Molecular regulation of hyphal alignment in the human pathogenic fungus Candida albicans

Lead Research Organisation: University of Aberdeen
Department Name: School of Medical Sciences

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
 
Description MRC New Investigator Research Grant
Amount £484,840 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2010 
End 01/2013
 
Description Royal Society University Resarch Fellowship
Amount £409,486 (GBP)
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2009 
End 09/2014
 
Description Wellcome Trust Porgramme Grant renewal (Candida albicans cell surface: regulation of the host-fungus interaction)
Amount £1,302,659 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2006 
End 03/2012
 
Description Wellcome Trust equipment grant
Amount £118,721 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2008 
End 11/2010
 
Title New mutants strains developed 
Description Mutants that have altered orientation mechanisms have been developed. These mutants also have utility in the study of calcium signalling in fungi. 
Type Of Material Technology assay or reagent 
Year Produced 2006 
Provided To Others? Yes  
Impact May result in future joint publications - but not as yet. These materials have been provided to other research groups upon request and are also important in framing new research proposals that are now being written (BBSRC LOLA grant). 
 
Description Dr Cheryl Gale, University of Minnesota 
Organisation University of Minnesota
Country United States 
Sector Academic/University 
PI Contribution Dr Brand characterised a mutant in the RSR1 Ras-GtPase encoding gene that was generated in Dr Gale's lab and which had a strong phenotype in its hypha orientation response.
Collaborator Contribution Joint publication -as specified
Impact The following output was generated. This work also supported applications that were made for further funding and fellowships in this area. This led to a successful BBSRC funded project grant and two successful independent fellowship grants for Alex Brand (funded by the Royal Society and the MRC Young Investigators scheme). Brand A., Vacharaksa A., Bendel, C., Norton, J., Haynes, P., Henry-Stanley, M., Wells, C, Ross, K., Gow, N.A.R., & Gale, C.A. (2008). A Ras-like GTP-ase directs hyphal behavior in response to environmental stimuli. Eukaryotic Cell 7, 712-720.
Start Year 2007
 
Description School visits 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact Talks to school children (2 schools) both involving children between 4th and 6th year on medical mycology and microbiology. Talks were also given to two PROBIS (Professional Businessmen) clubs on the topic of medical mycology. A press release was made in 2009 that includes reference to work generated in this grant ( http://www.abdn.ac.uk/news/archive-details-3525.php ). In addition our work on medical mycology was highlighted in "Aberdeen Magazine" 2009 (Insight - Fungal Science - The Enemy Within), Sept pp 52-57.

Mainly in dissemination of information, but also helped in maintaining relations with local school teachers in biology.
Year(s) Of Engagement Activity 2006,2007,2009
 
Description Talk and workshops at a scientific exhibition (From Another Kingdom) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Over 100 members of the general public attended this interactive session discussing various aspects of the growth and diseases caused by fungi. The venue was the Royal Botanical Gorden at Edinburgh.

This was a workshop accompanied a major exhibition and a by a book published in 2010. The exhibition was the largest ever to be mounted covering the fungi.
Year(s) Of Engagement Activity 2010