Role of complement and receptors for the Fc Fragment of Immunoglobin G (FcyR) in immunity to Salmonella

Lead Research Organisation: University of Cambridge
Department Name: Veterinary Science

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Dougan G (2011) Immunity to salmonellosis. in Immunological reviews

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Gondwe EN (2010) Importance of antibody and complement for oxidative burst and killing of invasive nontyphoidal Salmonella by blood cells in Africans. in Proceedings of the National Academy of Sciences of the United States of America

 
Description Bacterial pathogenesis, immunology and vaccine development. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The talk generated interest in the subject and many Brazilian students and academics have made further contacts with us

I was asked by students about the possibility of visiting my lab in the UK
Year(s) Of Engagement Activity 2015
 
Description Departmental open days 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact General Public and potential students visit to the Department

unknown
Year(s) Of Engagement Activity 2006,2007
 
Description Immunity to invasive Salmonella infections: should lessons from mice and man inform vaccine development? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The visit to Malawi and the talk sparked a large collaborative Grant application to the Wellcome Trust

After my talk several colleagues expressed the wish to integrate their epidemiological research with immunological studies in humans in Malawi
Year(s) Of Engagement Activity 2015
 
Description The importance of understanding bacterial spread in the tissues in relation to the host inflammatory response for the generation of safer and less reactogenic vaccines. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The talk made postgraduate and undergraduate students aware of the importance of tailoring vaccines to the specific biological characteristics of the pathogen

Several students asked for my papers and reviews on the subject and expressed an interest in undertaking research on vaccines and immunity
Year(s) Of Engagement Activity 2013
 
Description Why live vaccines may be most effective for preventing Salmonella infections 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact The press release will engage media and general public with our research


Just issues. Impact will be monitored over the next few months
Year(s) Of Engagement Activity 2014
URL http://www.cam.ac.uk/research/news/why-live-vaccines-may-be-most-effective-for-preventing-salmonella...
 
Description Within host infection dynamics in bacterial immunology and vaccine development. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The activity generated a more informed assessment of vaccine strategies for invasive salmonelloses and also generated discussion between people involved in decisions on the selection of vaccine candidates.

Impacts on rationale choice of vaccine candidates
Year(s) Of Engagement Activity 2013