Hypoxia/ischaemia in children: Patterns of neuropathology and associated memory impairment

Lead Research Organisation: University College London
Department Name: Unlisted

Abstract

We will work with support groups for children with memory problems and their parents, including the Encephalitis Support Group, Children?s Head Injury Trust, and others, to provide them with information about the syndrome of developmental amnesia and other types of memory disorders, and to provide suggestions for obtaining help to overcome the educational difficulties of memory-impaired children. To reach a wider audience, we will communicate information about this programme and the ways in which the research is helping children with memory problems, through a website, with links to each of the collaborating institutions featured in this application. We will also continue our contacts with the news media and bring to the attention of the public the plight of children with memory impairments, in the hope of raising public awareness. These efforts will feed in due course into the establishment of rehabilitation techniques for treatment of children?s memory problems.

Technical Summary

Using a multidisciplinary approach, we propose to examine the neurodevelopmental basis of memory by studying children and adolescents who have developed frank memory problems or are at risk of developing such problems as a result of damage to the medial temporal lobes. Building on our past research in this area, we aim to characterize the different types of memory disorders arising from hypoxia/ischaemia and other adverse events and to relate these to specific foci of pathology within the medial temporal lobes using structural and functional magnetic resonance imaging and event-related potential (ERP) techniques. We will seek to characterize the impairments in terms of the various aspects or components of long-term memory, including fact or semantic memory, and event or episodic memory, using measures of both recognition and recall. We also propose to carry out a normative study to chart the development of these same aspects of memory function and of their neural correlates. In addition to the search for structure/function relationships, our aims are to search for early signs of impending memory disorders in children with neonatal damage to the medial temporal lobe, and to determine whether the effects of such damage sustained at different stages of childhood differ from those reported after similar damage incurred in adulthood.

Publications

10 25 50
 
Title A video clip to familiarise teachers and SENCOs with the learning difficulties of young patients with the amnesic syndrome 
Description This short video clip is developed to familiarise teachers and special education support workers with the learning problems that developmental amnesic patients face in everyday life, and in particular in the classroom situation. Amnesic patients describe their problems and seek help from their carers in ways that can improve their quality of life and their learning to gain more independence. 
Type Of Art Film/Video/Animation 
Year Produced 2015 
Impact Once completed, this video clip can be distributed to schools and special education specialists. It can also be made available via web-based channels along with reports on paediatric memory problems for families and carers. 
 
Title Gallery exhibition of drawings by children who have suffered traumatic brain injury 
Description As part of Beyond My Brain series, the London Brain Project launched at a gallery an exhibition funded by the GOSH BRC and Arts Council England. The exhibition showcased collaborative art created by children with acquired brain injury and their families, scientists and artists. 
Type Of Art Artwork 
Year Produced 2016 
Impact Brought increased awareness of the mental and physical state of children with brain injury and provided an opportunity for the families to share their experiences of the difficulties encountered. Potential for setting up family support groups to help with educational problems of those affected. 
 
Description Contribution to Early Childhood in Focus Series 7 for policy makers
Geographic Reach National 
Policy Influence Type Citation in systematic reviews
 
Description Contribution to the Public Service Review of Science and Technology
Geographic Reach Europe 
Policy Influence Type Citation in systematic reviews
 
Description Development of a doctorate programme in clinical paediatric neuropsychology
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Expert advice on clinical negligence re the relationship between hippocampal damage and memory dysfunction using brain imaging
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Habit Learning in an educational setting for children with severe epilepsy
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Institute of Medicine Epilepsies Workshop; Health Care Quality and Access and Education of Health Care Providers, Patients and the Public, June 2011
Geographic Reach North America 
Policy Influence Type Participation in advisory committee
 
Description Paediatric Clinical Neuropsychology Post Graduate Diploma (PgDip)
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact This additional training route for those interested in clinical neuropsychology provides training in theoretical and practical experience for post graduate psychology students who will progress to work within the health service in preparation for clinical training.
 
Description Recording of medical variables potentially impacting on management of hypoxia during neonatal stages
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description The Vatican statement on neuroplasticity and education
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
 
Description CEL-LCRN Division 5 Funding
Amount £8,379 (GBP)
Organisation National Institute for Health Research 
Department NIHR Clinical Research Network (CRN)
Sector Public
Country United Kingdom
Start 04/2013 
End 03/2014
 
Description CLRN Contingency Support
Amount £1 (GBP)
Funding ID CEL1747 
Organisation National Institute for Health Research 
Department NIHR Clinical Research Network North Thames
Sector Public
Country United Kingdom
Start 04/2013 
End 03/2014
 
Description Comprehensive Local Research Network (NHS) Infrastructure Support
Amount £63,027 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 07/2009 
End 10/2011
 
Description Doctoral Training Support Fund
Amount £2,500 (GBP)
Organisation Great Ormond Street Hospital (GOSH) 
Sector Hospitals
Country United Kingdom
Start 04/2017 
End 03/2018
 
Description EC Marie Curie Re-integrationFellowship
Amount £54,116 (GBP)
Organisation Marie Sklodowska-Curie Actions 
Sector Academic/University
Country Global
Start 05/2007 
End 07/2008
 
Description Great Ormond Street Hospital Comprehensive Local Research Network (CLRN) Funding
Amount £33,397 (GBP)
Funding ID 5177 
Organisation Great Ormond Street Hospital (GOSH) 
Sector Hospitals
Country United Kingdom
Start 04/2012 
End 03/2013
 
Description Great Ormond Street Hospital Comprehensive Local Research Network (CLRN) Funding Scheme
Amount £20,723 (GBP)
Funding ID 5177 
Organisation Great Ormond Street Hospital (GOSH) 
Sector Hospitals
Country United Kingdom
Start 04/2012 
End 03/2013
 
Description Research Capability Funding
Amount £12,057 (GBP)
Funding ID 12CN02 
Organisation University College London 
Department Institute of Child Health
Sector Academic/University
Country United Kingdom
Start 04/2013 
End 03/2014
 
Title Autobiographical Memory fMRI Paradigm 
Description The development of an fMRI paradigm to evaluate autobriographical memroy in healthy children and paediatric patients 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2008 
Provided To Others? Yes  
Impact Data collection for the behavioural and fMRI paradigms was completed in December 2009, and data analysis has been in progress during the past year. The behavioural paradigm was published (doi:10.1016/j.neuropsychologia.2011.03.008), but the fMRI revealed too weak a signal in the young cohort studied. Two new fMRI paradigms (Reinstatement in Developmental Amnesia; Interaction of memory and language using a recall fMRI Test) are now in progress. 
 
Title DTI analysis of children who received ECMO neonatally 
Description Analysis of MRI datasets of 42 healthy controls and 32 patients treated with ECMO neonatally using tract-based spatial statistics (TBSS; Smith et al, 2006), a method for quantitative analysis of diffusion tensor properties, including fractional anisotropy (FA) and mean diffusivity (MD). 
Type Of Material Biological samples 
Provided To Others? No  
Impact Presentation of a poster at Society for Neuroscience 2013: E. Patai, J. Cooper, M. Mishkin, F. Vargha-Khadem. Exploration of white matter damage in patients who underwent extracorporeal membrane oxygenation treatment in childhood. http://www.abstractsonline.com/Plan/SSResults.aspx 
 
Title Extra-hippocampal damage in macaque monkeys with hippocampal lesions 
Description In association with National Institute of Health, we developed a manual segmentation technique to assess thalamic volumes in macaque monkeys with hippocampal lesions, using in-vivo MRI images. This allowed to investigate the secondary degeneration of extra-hippocampal structures, following damage to the hippocampus. The manual measurement protocol used was directly comparable with measurement technique used in humans, allowing for direct comparison between monkeys with hippocampal lesions and patients with Developmental Amnesia. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2015 
Provided To Others? Yes  
Impact Using MRi images, we are assessing thalamic abnormalities in macaque monkeys with hippocampal lesions, to determine whether secondary degeneration impacts global thalamic volumes. 
 
