Tanslational Cardiovascular Biology: Atherosclerosis, Thrombosis and Arrhythmias

Lead Research Organisation: University of Cambridge
Department Name: Biochemistry

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Killeen MJ (2007) Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heart. in Acta physiologica (Oxford, England)

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Lei M (2007) SCN5A and sinoatrial node pacemaker function. in Cardiovascular research

 
Description Analysis of the ventricular conduction properties of genetically modified mice with ion channel mutations, Studentship for K Stokoe; FS/03/046/15456; RG 36967 [With A. A. Grace]
Amount £71,154 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Arrhythmogenic effects of imposed ischaemia in genetically modified mice. Clinical PhD Studentship for G. Thomas, FS/03J063/15943 [With_A._A._Grace]
Amount £143,034 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Capacity building studentship in integrative physiology
Amount £63,358 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2006 
End 09/2009
 
Description Electrophysiological and molecular characterization of cardiac conduction system in murine models of Scn5a sodium channel diseases [With Dr. Ming Lei, University of Manchester, and Dr. Andrew Grace] 081283/Z/06/Z
Amount £372,044 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Functional characterization of PGC1I3 using genetically modified mouse models [with A. Vidal-Puig]
Amount £195,431 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Integrative Physiology of Cardiac Arrhythmias, 077156/Z/05/Z, RG42209; UFS project PHZC/026, [With AA Grace]
Amount £573,072 (GBP)
Funding ID 077156/Z/05/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2005 
End 08/2008
 
Description AA Grace, C-L Huang collaborations 
Organisation Aarhus University
Country Denmark 
Sector Academic/University 
PI Contribution [1] Dr. Ming Lei/University of Manchester/scientific /duration 2y, but continuing/ Extension of studies to atrial fibrillation in the Scn5a+/- [has already led to publications, as indicated in reference list] [2] Prof. AJ Williams/Imperial College London [now at Cardiff University School of Medicine]/scientific/2 y/ possible extension of our techniques to RyR mutant mouse models. [3] Prof Soren Olesen/University of Copenhagen/Scientific and provision of novel reagents/duration ly so far but continuing/ Strategies involving K+ channel modification on restitution arrhythmogenesis. [4] Neurosearch AG, Copenhagen, Denmark/scientific/use of HERG channel opening agents. [5] Prof. A. Ma/University of Xi'an, Peoples Republic of China/scientific/duration 1 y/ two family studies involving HERG [has already led to publications, as indicated in reference list]. [6] Prof. Ole Neilsen/University of Aarhus, Denmark/scientific/ongoing/ This has involved Dr. Thomas Pedersen from his laboratory joining us to investigate metabolic- membrane linkages in arrhythmogenesis in the Scn5a+/- and Scn5a +/A hearts.
Impact NA
 
Description AA Grace, C-L Huang collaborations 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution [1] Dr. Ming Lei/University of Manchester/scientific /duration 2y, but continuing/ Extension of studies to atrial fibrillation in the Scn5a+/- [has already led to publications, as indicated in reference list] [2] Prof. AJ Williams/Imperial College London [now at Cardiff University School of Medicine]/scientific/2 y/ possible extension of our techniques to RyR mutant mouse models. [3] Prof Soren Olesen/University of Copenhagen/Scientific and provision of novel reagents/duration ly so far but continuing/ Strategies involving K+ channel modification on restitution arrhythmogenesis. [4] Neurosearch AG, Copenhagen, Denmark/scientific/use of HERG channel opening agents. [5] Prof. A. Ma/University of Xi'an, Peoples Republic of China/scientific/duration 1 y/ two family studies involving HERG [has already led to publications, as indicated in reference list]. [6] Prof. Ole Neilsen/University of Aarhus, Denmark/scientific/ongoing/ This has involved Dr. Thomas Pedersen from his laboratory joining us to investigate metabolic- membrane linkages in arrhythmogenesis in the Scn5a+/- and Scn5a +/A hearts.
Impact NA
 
