A cognitive-experimental and genetic study of ADHD and control sibling pairs

Lead Research Organisation: King's College London
Department Name: Unlisted

Abstract

Attention deficit hyperactivity disorder (ADHD) is the most common cause of referral to child mental health services. ADHD consists of severe overactive, impulsive and inattentive behaviours, which cause considerable social and academic difficulties. The risk for developing ADHD is largely genetic, with evidence that genes affecting the regulation of dopamine, an important brain chemical, increase risk for the disorder. On specific psychological tests children with ADHD show an unusual profile. They often have difficulties inhibiting inappropriate responses and sustaining attention over time, but when the tasks are made faster or more rewarding, their performance can improve drastically. This suggests difficulties in regulating levels of activation and arousal, and sustained attention.
 
This project brings together genetic and psychological research to identify the psychological processes that mediate the genetic influences on behaviour. We will compare the performance of children with ADHD and their nearest-age siblings, and comparison sibling pairs, on a detailed psychological test battery. Comparing sibling pairs enables us to estimate familial influences. We will also collect DNA samples, which will allow us to study the contribution of specific genes to ADHD and performance on the psychological tests. Further work will use brain imaging to study the processes involved in more detail. We hope this research will contribute to improved diagnosis and treatment through improved knowledge of the processes involved. In addition, the findings are likely to help reduce stigma by raising awareness and understanding of ADHD by parents and teachers.

Technical Summary

The main aim of this five-year project is to identify psychological processes that mediate genetic influences on attention deficit hyperactivity disorder (ADHD) and provide a functional understanding of the mechanisms involved. ADHD is one of the most prevalent, stable and heritable disorders of childhood. Recent research on both the genetics of ADHD and on the possible psychological mechanisms have led to an improved understanding of the aetiology and processes involved. Nevertheless, little is known about how these findings fit together. We propose to apply cognitive-experimental, quantitative genetic and molecular genetic approaches to 400 children with DSM-IV ADHD and their nearest-age siblings, as well as to 150 control probands and their nearest-age siblings. We will assess the performance of each child on experimental, theory-driven tasks that have been associated with ADHD or which tap into reward mechanisms. Model-fitting analyses on the sibling-pair data enable us to test the hypothesis that the psychological processes associated with ADHD show significant familiality and significant shared familiality with ADHD. Molecular genetic analyses enable us to test the second main hypothesis that dopamine and related neurotransmitter pathway genes are associated with these psychological processes, as well as with the ADHD diagnosis. Combining these different approaches enables us to study potential endophenotypes, at the level of psychological processes, that will help explain how genetic risk factors give rise to the behavioural disorder of ADHD. In the final phase of the project we propose to extend the investigation to brain processes, by carrying out a pilot functional brain imaging study that aims to establish procedures for a future larger-scale brain imaging investigation into ADHD and associated genotypes.

Publications

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Banaschewski T (2012) Neuropsychological correlates of emotional lability in children with ADHD. in Journal of child psychology and psychiatry, and allied disciplines

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Cadman T (2016) Six-year follow-up study of combined type ADHD from childhood to young adulthood: Predictors of functional impairment and comorbid symptoms. in European psychiatry : the journal of the Association of European Psychiatrists

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Chen W (2008) DSM-IV combined type ADHD shows familial association with sibling trait scores: a sampling strategy for QTL linkage. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

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Cheung CH (2015) Childhood predictors of adolescent and young adult outcome in ADHD. in Journal of psychiatric research

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Cheung CH (2012) Aetiology for the covariation between combined type ADHD and reading difficulties in a family study: the role of IQ. in Journal of child psychology and psychiatry, and allied disciplines

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Cheung CH (2016) Cognitive and neurophysiological markers of ADHD persistence and remission. in The British journal of psychiatry : the journal of mental science

 
Description Citation in a clinical review on ADHD (Asherson, Buitelaar, Faraone, Rohde, 2016, Lancet Psychiatry)
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical reviews
URL http://dx.doi.org/10.1016/S2215-0366(16)30032-3
 
Guideline Title Evidence-based guidelines for the pharmacological management of attention deficit hyperactivity disorder: Update on Journal of Psychopharmacology recommendations from the British Association for Psychopharmacology (Journal of Psychopharmacology)
Description Citation in the British Association for Psychopharmacology guidelines for ADHD
Geographic Reach Europe 
Policy Influence Type Citation in clinical guidelines
 
Guideline Title Updated European Consensus Statement on diagnosis and treatment of adult ADHD (European Psychiatry Volume 56, February 2019, Pages 14-34)
Description Citation in the Updated European Consensus Statement on diagnosis and treatment of adult ADHD
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
 