Title Hippocampal volume measurements from MRI scans 
Description Hippocampal volume measurements have been obtained on 337 patients (children, adolescents and adults) exposed to neonatal hypoxia-ischaemia in early life and 126 healthy control children, adolescents and adults have been obtained (Total sample of patients & controls,N= 463). These measurements have been related to measures of memory function. 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact Hand measured hippocampal volume measurements are considered the gold standard in providing an indication of hippocampal integrity. Subgroups from this sample have been used to relate hippocampal volume measurements to aspects of recall of spatial memory. 
 
Title Neuropsychological and structural and functional MRI in a cohort with early onset of cardiac arrest 
Description A cohort of 28 patients with a history of early cardiac arrest associated with cardiorespiratory disease, and a group of age and gender-matched healthy controls have undergone complete neuropsychological investigations of memory and language function in relation to structural and functional MRI indices of white and grey matter integrity. 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact Data analysis in progress. 
 
Title Norms for children on a test assessing recognition and recall 
Description Provision of normative data for children on the Doors and People Test. This diagnostic tool compares directly the mnemonic processes of recognition and recall. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2006 
Provided To Others? Yes  
Impact The normative data have been published making it possible for researchers to use this test as a diagnostic tool for children. 
URL https://www.pearsonclinical.co.uk/Psychology/ChildCognitionNeuropsychologyandLanguage/ChildMemory/Do...
 
Title tracking the hippocampal circuitry in developmental amnesia 
Description For this project, we a mixture of manual and automatic techniques to investigate extra-hippocampal damage in patients with Developmental Amnesia. Voxel-based morphometry was used to provide whole-brain, automatic measure of grey matter density. In addition, volumes of thalamus and mammillary bodies were measured manually according to a protocol developed in association with collaborators at NIH and Emory University. Volumes of subcortical structures were also obtained automatically using FSL FIRST. Finally, white matter diffusion abnormalities were assessed automatically using Tract-Based Spatial Statistics (TBSS, Smith et al., 2006). 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact Using these approaches, we identified that in addition to the hippocampal atrophy, patients with Developmental Amnesia have abnormalities in the thalamus and the mammillary bodies, as well as the white matter. These abnormalities were found to relate to cognitive deficits in patients. 
 
Title Data base of MRI, DTI, fMRI on neonates and young infants. 
Description Data base of MRI, DTI, fMRI on neonates and young infants. A series of 25 patients with treated Transposition of the Great Arteries and those with Hypoplastic Left Heart Syndrome) and 12 healthy controls with structural and functional MRI data sets (at 8-12 weeks of age), Bailey Scales Neurodevelopmental Assessment, EEG, and Visual Paired Comparison tasks (both at 6-8 months, and at 12-14 months) have been acquired.. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact These data are longitudinal and involve 4 time points up to age 24-30 months. We have not yet reported any of the findings, but the first set of data will be presented at the forthcoming meetings of the Society for Neuroscience in San Diego USA in November 2016. 
 
Title Data base of healthy controls on fMRI of memory and language 
Description A group of 28 healthy controls have undergone fMRI of language and memory to provide standards for the evaluation of these functions in pre- and post-operative assessment of patients undergoing epilepsy surgery 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? No  
Impact We now have a paradigm that will be used with patients to determine at an individual the status of language and memory representation in patients 
 
Title Data base on 130 children and adolescents ranging in age from 8-18 on the memory and learning Application 
Description Normative data have been collected on a memory and learning application to generate standards for evaluation of learning and memory abilities of young patients undergoing temporal lobe surgery and follow up after surgery. 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? No  
Impact This is part of a PhD studentship project that is being submitted as a thesis in the first instance before publication. 
 
Title Database of kinematics 
Description Data base of kinematics (movement analysis) on infants at 6 months and 12 months of age 25 data sets at each age level. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact Data analysis is in progress to chart the development of joint movements of the limbs in infants using motion capture. The findings will be presented at the meetings of the Society for Neuroscience in San Diego, USA in November 2016. 
 
Title Database of neuropsychological function in 126 healthy children 
Description 1) A database on healthy children, adolescents and adults (N= 126) ranging in age from 8 to 35 years providing measures of intelligence, memory, academic attainments, and socioemotional development. 2) A structural MRI database on healthy children (n=126) ranging in age from 8 to 35 years, including T1, T2, volumes, diffusion tensor imaging data sets. 3) A fMRI data set on high-functioning patients with developmental amnesia (n=5) and age and gender-matched healthy controls (n= 10) on two functional paradigms (Reinstatement; Artificial Grammar Learning). 
Type Of Material Database/Collection of data 
Year Produced 2009 
Provided To Others? Yes  
Impact Briefly describe any notable impact(s) resulting from the development of this research tool or method. * The following developments have resulted: 1) Charting the development of white matter tracts in health children in relation to age and gender (x 1 publication) 2) Delineating the thalamocortical white matter connections in individual datasets using diffusion tensor imaging (1 publication + 1 M.Sc student project in progress) 3) Sexual dimorphism in white matter development in pre-adolescence using tract-based spatial statistics 4) Optic radiation changes assessed with diffusion tensor imaging (1 publication) 
 
Title Database on children exposed to neonatal hypoxia-ischaemia associated with prematurity 
Description A large cohort (n=41) of children (8-17 years) exposed to neonatal hypoxia-ischaemia associated with extreme prematurity has been studied. The database consists of detailed neuropsychological and neuroimaging findings relating memory and other cognitive functions to extent of hippocampal pathology and measures of white matter integrity using DTI. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact White matter abnormality is well documented in cohorts of children born extremely premature. While language and intellectual functions have been related to extent of white matter integrity, similar work has not been carried out in similar samples looking at the integrity of different aspects of white matter integrity in the memory circuit. This is the focus of our investigation in this cohort. 
 
Title Database on patients with developmental amnesia 
Description This is the largest database in the world (n=23) of patients with developmental amnesia associated with selective hippocampal pathology resulting from early exposure to hypoxia-ischaemia. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact The discovery of the syndrome of developmental amnesia has challenged existing models of long term memory in relation to its neural substrate. 
 
Title MEG Database 
Description A group of patients with severe and moderate memory impairment, together with a group of healthy controls, have undergone a MEG study to examine associative memory using pattern classifier techniques. The paradigm has been adapted to be suitable for children. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact Acquisition and analysis of electrophysiological data on the encoding of associative memories and their subsequent replay. 
 
Title data base on patients with focal epilepsy and identifiable lesions on MRI 
Description We have collected a data base of approximately 1000 paediatric patients undergoing investigations for focal resections to relieve epilepsy. The data base is divided into focal seizures affecting different lobes and hemispheric side of involvement (Frontal, Temporal, Occipito-parietal, Multi lobar). The neuropsychological data base has access to complete set of neurological, electrophysiological and radiological information, the latter consisting of measures of memory, IQ, and academic attainments. 
Type Of Material Database/Collection of data 
Year Produced 2012 
Provided To Others? Yes  
Impact The data base is being accessed by the Epilepsy Surgery Team at Great Ormond Street Hospital as part of the commissioned Children's Epilepsy Surgery Services(CESS). The neuropsychology data are part of the required investigations being carried out as part of CESS according to NICE guidelines. 
 
Title data base on patients with hypoglycaemia 
Description A data base on a large group of patients with neonatal / infantile onset of hypoglycaemia, investigating cognitive, behavioural, and neuroimaging markers of brain injury and long term outcome at school age. 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact Analyses of data reveal extent of subcortical white matter damage in systems regulating executive dysfunction, movement coordination, and in one subgroup of patients, memory and learning. Disproved the hypothesis that ketotic hypoglycaemia protects the brain against injury. 
 
