The origins of Parkinson's disease and its heterogenity
Lead Research Organisation:
University of Cambridge
Department Name: Cambridge Centre for Brain Repair
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Barker RA
(2004)
The future challenges in Parkinson's disease.
in Journal of neurology
Foltynie T
(2005)
A genome wide linkage disequilibrium screen in Parkinson's disease.
in Journal of neurology
Foltynie T
(2005)
The BDNF Val66Met polymorphism has a gender specific influence on planning ability in Parkinson's disease.
in Journal of neurology
Foltynie T
(2004)
The cognitive ability of an incident cohort of Parkinson's patients in the UK. The CamPaIGN study.
in Brain : a journal of neurology
Foltynie T
(2004)
Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphism.
in Movement disorders : official journal of the Movement Disorder Society
Goris A
(2006)
No evidence for association with Parkinson disease for 13 single-nucleotide polymorphisms identified by whole-genome association screening.
in American journal of human genetics
Lewis S
(2004)
Striatal contributions to working memory: a functional magnetic resonance imaging study in humans
in European Journal of Neuroscience
Lewis SJ
(2005)
Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach.
in Journal of neurology, neurosurgery, and psychiatry
Liu G
(2017)
Prediction of cognition in Parkinson's disease with a clinical-genetic score: a longitudinal analysis of nine cohorts
in The Lancet Neurology
Liu G
(2016)
Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's.
in Annals of neurology
Michell AW
(2006)
Saccadic latency distributions in Parkinson's disease and the effects of L-dopa.
in Experimental brain research
Michell AW
(2004)
Biomarkers and Parkinson's disease.
in Brain : a journal of neurology
Williams-Gray CH
(2006)
No alterations in alpha-synuclein gene dosage observed in sporadic Parkinson's disease.
in Movement disorders : official journal of the Movement Disorder Society
Williams-Gray CH
(2006)
Cognitive deficits and psychosis in Parkinson's disease: a review of pathophysiology and therapeutic options.
in CNS drugs
Williams-Gray CH
(2006)
Prevalence of the LRRK2 G2019S mutation in a UK community based idiopathic Parkinson's disease cohort.
in Journal of neurology, neurosurgery, and psychiatry
| Description | Predicting dementia in Parkinson's disease: A genotypic and phenotyic study |
| Amount | £1,184,209 (GBP) |
| Funding ID | J-0802 |
| Organisation | Parkinson's UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2008 |
| End | 03/2013 |
| Description | TRANSEURO Neural transplantation in the treatment of patients with Parkinson's Disease (12m euros across 14 participants) |
| Amount | £3,316,100 (GBP) |
| Funding ID | 242003 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2010 |
| End | 12/2014 |
| Title | DNA samples matched to clinical data |
| Description | All patients enrolled to this study have DNA banked |
| Type Of Material | Database/Collection of Data/Biological Samples |
| Year Produced | 2008 |
| Provided To Others? | Yes |
| Impact | Samples from this cohort have been used in recent GWAS study in PD |
| Description | Set up an international working group in transplantation for PD |
| Organisation | Lund University |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | I set this group up with Professor Anders Bjorklund in Sweden. |
| Impact | It led to the successful award of a 12, million EURO FP7 grant to look at neural grafting in PD |
| Start Year | 2006 |
| Description | Local branches of PDS |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | i describe the work we have done defining different types of PD More people volunteered to help us with our work |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009 |