Enhancing stem cell delivery into the CNS

Lead Research Organisation: University of Cambridge
Department Name: Unlisted

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50
 
Description BIRAX
Geographic Reach Europe 
Policy Influence Type Membership of a guideline committee
 
Description Bristol review
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Panel discussion at the House of Lords. Tuesday 30 October 2012, London. Charles ffrench-Constant was aksed to give evidence to the Science and Technology Select Committee at the House of Lords. They recently launched their regenerative medicine inquiry and Charles was asked to give oral evidence by being a member of panel (session lasted 55min). In accordance with Lords usual practice, possible questions were provided in advance and the session were be in public and transcribed. The House of Lords Science and Technology Committee, under the Chairmanship of Lord Krebs, is conducting an inquiry into regenerative medicine. The Committee will be looking, in particular, at whether the UK is in a position to facilitate the translation of knowledge from world-leading research to treatments and to benefit from thecommercial opportunities that they present. It also seeks to explore how realistic some of the reported claims of regenerative treatments and therapies are, both in the UK andinternationally.
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
 
Description Quantum Grant
Amount £100,000 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 01/2007 
End 09/2010
 
Description US MS Society Promise 2010
Amount £300,000 (GBP)
Organisation National Multiple Sclerosis Society 
Sector Charity/Non Profit
Country United States
Start 09/2006 
End 01/2011
 
Description University of Edinburgh - MS Society Clinical Science Centre
Amount £35,000 (GBP)
Organisation Multiple Sclerosis Society 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2011 
End 08/2014
 
Description Wellcome Trust Investigator award
Amount £1,900,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2015 
End 02/2020
 
Title GFP labelled rats for derivation of cells for transplantation 
Description enables transplanted cells to be identified without further labelling 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Used in other projects in the lab 
 
Description CffC/Karolinska 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution Expertise in neural stem cell biology and extracellular matrix
Collaborator Contribution Generation of RNAseq datasets
Impact List of ECM genes expressed in develiping CNS
Start Year 2015
 
Description EU FP7 neuromatrix invitation 
Organisation Karolinska Institute
Department Department of Medical Biochemistry and Biophysics
Country Sweden 
Sector Academic/University 
PI Contribution Invited to join FP7 application based on our expertise in integrin signalling in neural stem cells
Collaborator Contribution expertise in laminin biology for our stem cell work
Impact Application to EU
Start Year 2010
 
Description Quantum grant collaboration 
Organisation Baylor College of Medicine
Department Bioengineering
Country United States 
Sector Academic/University 
PI Contribution expertise in stem and endothelial cell biology
Collaborator Contribution expertise in hydrogel engineering to create artificial niches using endothelial cells - with our contribution being an understanding of stem cell/endothelial cell interactions
Impact Publication in J Neurosci
Start Year 2008
 
Description integrin signalling in stem cell entry into CNS 
Organisation San Raffaele Hospital
Department San Raffaele Scientific Institute (SRSI)
Country Italy 
Sector Academic/University 
PI Contribution Knowledge of integrin signalling
Collaborator Contribution Partnership in successful NMSS grant application and ongoing collaborative work
Impact NMSS grant award
 
Description yale 
Organisation Yale University
Department School of Medicine
Country United States 
Sector Academic/University 
PI Contribution Expertise in stem cell biology and extracellular matrix
Collaborator Contribution expertise in vascular biology and stroke models
Impact Grant from NIH
Start Year 2014
 
Description Charles frrench-Constant lecture at MS Space North annual meeting 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact MS Space North annual meeting, 16 August 2013, Exhibition Centre, Aberdeen, Scotland. Prof Charles ffrench-Constant was invited to give a keynote lecture. 150 patients with MS and their families attended. Lecture was recorded and is available online (214 views so far): http://www.mssociety.org.uk/ms-events/2013/06/ms-space-north-2013-aberdeen.

Part of a general objective of disseminating information concerning regenerative medicine, generating interest in this field.
Year(s) Of Engagement Activity 2013
URL http://www.mssociety.org.uk/ms-events/2013/06/ms-space-north-2013-aberdeen
 
Description Edinburgh science festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Questions afterwards

none
Year(s) Of Engagement Activity 2014
 
Description Film evening 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Chaired discussion after film to public on regenerative medicine "filmosophy"
Year(s) Of Engagement Activity 2015
 
Description Interview for newspaper 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview for i newspaper, subsequent article on mS research
Year(s) Of Engagement Activity 2018
 
Description RSE lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact Discussion about MS therapies

None
Year(s) Of Engagement Activity 2014
 
Description Talks to MS Society meetings 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Participants in your research and patient groups
Results and Impact Platform presentations at MS Meetings for patients

Dissemination of information, and funding donations to Society
Year(s) Of Engagement Activity 2008,2009