Description An MEG study of associative memory using multivariate pattern classifier techniques 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution Development of the paradigm and modifications to administer the test to children.
Collaborator Contribution Providing access to MEG system and design of paradigm to enable conducting a pilot study to examine associative memory in healthy children, patients with memory impairments and patients with developmental amnesia.
Impact The following publication has resulted from this collaboration: Pub Med ID 23177479 Presentation of poster at Society for Neuroscience 2011 A. J. HORNER, D. GADIAN, S. JENTSCHKE, L. FUENTEMILLA, T. BALDEWEG, M. MISHKIN, E. DUZEL, F. VARGHA-KHADEM. Hippocampal volume predicts source memory performance in individuals with a history of early hypoxia-ischaemia.
Start Year 2010
 
Description Analysis of white matter abnormalities in the cohort with transposition of the great arteries using the FSL Toolbox 
Organisation University of Oxford
Department Department of Experimental Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution Made the DTI data set available and contributed the expertise of the post doctoral researcher on the project in terms of anatomical specification of the white matter pathways.
Collaborator Contribution Adoption of a method of analysis of diffusion tensor data sets obtained from the TGA cohort
Impact Poster presented at Society for Neuroscience 2010: M. MUNOZ, K. E. WATKINS, M. CHADWICK, D. G. GADIAN, A. HOSKOTE, M. MISHKIN, F. VARGHA-KHADEM. White matter integrity after neonatal hypoxia/ischaemia associated with congenital heart disease
Start Year 2010
 
Description Autobiographical Memory Study 
Organisation Wellcome Trust
Department Wellcome Trust Cente for Neuroimaging
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of the patient and control groups with verified extent of hippocampal pathology and associated levels of memory dysfunction. Provision of neuropsychological characterization of the groups studied with fMRI.
Collaborator Contribution This collaboration involved implementing a functional imaging paradigm of episodic memory on the MRI system at Great Ormond Street to acquire the first functional imaging data set of autobiographical memory in children. Data acquisition on a group of 22 patients with memory impairment and moderate to severe hippocampal pathology, and 15 healthy children has been completed and the data are currently being analyzed.
Impact The following publications have resulted from this collaboration: 1. Pub Med ID 21414334 2. Pub Med ID: 20603137
Start Year 2008
 
Description Cardiac Arrest Collaboration 
Organisation Great Ormond Street Hospital (GOSH)
Department Cardiac Surgery
Country United Kingdom 
Sector Hospitals 
PI Contribution We are in the process of assessing long term memory outcome in relation to indices of hippocampal pathology, and also imaging indices of in brain white matter integrity in a cohort of children who have had cardiac arrest. So far we have collected data on 12 patients and 10 controls.
Collaborator Contribution Selection of the group of patients and medical input into the identification of inclusion criteria.
Impact Data collection still in progress.
Start Year 2013
 
Description Charting the hippocampal-thalamic circuitry using Diffusion Tensor Imaging in developmental amnesia 
Organisation University College London
Department Institute of Child Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Selection of patients and controls, and provision of data sets.
Collaborator Contribution Expertise and advice in analysing Diffusion Tensor Imaging data sets.
Impact Presentation of a poster at Society for Neuroscience 2011: A. M. DZIECIOL, T. BALDEWEG, D. G. GADIAN, S. JENTSCHKE, M. MISHKIN, F. VARGHA-KHADEM. Morphometric brain abnormalities in patients with two different degrees of hippocampal atrophy and memory impairment.
Start Year 2010
 
Description Cognitive outcome in full term children with perinatal hypoxia 
Organisation Imperial College London
Department Faculty of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Our team designed the neuropsychological protocols and conducted the evaluation of the entire cohort. The data have been analyzed and we are awaiting the results of the brain scans.
Collaborator Contribution This collaboration provided access to a group of 44 full term children with a history of perinatal hypoxia/ischaemia. The cohort had undergone neuroimaging studies at various stages of development.
Impact Neuropsychological data analysis has been completed; awaiting the results of the MRI analyses before publication can proceed.
Start Year 2007
 
Description Dissociation between hippocampal versus neostriatal function in spatial memory 
Organisation National Institutes of Health (NIH)
Department Laboratory of Neuropsychology
Country United States 
Sector Public 
PI Contribution Provision of neuropsychology and neuroimaging datasets of patients with developmental amnesia and memory impairment, as well as controls.
Collaborator Contribution Data analysis and relating findings to neuroanatomy of the neostriatal and the hippocampal circuitry.
Impact papers in preparation
Start Year 2013
 
Description Dissociations in cognitive memory in Developmental Amnesia 
Organisation Keele University
Department School of Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributions to data collection, analysis and preparation of publications.
Collaborator Contribution Design of experiments, and methodology for selection of controls to compare with patients with developmental amnesia. Design of experiments, and methodology for selection of controls to compare with patients with developmental amnesia. Design of experiments, and methodology for selection of controls to compare with patients with developmental amnesia. Design of experiments, and methodology for selection of controls to compare with patients with developmental amnesia.
Impact Publications with the following Pub Med ID numbers: 16791103; 19090415; 18589461; 21049360; 19524088; 20006631
Start Year 2006
 
Description Dissociations in cognitive memory in Developmental Amnesia 
Organisation National Institutes of Health (NIH)
Country United States 
Sector Public 
PI Contribution Contributions to data collection, analysis and preparation of publications.
Collaborator Contribution Design of experiments, and methodology for selection of controls to compare with patients with developmental amnesia. Design of experiments, and methodology for selection of controls to compare with patients with developmental amnesia. Design of experiments, and methodology for selection of controls to compare with patients with developmental amnesia. Design of experiments, and methodology for selection of controls to compare with patients with developmental amnesia.
Impact Publications with the following Pub Med ID numbers: 16791103; 19090415; 18589461; 21049360; 19524088; 20006631
Start Year 2006
 
Description Dissociations in cognitive memory in Developmental Amnesia 
Organisation University of Sussex
Department School of Psychology Sussex
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributions to data collection, analysis and preparation of publications.
Collaborator Contribution Design of experiments, and methodology for selection of controls to compare with patients with developmental amnesia. Design of experiments, and methodology for selection of controls to compare with patients with developmental amnesia. Design of experiments, and methodology for selection of controls to compare with patients with developmental amnesia. Design of experiments, and methodology for selection of controls to compare with patients with developmental amnesia.
Impact Publications with the following Pub Med ID numbers: 16791103; 19090415; 18589461; 21049360; 19524088; 20006631
Start Year 2006
 
Description Dissociations in cognitive memory in Developmental Amnesia 
Organisation University of York
Department Department of Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributions to data collection, analysis and preparation of publications.
Collaborator Contribution Design of experiments, and methodology for selection of controls to compare with patients with developmental amnesia. Design of experiments, and methodology for selection of controls to compare with patients with developmental amnesia. Design of experiments, and methodology for selection of controls to compare with patients with developmental amnesia. Design of experiments, and methodology for selection of controls to compare with patients with developmental amnesia.
Impact Publications with the following Pub Med ID numbers: 16791103; 19090415; 18589461; 21049360; 19524088; 20006631
Start Year 2006
 
Description ECMO collaboration 
Organisation Great Ormond Street Hospital (GOSH)
Country United Kingdom 
Sector Hospitals 
PI Contribution We determined the high incidence (44%) of significant memory impairment in relation to prounouced hippocampal pathology in the cohort of ECMO patients treated for cardiorespiratory disease.
Collaborator Contribution The collaboration with Consultants in Intensive Care provided access to a large cohort of children treated with cardiorespiratory disease who received treatment with extracorporeal membrane oxygenation as neonates. This collaboration also enabled access to the longitudinal medical data of the cohort involved in UK Clinical Trials for children with cardiorespiratory disease receiving Extra Corporeal Oxygenation versus Conventional Management, and substantially increased the sample size of the cohort for neuropsychological and neuroimaging studies. Once recruited, our team carried out the investigations to determine the relationship between hypoxia/ischaemia and memory outcome in relation to hippocampal pathology. This collaboration enabled access to the longitudinal medical data of the children involved in UK Clinical Trials for children with cardiorespiratory disease receiving Extra Corporeal Oxygenation versus Conventional Management, and substantially increased the sample size of the cohort for neuropsychological and neuroimaging studies. Once recruited, our team carried out the investigations involved to determine the relationship between hypoxia/ischaemia and memory outcome in relation to hippocampal pathology. The collaboration with the data management and clinical trials team enabled access to the longitudinal medical data of patients involved in UK Clinical Trials for children with cardiorespiratory disease receiving Extra Corporeal Oxygenation versus those receiving Conventional Management, and substantially increased the sample size of the cohort for neuropsychological and neuroimaging studies. Once recruited, our team carried out the investigations involved to determine the relationship between hypoxia/ischaemia and memory outcome in relation to hippocampal pathology.
Impact 1.We have obtained a neuropsychological and neuroimaging data set on 44 paediatric patients with a history of cardiorespiratory disease as neonates, and 65 healthy controls. 2. We submitted to Lancet the first paper reporting the findings in this cohort - Cooper, J.M., Gadian, D.G., Jentschke, S., Goldman, A., Munoz, M., Banks, T., Hoskote, A., Deanfield, J., Baldeweg, T., de Haan, M., Mishkin, M. & Vargha-Khadem, F. Incidence of Selective Memory Impairment after Neonatal Hypoxia/Ischaemia Resulting from Cardiorespiratory Disease.
Start Year 2006
 
