Monitoring and modelling prognosis in the era of HAART (Extension to Strategic Grant G0100221)

Lead Research Organisation: University of Bristol
Department Name: Social Medicine

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Antiretroviral Therapy Cohort Collaboration (2010) Causes of death in HIV-1-infected patients treated with antiretroviral therapy, 1996-2006: collaborative analysis of 13 HIV cohort studies. in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Antiretroviral Therapy Cohort Collaboration (ART-CC) (2016) Mortality of treated HIV-1 positive individuals according to viral subtype in Europe and Canada: collaborative cohort analysis. in AIDS (London, England)

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Antiretroviral Therapy In Low-Income Countries Collaboration Of The International Epidemiological Databases To Evaluate AIDS (IeDEA) (2007) Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries. in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Balestre E (2016) Immunologic response in treatment-naïve HIV-2-infected patients: the IeDEA West Africa cohort in Journal of the International AIDS Society

 
Guideline Title Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents
Description DHHS Panel on Antiretroviral Guidelines
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
Impact The most recent US guidelines on antiretroviral therapy for HIV-infected individuals cite papers from the ART Cohort Collaboration, including and extensive discussion of our 2009 Lancet paper on timing of antiretroviral therapy (19361855) and our 2007 paper on 5 year prognosis (17502729)
 
Guideline Title Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society-USA panel
Description US HIV treatment guidelines
Geographic Reach North America 
Policy Influence Type Citation in clinical guidelines
 
Description MRC Research Grant (G0700820)
Amount £800,000 (GBP)
Funding ID G0700820 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2007 
End 08/2011
 
Title Prognostic model 
Description Our website at www.art-cohort-collaboration.org provides a prognostic model for use by patients and their carers. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2007 
Provided To Others? Yes  
Impact The web site has been accessed tens of thousands of times 
URL http://www.art-cohort-collaboration.org
 
Description ART-LINC 
Organisation National Institute of Health and Medical Research (INSERM)
Department INSERN (1053) (Université Bordeaux Segalen)
Country France 
Sector Academic/University 
PI Contribution Professors Matthias Egger and Francois Dabis established this sister collaboration based on HIV clinic cohorts in developing countreis. Sterne and May provided statistical support. We shared data for a study comparing outcomes in high and low income settings.
Collaborator Contribution Knowledge of HIV in low income countries.
Impact Publication of 7 papers with authors funded by this grant or next grant. 17990236 19142294 18981768 18670668 18373510 18240981 16530575
 
Description ART-LINC 
Organisation University of Bern
Department Institute of Social and Preventive Medicine
Country Switzerland 
Sector Academic/University 
PI Contribution Professors Matthias Egger and Francois Dabis established this sister collaboration based on HIV clinic cohorts in developing countreis. Sterne and May provided statistical support. We shared data for a study comparing outcomes in high and low income settings.
Collaborator Contribution Knowledge of HIV in low income countries.
Impact Publication of 7 papers with authors funded by this grant or next grant. 17990236 19142294 18981768 18670668 18373510 18240981 16530575
 
Description CNICS 
Organisation University of Alabama at Birmingham
Country United States 
Sector Academic/University 
PI Contribution Statistical modelling.
Collaborator Contribution Data contributed to opportunistic infection modelling.
Impact dataset
Start Year 2013
 
Description COHERE 
Organisation National Institute of Health and Medical Research (INSERM)
Department INSERN (1053) (Université Bordeaux Segalen)
Country France 
Sector Academic/University 
PI Contribution Scientific advice.
Collaborator Contribution Management of database and scientific advice.
Impact Published papers by ART-CC used data managed by COHERE.
Start Year 2010
 
Description COHERE 
Organisation National Institute of Health and Medical Research (INSERM)
Department INSERN (1053) (Université Bordeaux Segalen)
Country France 
Sector Academic/University 
PI Contribution Sterne was involved in negotiations establishing this collaboration of European HIV cohort studies and is a member of the steering committee. Egger raised funds for and led work on non-Hodgkins lymphoma. May provided statistical advice.
Collaborator Contribution Knowledge of Non-hodgkins lymphoma in HIV infected persons
Impact 2 papers published 19531926 ?
Start Year 2007
 
Description COHERE 
Organisation University of Copenhagen
Department Copenhagen HIV Programme (CHIP)
Country Denmark 
Sector Academic/University 
PI Contribution Scientific advice.
Collaborator Contribution Management of database and scientific advice.
Impact Published papers by ART-CC used data managed by COHERE.
Start Year 2010
 
Description COHERE 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution Sterne was involved in negotiations establishing this collaboration of European HIV cohort studies and is a member of the steering committee. Egger raised funds for and led work on non-Hodgkins lymphoma. May provided statistical advice.
Collaborator Contribution Knowledge of Non-hodgkins lymphoma in HIV infected persons
Impact 2 papers published 19531926 ?
Start Year 2007
 
Description HIV-CAUSAL 
Organisation Harvard University
Department Harvard T.H. Chan School of Public Health
Country United States 
Sector Academic/University 
PI Contribution Statistical modelling and data.
Collaborator Contribution Data and statistical modelling.
Impact Paper of effect of ART.
 
Description IeDEA Southern Africa 
Organisation University of Bern
Country Switzerland 
Sector Academic/University 
PI Contribution Prognostic modelling for pediatric HIV patients and comparative prognosis for adults comparing mortality with Europe and North America.
Collaborator Contribution Data and statistical modelling.
Impact publications as listed.
 
Description IeDEA Southern Africa 
Organisation University of Cape Town
Country South Africa 
Sector Academic/University 
PI Contribution Prognostic modelling for pediatric HIV patients and comparative prognosis for adults comparing mortality with Europe and North America.
Collaborator Contribution Data and statistical modelling.
Impact publications as listed.
 
Description IeDEA West Africa 
Organisation International Epidemiologic Databases to Evaluate AIDS (IeDEA)
Department IeDEA West Africa Region
Country Central African Republic 
Sector Charity/Non Profit 
PI Contribution Prognostic modelling methodology for HIV-1 and HIV-2 modelling
Collaborator Contribution Prognostic modelling methodology for HIV-1 and HIV-2 modelling
Impact Paper in Press
Start Year 2012
 
Description Conference on Retroviruses and Opportunistic Infections 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Attended the Conference on Retroviruses and Opportunistic Infections every year to present work, support team members and lead the ART-CC collaboration in its work on HIV-1 patients. This is a major, international conference with an audience of around 4,000 researchers in the field of opportunistic infections and retroviruses.
Year(s) Of Engagement Activity Pre-2006,2006,2007,2008,2009,2010,2011,2012,2013,2014,2015,2016
URL http://www.croiconference.org/
 
Description Media appearances 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Television and radio appearances by Sterne, describing improved life expectancy of HIV-infected individuals, following publication of article in the Lancet (18657708)

Wider knowledge of the benefits of antiretroviral therapy
Year(s) Of Engagement Activity 2008
 
Description Press conference 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Appeared at a press conference during the 2009 Conference on Retrovirus and Opportunistic Infections, to describe work examining when HIV-infected individuals should start antiretroviral therapy

Coverage on several web sites providing information to HIV infected patients
Year(s) Of Engagement Activity 2009