Detecting Susceptibility Genes for Late-Onset Alzheimer s Disease

Lead Research Organisation: University of Wales
Department Name: UNLISTED

Abstract

Alzheimer s disease (AD) is a serious debilitating disorder which costs society more than stroke, heart disease and cancer combined. As more people survive to a greater age, the number of AD sufferers is likely to grow considerably. In recent years the identification of some of the genes involved in AD has resulted in a deeper understanding of how the disease develops. However, there are more genes involved, especially in the common forms of AD with onset in later life. This programme of research aims to identify a gene or genes in a region of chromosome 10 showing very strong evidence of containing at least one susceptibility gene for late-onset AD. We will screen this region intensively using a large sample of over 3000 individuals (MRC Genetic Resource for AD) with AD and without. We will also look for relationships between AD and genes showing compelling evidence of functional involvement in other chromosomal regions likely to contain genes. Finally, we will follow-up the MRC Genetic Resource to produce a sample capable of detecting genes which modify disease symptoms (e.g. Psychosis) and course, as well as those that increase disease risk. The knowledge gained from identifying new genes for AD will provide an important platform for future therapeutic developments.

Technical Summary

Alzheimer?s disease (AD) is a common debilitating disorder with a prevalence that rises steeply with age from below 1% at 65 years to as high as 40% after the age of 90. Current projections suggest that the number of elderly will double in the next generation, resulting in more than a billion people over the age of 60 by 2025 in Europe alone. In the UK the direct costs of AD are between 7 and 14 billion pounds per year, approximately the same as those of stroke, heart disease and cancer combined. The predicted increase in the prevalence of AD will undoubtedly have an enormous impact on society. Therefore, gaining a more complete understanding of the genetic contribution to AD must be a priority, as it will provide a strong platform for the development of future preventative and therapeutic strategies. There is no doubt that genes play an important role in the aetiology of late-onset AD, the most common form of Alzheimer s disease (LOAD). This research programme seeks to identify novel genes contributing to the risk and/or the course of LOAD. There is compelling evidence for a gene or genes on chromosome 10. We will localize the peak/s within this region using high density linkage in a large series of families with AD.

We will identify the susceptibility genes in the peak/s, using linkage disequilibrium mapping and direct gene analysis. In addition, we will test for association between AD and functional candidate genes in other regions of linkage throughout the genome. Finally, we will maintain and consolidate the largest case-control sample available to the AD genetics research community and create a resource capable of identifying disease modifying, as well as disease susceptibility genes.

Publications

10 25 50
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Abraham R (2009) An association study of common variation at the MAPT locus with late-onset Alzheimer's disease. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

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Ahmad S (2018) Disentangling the biological pathways involved in early features of Alzheimer's disease in the Rotterdam Study. in Alzheimer's & dementia : the journal of the Alzheimer's Association

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Archer N (2007) Premorbid personality and behavioral and psychological symptoms in probable Alzheimer disease. in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

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Baig S (2010) Distribution and expression of picalm in Alzheimer disease. in Journal of neuropathology and experimental neurology

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Belbin O (2011) A multi-center study of ACE and the risk of late-onset Alzheimer's disease. in Journal of Alzheimer's disease : JAD

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Blom ES (2008) Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13? in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

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Chouraki V (2016) Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease. in Journal of Alzheimer's disease : JAD

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DeMichele-Sweet MAA (2018) Genetic risk for schizophrenia and psychosis in Alzheimer disease. in Molecular psychiatry

 
Description Academy Medical Sciences Council Member
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Academy Medical Sciences Fellow
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
 
Description Academy Medical Sciences Wales Ambassador
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Chief Scientific Advisor to Alzheimer's Research Trust
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in advisory committee
 
Description Department of Health Advisory Group on Dementia
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
 
Description Department of Health Advisory Group on Dementia
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description EPAD LCS sample access committe
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
 
Description Medicines Discovery Institute MDI
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description NMHRI management
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Welsh Assembly Government Advisory Group on Dementia
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description A high content analysis platform for analysing dementia-associated genetic variation
Amount £108,300 (GBP)
Funding ID ARUK-EG2017A-1 
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2017 
End 09/2017
 