Description ECMO collaboration 
Organisation Leicester Royal Infirmary
Country United Kingdom 
Sector Hospitals 
PI Contribution We determined the high incidence (44%) of significant memory impairment in relation to prounouced hippocampal pathology in the cohort of ECMO patients treated for cardiorespiratory disease.
Collaborator Contribution The collaboration with Consultants in Intensive Care provided access to a large cohort of children treated with cardiorespiratory disease who received treatment with extracorporeal membrane oxygenation as neonates. This collaboration also enabled access to the longitudinal medical data of the cohort involved in UK Clinical Trials for children with cardiorespiratory disease receiving Extra Corporeal Oxygenation versus Conventional Management, and substantially increased the sample size of the cohort for neuropsychological and neuroimaging studies. Once recruited, our team carried out the investigations to determine the relationship between hypoxia/ischaemia and memory outcome in relation to hippocampal pathology. This collaboration enabled access to the longitudinal medical data of the children involved in UK Clinical Trials for children with cardiorespiratory disease receiving Extra Corporeal Oxygenation versus Conventional Management, and substantially increased the sample size of the cohort for neuropsychological and neuroimaging studies. Once recruited, our team carried out the investigations involved to determine the relationship between hypoxia/ischaemia and memory outcome in relation to hippocampal pathology. The collaboration with the data management and clinical trials team enabled access to the longitudinal medical data of patients involved in UK Clinical Trials for children with cardiorespiratory disease receiving Extra Corporeal Oxygenation versus those receiving Conventional Management, and substantially increased the sample size of the cohort for neuropsychological and neuroimaging studies. Once recruited, our team carried out the investigations involved to determine the relationship between hypoxia/ischaemia and memory outcome in relation to hippocampal pathology.
Impact 1.We have obtained a neuropsychological and neuroimaging data set on 44 paediatric patients with a history of cardiorespiratory disease as neonates, and 65 healthy controls. 2. We submitted to Lancet the first paper reporting the findings in this cohort - Cooper, J.M., Gadian, D.G., Jentschke, S., Goldman, A., Munoz, M., Banks, T., Hoskote, A., Deanfield, J., Baldeweg, T., de Haan, M., Mishkin, M. & Vargha-Khadem, F. Incidence of Selective Memory Impairment after Neonatal Hypoxia/Ischaemia Resulting from Cardiorespiratory Disease.
Start Year 2006
 
Description ECMO collaboration 
Organisation University of Oxford
Department Nuffield Department of Primary Care Health Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution We determined the high incidence (44%) of significant memory impairment in relation to prounouced hippocampal pathology in the cohort of ECMO patients treated for cardiorespiratory disease.
Collaborator Contribution The collaboration with Consultants in Intensive Care provided access to a large cohort of children treated with cardiorespiratory disease who received treatment with extracorporeal membrane oxygenation as neonates. This collaboration also enabled access to the longitudinal medical data of the cohort involved in UK Clinical Trials for children with cardiorespiratory disease receiving Extra Corporeal Oxygenation versus Conventional Management, and substantially increased the sample size of the cohort for neuropsychological and neuroimaging studies. Once recruited, our team carried out the investigations to determine the relationship between hypoxia/ischaemia and memory outcome in relation to hippocampal pathology. This collaboration enabled access to the longitudinal medical data of the children involved in UK Clinical Trials for children with cardiorespiratory disease receiving Extra Corporeal Oxygenation versus Conventional Management, and substantially increased the sample size of the cohort for neuropsychological and neuroimaging studies. Once recruited, our team carried out the investigations involved to determine the relationship between hypoxia/ischaemia and memory outcome in relation to hippocampal pathology. The collaboration with the data management and clinical trials team enabled access to the longitudinal medical data of patients involved in UK Clinical Trials for children with cardiorespiratory disease receiving Extra Corporeal Oxygenation versus those receiving Conventional Management, and substantially increased the sample size of the cohort for neuropsychological and neuroimaging studies. Once recruited, our team carried out the investigations involved to determine the relationship between hypoxia/ischaemia and memory outcome in relation to hippocampal pathology.
Impact 1.We have obtained a neuropsychological and neuroimaging data set on 44 paediatric patients with a history of cardiorespiratory disease as neonates, and 65 healthy controls. 2. We submitted to Lancet the first paper reporting the findings in this cohort - Cooper, J.M., Gadian, D.G., Jentschke, S., Goldman, A., Munoz, M., Banks, T., Hoskote, A., Deanfield, J., Baldeweg, T., de Haan, M., Mishkin, M. & Vargha-Khadem, F. Incidence of Selective Memory Impairment after Neonatal Hypoxia/Ischaemia Resulting from Cardiorespiratory Disease.
Start Year 2006
 
Description Egocentric versus allocentric spatial working memory in developmental amnesia 
Organisation University of Leeds
Department Institute of Psychological Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Input into the design of the experiments and recruitment of the case with developmental amnesia.
Collaborator Contribution Design of experiments and administration to normal controls and a single case with developmental amnesia.Design of experiments and administration to a group of normal controls and a single case with developmental amnesia
Impact Data analysis in progress
Start Year 2011
 
Description Egocentric versus allocentric spatial working memory in developmental amnesia 
Organisation University of York
Department Department of Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution Input into the design of the experiments and recruitment of the case with developmental amnesia.
Collaborator Contribution Design of experiments and administration to normal controls and a single case with developmental amnesia.Design of experiments and administration to a group of normal controls and a single case with developmental amnesia
Impact Data analysis in progress
Start Year 2011
 
Description Episodic memory and motor skill learning associated with selective brain damage in children with low blood sugar (hypoglycaemia) 
Organisation Great Ormond Street Hospital (GOSH)
Department Department of Endocrinology
Country United Kingdom 
Sector Hospitals 
PI Contribution Devising of neuropsychological protocols to identify the phenotype of children with ketotic and non-ketotic hypoglycaemia.
Collaborator Contribution Provision of cohort and identification of patients into ketotic and non-ketotic sub-groups.
Impact Data collection in progress.
Start Year 2012
 
Description Foxp2 expression using antibody tracing in macaques and marmosets 
Organisation National Institutes of Health (NIH)
Department National Institute of Mental Health (NIMH)
Country United States 
Sector Public 
PI Contribution Extending the behavioural phenotype of the FOXP2 mutation from humans to old and new world monkeys.
Collaborator Contribution Identifying the neuroanatomical structures involved in expression of the Foxp2 gene using antibody tracings.
Impact The collaboration is multidisciplinary involving expertise in neuroanatomy, auditory memory in monkeys, antibody tracing, clinical neuropsychology,
Start Year 2016
 
Description Foxp2 expression using antibody tracing in macaques and marmosets 
Organisation RIKEN
Department RIKEN Brain Science Institute
Country Japan 
Sector Public 
PI Contribution Extending the behavioural phenotype of the FOXP2 mutation from humans to old and new world monkeys.
Collaborator Contribution Identifying the neuroanatomical structures involved in expression of the Foxp2 gene using antibody tracings.
Impact The collaboration is multidisciplinary involving expertise in neuroanatomy, auditory memory in monkeys, antibody tracing, clinical neuropsychology,
Start Year 2016
 
Description High Altitude Study 
Organisation University of Southampton
Department Faculty of Health Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Contribution of electrophysiological expertise to the investigating team.
Collaborator Contribution Participation in an international collaboration examining the potential role of brain adaptation to low oxygen levels, and examining potential contribution of genetic neuroprotection to hypoxic injury.
Impact The following publications have resulted: Pub Med ID: 19807809; 20443973
Start Year 2007
 