Description BGA Travel Fellowship (to postdoc Dr Michelini, to attend Behaviour Genetics Association Conference in Oslo, Norway)
Amount $100 (USD)
Organisation Behavior Genetics Association 
Sector Charity/Non Profit
Country Global
Start 06/2017 
End 07/2017
 
Description EMBO short-term fellowship to PhD student Giorgia Michelini
Amount € 4,820 (EUR)
Organisation European Molecular Biology Organisation 
Sector Learned Society
Country European Union (EU)
Start 05/2015 
End 07/2015
 
Description European Commission (MARIE SKLODOWSKA-CURIE ETN)
Amount € 410,907 (EUR)
Funding ID 643051 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2015 
End 12/2018
 
Description European Commission Horizon 2020
Amount € 569,000 (EUR)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2016 
End 12/2020
 
Description Guarantors of Brain Travel Award to PhD student Celeste Cheung
Amount £600 (GBP)
Organisation Guarantors of Brain 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2014 
End 05/2014
 
Description KCL Graduate School Travel Award (to postdoc Dr Michelin, to attend Behaviour Genetics Association Conference in Oslo, Norway)
Amount £300 (GBP)
Organisation King's College London 
Sector Academic/University
Country United Kingdom
Start 06/2017 
End 07/2017
 
Description KCL Graduate School Travel Award to PhD student Giorgia Michelini
Amount £300 (GBP)
Organisation King's College London 
Sector Academic/University
Country United Kingdom
Start 05/2015 
End 05/2015
 
Description King's Together strategic grant
Amount £100,189 (GBP)
Organisation King's College London 
Sector Academic/University
Country United Kingdom
Start 04/2019 
End 04/2020
 
Description NIHR Maudsley Biomedical Research Centre Post-Doctoral Research Associate Fellowship
Amount £60,000 (GBP)
Organisation NIHR London (South) CRN 
Sector Public
Country United Kingdom
Start 08/2017 
End 08/2018
 
Description PhD Studentship (Open Competition)
Amount £85,000 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 10/2010 
End 09/2014
 
Description Project grant
Amount £194,527 (GBP)
Funding ID SP4546 
Organisation Action Medical Research 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2010 
End 02/2014
 
Description Project grant
Amount £169,944 (GBP)
Funding ID Gn2080 
Organisation Action Medical Research 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2013 
End 02/2016
 
Description Psychology Postgraduate Affairs Group study visit bursary to PhD student Giorgia Michelini
Amount £200 (GBP)
Organisation Psychology Postgraduate Affairs Group (PsyPAG) 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2015 
End 05/2015
 
Description Sagvolden Eunethydis Junior Travel Scholarship to PhD student Celeste Cheung
Amount £1,500 (GBP)
Organisation Eunethydis 
Sector Charity/Non Profit
Country Unknown
Start 05/2012 
End 05/2012
 
Title Development of a new task: the "fast task" 
Description We developed a task, the "fast task", to study reaction time variability (RTV) in ADHD, and the extent to which RTV can be normalised when using task manipulations with rewards and event rate. We developed this task initially for use both in our MRC-funded project (PI Kuntsi) and in a second project funded by the Wellcome trust (PI Kuntsi). We have established test-retest reliability and heritability for performance on the task (Kuntsi et al. 2006), and have shown how performance on the task is very strongly associated with ADHD both at the phenotypic and the genetic/familial level (Andreou et al. 2007; Kuntsi et al. 2009; Kuntsi et al. 2010; Wood et al. 2010; Wood et al. 2011; Kuntsi et al. 2012). 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2006 
Provided To Others? Yes  
Impact We have subsequently modified the task also for use within EEG; data collection is ongoing on several projects. We have made the task available to other scientists and it is being used in several studies across disorders (such as a comparison across ADHD and autism), which will provide further insight into intra-individual variability and its causes across disorders. 
 
Title ADHD GWAS Neuropsychology Consortium 
Description We have shared our cognitive and genetic data with an international ADHD GWAS Neuropsychology group to enable large-scale GWAS analyses across sites. We are one of the currently three leading teams of this international collaboration, leading one of three ongoing sets of analyses. 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? Yes  
Impact Analyses are ongoing. 
 
