A North West Centre for DNA sample archiving and genotyping
Lead Research Organisation:
University of Manchester
Department Name: Medical and Human Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- University of Manchester, Manchester, United Kingdom (Lead Research Organisation)
- UK Biobank, United Kingdom (Collaboration)
- Public Health England, United Kingdom (Collaboration)
- Motor Neurone Disease Association (MND) (Collaboration)
- Versus Arthritis (Collaboration)
- EMBL - European Bioinformatics Institute, United Kingdom (Collaboration)
Publications
Lilleker JB
(2018)
Response to: 'Antisynthetase syndrome or what else? Different perspectives indicate the need for new classification criteria' by Cavagna .
in Annals of the rheumatic diseases
Lee JJ
(2018)
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
in Nature genetics
Lam M
(2019)
Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.
in American journal of human genetics
Lam M
(2018)
Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018).
in Twin research and human genetics : the official journal of the International Society for Twin Studies
Karlsson Linnér R
(2019)
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
in Nature genetics
Joshi PK
(2017)
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity.
in Nature communications
Jani M
(2014)
Genotyping of immune-related genetic variants identifies TYK2 as a novel associated locus for idiopathic inflammatory myopathies.
in Annals of the rheumatic diseases
International Multiple Sclerosis Genetics Consortium
(2011)
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
in Nature
Hudson G
(2013)
No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls.
in Annals of the rheumatic diseases
| Description | National and international guidelines on biobanking |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in advisory committee |
| Impact | UDBN has contributed significantly through the European Science Foundation Guidelines for Biobanking. |
| Description | MRC Research Grant |
| Amount | £835,372 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2007 |
| End | 01/2010 |
| Description | MRC Research Project/MRC |
| Amount | £1,025,475 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2010 |
| End | 01/2013 |
| Title | New UDBN disease collections |
| Description | New diabetes, renal failure, myositis, osteoarthritis, cognitive decline, childhood leukaemia, hip dysplasia, arthroplasty failure collections, |
| Type Of Material | Database/Collection of Data/Biological Samples |
| Year Produced | 2010 |
| Provided To Others? | Yes |
| Impact | These collaborations are allowing UK research groups to work more effectively, gain funding and generate experiments. |
| Title | New sample collections |
| Description | New sample collections |
| Type Of Material | Database/Collection of Data/Biological Samples |
| Year Produced | 2006 |
| Provided To Others? | Yes |
| Impact | Access to sample collections and phenotype data, opportunities for increased collaborations, opportunities for research funding. |
| Description | Archiving of genotype and phenotype data of UDBN collections within European genotype/phenotype archive |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This collaboration is providing a long-term and secure solution for genotype and phenotype data relating to national sample collections and the access to archive data. |
| Impact | None. |
| Start Year | 2010 |
| Description | Closer working and operational relationship between UK Biobank and UDBN |
| Organisation | UK Biobank |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | We are working towards co-location of UDBN to UK Biobank at Cheadle and the centralisation of all collections and services. UDBN will also be contributing to infrastructure of the proposed UK Biocentre at Cheadle. |
| Impact | Collaborative joint funding between UK Biobank and UDBN has been awarded for further sample collections. These include National Childhood Leukaemic Sample Banking (LRF) and asthma (Innovations in Medicines Initiative). |
| Start Year | 2010 |
| Description | Management of National collections of Motor Neurone disease samples |
| Organisation | Motor Neurone Disease Association (MND) |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | UK DNA Banking Network (UDBN) now manages sample processing and sample distribution for all motor neurone disease research samples for genetic studies. |
| Impact | Requests for samples have been processed resulting in funded studies. |
| Start Year | 2008 |
| Description | Relocation of MRC EBV cell line collections to Manchester from ECACC |
| Organisation | Public Health England |
| Department | Centre for Applied Microbiology and Research (CAMR) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Negotiation, planning and operational execution of relocation of exisiting MRC EBV cell line collections to UK Biobank, as part of UK DNA Banking Network infrastructure. |
| Impact | PIs of other associated collections of EBV cell lines have approached UK DNA Banking Network (UDBN) to also relocate their collections to UK Biobank. |
| Start Year | 2010 |
| Description | arcOGEN-whole genome association studies of osteoarthritis |
| Organisation | Versus Arthritis |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | UDBN processed and distributed 5500 DNA samples for a series of GWAS and other genetic studies within this project. |
| Impact | A series of publications |
| Start Year | 2008 |
| Description | DNA Banking Genetics and Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | 100 6 Form pupils at Urmston Grammar School. 50 people at The University of Manchester extra mural programme. 50 people at Manchester Cafe Scientifique Visits from 6th Form pupils. Pupils on work experience. |
| Year(s) Of Engagement Activity | 2007,2008 |
| Description | Information regarding materials stored in UDBN |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | New collections and new requests for existing samples Requests for talks from local hospitals. |
| Year(s) Of Engagement Activity | 2010 |