Description ABBUK Brains for Dementia Research Programme (extension)
Amount £404,390 (GBP)
Funding ID 504291 
Organisation Alzheimer’s Brain Bank UK 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2013 
End 03/2018
 
Description Brains for dementia research
Amount £161,915 (GBP)
Funding ID ART-RF2009-3 
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Centre for Ageing and Dementia Research - 2 Year Extension
Amount £1,200,000 (GBP)
Funding ID 514840 
Organisation Government of Wales 
Sector Public
Country United Kingdom
Start 04/2018 
End 03/2020
 
Description Clinical collection supply agreement to investigate the genetics of Alzheimer's disease/Glaxosmithkline Research & Development
Amount £532,000 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start  
 
Description Dyslexia genes and neurobiological pathways (NEURODYS)
Amount £251,460 (GBP)
Funding ID 18696 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start  
 
Description Evaluation of candidate genomic regions to determine genetic pedisposition in populations of Alzheimer's patients
Amount £168,514 (GBP)
Funding ID 092008 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Grant for the establishment of an ART AD research centre
Amount £203,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description In vivo imaging of Tau distribution in the brain
Amount £44,743 (GBP)
Organisation Welsh Local Government Association 
Sector Public
Country United Kingdom
Start 01/2016 
End 03/2017
 
Description Industrial Collaborative Studentship - A novel approach to identifying new susceptibility genes for late on-set Alzheimer's disease and its sub components
Amount £52,645 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description NEURODEM/National Assembly for Wales via Bangor University
Amount £41,674 (GBP)
Organisation Health and Care Research Wales 
Sector Public
Country United Kingdom
Start  
 
Description The development and implementation of polygenic risk algorithms for stratifying individuals for future cognitive decline due to Alzheimers disease
Amount £298,040 (GBP)
Funding ID 2018/20180222 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 03/2018 
End 03/2020
 
Description Therapeutic targeting of impaired lysosomal flux in Alzheimer's disease
Amount £136,502 (GBP)
Funding ID MR/P007651/1 
Organisation Network of Centres of Excellence in Neurodegeneration (COEN) 
Sector Public
Country United Kingdom
Start 08/2016 
End 10/2017
 
Description Translating new susceptibility genes for Alzheimer's Disease through clinical characterisation and epidemiology/Welsh Assembly Government
Amount £148,348 (GBP)
Organisation Health and Care Research Wales 
Sector Public
Country United Kingdom
Start  
 
Description Wellcome Trust Project Grant (A Powerful, Genome-Wide Association Scan for Susceptibility Genes for late-onset Alzheimer's disease)
Amount £286,504 (GBP)
Funding ID 082604/B/07/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Title AD Genetics Scotland 
Description Blood samples are collected from participants and sent directly from research sites to European Collection of Authenticated Cell Cultures (ECACC), a Culture Collection of Public Health England. Upon arrival, ECACC process the blood and transform into cell lines- peripheral blood lymphocytes (PBLs) and Lymphoblastoid cell lines (LCLs). Cell lines are frozen and stored at ECACC until they are required by the team at Cardiff. 
Type Of Material Biological samples 
Year Produced 2018 
Provided To Others? No  
Impact Ongoing collection of samples, no publications to date. 
 
Title Brain Bank - Alzheimers 
Description We have recently created a brain bank based upon the longitudinal sample, to provide the wider research community with multiple tissue samples on well characterised individuals. 
Type Of Material Biological samples 
Year Produced 2007 
Provided To Others? Yes  
Impact Multiple publications and media coverage 
 
Title DLB Genetics 
Description Blood samples are collected from participants and sent directly from research sites to European Collection of Authenticated Cell Cultures (ECACC), a Culture Collection of Public Health England. Upon arrival, ECACC process the blood and transform into cell lines- peripheral blood lymphocytes (PBLs) and Lymphoblastoid cell lines (LCLs). Cell lines are frozen and stored at ECACC until they are required by the team at Cardiff 
Type Of Material Biological samples 
Year Produced 2018 
Provided To Others? No  
Impact Ongoing collection of samples, no publications to date 
 