Description Incidental Memory Study 
Organisation Great Ormond Street Hospital (GOSH)
Country United Kingdom 
Sector Hospitals 
PI Contribution The study had two parts: (a) to identify anatomical landmarks outside the medial temporal lobe for measuring the volumes of the parahippocampal cortices, and (b) to study the relationship between hippocampal pathology and novelty preference in patients with developmental amnesia. The second part of the study involved the development and validation of the novelty preference paradigm in normal controls and patients with developmental amnesia. This study was carried out by our team. The task is being adapted for functional imaging.
Collaborator Contribution This is the first study of novelty preference in relation to hippocampal pathology in patients with developmental amnesia. The anatomical study is in progress in the laboratory of Anatomy where post mortem brains providing detailed measurements of the hippocampal and parahippocampal regions during various stages of development have been collected. . This collaboration with Consultant Pathologists has provided the opportunity to perform post mortem analyses of brains of children, some exposed to hypoxia. . The collaboration with the Laboratory of Neuropsychology at NIMH, has enabled comparisons to be drawn between visual processing systems of humans and monkeys in relation to hippocampal-dependent recognition memory.
Impact The first paper based on the novelty preference paradigm has been presented at scientific meetings in the US and UK and the relevant paper was published in 2010. Pub Med ID: 20882542
Start Year 2006
 
Description Incidental Memory Study 
Organisation National Institutes of Health (NIH)
Country United States 
Sector Public 
PI Contribution The study had two parts: (a) to identify anatomical landmarks outside the medial temporal lobe for measuring the volumes of the parahippocampal cortices, and (b) to study the relationship between hippocampal pathology and novelty preference in patients with developmental amnesia. The second part of the study involved the development and validation of the novelty preference paradigm in normal controls and patients with developmental amnesia. This study was carried out by our team. The task is being adapted for functional imaging.
Collaborator Contribution This is the first study of novelty preference in relation to hippocampal pathology in patients with developmental amnesia. The anatomical study is in progress in the laboratory of Anatomy where post mortem brains providing detailed measurements of the hippocampal and parahippocampal regions during various stages of development have been collected. . This collaboration with Consultant Pathologists has provided the opportunity to perform post mortem analyses of brains of children, some exposed to hypoxia. . The collaboration with the Laboratory of Neuropsychology at NIMH, has enabled comparisons to be drawn between visual processing systems of humans and monkeys in relation to hippocampal-dependent recognition memory.
Impact The first paper based on the novelty preference paradigm has been presented at scientific meetings in the US and UK and the relevant paper was published in 2010. Pub Med ID: 20882542
Start Year 2006
 
Description Incidental Memory Study 
Organisation University of Castile-La Mancha
Country Spain 
Sector Academic/University 
PI Contribution The study had two parts: (a) to identify anatomical landmarks outside the medial temporal lobe for measuring the volumes of the parahippocampal cortices, and (b) to study the relationship between hippocampal pathology and novelty preference in patients with developmental amnesia. The second part of the study involved the development and validation of the novelty preference paradigm in normal controls and patients with developmental amnesia. This study was carried out by our team. The task is being adapted for functional imaging.
Collaborator Contribution This is the first study of novelty preference in relation to hippocampal pathology in patients with developmental amnesia. The anatomical study is in progress in the laboratory of Anatomy where post mortem brains providing detailed measurements of the hippocampal and parahippocampal regions during various stages of development have been collected. . This collaboration with Consultant Pathologists has provided the opportunity to perform post mortem analyses of brains of children, some exposed to hypoxia. . The collaboration with the Laboratory of Neuropsychology at NIMH, has enabled comparisons to be drawn between visual processing systems of humans and monkeys in relation to hippocampal-dependent recognition memory.
Impact The first paper based on the novelty preference paradigm has been presented at scientific meetings in the US and UK and the relevant paper was published in 2010. Pub Med ID: 20882542
Start Year 2006
 
Description Kilifi Study 
Organisation Wellcome Trust
Department KEMRI-Wellcome Trust Research Programme
Country Kenya 
Sector Multiple 
PI Contribution We provided input and project supervision for a Ph.D. student and oversaw the adaptation of the test of everyday memory for the children participating in the study.
Collaborator Contribution Opportunity to adapt the everyday memory test for young children for use in a different cultural environment. A large cohort of children (approximately 300) exposed to malaria were examined on this test, providing the first systematic evaluation of episodic memory in relation to malaria.
Impact The following publications have resulted: Pub Med ID: 19951424; 20080442; 20566207
Start Year 2006
 
Description Measuring cortical thickness to investigate memory dissociations in developmental amnesia 
Organisation University College London
Department Division of Psychology & Language Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of MRI data sets and expertise in data analysis.
Collaborator Contribution Analysing MRI data sets using Freesurfer to measure volumes and cortical thickness of medial temporal lobe structures.
Impact Undergraduate thesis and preparation of data for publication in a peer-reviewed journal.
Start Year 2010
 
Description Memory follow up of adults with a history of heart or lung transplant 
Organisation Great Ormond Street Hospital (GOSH)
Country United Kingdom 
Sector Hospitals 
PI Contribution I will lead on the Memory outcome component of the multidisciplinary team
Collaborator Contribution psychiatric and adjustment of patients; tracking access to health care and educational prospects of patients; digital tracking tools to ensure that patients receive the necessary follow-ups; psychological outcomes of the cohorts
Impact Wellcome Trust application submitted but declined; NIHR application being prepared
Start Year 2018
 
Description Movement analysis using kinematics to monitor motor coordination 
Organisation Imperial College London
Department Department of Electrical and Electronic Engineering
Country United Kingdom 
Sector Academic/University 
PI Contribution Access to patients and the kinematics laboratory. Research design and generation of questions to be studied.
Collaborator Contribution Technical input into data capture and experimental design.
Impact Design of protocol completed. Data collection has begun, and data collected on a cohort of healthy infants. Data collection will be extended to a cohort of infants with hypoplastic left heart syndrome as well as an additional cohort undergoing deep circulatory arrest; patients treated surgically for transposition of the great arteries as neonates; and patients cardiorespiratory disease who received treatment with extracorporeal membrane oxygenation as neonates.
Start Year 2012
 
Description Movement analysis using kinematics to monitor motor coordination 
Organisation University of Sussex
Department Centre for Computational Neuroscience and Robotics (CCNR)
Country United Kingdom 
Sector Academic/University 
PI Contribution Access to patients and the kinematics laboratory. Research design and generation of questions to be studied.
Collaborator Contribution Technical input into data capture and experimental design.
Impact Design of protocol completed. Data collection has begun, and data collected on a cohort of healthy infants. Data collection will be extended to a cohort of infants with hypoplastic left heart syndrome as well as an additional cohort undergoing deep circulatory arrest; patients treated surgically for transposition of the great arteries as neonates; and patients cardiorespiratory disease who received treatment with extracorporeal membrane oxygenation as neonates.
Start Year 2012
 
Description NIMH Study 
Organisation National Institutes of Health (NIH)
Country United States 
Sector Public 
PI Contribution All the human experiments, including the studies with patients is being carried out by our research team at UCL.
Collaborator Contribution The sum of £210K over 4 years paid by the Laboratory of Neuropsychology to the UCL Institute of Child Health to support a post doctoral research fellow to conduct research on auditory memory in humans (both normal controls and patients with developmental amnesia and associated hippocampal atrophy). The collaboration involves the development of appropriate paradigms for use with both humans and monkeys to enable comparison across species. The research on monkeys is being carried out in the Laboratory of Neuropsychology at NIH.
Impact Two experiments on working memory and long term memory for auditory sounds were conducted with normal controls. Results of these experiments were presented at scientific meetings in the US and UK, and the papers are in preparation for publication in this under researched area. During the past year, the tests validated with normal controls have been administered to patients with developmental amnesia. Data analysis is in progress.
Start Year 2008
 
Description Navigation, space, scenes, and the hippocampus 
Organisation University College London
Department Institute of Cognitive Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Our team provided the neuropsychological data pertaining to patients with developmental amnesia, and provided access to the patients for the experiments.
Collaborator Contribution Design and implementation of experiments to determine the relationship between hippocampal pathology and deficits in spatial navigation, scene memory, and configural learning in patients with amnesia, including those with developmental amnesia.
Impact Some of the tasks developed as part of this collaboration have now been adapted for use with young children and will be adopted in the latest phase of our programme grant due to commence early in 2010. Pub Med ID Numbers: 17143905; 17507060; 18155255
Start Year 2006
 