Title Analysis method: application of multivariate familial factor analysis to sibling data 
Description In a paper published in the Archives of General Psychiatry (Kuntsi et al. 2010), we described and applied a multivariate familial factor analysis method that can be used on sibling data to investigate the number of familial cognitive impairment (or other objectively-measured) factors that underlie a disorder such as ADHD. Kuntsi J, Wood AC, Rijsdijk F, Johnson KA, Andreou P, Albrecht B, Arias-Vasquez A, Buitelaar JK, Mcloughlin G., Rommelse NNJ, Sergeant JA, Sonuga-Barke EJS, Uebel H, van der Meere JJ, Banaschewski T, Gill M, Manor I, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Steinhausen HC, Faraone SV, Asherson P. (2010). Separation of cognitive impairments in attention-deficit/hyperactivity disorder into 2 familial factors, Archives of General Psychiatry, 67, 1159-1166. http://dx.doi.org/10.1001/archgenpsychiatry.2010.139 PMid:21041617 
Type Of Material Data analysis technique 
Year Produced 2010 
Provided To Others? Yes  
Impact The analysis method has since been applied to a separate Dutch ADHD and control sibling-pair dataset, with the PI and other team members invited to be co-authors and consultants. Frazier-Wood AC, Bralten J et al. (2012). American Journal of Medical Genetics (Neuropsychiatric Genetics), 159B, 131-140. 
URL http://dx.doi.org/10.1001/archgenpsychiatry.2010.139
 
Title Analysis method: application of the bivariate DeFries and Fulker method to sibling data 
Description In our publication (below) we described a new statistical analysis method which represents an application of the bivariate DeFries and Fulker method to sibling data. Professor Pak Sham and Dr Ben Neale (co-authors on the publication) played key roles in developing this method. Andreou, P., Chen, W., Christiansen, H., Gabriels, I., Heise, A., Meidad, S., Muller, U.C., Uebel, H., Banaschewski, T., Manor, I., Neale, B., Oades, R., Roeyers, H., Rothenberger, A., Sham. P., Steinhausen, H.-C., Asherson, P., Kuntsi, J. (2007). Reaction time performance in ADHD: improvement under fast-incentive condition and familial effects. Psychological Medicine, 37, 1703-1716. 
Type Of Material Data analysis technique 
Year Produced 2007 
Provided To Others? Yes  
Impact The paper was published in December 2007; 72 citations (by September 2014) suggest significant impact of this paper. 
 
Title ENIGMA ADHD fMRI consortium 
Description We have shared our fMRI data with an international consortium 'ENIGMA' to enable large-scale analyses across international sites. 
Type Of Material Database/Collection of data 
Year Produced 2014 
Provided To Others? Yes  
Impact Initial results have been presented at conferences such as the World Congress of Psychiatry, Madrid, 18/9/2014 (Hoogman et al.). The following paper has been published: Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis. Hoogman M, Bralten J, Hibar DP, Mennes M, Zwiers MP, Schweren LS, van Hulzen KJ, Medland SE, Shumskaya E, Jahanshad N, Zeeuw P, Szekely E, Sudre G, Wolfers T, Onnink AM, Dammers JT, Mostert JC, Vives-Gilabert Y, Kohls G, Oberwelland E, Seitz J, Schulte-Rüther M, Ambrosino S, Doyle AE, Høvik MF, Dramsdahl M, Tamm L, van Erp TG, Dale A, Schork A, Conzelmann A, Zierhut K, Baur R, McCarthy H, Yoncheva YN, Cubillo A, Chantiluke K, Mehta MA, Paloyelis Y, Hohmann S, Baumeister S, Bramati I, Mattos P, Tovar-Moll F, Douglas P, Banaschewski T, Brandeis D, Kuntsi J, Asherson P, Rubia K, Kelly C, Martino AD, Milham MP, Castellanos FX, Frodl T, Zentis M, Lesch KP, Reif A, Pauli P, Jernigan TL, Haavik J, Plessen KJ, Lundervold AJ, Hugdahl K, Seidman LJ, Biederman J, Rommelse N, Heslenfeld DJ, Hartman CA, Hoekstra PJ, Oosterlaan J, Polier GV, Konrad K, Vilarroya O, Ramos-Quiroga JA, Soliva JC, Durston S, Buitelaar JK, Faraone SV, Shaw P, Thompson PM, Franke B. Lancet Psychiatry. 2017 Feb 16. pii: S2215-0366(17)30049-4. doi: 10.1016/S2215-0366(17)30049-4. [Epub ahead of print] PMID: 28219628 
URL http://enigma.ini.usc.edu
 
Title Sharing EEG ADHD data for collaborative analyses 
Description We have shared some of our EEG data from ADHD-control samples as part of a large international collaboration. 
Type Of Material Database/Collection of data 
Year Produced 2015 
Provided To Others? Yes  
Impact Several research groups, including ours, are in the process of analysing these new collaborative datasets or planning such analyses; papers will follow. 
 
Title Sharing cognitive data for polygenic prediction analyses on a large collaborative dataset 
Description We have shared our cognitive data from our ADHD-control studies for new databases that have been created in 2015 and 2016, and will be used as part of a large international collaboration on polygenic prediction/GWAS analyses. 
Type Of Material Database/Collection of data 
Year Produced 2015 
Provided To Others? Yes  
Impact Several research groups, including ours, are now in the process of analysing these data. 
 
