Molecular Epigenetics

Lead Research Organisation: Imperial College London
Department Name: Unlisted

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Festenstein R (2003) Decoding the epigenetic effects of chromatin. in Genome biology

 
Description Response mode project grant
Amount £863,446 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2012 
End 09/2016
 
Title Identification of histone H3 K4acetylation as a novel post-translational modification using a novel antibody 
Description Polyclonal antibody specific to histone H3 lysine 4 acetylation 
Type Of Material Technology assay or reagent 
Year Produced 2011 
Provided To Others? Yes  
Impact Identification that histone H3 is modified on a key residue, lysine 4, in yeast and mammals. This changes our understanding of how gene's are regulated in eukaryotes as indicated by our genome-wide epigenomic and functional studies. 
 
Description AF 
Organisation Medical Research Council (MRC)
Department MRC Clinical Sciences Centre (CSC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided variegating murine model for analysis
Collaborator Contribution Joint publication prior to 2006 in Nature Cell Biology
Impact Demonstrated late replication of heterochromatin-silenced gene. Published in Nature Cell Biology.
 
Description DK 
Organisation Medical Research Council (MRC)
Department MRC National Institute for Medical Research (NIMR)
Country United Kingdom 
Sector Public 
PI Contribution Interchange of ideas and collaboration on papers published before period.
Collaborator Contribution Provision of expertise and transgenic lines
Impact Publication prior to 2006 in Science (2003) demonstrating increased mobility of heterochromatin protein 1 on T cell activation.
 
Description PF 
Organisation Babraham Institute
Country United Kingdom 
Sector Private 
PI Contribution Scientific discussions and presentations at coop meetings
Collaborator Contribution Transfer of 3D FISH technique to our lab.
Impact Transfer of 3D FISH technology. Data included in publication in Nature 2003.
 
Description WR 
Organisation Babraham Institute
Country United Kingdom 
Sector Private 
PI Contribution Made transgenic lines and analysed them to test hypothesis.
Collaborator Contribution Established collaboration on function of DNA methylation in establishing gene silencing by inducing variegation
Impact Discovered that a direct-repeat associated with the Igf2 gene confers variegation on a linked reporter gene in vivo and that this variegation is suppressed by HP1 overexpression. Manuscript in progress.
 
Description TV documentary 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interviewed for EU funded TV documentarty on Epigenetics

Communicated key ideas to a large lay audience
Year(s) Of Engagement Activity 2009
 
Description TV-interview Dublin 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Interviewed at International conference for Friedreich's Ataxia

Raised the profile of the need for research in triplet-repeat diseases
Year(s) Of Engagement Activity 2008