Description Network Dysfunction following paediatric traumatic brain injury 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Detailed neuropsychological and clinical assessment will be performed by Prof. Vargha Khadem's team (UCL/GOSH), with clinical input from the neurodisability team
Collaborator Contribution The Imperial TBI research group will use advanced magnetic resonance imaging (MRI) methods to study brain networks
Impact No outcomes yet, research grant request
Start Year 2014
 
Description New Semantic Learning in patients with severe versus moderate bilateral hippocampal pathology 
Organisation University of Wisconsin-Madison
Department Department of Psychology
Country United States 
Sector Academic/University 
PI Contribution We administered the New Semantic Learning task to a group of 14 patients with developmental amnesia and severe bilateral hippocampal pathology, 14 patients with moderate memory impairment and moderate hippocampal pathology and a large group of normal controls.
Collaborator Contribution Design of New Semantic Learning task (Satellite Learning).
Impact Data acquisition has been completed and data analysis is in progress.
Start Year 2010
 
Description Remote ischaemic tissue preconditioning in neonates undergoing deep circulatory arrest for treatment of major cardiac abnormality 
Organisation Great Ormond Street Hospital (GOSH)
Department Cardiac Surgery
Country United Kingdom 
Sector Hospitals 
PI Contribution Payment of MRI scanning costs for the patient cohort, purchase of DTI sequence for the MRI scanner, assessment of cognitive outcome in those patients recruited to the study
Collaborator Contribution Selection of the group of patients with Hypoplastic left heart syndrome and additional cohort undergoing deep circulatory arrest.
Impact Ethics application submitted. Grant application to the British Heart Foundation in progress.
Start Year 2012
 
Description TGA Collaboration 
Organisation Great Ormond Street Hospital (GOSH)
Country United Kingdom 
Sector Hospitals 
PI Contribution We assessed long term memory outcome in relation to indices of hippocampal pathology, and also imaging indices of brain white matter integrity, in 45 children who had undergone major open heart surgery during neonatal period. We compared the performance of patients with ventricular septal defect to those with intact ventricular septum, and also healthy controls of comparable age, sex, and IQ (n= 65).
Collaborator Contribution Through collaboration with Consultants in intensive care and Cardiac Surgery, we had the opportunity to evaluate the effects of duration of hypoxia on memory outcome in relation to hippocampal integrity in a cohort of children treated for transposition of the great arteries as neonates. The cohort comprised a subgroup with ventricular septal defect and another with intact ventricular septum.
Impact 1. Through this collaboration we identified a high incidence of memory deficits (28%) in patients who had received open heart surgery for treatment of transposition of the great arteries. The severity of the memory impairment was associated with the degree of hippocampal pathology. In addition, the extent of hippocampal volume reduction was related to duration of hypoxia, as indicated by the longer duration of open heart surgery. 2. The following manuscript has been prepared for publication - Munoz, M., Hoskote, A., Gadian, D.G., Chadwick, M.J., Jentschke, S., Cooper, J., Banks, T., Chong, W.K., Khambadkone, S., Deanfield, J., de Haan, M., Baldeweg, T., Mishkin, M. & Vargha-Khadem, F. Selective memory impairment in children with neonatal cyanosis due to transposition of the great arteries.
Start Year 2006
 
Description UCLH Preterm Collaboration 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution We assessed a cohort (n=40) of extremely preterm born children who had been at risk of hypoxia/ischaemia during the neonatal period to determine the incidence and extent of memory deficits and associated hippocampal abnormality. The performance of the patient group was compared to that of a control group of healthy children (n=65) who were of comparable age and intelligence to the patient group.
Collaborator Contribution Consultant Neonatology input helped with identification of appropriate children born extremely preterm suitable for recruitment into the study. We were provided with the relevant medical information to correlate with the neuropsychological and neuroimaging results collected by our team. This collaboration with UCLH enabled the recruitment of a cohort of extremely preterm born children who were studied with neuropsychological and neuroimaging techniques, and compared with a group of healthy controls. on both neuropsychological performance and brain indices indicative of hippocampal integrity. This collaboration also contributed to the study the medical variables and information about ultrasound scans that were obtained on this cohort during the neonatal period, and subsequently at 1 year and 4 year follow-up investigations.
Impact 1. We have obtained a valuable neuropsychological and neuroimaging data base on a cohort of children who have experienced hypoxic/ischaemic episodes during neonatal life, and a large group of healthy controls. The three phases of this study have been completed, and pending completion of data analysis, the results are in the process of preparation for publication. 2. The following publications have resulted from this collaboration: Pub Med ID: 16750273 ; 16764608; 20712735 3. The following poster was presented at Society for Neuroscience 2010: S. JENTSCHKE, M. MUNOZ, J. COOPER, T. BALDEWEG, D. G. GADIAN, M. DE HAAN, M. MISHKIN, F. VARGHA-KHADEM. Reduced gray matter density in the memory circuit after neonatal hypoxia/ischaemia.
Start Year 2006
 
Description UCLH Preterm Collaboration 
Organisation University College London Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution We assessed a cohort (n=40) of extremely preterm born children who had been at risk of hypoxia/ischaemia during the neonatal period to determine the incidence and extent of memory deficits and associated hippocampal abnormality. The performance of the patient group was compared to that of a control group of healthy children (n=65) who were of comparable age and intelligence to the patient group.
Collaborator Contribution Consultant Neonatology input helped with identification of appropriate children born extremely preterm suitable for recruitment into the study. We were provided with the relevant medical information to correlate with the neuropsychological and neuroimaging results collected by our team. This collaboration with UCLH enabled the recruitment of a cohort of extremely preterm born children who were studied with neuropsychological and neuroimaging techniques, and compared with a group of healthy controls. on both neuropsychological performance and brain indices indicative of hippocampal integrity. This collaboration also contributed to the study the medical variables and information about ultrasound scans that were obtained on this cohort during the neonatal period, and subsequently at 1 year and 4 year follow-up investigations.
Impact 1. We have obtained a valuable neuropsychological and neuroimaging data base on a cohort of children who have experienced hypoxic/ischaemic episodes during neonatal life, and a large group of healthy controls. The three phases of this study have been completed, and pending completion of data analysis, the results are in the process of preparation for publication. 2. The following publications have resulted from this collaboration: Pub Med ID: 16750273 ; 16764608; 20712735 3. The following poster was presented at Society for Neuroscience 2010: S. JENTSCHKE, M. MUNOZ, J. COOPER, T. BALDEWEG, D. G. GADIAN, M. DE HAAN, M. MISHKIN, F. VARGHA-KHADEM. Reduced gray matter density in the memory circuit after neonatal hypoxia/ischaemia.
Start Year 2006
 
Description White matter development and connectivity in healthy children 
Organisation University College London
Department Institute of Child Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided the Diffusion Tensor Imaging database from a cohort of 65 healthy children and contributed to analysis and interpretation of results.
Collaborator Contribution Contributed to the analysis and interpretation of the diffusion tensor imaging data sets.
Impact Two papers have been published: 1. PMID: 21570472 2. PMID: 21940703 One manuscript is in preparation: Seunarine, K.K., Clayden, J.D., Jentschke, J., Muñoz, M., Cooper, J., Chadwick, M.J., Banks, T., Vargha-Khadem, F. & Clark, C.A. Sexual dimorphism in white matter development in pre-adolescence: a tract based spatial statistics study.
Start Year 2009
 
Description Working memory in developmental amnesia 
Organisation University of York
Department Department of Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution The novel paradigms have been validated on patients with developmental amnesia. We selected the patients to be studied on the basis of criteria developed by our team.
Collaborator Contribution Design of experiments on working memory.
Impact 1. Pub Med ID Number: 20006631. 2. Pub Med ID Number: 21671734
Start Year 2008
 
Title A novel technique for learning new information in the classroom 
Description We have developed a technique for teaching new information to children who suffer from memory and learning problems. This method is particularly helpful for children who have damage to the memory structures as a result of lack of oxygen to the brain associated with epilepsy, cardiac surgery, respiratory problems, etc. The development of this technique has been facilitated by our current programme grant funding from the MRC. We have been in touch with the UCL Translational Office and the UCL Digital Health Office to seek partnership with industry, and to find another partner through the UCL Institute of Education to further this development. 
Type Therapeutic Intervention - Psychological/Behavioural
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2015
Development Status Actively seeking support
Impact This development could lead to new ways of teaching and examining students with memory problems in primary and secondary level education 
 
Title Memory Disorders Clinic at Great Ormond Street Hospital for Children 
Description Development of a monthly clinic for diagnosis of memory disorders and appropriate educational interventions for children with damage to the memory circuits of the brain. This clinic is funded by the NHS. 
Type Therapeutic Intervention - Psychological/Behavioural
Current Stage Of Development Refinement. Clinical
Year Development Stage Completed 2011
Development Status Under active development/distribution
Impact This clinic provides a specialist service and contributes to evaluation of learning outcomes for children who have undergone epilepsy surgery. 
 
