Corneal Transparency, Dioptric Power and their Alterations in Pathological Conditions

Lead Research Organisation: Cardiff University
Department Name: School of Medicine

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Akhtar S (2011) Role of keratan sulphate (sulphated poly -N-acetyllactosamine repeats) in keratoconic cornea, histochemical, and ultrastructural analysis. in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

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Beecher N (2006) Neonatal development of the corneal stroma in wild-type and lumican-null mice. in Investigative ophthalmology & visual science

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Beecher N (2005) An x-ray diffraction study of corneal structure in mimecan-deficient mice. in Investigative ophthalmology & visual science

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Boote C (2005) Lamellar orientation in human cornea in relation to mechanical properties. in Journal of structural biology

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Boote C (2006) Mapping collagen organization in the human cornea: left and right eyes are structurally distinct. in Investigative ophthalmology & visual science

 
Description EPSRC Project Grant responsive mode
Amount £836,976 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start  
 
Description Planning Division, Cardiff University, International Collaboration Award-Early Career Researcher 2007/08
Amount £2,300 (GBP)
Organisation Cardiff University 
Sector Academic/University
Country United Kingdom
Start  
 
Description Project grant
Amount £1,350,000 (GBP)
Funding ID G0600755 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2007 
End 12/2011
 
Description Royal Society/Wolfson Research Merit Award
Amount £75,000 (GBP)
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Title quantitative x-ray scattering mapping technique 
Description We have developed a method to scan connective tissue samples using synchrotron x-ray scattering and display the resulting maps in a clear and accessible manner 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2006 
Provided To Others? Yes  
Impact The method has been used in a myxamatous heart valve publication by a group in Edinburgh 
 
Title Elsheikh modelling of chick corneas 
Description Our quantitative x-ray data have been used to model the biomechanical behaviour of the cornea. 
Type Of Material Computer model/algorithm 
Year Produced 2008 
Provided To Others? Yes  
Impact Data helped explain the importance of the limbal annulus in maintaining corneal shape. This work was published. 
 
Description Collaboration with Prof. J. Funderburgh in University of Pittsburgh Medical Centre 
Organisation University of Pittsburgh Medical Center (UPMC)
Country United States 
Sector Hospitals 
PI Contribution collagen ultrastructural x-ray studies of scarred corneas treated with stromal stem cells
Collaborator Contribution Provided wounded mouse corneas for stem cell baseline studies
Impact International Collaboration Award-Early Career Researcher 2007/08, Cardiff University. Funding was allocated to Dr. Christina Kamma-Lorger to visit collaborative lab in in Pittsburgh University for 4 weeks, to receive training in corneal stem cell techniques and establishing a new collaboration (2300GBP)+ publications (see list). Multidisciplinary: Ophthalmology, Biophysics, Biology, Molecular Biology
Start Year 2007
 
Description Dr Ahmed ElSheikh 
Organisation University of Dundee
Country United Kingdom 
Sector Academic/University 
PI Contribution Modelling corneal structure and biomechanics. Our structural data is being used to model corneal biomechannical behaviour. We are also working together to simultaneously monitor changes in corneal structure and stress-strain behaviour by covering corneas with a fine-particle speckle pattern and then collecting x-ray scattering data at the same time as collecting images of the corneal surface on spatially oriented cameras.
Collaborator Contribution Allowed us to progress the biomechanical implications of our structural data
Impact Multiple publications as co-authors: doi:10.1098/rsif.2010.0108; doi: 10.1016/j.actbio.2017.11.015.; doi:10.1016/j.jmbbm.2014.11.006
Start Year 2008
 
Description Dr Paul Hocking 
Organisation University of Edinburgh
Department The Roslin Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution We have used our structural data to help understand the changes in eye shape in genetically mutated chicks
Collaborator Contribution Partnership led to successful grant application to MRC for studies of corneas of chicks with various retinal defects.
Impact Collaboration formed part of a following grant and publications are listed under G0600755
Start Year 2006
 
Description Prof Peter Pinsky 
Organisation Stanford University
Country United States 
Sector Academic/University 
PI Contribution We supplied quantitative structural data from the cornea to enable him to create a finite element model of the cornea
Collaborator Contribution Peter Pinsky and his team developed computational models of collagen organisation in the healthy and diseased cornea
Impact Our data has been shared with Pinksy's team and used to create mathematical models for corneal collagen organisation which have subsequently been published. In all of these publications the source of the data is acknowledged as originating from our research. In one of the publications we are listed as co-authors: A simple mathematical model for collagen fibril organization in normal and keratoconic corneas. 2018;1:7-11.
Start Year 2009
 
Description ARVO meeting, Ft. Lauderdale 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote speaker at Keratocyte Klub meeting, ARVO, Ft. Lauderdale

New collaborations and added prestige for our research.
Year(s) Of Engagement Activity 2006
 
Description ESCRS meeting, Lisbon 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker: special symposium on corneal biomechanics

Reported in EuroTimes
Year(s) Of Engagement Activity 2006
 
Description EVER meeting, Vilamoura, Portugal 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Speaker/poster

None
Year(s) Of Engagement Activity 2006
 
Description Eye Surgery Seminar, Moorfields Eye Hospital 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Oral presentation

Increased awareness of the revelvance of our structural corneal work for refractive surgery amongst the clinical community
Year(s) Of Engagement Activity 2006
 
Description Keratoconus symposium, Bilbao 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker

Led to numerous invitations to speak at biomechanics meetings
Year(s) Of Engagement Activity 2006
 
Description MCLOSA meeting, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker

Disseminated our research to a wide professional audience
Year(s) Of Engagement Activity 2006
 
Description MDA Clinic - Eye Surgery Update 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Keynote Speaker

None
Year(s) Of Engagement Activity 2006