Title Sharing of databases through MiND collaboration 
Description We are sharing parts of the two databases based on the two Action Medical Research -funded projects and the MRC-funded project with colleagues through the MiND project collaboration (new collaborative EU grant). 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact Analyses are ongoing. There have been several conference presentations on the findings, which I summarised in the earlier 'MiND' section. 
 
Description Collaboration with Dutch-IMAGE 
Organisation Radboud University Nijmegen Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution The collaboration between our team and the Dutch-IMAGE team included the application of the multivariate sibling model fitting methods that we developed and applied previously (Kuntsi et al. 2010 Archives of General Psychiatry) to the Dutch-IMAGE dataset. The collaboration has also involved separate analyses on combined datasets and a paper (led by PI Kuntsi's team) on the co-occurrence of reading difficulties and ADHD. From 2015, the collaboration between our teams has involved an EU-funded research fellow carrying out analyses on the joint Dutch and London IMAGE longitudinal datasets. See 'MiND' for description of outputs from this collaboration.
Collaborator Contribution The Dutch-IMAGE team have provided datasets for the analyses and took the lead in writing up one of the publications.
Impact Wood AC, Bralten J, Arias-Vasquez A, Luman M, Oosterlaan J, Sergeant J, Buitelaar J, Franke B, Kuntsi J & Rommelse NN (2012). Neuropsychological intra-individual variability explains unique genetic variance of ADHD and shows suggestive linkage to chromosomes 12, 13 and 17. American Journal of Medical Genetics (Neuropsychiatric Genetics), 159B, 131-140. Cheung CHM, Wood AC, Paloyelis Y, Arias-Vasquez A, Buitelaar JK, Franke B, Miranda A, Rommelse NNJ, Sergeant JA, Sonuga-Barke EJ, Faraone SV, Asherson P & Kuntsi J (2012). The aetiology for the covariation between combined type ADHD and reading difficulties in a family study: The role of IQ. Journal of Child Psychology and Psychiatry, 53, 864-873.
Start Year 2009
 
Description Cross-site ADHD EEG collaboration 
Organisation Heidelberg University
Department Mannheim Faculty of Medicine
Country Germany 
Sector Academic/University 
PI Contribution We have contributed a specific set of our EEG data to this international collaboration (including our follow-up data from ADHD and control sib pairs); have set up a database; and will be analysing data soon.
Collaborator Contribution The other teams have also contributed data to this collaboration and will put forward proposals for analyses.
Impact Arns M, Loo S, Sterman B, Heinrich H, Kuntsi J, Asherson P, Banaschewski T, Brandeis D (2016). Editorial Perspective: How should child psychologists and psychiatrists interpret FDA device approval? Caveat emptor. Journal of Child Psychology and Psychiatry;57(5):656-8. doi: 10.1111/jcpp.12524. Analyses on the collaborative dataset are ongoing.
Start Year 2014
 
Description Cross-site ADHD EEG collaboration 
Organisation University of California, Los Angeles (UCLA)
Department School of Medicine UCLA
Country United States 
Sector Academic/University 
PI Contribution We have contributed a specific set of our EEG data to this international collaboration (including our follow-up data from ADHD and control sib pairs); have set up a database; and will be analysing data soon.
Collaborator Contribution The other teams have also contributed data to this collaboration and will put forward proposals for analyses.
Impact Arns M, Loo S, Sterman B, Heinrich H, Kuntsi J, Asherson P, Banaschewski T, Brandeis D (2016). Editorial Perspective: How should child psychologists and psychiatrists interpret FDA device approval? Caveat emptor. Journal of Child Psychology and Psychiatry;57(5):656-8. doi: 10.1111/jcpp.12524. Analyses on the collaborative dataset are ongoing.
Start Year 2014
 
Description Cross-site ADHD EEG collaboration 
Organisation University of Göttingen
Department Medical School
Country Germany 
Sector Academic/University 
PI Contribution We have contributed a specific set of our EEG data to this international collaboration (including our follow-up data from ADHD and control sib pairs); have set up a database; and will be analysing data soon.
Collaborator Contribution The other teams have also contributed data to this collaboration and will put forward proposals for analyses.
Impact Arns M, Loo S, Sterman B, Heinrich H, Kuntsi J, Asherson P, Banaschewski T, Brandeis D (2016). Editorial Perspective: How should child psychologists and psychiatrists interpret FDA device approval? Caveat emptor. Journal of Child Psychology and Psychiatry;57(5):656-8. doi: 10.1111/jcpp.12524. Analyses on the collaborative dataset are ongoing.
Start Year 2014
 