Title Tablet-based assessment of verbal and nonverbal learning and memory 
Description This tablet-based set of learning games has been developed to provide diagnostic information about the status of learning and memory in patients considered for epilepsy surgery, and to provide prognostic indicators of language and memory outcome after surgery for clinicians and families. This information will guide the educational programmes of the children returning to the classroom after their surgical treatment. Now seeking support to expand the patient cohort and determine the efficacy of the product. 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2017
Development Status Actively seeking support
Impact This development may lead to shortening the neuropsychological assessments that currently take several hours. It may also lead to test development that can be made commercially available. 
 
Description 'How does your Memory work?' - BBC Horizon 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact An interview describing how the brain memory network works and how it is divided into different components, each subserving a different aspect of mnemonic function.

There is now a recognition that memory problems are a feature of many neurodevelopmental disorders requiring educational assistance. At Great Ormond Street Hospital, we will be starting a memory disorders clinic for children with brain disease/insult.
Year(s) Of Engagement Activity 2008
 
Description 'Me & My Memory' - Radio 4 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A radio interview about normal and abnormal memory function.

Contributed to further recognition by parents, health professionals, and educators of the importance of memory dysfunction.
Year(s) Of Engagement Activity 2006
 
Description 'Preverbal Memories'- BBC News 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Discussed the concept of preverbal memories and the possibility that infantile amnesia was due to the inability of the young child to verbalize their memories of events and episodes experienced.

Many parents wrote asking to have their child assessed because of memory problems.
Year(s) Of Engagement Activity 2007
 
Description 'Working Memory' - Radio 4 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A radio interview about normal and abnormal memory function.

Contributed to the further recognition by parents, health professionals, and educators of the importance of memory dysfunction and the way this problem interferes with schooling and behaviour.
Year(s) Of Engagement Activity 2008
 
Description 103. Report on Bird et al., (2015), Today.com 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact 103. Report on Bird et al., (2015), Today.com, 02 Nov 2015: http://www.today.com/health/want-preserve-memory-more-vividly-follow-these-steps-t52596
Year(s) Of Engagement Activity 2015
URL http://www.today.com/health/want-preserve-memory-more-vividly-follow-these-steps-t52596
 
Description 103. Report on Bird et al., (2015), Today.com - Neil Burgess 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact 103. Report on Bird et al., (2015), Today.com, 02 Nov 2015: http://www.today.com/health/want-preserve-memory-more-vividly-follow-these-steps-t52596
Year(s) Of Engagement Activity 2015
URL http://www.today.com/health/want-preserve-memory-more-vividly-follow-these-steps-t52596
 
Description Al-Jazeera English interview 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Al-Jazeera interview with Faraneh Vargha-Khadem
Year(s) Of Engagement Activity 2015
 
Description Associated Press interview 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Associated Press interview, Faraneh Vargha-Khadem and Michelle De Haan
Year(s) Of Engagement Activity 2014
 
Description BBC 5Live Science Night with The Naked Scientists 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact One hour live radio talking about memory and taking calls from the general public

TBC
Year(s) Of Engagement Activity 2012
 
Description Centre for Brain and Cognitive Development Seminar Series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact PI invited to deliver a seminar entitled, 'Neonatal hypoxia, hippocampal damage and selective memory impairment'

Dissemination of new knowledge to an expert audience
Year(s) Of Engagement Activity 2013
 
Description Chaucer Club 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact PI invited to deliver talk at the Chaucer Club, MRC Brain & Cognition Unit, Cambridge
Title: Neonatal hypoxia, hippocampal damage and episodic memory impairment: A causal sequence?

Dissemination of new knowledge to an expert audience
Year(s) Of Engagement Activity 2013
 
Description Collaboration with the artist, Gayle Chong Kwan 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Collaborated with Gayle Chong Kwan who created an installation for the Wellcome Trust, Euston Road, London, UK

TBC
Year(s) Of Engagement Activity 2012
 
Description Comment in New Scientist on research on implanting memories during sleep - Neil Burgess 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Comment in New Scientist on research on implanting memories during sleep - Neil Burgess
Year(s) Of Engagement Activity 2015
URL http://www.newscientist.com/article/dn27115-new-memories-implanted-in-mice-while-they-sleep.html#.VP...
 
Description Comment on how the brain recollects episodic memory. Neil Burgess 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact 100. Comment on how the brain recollects episodic memory. 02 July 2015.
Year(s) Of Engagement Activity 2015
URL http://www.ucl.ac.uk/news/news-articles/0715/020615-how-brain-reconstructs-past.
 
Description Commentary for "Nature" 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Faraneh Vargha-Khadem - commentary in "Nature"
Year(s) Of Engagement Activity 2014
 
Description Dhaka Shishu Hospital 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact Principal investigator delivered a week of lectures and workshops to local health professionals. This included training in neuropsychological testing procedures.

Local health professionals have started administering neuropsychological assessments as part of their developmental assessments.
Year(s) Of Engagement Activity 2012
 
Description Effects of neonatal hypoxia on the developing brain 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation to the professional healthcare workers, mainly neonatologists, to introduce diagnostic and recording measures to monitor extent of hypoxia and potential to damage the memory circuit of the developing brain
Year(s) Of Engagement Activity 2018
 
Description Institute of Psychiatry Clinical Neuroanatomy Seminar Series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact PI invited to deliver a talk at the IoP Clinical Neuroanatomy Seminar Series
Title: Growing up without Episodic Memory

Dissemination of new knowledge to an expert audience
Year(s) Of Engagement Activity 2012
 
Description Korean TV interview 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Korean TV, KBS interview, Faraneh Vargha-Khadem
Year(s) Of Engagement Activity 2015
 
Description Lecture (Royal Institution) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Delivered the prestigious Friday Evening Discourse at the Royal Institution to members of the RI and members of the public. The lecture was recorded and is now free to view online via the Ri Channel and on YouTube.

The lecture was recorded and is now free to view online via the Ri Channel and on YouTube.
Year(s) Of Engagement Activity 2014
 
Description Lecture - Jerusalem 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact PI invited to deliver a seminar entitled, Hypoxia-Ischaemia, hippocampal damage and memory impairment: A causal hypothesis?

Dissemination of new knowledge to an expert audience
Year(s) Of Engagement Activity 2014
 
Description Lecture Vienna 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact PI invited to give a lecture, entitled Abnormalities of the articulation brain network at European Academy of Childhood Disability, Vienna, Austria.