Description AA Grace, C-L Huang collaborations 
Organisation Neurosearch AG, Copenhagen
Country Denmark 
Sector Private 
PI Contribution [1] Dr. Ming Lei/University of Manchester/scientific /duration 2y, but continuing/ Extension of studies to atrial fibrillation in the Scn5a+/- [has already led to publications, as indicated in reference list] [2] Prof. AJ Williams/Imperial College London [now at Cardiff University School of Medicine]/scientific/2 y/ possible extension of our techniques to RyR mutant mouse models. [3] Prof Soren Olesen/University of Copenhagen/Scientific and provision of novel reagents/duration ly so far but continuing/ Strategies involving K+ channel modification on restitution arrhythmogenesis. [4] Neurosearch AG, Copenhagen, Denmark/scientific/use of HERG channel opening agents. [5] Prof. A. Ma/University of Xi'an, Peoples Republic of China/scientific/duration 1 y/ two family studies involving HERG [has already led to publications, as indicated in reference list]. [6] Prof. Ole Neilsen/University of Aarhus, Denmark/scientific/ongoing/ This has involved Dr. Thomas Pedersen from his laboratory joining us to investigate metabolic- membrane linkages in arrhythmogenesis in the Scn5a+/- and Scn5a +/A hearts.
Impact NA
 
Description AA Grace, C-L Huang collaborations 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution [1] Dr. Ming Lei/University of Manchester/scientific /duration 2y, but continuing/ Extension of studies to atrial fibrillation in the Scn5a+/- [has already led to publications, as indicated in reference list] [2] Prof. AJ Williams/Imperial College London [now at Cardiff University School of Medicine]/scientific/2 y/ possible extension of our techniques to RyR mutant mouse models. [3] Prof Soren Olesen/University of Copenhagen/Scientific and provision of novel reagents/duration ly so far but continuing/ Strategies involving K+ channel modification on restitution arrhythmogenesis. [4] Neurosearch AG, Copenhagen, Denmark/scientific/use of HERG channel opening agents. [5] Prof. A. Ma/University of Xi'an, Peoples Republic of China/scientific/duration 1 y/ two family studies involving HERG [has already led to publications, as indicated in reference list]. [6] Prof. Ole Neilsen/University of Aarhus, Denmark/scientific/ongoing/ This has involved Dr. Thomas Pedersen from his laboratory joining us to investigate metabolic- membrane linkages in arrhythmogenesis in the Scn5a+/- and Scn5a +/A hearts.
Impact NA
 
Description AA Grace, C-L Huang collaborations 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution [1] Dr. Ming Lei/University of Manchester/scientific /duration 2y, but continuing/ Extension of studies to atrial fibrillation in the Scn5a+/- [has already led to publications, as indicated in reference list] [2] Prof. AJ Williams/Imperial College London [now at Cardiff University School of Medicine]/scientific/2 y/ possible extension of our techniques to RyR mutant mouse models. [3] Prof Soren Olesen/University of Copenhagen/Scientific and provision of novel reagents/duration ly so far but continuing/ Strategies involving K+ channel modification on restitution arrhythmogenesis. [4] Neurosearch AG, Copenhagen, Denmark/scientific/use of HERG channel opening agents. [5] Prof. A. Ma/University of Xi'an, Peoples Republic of China/scientific/duration 1 y/ two family studies involving HERG [has already led to publications, as indicated in reference list]. [6] Prof. Ole Neilsen/University of Aarhus, Denmark/scientific/ongoing/ This has involved Dr. Thomas Pedersen from his laboratory joining us to investigate metabolic- membrane linkages in arrhythmogenesis in the Scn5a+/- and Scn5a +/A hearts.
Impact NA
 
Description AA Grace, C-L Huang collaborations 
Organisation Xi'an Jiaotong University
Department School of Medicine Xi'an Jiaotong
Country China 
Sector Academic/University 
PI Contribution [1] Dr. Ming Lei/University of Manchester/scientific /duration 2y, but continuing/ Extension of studies to atrial fibrillation in the Scn5a+/- [has already led to publications, as indicated in reference list] [2] Prof. AJ Williams/Imperial College London [now at Cardiff University School of Medicine]/scientific/2 y/ possible extension of our techniques to RyR mutant mouse models. [3] Prof Soren Olesen/University of Copenhagen/Scientific and provision of novel reagents/duration ly so far but continuing/ Strategies involving K+ channel modification on restitution arrhythmogenesis. [4] Neurosearch AG, Copenhagen, Denmark/scientific/use of HERG channel opening agents. [5] Prof. A. Ma/University of Xi'an, Peoples Republic of China/scientific/duration 1 y/ two family studies involving HERG [has already led to publications, as indicated in reference list]. [6] Prof. Ole Neilsen/University of Aarhus, Denmark/scientific/ongoing/ This has involved Dr. Thomas Pedersen from his laboratory joining us to investigate metabolic- membrane linkages in arrhythmogenesis in the Scn5a+/- and Scn5a +/A hearts.
Impact NA
 
