Fate Mapping Stem Cells in the Damaged CNS
Lead Research Organisation:
University of Cambridge
Department Name: Cambridge Centre for Brain Repair
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Fawcett JW
(2015)
The extracellular matrix in plasticity and regeneration after CNS injury and neurodegenerative disease.
in Progress in brain research
Gaughwin PM
(2006)
Astrocytes promote neurogenesis from oligodendrocyte precursor cells.
in The European journal of neuroscience
Hampton DW
(2007)
Spinally upregulated noggin suppresses axonal and dendritic plasticity following dorsal rhizotomy.
in Experimental neurology
Hampton DW
(2007)
A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo.
in The European journal of neuroscience
Hampton DW
(2004)
The responses of oligodendrocyte precursor cells, astrocytes and microglia to a cortical stab injury, in the brain.
in Neuroscience
Rhodes KE
(2006)
The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines.
in Neuroscience
Setoguchi T
(2004)
Nuclear export of OLIG2 in neural stem cells is essential for ciliary neurotrophic factor-induced astrocyte differentiation.
in The Journal of cell biology
Zhao JW
(2009)
Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choice.
in The European journal of neuroscience
| Description | policy on oligodendrocyte precursors |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | MRC |
| Amount | £400,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2008 |
| End | 07/2012 |
| Description | Research Grant |
| Amount | £185,000 (GBP) |
| Organisation | The Henry Smith Charity |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2007 |
| End | 07/2010 |
| Description | Research Grant |
| Amount | £125,000 (GBP) |
| Organisation | The Henry Smith Charity |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2007 |
| End | 07/2010 |
| Description | Matt Ramer |
| Organisation | University of British Columbia |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | BMP noggin and CNS injury |
| Impact | 2 papers on noggin |
| Start Year | 2006 |
| Description | Cambridge Science week |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The talk was very well received and stimulate interest and discussion Several people became interested in more depth on the topic according to the questions and interest |
| Year(s) Of Engagement Activity | 2014 |
| Description | Conferences, patient groups, public seminars |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Presented data at various types of meetings Further collaborations |
| Year(s) Of Engagement Activity | 2007,2008,2009 |
| Description | Interviewed by BBC world radio to talk about Parkinson's disease, research direction and future targets for treatment |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The public and experts were informed of the state of the art on Parkinson's research and possible avenue for treatment |
| Year(s) Of Engagement Activity | 2017 |
| Description | Lecture to Summer School in Galway (Ireland), October 9-10, 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | I gave a talk to postgraduate students and principle investigators about our work on alpha-synuclein |
| Year(s) Of Engagement Activity | 2017 |
| Description | Lecture to summer school in Desenzano del Garda September 24-27, 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | I gave a talk in the summer school about protein aggregation in neurodegenerative diseases and their meaning for disease progression |
| Year(s) Of Engagement Activity | 2017 |
| Description | Pint of Science 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | I gave a talk about the work we are carrying out in a pub to general public |
| Year(s) Of Engagement Activity | 2017 |
| Description | Plenary Lecture to Neuroscience Undergraduate students of London University |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Plenary Lecture London Universities Neuroscience undergraduate students |
| Year(s) Of Engagement Activity | 2016 |
| Description | Poster presentation to GSK |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Cambridge Neuroscience arranged a visit from GSK to Cambridge Neuroscience on July 29th. They wish to support more research and are particularly interested in the area of neurodegeneration. A half day meeting was held whereby they gave us an overview of their future plans and interests and we showcased experts that we have in these areas |
| Year(s) Of Engagement Activity | 2015 |
| Description | Presentation to the Italian Cultural association "Il Circolo" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited to give a talk to a general audience on the state of art on Parkinson's and frontotemporal dementia to member of the public. The attendee were excited by the result of our research and organised a small fund raising to support a 6 month visit from an Italian postdoctoral fellow. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Soapbox |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Given a talk about our work in Cambridge Market Square in occasion of the Soapbox event |
| Year(s) Of Engagement Activity | 2016 |
| Description | Spinal cord injury patients- various meetings |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Speaking to spinal injury patients knowledge of their condition |
| Year(s) Of Engagement Activity | 2006,2007 |
| Description | Student organisation conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | I was invited to give a plenary lecture at the Meeting organised by London universities postgraduate student association |
| Year(s) Of Engagement Activity | 2016 |
| Description | Talk PD group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Invited to give a talk to the Parkinson's group in Horsham The interaction with patients was very good and they were very interested |
| Year(s) Of Engagement Activity | 2013 |