Dissemination of new knowledge to an expert audience
Year(s) Of Engagement Activity 2014
 
Description Lecture at NIMH Bethesda, Maryland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact PI invited to deliver lecture at entitled Growing up without an autobiography

Dissemination of new knowledge to an expert audience
Year(s) Of Engagement Activity 2014
 
Description London Brain Project - The Beyond Series 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The Beyond Series have been launched by a group of Ph.D students in the PI's and Co-PI's academic groups to bring public awareness to the medical conditions that young patients suffer from (e.g. Epilepsy, Tourette's Syndrome). Patients are encouraged to use the arts to express their journey through their illness.
Year(s) Of Engagement Activity 2015
URL http://www.londonbrainproject.com
 
Description Memory research on A level Syllabus 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Research on hippocampal plasticity is core reading on the A-Level syllabus. I continued to liaise directly with students and teachers, and provided materials to assist with the continuing professional development for teachers.
Year(s) Of Engagement Activity 2016
 
Description New York Times magazine - 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A story on navigation and memory for the March 20th 2016 issue of the New York Times Magazine featuring the work of Eleanor Maguire
Year(s) Of Engagement Activity 2016
 
Description Public Science festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Dissemination of information to public
Year(s) Of Engagement Activity 2014
 
Description STEM ambassador 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Luc Berthouze -I have been a STEM ambassador (http://www.stemnet.org.uk/ambassadors/) since 2014.
As part of this I have been engaged in the following activities:

STEM Career fair, Ardingly College, 06/2014 (about 300 pupils) Science Open Day, Burgess Hill School for Girls, 10/2014 (about 100 pupils) How the brain works, Estcots Primary School, East Grinstead, 05/06/2015 (about 50 pupils) Development of a end-to-end STEM development plan, Burgess Hill School for Girls, 03/2016-ongoing

Also I have been involved in Widening Participation whereby schools come to the University.

The Brain as a Complex System, 11-13/05/2015 (about 150 pupils)
Year(s) Of Engagement Activity 2014,2015,2016
URL http://www.stemnet.org.uk/ambassadors
 
Description Science Museum London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Inclusion of research on the hippocampus and autobiographical memory in the 'Who Am I' gallery at the Science Museum, London.

This display informs the general public about autobiographical and spatial memory and the brain.
Year(s) Of Engagement Activity 2010
 
Description Science Network Interview 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Invited to participate in a discussion with Madeleine Keehner and Mary Hegarty on spatial cognition

TBC
Year(s) Of Engagement Activity 2011
 
Description Society for Neuroscience 2012 Nanosymposium 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact A. M. DZIECIOL, D. G. GADIAN, T. BALDEWEG, M. MISHKIN, F. VARGHA-KHADEM; White matter abnormalities associated with severe hippocampal atrophy in patients with developmental amnesia. Program No. 18.09. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online. www.sfn.org

TBC
Year(s) Of Engagement Activity 2012
 
Description Society for Neuroscience 2012 poster presentation 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact S. GEVA, J. COOPER, D. GADIAN, M. MISHKIN, F. VARGHA-KHADEM; Performance on an immediate memory task with increasing memory load is impaired in patients with selective hippocampal pathology of early onset. Program No. 197.01/ZZ11 . 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online.
www.sfn.org

TBC
Year(s) Of Engagement Activity Pre-2006,2012
 
Description Society for Neuroscience 2012 poster presentation 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact E. PATAI, J. COOPER, A. M. DZIECIOL, D. G. GADIAN, F. VARGHA-KHADEM; . Visual recall and recognition are correlated with extent of selective hippocampal injury of early onset. Program No.194.24/XX10 . 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online.
www.sfn.org.

TBC
Year(s) Of Engagement Activity 2012
 
Description Society for Neuroscience 2013 Poster Presentation 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Geva S, Jentschke S, Vargha-Khadem F. Motor function in children exposed to hypoxia-ischemia. Program 77.03/SS9. 2013 Neuroscience Meeting Planner, San Diego, CA. Society for Neuroscience. Online. www.sfn.org.

Dissemination of results to academic audience; opportunity for postdoc presenting to receive critical feedback from peers.
Year(s) Of Engagement Activity 2013
URL http://www.abstractsonline.com/plan/AdvancedSearch.aspx
 
Description Society for Neuroscience 2013 Poster Presentation 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Patai E, Cooper J, Mishkin M, Vargha-Khadem F. Exploration of white matter damage in patients who underwent extracorporeal membrane oxygenation treatment in childhood. Program 145.10/M12. 2013 Neuroscience Meeting Planner, San Diego, CA. Society for Neuroscience. Online. www.sfn.org.

Dissemination of results to academic audience; opportunity for postdoc presenting to receive critical feedback from peers.
Year(s) Of Engagement Activity 2013
URL http://www.abstractsonline.com/plan/AdvancedSearch.aspx
 
Description Society for Neuroscience 2013 Poster Presentation 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dzieciol AM, Saleem KS, Saunders RC, Bachevalier J, Mishkin M, Vargha-Khadem F. Thalamic and mammillary body damage in developmental amnesia. Program 761.18/GGG26. 2013 Neuroscience Meeting Planner, San Diego, CA. Society for Neuroscience. Online. www.sfn.org.

Dissemination of results to academic audience; opportunity for postdoc presenting to receive critical feedback from peers.
Year(s) Of Engagement Activity 2013
URL http://www.abstractsonline.com/plan/AdvancedSearch.aspx
 
Description TED Salon Interview 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Online talk entitled, "Where did I park my car?" which was previously delivered at the Unicorn Theatre, London, in November 2011

TBC
Year(s) Of Engagement Activity 2011
 
Description The Great Brain Experiment 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Participation in a Wellcome Trust funded project that included the development of an app that was launched during Brain Awareness Week in March 2013. The app engaged the public using games based on cognitive research.

TBC
Year(s) Of Engagement Activity 2013
URL http://www.thegreatbrainexperiment.com/
 
Description The Ideas That Make Us 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Interview for a BBC Radio 4 series of programmes on the history of ideas. In this particular programme, the PI discussed the impact of memory on the representation of ideas.

TBC
Year(s) Of Engagement Activity 2013
URL http://www.bbc.co.uk/programmes/b03b2g2j
 
Description United Nations Session 55: Commission on the Status of Women - Non-Governmental Organizations side event, New York, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Presented two talks as part of a panel of speakers addressing the potential for educating girls beyond the basic curricula.
Title of Talk 1: Rethinking education for girls and women: Beyond basic curricula
Title of Talk 2: Neuroplasticity and transformation: From the individual to society


Plans to collaborate with Stonybrook University, New York, to develop a curriculum for primary school children to improve attention and social skills to enhance learning and academic development.
Year(s) Of Engagement Activity 2011
 
Description Wondermind 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The design and development of a series of interactive games, videos and an online blog to help children learn about the science of the developing human brain. Children can access these games and other media at the Alice in Wonderland exhibition at Tate Liverpool and also via the Tate website.

Wondermind mixes science and artwork related to Alice in Wonderland in a series of pioneering interactive games, videos and an online blog to help children learn about the science of the developing human brain. It was developed through collaboration between UCL, the Tate Modern and Preloaded and funded by a Wellcome Trust Society Award. Wondermind was accessed 257, 352 times between its launch in the fall of 2011 and August 2012, with an additional 38, 010 people accessing it at terminals in the Tate Liverpool during the Alice in Wonderland exhibit. The online user survey showed that 93% of respondents said they had enjoyed using Wondermind and would use it again, and 64% agreeing that they knew 'more about the parts and development of the brain' after playing the games. The Wondermind website blog, which provided a forum for public debate and discussion, includes 469 approved user comments. The project also produced a learning resource, with accompanying teacher notes and a pupil pack for KS2-aged children. Teacher observations undertaken by EdComs indicated that teachers favourably compared Wondermind to other digital learning resources, noting the design quality and reactions from students. Wondermind has been nominated for several awards including two British Interactive Media Awards (BIMAs) - in the Leisure&Culture and Education&Outreach
Year(s) Of Engagement Activity 2011
 
Description journal articles 2015 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Eleanor Maguire - My work was also reported in a range of popular magazines (e.g. National Geographic, New Scientist, NZZ-Folio Zurich), and I gave interviews for pieces on the BBC Website, National Geographic TV, National Radio of Slovenia. I was also interviewed by a number of authors who are writing popular science books on memory or navigation (Helen Thomson; Ylva and Hilde Østby; Merim Bilalic).
Year(s) Of Engagement Activity 2015
 
Description work reported in journals 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Towards the end of 2014, my work was covered in many media publications, for example in the New York Times, Scientific American, National Geographic. It was widely reported on the web - e.g. on the BBC website. This was linked to my UCL colleague, John O'Keefe, winning the Nobel Prize.
Year(s) Of Engagement Activity 2014