases (NIH, Bethesda 2018), Gordon Conference -Autophagy in Stress, Development and Disease (Il Ciocco, 2018), Interact (Munich, 2018), Autophagy and Neuroprotection (Teaching course, Venice 2018), 83rd Harden Conference Autophagy - from Molecules to Disease (Warwick 2018), Gordon conference - Neurobiology of Brain Disorders (Castelldefels, Spain, 2018), Workshop on Autophagy in model organisms (Budapest, 2018), Autophagy in the healthy and diseased brain - Lake Como School of Advanced Studies (2018), 7th International Student Symposium conducted by the International Max Planck Research School in Chemical and Molecular Biology (Dortmund) (2018)
Year(s) Of Engagement Activity 2018
 
Description Talks at international conferences 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keystone Symposium: Autophagy: From Model Systems to Therapeutic Opportunities (Santa Fe 2019), Autophagy, Inflammation & Metabolism Annual Meeting & Symposium (Albuquerque (2019), British Inflammation Research Association meeting on Autophagy (2019), FASEB - The Protein Aggregation Conference (Snowmass, 2019), Gordon Research Conference on Stress Proteins in Growth, Development and Disease (Barga, 2019), Imperial College Alzheimer's Research Network Symposium (London 2019), EMBO Autophagy Workshop 2019 (Crieff, Scotland), European Society of Neurochemistry 2019 (Milan), Basel Life - Aging and drug discovery and AI (Basel, 2019), Inaugural International Symposium of Cell Fate Determination (Shanghai 2019)
Year(s) Of Engagement Activity 2019
 
Description Talks for Medical Students societies 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact St Johns College Medical Society Cambridge (2017)
Trinity College Medical Society (2019)
Year(s) Of Engagement Activity 2017,2019
 
Description Talks for lay audiences/patients 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Addenbrooke's Hospital Huntington's disease patients (2018); Addenbrooke's Hospital Parkinson's disease patients (2018)
Year(s) Of Engagement Activity 2018