Description Cross-site ADHD EEG collaboration 
Organisation University of Zurich
Department Neurosciences
Country Switzerland 
Sector Academic/University 
PI Contribution We have contributed a specific set of our EEG data to this international collaboration (including our follow-up data from ADHD and control sib pairs); have set up a database; and will be analysing data soon.
Collaborator Contribution The other teams have also contributed data to this collaboration and will put forward proposals for analyses.
Impact Arns M, Loo S, Sterman B, Heinrich H, Kuntsi J, Asherson P, Banaschewski T, Brandeis D (2016). Editorial Perspective: How should child psychologists and psychiatrists interpret FDA device approval? Caveat emptor. Journal of Child Psychology and Psychiatry;57(5):656-8. doi: 10.1111/jcpp.12524. Analyses on the collaborative dataset are ongoing.
Start Year 2014
 
Description ENIGMA ADHD 
Organisation Radboud University Nijmegen
Country Netherlands 
Sector Academic/University 
PI Contribution We have contributed data to the collaborative analyses and are contributing to the write up of findings.
Collaborator Contribution Participating sites contribute data and expertise to this collaborative effort.
Impact Initial results were presented at the World Congress of Psychiatry in Madrid on 18/9/2014 (Hoogman et al.). Further conference presentations by Hoogman et al. followed in 2015 and 2016. The following paper has just been published: Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis. Hoogman M, Bralten J, Hibar DP, Mennes M, Zwiers MP, Schweren LS, van Hulzen KJ, Medland SE, Shumskaya E, Jahanshad N, Zeeuw P, Szekely E, Sudre G, Wolfers T, Onnink AM, Dammers JT, Mostert JC, Vives-Gilabert Y, Kohls G, Oberwelland E, Seitz J, Schulte-Rüther M, Ambrosino S, Doyle AE, Høvik MF, Dramsdahl M, Tamm L, van Erp TG, Dale A, Schork A, Conzelmann A, Zierhut K, Baur R, McCarthy H, Yoncheva YN, Cubillo A, Chantiluke K, Mehta MA, Paloyelis Y, Hohmann S, Baumeister S, Bramati I, Mattos P, Tovar-Moll F, Douglas P, Banaschewski T, Brandeis D, Kuntsi J, Asherson P, Rubia K, Kelly C, Martino AD, Milham MP, Castellanos FX, Frodl T, Zentis M, Lesch KP, Reif A, Pauli P, Jernigan TL, Haavik J, Plessen KJ, Lundervold AJ, Hugdahl K, Seidman LJ, Biederman J, Rommelse N, Heslenfeld DJ, Hartman CA, Hoekstra PJ, Oosterlaan J, Polier GV, Konrad K, Vilarroya O, Ramos-Quiroga JA, Soliva JC, Durston S, Buitelaar JK, Faraone SV, Shaw P, Thompson PM, Franke B. Lancet Psychiatry. 2017 Feb 16. pii: S2215-0366(17)30049-4. doi: 10.1016/S2215-0366(17)30049-4. [Epub ahead of print] PMID: 28219628
Start Year 2013
 
Description International Multicentre persistent ADHD CollaboraTion (IMpACT) 
Organisation International Multicentre persistent ADHD CollaboraTion (IMpACT)
Country Global 
Sector Academic/University 
PI Contribution The MRC funded project (PI Kuntsi) and the subsequent follow-up project of the same sample (funded by Action Medical Research, PI Kuntsi) have led us increasingly becoming aware of developmental pathways in ADHD and the importance of extending our research on ADHD into adulthood. In 2011 PI Kuntsi joined the 'IMpACT' network of researchers investigating adult ADHD, led by Professor Barbara Franke. The group meets regularly and writes grant applications and papers together.
Collaborator Contribution The IMpACT collaboration enables a group of experts on adult ADHD to work together on grant proposals and papers. The group also organises regular meetings, as well as symposia for conferences.
Impact The group has produced many outputs (see http://www.impactadhdgenomics.com). The group has obtained three large EU grants: AGGRESSOTYPE (6 million euros, 2013-2018; Kuntsi co-investigator), MiND (3.9 million euros, 2015-2018; Kuntsi KCL PI and Work Package Leader) and CoCA (5.9 million euros, 2016-2020; Kuntsi KCL PI and Work Package Leader). Some of this collaborative research uses data from the MRC-funded project and the follow up study of the sample, funded by Action Medical Research.
Start Year 2011
 
