The origins of Parkinson's disease and its heterogenity

Lead Research Organisation: University of Cambridge
Department Name: Cambridge Centre for Brain Repair

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Michell AW (2004) Biomarkers and Parkinson's disease. in Brain : a journal of neurology

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Lewis SJ (2005) Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach. in Journal of neurology, neurosurgery, and psychiatry

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Williams-Gray CH (2006) No alterations in alpha-synuclein gene dosage observed in sporadic Parkinson's disease. in Movement disorders : official journal of the Movement Disorder Society

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Foltynie T (2004) Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphism. in Movement disorders : official journal of the Movement Disorder Society

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Williams-Gray CH (2006) Prevalence of the LRRK2 G2019S mutation in a UK community based idiopathic Parkinson's disease cohort. in Journal of neurology, neurosurgery, and psychiatry

 
Description Predicting dementia in Parkinson's disease: A genotypic and phenotyic study
Amount £1,184,209 (GBP)
Funding ID J-0802 
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2008 
End 03/2013
 
Description TRANSEURO Neural transplantation in the treatment of patients with Parkinson's Disease (12m euros across 14 participants)
Amount £3,316,100 (GBP)
Funding ID 242003 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2010 
End 12/2014
 
Title DNA samples matched to clinical data 
Description All patients enrolled to this study have DNA banked 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2008 
Provided To Others? Yes  
Impact Samples from this cohort have been used in recent GWAS study in PD 
 
Description Set up an international working group in transplantation for PD 
Organisation Lund University
Country Sweden 
Sector Academic/University 
PI Contribution I set this group up with Professor Anders Bjorklund in Sweden.
Impact It led to the successful award of a 12, million EURO FP7 grant to look at neural grafting in PD
Start Year 2006
 
Description Local branches of PDS 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact i describe the work we have done defining different types of PD

More people volunteered to help us with our work
Year(s) Of Engagement Activity 2006,2007,2008,2009