Genomics approaches to conserved neural stem cell biology in mouse and Drosophila

Lead Research Organisation: University of Cambridge
Department Name: Unlisted

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Brand AH (2008) A new dawn for Aurora? in Nature cell biology

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Edoff K (2007) Detection of GFP during nervous system development in Drosophila melanogaster. in Methods in molecular biology (Clifton, N.J.)

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Egger B (2008) Insights into neural stem cell biology from flies. in Philosophical transactions of the Royal Society of London. Series B, Biological sciences

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Elliott DA (2008) The GAL4 system : a versatile system for the expression of genes. in Methods in molecular biology (Clifton, N.J.)

 
Description 083837/Z/07/Z (Intrinsic determinants of electrical development of embryonic neurons) Richard Baines
Amount £137,462 (GBP)
Funding ID 083837/Z/07/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2008 
End 03/2010
 
Description 084095/Z/07/Z (Genetic control of the formation of neocortical areas) Dr Frederick J Livesey
Amount £546,642 (GBP)
Funding ID 084095/Z/07/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2008 
End 08/2011
 
Description Wellcome Trust Project grant 072441/Z/03/Z (A molecular genetic analysis of cell recruitment in Drosophila nephrogenesis) Helen Skaer
Amount £341,909 (GBP)
Funding ID 072441/Z/03/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2004 
End 08/2007
 
Title DamID vectors 
Description DNA constructs for mapping protein/DNA interactions in vivo in Drosophila 
Type Of Material Technology assay or reagent 
Year Produced 2006 
Provided To Others? Yes  
Impact Freely available research materials 
 
Title www.neuroblast.org 
Description Database 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2006 
Provided To Others? Yes  
Impact Freely available database 
URL http://www.neuroblast.org
 
Description Design of whole genome tiling arrays 
Organisation Netherlands Cancer Institute (NKI)
Country Netherlands 
Sector Academic/University 
PI Contribution Scientific collaboration with Dr Bas van Steensel's lab, Netherlands Cancer Institute, to design whole genome tiling arrays for Drosophila DamID, resulting in a peer-reviewed publication
Collaborator Contribution Scientific collaboration to design whole genome tiling arrays for Drosophila DamID
Impact 17141154
 
Description Dr Helen Skaer's lab, University of Cambridge 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution NA
Collaborator Contribution Scientific collaboration with Dr Helen Skaer's lab, University of Cambridge, to conduct a genome-wide screen for transcriptional targets of Kr, Ct, Doc and Brk, and to determine their role in the development of the Drosophila malphigian tubules (ongoing).
Impact NA
 
Description Dr Stephen Goodwin's lab, University of Glasgow 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution NA
Collaborator Contribution Scientific collaboration with Dr Stephen Goodwin's lab, University of Glasgow, on the identification of target genes of the transcription factor fruitless. Male-specific forms of Fruitless specify the neural circuitry that governs courtship behaviour (ongoing).
Impact NA
 
Description Gifford lab, MIT 
Organisation Massachusetts Institute of Technology
Country United States 
Sector Academic/University 
PI Contribution NA
Collaborator Contribution Livesey group, scientific collaboration with Gifford lab, MIT, on analysis of ChIP on chip data for ~6 months. Benefit to the lab was analysis of primary data and training of postdoctoral fellow on genomic data analysis methods.
Impact NA
 
Description Gotz group, Munich 
Organisation Ludwig Maximilian University of Munich (LMU Munich)
Country Germany 
Sector Academic/University 
PI Contribution NA
Collaborator Contribution Scientific collaboration with Gotz group, Munich, on analyses of regulation of expression of genes bound by neural stem cell transcription factors. 6 months. Benefit to lab was provision of data that was included in submitted manuscript.
Impact NA
 
Description Identifying target genes of the homeobox transcription factor, Even-skipped 
Organisation University of Warwick
Department School of Life Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution We mapped the target genes of Even-skipped throughout the genome.
Collaborator Contribution Dr Baines group, now at the University of Manchester, demonstrated that the homeobox transcription factor, Even-skipped, regulates the acquisition of electrical properties in Drosophila neurons.
Impact 17147779
Start Year 2006
 
Description Interview, The Lancet 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Interview: 'Molecular biologist Andrea Brand: encouraging women in science',The Lancet, 2008, Volume 371, Issue 9617, Page 979

Exposure to health professionals.
Year(s) Of Engagement Activity 2008
 
Description Interview, The Science Show, ABC National Radio, Australia 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Radio interview: 'Regulating genes and neurons in brains', the Science Show, ABC National Radio, Australia, Interview by Robyn Williams, 20 December, 2008

International exposure to the general public.
Year(s) Of Engagement Activity 2008
 
Description Interview, The Times Higher Education Supplement 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Media (as a channel to the public)
Results and Impact Interview: 'Passion drives the best and brightest in biology', The Times Higher Education Supplement, 14 July 2006

Exposure to the general public.
Year(s) Of Engagement Activity 2006
 
Description The Royal Society Rosalind Franklin Award Lecture 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact 2006 Public Lecture: 'Constructing a nervous system: stem cells to synapses', The Royal Society Rosalind Franklin Award Lecture, London

2007 Royal Society Rosalind Franklin Award Project: Organised and led Science Days at University of Cambridge for 180 school children (ages 9-11), including lectures on cell and developmental biology, laboratory experience (made their own DNA, observed their cheek cells under a microscope), visit to the Zoology Museum, and design a web site (see: http://summersciencedays.buzzwebz.com).
Year(s) Of Engagement Activity 2006