Description MiND (EU MARIE SKLODOWSKA-CURIE GRANT) 
Organisation Radboud University Nijmegen
Country Netherlands 
Sector Academic/University 
PI Contribution The data we have collected as part of our MRC and Action Medical Research -funded projects was included in this successful EU Marie Sklodowska-Curie grant application (www.MiND-project.eu). The new analyses that are part of the 'MiND' project will go beyond the initial questions addressed by the previously-funded projects and are therefore secondary analyses on these useful datasets that will combine our data with data from our Dutch collaborations. Kuntsi, who is PI on the two AMR grants and the MRC grant, is local (King's College London) PI also for MiND and one of the Work Package leaders of this large international project. The new analyses are being performed by new staff employed by MiND. We therefore contribute to this collaboration expertise, intellectual input, access to data and training of staff/PhD students.
Collaborator Contribution MiND co-ordinator is based at Radboud University, Nijmegen. Many other EU countries also participate in MiND, including Norway, Spain, Sweden, Germany, as well as the USA. The partners in this collaboration all contribute expertise, intellectual input, access to data and training of staff/PhD students.
Impact Conference presentations: Title: Do polygenic risk scores predict persistence and remission of ADHD in young adulthood? Type: Oral presentation Authors: Adamo, Nicoletta; O'Reilly, Paul; Cheung, Celest; Franke, Barbara; Faraone, Stephen; Asherson, Philip; Bau, Claiton; Zayats, Tetyana; Dalsgaard, Soren; Demontis, Ditte; Mattheisen, Manuel; Bertalan, Marcelo; Thompson, Wes; Børglum, Anders; Psychiatric Genomics Consortium ADHD Working Group, Buitelaar, Jan; Kuntsi Jonna. Conference details: 44th Annual Meeting of the International Neuropsychological Society (INS), February 3-6, 2016 at the Marriott Copley Place Boston (MA), USA. Sponsor(s): EU Marie Sklodowska-Curie project MiND; Action Medical Research for Children; Medical Research Council; Netherlands Organization for Scientific Reseach; The Netherlands Organisation for Health Research and Development (ZonMw); Source: http://www.the-ins.org/includes/ckfinder/userfiles/files/Program_INS-2016-Boston.pdf Title: Rischio poligenico per l'ADHD: e' possibile predire la persistenza del disturbo? Type: Oral presentation. Authors: Adamo, Nicoletta; O'Reilly, Paul; Cheung, Celest; Franke, Barbara; Faraone, Stephen; Asherson, Philip; Bau, Claiton; Zayats, Tetyana; Dalsgaard, Soren; Demontis, Ditte; Mattheisen, Manuel; Bertalan, Marcelo; Thompson, Wes; Børglum, Anders; Psychiatric Genomics Consortium ADHD Working Group; iPSYCH-Broad ADHD Group; NeuroIMAGE Consortium; Buitelaar, Jan; Kuntsi Jonna. Conference details: XXVII Congresso Nazionale della SINPIA (27th national meeting of the Italian association for Child and Adolescent Psychiatry). Sponsor(s): EU Marie Sklodowska-Curie project MiND; Action Medical Research for Children; Medical Research Council; Netherlands Organization for Scientific Reseach; The Netherlands Organisation for Health Research and Development (ZonMw). Source: http://www.sinpia.eu/atom/allegato/1405.pdf. Title: Long-term outcomes of ADHD: is there a role for common genetic variants related to autism spectrum disorder? Type: Oral presentation. Authors: Adamo, Nicoletta; O'Reilly, Paul; Cheung, Celest; Franke, Barbara; Faraone, Stephen; Asherson, Philip; Bau, Claiton; Zayats, Tetyana; Dalsgaard, Soren; Demontis, Ditte; Mattheisen, Manuel; Bertalan, Marcelo; Thompson, Wes; Børglum, Anders; Psychiatric Genomics Consortium ADHD Working Group; iPSYCH-Broad ADHD Group; NeuroIMAGE Consortium; Buitelaar, Jan; Kuntsi Jonna. Conference details: XXVII SINPIA Congress-Satellite Seminar, "International views in child & adolescent psychopathology". Sponsor(s): EU Marie Sklodowska-Curie project MiND; Action Medical Research for Children; Medical Research Council; Netherlands Organization for Scientific Reseach; The Netherlands Organisation for Health Research and Development (ZonMw); Source: http://www.sinpia.eu/atom/allegato/1527.pdf Title: Do polygenic risk scores predict persistence and remission of ADHD in young adulthood? Type: Poster presentation. Authors: Adamo, Nicoletta; O'Reilly, Paul; Cheung, Celest; Franke, Barbara; Faraone, Stephen; Asherson, Philip; Bau, Claiton; Zayats, Tetyana; Dalsgaard, Soren; Demontis, Ditte; Mattheisen, Manuel; Bertalan, Marcelo; Thompson, Wes; Børglum, Anders; Psychiatric Genomics Consortium ADHD Working Group; iPSYCH-Broad ADHD Group; NeuroIMAGE Consortium; Buitelaar, Jan; Kuntsi Jonna. Conference details: 4th Eunethydis International Conference on ADHD: ADHD - from basic neuroscience to optimized clinical care. Sponsor(s): EU Marie Sklodowska-Curie project MiND; Action Medical Research for Children; Medical Research Council; Netherlands Organization for Scientific Reseach; The Netherlands Organisation for Health Research and Development (ZonMw); Source: http://www.eunethydisconference2016.com/wp-content/uploads/2016/10/EIC-Berlin-2016-Abstract-Book.pdf (page 167)
Start Year 2015
 