Description Dr R W Farndale collaborations 
Organisation Tel Aviv University
Country Israel 
Sector Academic/University 
PI Contribution Collaborated with Prof 3 Emsley, University of Nottingham, on the structure of I domains, integrins and collagen-based peptides. This continues with RWF as a named collaborator on a 3 year CRUK grant to Prof Emsley and Prof Emsley is a collaborator with RWF on a 5 year MRC Programme Grant. The grant also facilitated continuing research interactions with Prof. J Heino (Turku), Prof D Gullberg (Bergen) and a new collaboration with Prof J lahav (Israel) arose directly form the COGG.
Collaborator Contribution Collaborated with Prof J Emsley, University of Nottingham, on the structure of I domains, integrins and collagen-based peptides. This continues with RWF as a named collaborator on a 3 year CRUK grant to Prof Emsley and Prof Emsley is a collaborator with RWF on a 5 year MRC Programme Grant.
Impact NA
 
Description Dr R W Farndale collaborations 
Organisation University of Bergen
Country Norway 
Sector Academic/University 
PI Contribution Collaborated with Prof 3 Emsley, University of Nottingham, on the structure of I domains, integrins and collagen-based peptides. This continues with RWF as a named collaborator on a 3 year CRUK grant to Prof Emsley and Prof Emsley is a collaborator with RWF on a 5 year MRC Programme Grant. The grant also facilitated continuing research interactions with Prof. J Heino (Turku), Prof D Gullberg (Bergen) and a new collaboration with Prof J lahav (Israel) arose directly form the COGG.
Collaborator Contribution Collaborated with Prof J Emsley, University of Nottingham, on the structure of I domains, integrins and collagen-based peptides. This continues with RWF as a named collaborator on a 3 year CRUK grant to Prof Emsley and Prof Emsley is a collaborator with RWF on a 5 year MRC Programme Grant.
Impact NA
 
Description Dr R W Farndale collaborations 
Organisation University of Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaborated with Prof 3 Emsley, University of Nottingham, on the structure of I domains, integrins and collagen-based peptides. This continues with RWF as a named collaborator on a 3 year CRUK grant to Prof Emsley and Prof Emsley is a collaborator with RWF on a 5 year MRC Programme Grant. The grant also facilitated continuing research interactions with Prof. J Heino (Turku), Prof D Gullberg (Bergen) and a new collaboration with Prof J lahav (Israel) arose directly form the COGG.
Collaborator Contribution Collaborated with Prof J Emsley, University of Nottingham, on the structure of I domains, integrins and collagen-based peptides. This continues with RWF as a named collaborator on a 3 year CRUK grant to Prof Emsley and Prof Emsley is a collaborator with RWF on a 5 year MRC Programme Grant.
Impact NA
 
Description Dr R W Farndale collaborations 
Organisation University of Turku
Country Finland 
Sector Academic/University 
PI Contribution Collaborated with Prof 3 Emsley, University of Nottingham, on the structure of I domains, integrins and collagen-based peptides. This continues with RWF as a named collaborator on a 3 year CRUK grant to Prof Emsley and Prof Emsley is a collaborator with RWF on a 5 year MRC Programme Grant. The grant also facilitated continuing research interactions with Prof. J Heino (Turku), Prof D Gullberg (Bergen) and a new collaboration with Prof J lahav (Israel) arose directly form the COGG.
Collaborator Contribution Collaborated with Prof J Emsley, University of Nottingham, on the structure of I domains, integrins and collagen-based peptides. This continues with RWF as a named collaborator on a 3 year CRUK grant to Prof Emsley and Prof Emsley is a collaborator with RWF on a 5 year MRC Programme Grant.
Impact NA
 
Description J Metclafe Collaborations 
Organisation Papworth Hospital NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Major collaborations with Drs Clarke and Schofield at Papworth Hospital on clinical studies of: (i) endothelial function in male patients with coronary artery disease treated with SERMs (from 2002 ongoing). (U) Prediction of coronary artery disease by polyomic technologies (from 2003 ongoing). __________
Impact NA