A North West Centre for DNA sample archiving and genotyping

Lead Research Organisation: University of Manchester
Department Name: Medical and Human Sciences


Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.


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International Multiple Sclerosis Genetics Consortium (2011) Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. in Nature

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MacInnes SJ (2015) Genetic variation in inflammatory and bone turnover pathways and risk of osteolytic responses to prosthetic materials. in Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Description National and international guidelines on biobanking
Geographic Reach Europe 
Policy Influence Type Participation in advisory committee
Impact UDBN has contributed significantly through the European Science Foundation Guidelines for Biobanking.
Description MRC Research Grant
Amount £835,372 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 02/2007 
End 01/2010
Description MRC Research Project/MRC
Amount £1,025,475 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 02/2010 
End 01/2013
Title New UDBN disease collections 
Description New diabetes, renal failure, myositis, osteoarthritis, cognitive decline, childhood leukaemia, hip dysplasia, arthroplasty failure collections, 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2010 
Provided To Others? Yes  
Impact These collaborations are allowing UK research groups to work more effectively, gain funding and generate experiments. 
Title New sample collections 
Description New sample collections 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2006 
Provided To Others? Yes  
Impact Access to sample collections and phenotype data, opportunities for increased collaborations, opportunities for research funding. 
Description Archiving of genotype and phenotype data of UDBN collections within European genotype/phenotype archive 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom 
Sector Academic/University 
PI Contribution This collaboration is providing a long-term and secure solution for genotype and phenotype data relating to national sample collections and the access to archive data.
Impact None.
Start Year 2010
Description Closer working and operational relationship between UK Biobank and UDBN 
Organisation UK Biobank
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution We are working towards co-location of UDBN to UK Biobank at Cheadle and the centralisation of all collections and services. UDBN will also be contributing to infrastructure of the proposed UK Biocentre at Cheadle.
Impact Collaborative joint funding between UK Biobank and UDBN has been awarded for further sample collections. These include National Childhood Leukaemic Sample Banking (LRF) and asthma (Innovations in Medicines Initiative).
Start Year 2010
Description Management of National collections of Motor Neurone disease samples 
Organisation Motor Neurone Disease Association (MND)
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution UK DNA Banking Network (UDBN) now manages sample processing and sample distribution for all motor neurone disease research samples for genetic studies.
Impact Requests for samples have been processed resulting in funded studies.
Start Year 2008
Description Relocation of MRC EBV cell line collections to Manchester from ECACC 
Organisation Public Health England
Department Centre for Applied Microbiology and Research (CAMR)
Country United Kingdom 
Sector Public 
PI Contribution Negotiation, planning and operational execution of relocation of exisiting MRC EBV cell line collections to UK Biobank, as part of UK DNA Banking Network infrastructure.
Impact PIs of other associated collections of EBV cell lines have approached UK DNA Banking Network (UDBN) to also relocate their collections to UK Biobank.
Start Year 2010
Description arcOGEN-whole genome association studies of osteoarthritis 
Organisation Versus Arthritis
PI Contribution UDBN processed and distributed 5500 DNA samples for a series of GWAS and other genetic studies within this project.
Impact A series of publications
Start Year 2008
Description DNA Banking Genetics and Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact 100 6 Form pupils at Urmston Grammar School.
50 people at The University of Manchester extra mural programme.
50 people at Manchester Cafe Scientifique

Visits from 6th Form pupils.
Pupils on work experience.
Year(s) Of Engagement Activity 2007,2008
Description Information regarding materials stored in UDBN 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Participants in your research and patient groups
Results and Impact New collections and new requests for existing samples

Requests for talks from local hospitals.
Year(s) Of Engagement Activity 2010