Description 1st International Congress for the European Network Adult ADHD (London, UK) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk led to further discussions with members of the audience.

The talk raised awareness of the importance of developmental changes in individuals with ADHD and led to us setting up new contacts with members of the audience.
Year(s) Of Engagement Activity 2011
 
Description A Channel 5 documentary on ADHD ("My Secret Past - Living with ADHD") 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The documentary included our team assessing gymnast Louis Smith (who has ADHD) on our EEG test battery and interviews of PI Kuntsi and co-investigator Asherson, who compared his results to those we have obtained from our ADHD and control participants in the 'SEFOS' study (1777; follow-up study of MRC-funded study).

The programme was aired on Channel 5 in January 2014, reaching a large audience.

We received many queries about ADHD and our research from the general public and people affected by ADHD after the programme was shown.
Year(s) Of Engagement Activity 2014
 
Description A news item on the ITV Meridian 6pm News 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The news item described our Action Medical Research -funded ADHD follow-up project 'SEFOS' (1777; follow-up of MRC-funded project) and included an interview of PI Kuntsi and study participants. It reached a large audience.

Following the news item, we received many queries about ADHD and our research.
Year(s) Of Engagement Activity 2011
 
Description ADDIS ADHD Information Services website 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact We have shared information about this project through the "ADDIS" - ADHD Information Services - website.

Not known
Year(s) Of Engagement Activity 2006,2007,2008,2009
 
Description BBC Radio 4 programme All in the Mind - Adult ADHD (Prof Kuntsi) 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Prof Kuntsi was interviewed for the BBC Radio 4 Programme 'All in the Mind' regarding our findings from our ADHD follow-up study.
Year(s) Of Engagement Activity 2017
 
Description Blog on "Mind the Gap", describing our new findings on ADHD persistence and remission markers 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Giorgia Michelini (PhD student) and Jonna Kuntsi (PI) posted a blog "Brain activity and cognitive processes are linked to ADHD remission and persistence", to describe our new research findings in an accessible way to a wide audience.
Year(s) Of Engagement Activity 2016
URL https://mind-the-gap.live
 
Description International Scientific Board of Experts on ADHD (ISBEA) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Kuntsi was invited to join the International Scientific Board of Experts on ADHD (ISBEA) and their meeting on 27 September 2018 in Edinburgh. The meeting focused on issue relating to the transmission from child to adult services for individuals diagnosed with ADHD.
Year(s) Of Engagement Activity 2018
 
Description Medscape article on PhD student Giorgia Michelini's poster presentation 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact PhD student Giorgia Michelini presented findings from our ADHD follow-up study in a poster presentation at the 5th World Congress for ADHD, May 2015, Glasgow, Scotland, after which a journalist wrote up an article on these findings for Medscape.
Year(s) Of Engagement Activity 2015
URL http://www.medscape.com/viewarticle/845982
 
Description National Meeting on ADHD - Dublin 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact PI Kuntsi gave a talk 'Unravelling the complexity of ADHD' at Lilly National Meeting on ADHD, describing findings from the study and considering their clinical and treatment implications. Dublin, 4 September 2009.

We do not have access to records of specific impacts.
Year(s) Of Engagement Activity 2009
 
Description Newsletters to all ADHD and control families who participated in the study 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact Participants have received four-page glossy newsletters, where we have described findings from this study.

Now in 2013 we have sent newsletters to the families again, as we have completed the data collection on the follow-up study (that is funded by Action Medical Research).

In addition to reporting findings from the current study, we have included in the newsletters information on adulthood ADHD, which can be informative to the participants with ADHD, who are now approaching adolescence or early adulthood. It is not possible at this point to evaluate the impact directly.
Year(s) Of Engagement Activity 2006,2007,2009,2013
 
Description Newsletters to study participants 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact We sent a colourful, glossy four-page newsletter to every study participant. In the newsletter we summarised key research findings, written in an engaging style aimed at a non-expert audience and individuals with ADHD. Many families contacted us afterwards to thank for the newsletters and to let us know of any changes to their contact details.

