Molecular Epigenetics
Lead Research Organisation:
Imperial College London
Department Name: Unlisted
Abstract
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| Description | Response mode project grant |
| Amount | £863,446 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2012 |
| End | 09/2016 |
| Title | Identification of histone H3 K4acetylation as a novel post-translational modification using a novel antibody |
| Description | Polyclonal antibody specific to histone H3 lysine 4 acetylation |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2011 |
| Provided To Others? | Yes |
| Impact | Identification that histone H3 is modified on a key residue, lysine 4, in yeast and mammals. This changes our understanding of how gene's are regulated in eukaryotes as indicated by our genome-wide epigenomic and functional studies. |
| Description | AF |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Clinical Sciences Centre (CSC) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Provided variegating murine model for analysis |
| Collaborator Contribution | Joint publication prior to 2006 in Nature Cell Biology |
| Impact | Demonstrated late replication of heterochromatin-silenced gene. Published in Nature Cell Biology. |
| Description | DK |
| Organisation | Medical Research Council (MRC) |
| Department | MRC National Institute for Medical Research (NIMR) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Interchange of ideas and collaboration on papers published before period. |
| Collaborator Contribution | Provision of expertise and transgenic lines |
| Impact | Publication prior to 2006 in Science (2003) demonstrating increased mobility of heterochromatin protein 1 on T cell activation. |
| Description | PF |
| Organisation | Babraham Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Scientific discussions and presentations at coop meetings |
| Collaborator Contribution | Transfer of 3D FISH technique to our lab. |
| Impact | Transfer of 3D FISH technology. Data included in publication in Nature 2003. |
| Description | WR |
| Organisation | Babraham Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Made transgenic lines and analysed them to test hypothesis. |
| Collaborator Contribution | Established collaboration on function of DNA methylation in establishing gene silencing by inducing variegation |
| Impact | Discovered that a direct-repeat associated with the Igf2 gene confers variegation on a linked reporter gene in vivo and that this variegation is suppressed by HP1 overexpression. Manuscript in progress. |
| Description | TV documentary |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interviewed for EU funded TV documentarty on Epigenetics Communicated key ideas to a large lay audience |
| Year(s) Of Engagement Activity | 2009 |
| Description | TV-interview Dublin |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interviewed at International conference for Friedreich's Ataxia Raised the profile of the need for research in triplet-repeat diseases |
| Year(s) Of Engagement Activity | 2008 |