The newsletters were important in sharing the research findings with the study participants, as well as in keeping us in active contact with them, which will facilitate planned future follow ups of this sample.
Year(s) Of Engagement Activity 2013
 
Description Open Day at SGDP Centre, King's College London 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Open Day at our research centre, where we discussed our research studies and findings with members of the general public, and where the members of the public were able to participate in various science activities related to the research that we are carrying out.
Year(s) Of Engagement Activity 2017
 
Description Poster sessions at MRC SGDP Centre 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact We have presented findings from these projects in posters displayed at MRC SGDP Centre events, including those open to the wider public.

Not known
Year(s) Of Engagement Activity 2008,2009,2015,2016
 
Description School visits - several schools in SE England 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Members of our team gave talks to participating schools on our ADHD research and initial findings.

Not known
Year(s) Of Engagement Activity 2006,2007,2008
 
Description Swedish online medical journal discussion of our paper on ADHD remission/persistence 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Discussion in a Swedish medical journal of our paper Du Rietz et al. (2016), Self-report of ADHD shows limited agreement with objective markers of persistence and remittance. Journal of Psychiatric Research, 82, 91-99. The medical journal is available online and is sent to practitioners monthly.
Year(s) Of Engagement Activity 2018
URL https://bestprac.se/2018/01/15/koppling-mellan-sjalv-och-foraldraskattade-adhd-symtom-tonaren-ungdom...
 
Description Symposium on ADHD in Sweden 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Health professionals
Results and Impact Over 80 people attended the symposium on ADHD in Stockholm that was open to the public. Audience included health professionals and journalists.

I gave the invited talk last week and since then I have been contacted further by Swedish journalists, who had attended the symposium.
Year(s) Of Engagement Activity 2010
 
Description UK Adult ADHD Network (UKAAN) meeting on Clinical and Experimental Neuropsychology of ADHD in Adults - Implications for Diagnosis and Treatment. Cambridge. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact PI Kuntsi gave a talk 'Genetics, neuropsychology and electrophysiology of adult ADHD' at the UK Adult ADHD Network (UKAAN) meeting on Clinical and Experimental Neuropsychology of ADHD in Adults - Implications for Diagnosis and Treatment. The talk included a description of findings from the study and a consideration of their implications for diagnosis and treatment, to an audience largely consisting of clinicians. University of Cambridge, 18 September 2009.

The discussion of the study findings contributed to a subsequent discussion involving clinical psychologists on how to improve the use of neuropsychological tasks for assessment and treatment of ADHD in clinics.
Year(s) Of Engagement Activity 2009
 
Description UK Adult ADHD Network meeting (health professionals and general public) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact PI Kuntsi gave an invited lecture "Cognitive performance and developmental hypotheses of ADHD", 1st International Congress for the European Network Adult ADHD, London, 21-23 September 2011. Also attended as a member of the international expert panel during the Expert Workshop.

The talk slides were made available on the UKAAN website.
Year(s) Of Engagement Activity 2011
 
Description University press release on our ADHD persistence-remission findings and subsequent media articles 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact In August 2015 the Institute of Psychology, Psychiatry and Neuroscience, KCL, released a press release on our new findings on ADHD remittance and persistence published in the British Journal of Psychiatry. We received numerous media queries following this and articles appeared in at least the following newspapers/sites:

- Daily Telegraph
- Independent
- Bt.com
- Skynews.com.au
- Herald Sun
- Irish Examiner
- British Neuroscience Association
- Mental Health Today
- Yahoo News UK

Our paper was also mentioned in a BBC 2 programme on adult ADHD that included a panel discussion (27 August 2015).
Year(s) Of Engagement Activity 2015
URL http://www.kcl.ac.uk/ioppn/news/records/2015/August/BrainactivityshedslightonADHDpersistenceandrecov...
 
Description University press release on our ADHD persistence-remission findings and subsequent media articles 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact In August 2015 the Institute of Psychology, Psychiatry and Neuroscience, KCL, released a press release on our new findings on ADHD remittance and persistence published in the British Journal of Psychiatry. We received numerous media queries following this and articles appeared in at least the following newspapers/sites:

- Daily Telegraph
- Independent
- Bt.com
- Skynews.com.au
- Herald Sun
- Irish Examiner
- British Neuroscience Association
- Mental Health Today
- Yahoo News UK

Our paper was also mentioned in a BBC 2 programme on adult ADHD that included a panel discussion (27 August 2015).
Year(s) Of Engagement Activity 2015
URL http://www.kcl.ac.uk/ioppn/news/records/2015/August/BrainactivityshedslightonADHDpersistenceandrecov...