Title Plcg2 animal models 
Description To establish a functional pipeline for the study of disease associated genes and polymorphism in microglia and MØ in the context of dementia-related disease in vivo. The initial concentration is on the impact of coding mutations of PLCG2. In parallel, studies were initated on SPI1 and ABI3. Large scale 'omic and functional assay data derived from these studies will be used to bioinformatically identify potential causative abnormalities, by association with patient data 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2018 
Provided To Others? No  
Impact n/a 
 
Title Polygenic score 
Description With 80,000 variants included to create a measure of risk of Alzheimer's disease, the polygenic score is an excellent predictive tool to determine case/control status with high accuracy. The polygenic score encompasses the majority of genetic risk of disease, and can be fine-tuned to identify the pathways involved in disease, for example, immune cell activity or endocytosis. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2016 
Provided To Others? Yes  
Impact We are working to translate this method from the basic science environment in which it was created into a predictive tool used to select participants for clinical trials, based on their disease status and type. We are currently in discussions with a number of potential collaborators to take this forward. 
 
Title GERAD GWAS 
Description Genome-wide association study data of over 3,000 AD cases and 7,000 controls 
Type Of Material Database/Collection of data 
Year Produced 2009 
Provided To Others? Yes  
Impact multiple publications 
 
Title IGAP dataset 
Description Mega-meta analysis data of over 17,000 AD cases and 30,000 controls 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? Yes  
Impact Lambert et al. 2013 (PMID:24162737), Escott-Price et al. 2014(in press), Farrer et al. 2014 (submitted) 
 
Description ADES Collaboration 
Organisation Erasmus University Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this.
Collaborator Contribution as above
Impact n/a
Start Year 2016
 
Description ADES Collaboration 
Organisation Hospital de Sant Pau
Country Spain 
Sector Hospitals 
PI Contribution A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this.
Collaborator Contribution as above
Impact n/a
Start Year 2016
 
Description ADES Collaboration 
Organisation National Institute of Health and Medical Research (INSERM)
Country France 
Sector Public 
PI Contribution A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this.
Collaborator Contribution as above
Impact n/a
Start Year 2016
 
Description ADES Collaboration 
Organisation Pasteur Institute, Lille
Country France 
Sector Charity/Non Profit 
PI Contribution A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this.
Collaborator Contribution as above
Impact n/a
Start Year 2016
 
Description ADES Collaboration 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this.
Collaborator Contribution as above
Impact n/a
Start Year 2016
 
Description ADES Collaboration 
Organisation University of Bonn
Country Germany 
Sector Academic/University 
PI Contribution A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this.
Collaborator Contribution as above
Impact n/a
Start Year 2016
 
Description ADES Collaboration 
Organisation University of Pennsylvania
Country United States 
Sector Academic/University 
PI Contribution A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this.
Collaborator Contribution as above
Impact n/a
Start Year 2016
 
Description ADES Collaboration 
Organisation VU University Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this.
Collaborator Contribution as above
Impact n/a
Start Year 2016
 
Description Clinical collection supply agreement to investigate the genetics of Alzheimer's disease 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution We collected 200 AD cases with full clinical work up including volumetric neuroimaging and DNA sampling.
Collaborator Contribution GSK funded the collection and storage of DNA samples and clinical and neuroimaging measures on 200 Alzheimer's disease cases in the early stages of disease.
Impact 17998437 19013250
 
Description Finding genes for late onset Alzheimer's disease: Collaboration between Washington University, NIMH, Cardiff University and Celera Diagnostics 
Organisation Quest Diagnostics
Department Celera Diagnostics
Country United States 
Sector Private 
PI Contribution We undertook a genomewide association study of Alzheimer's disease using genetic pooling and also tested associations with candidate genes. The Celera Diagnostics through a sub-contract with MERCK paid for the genomewide association genotyping. Our group took the lead on some studies and contributed samples and intellectual input on others but at all stages all decisions about research design etc were undertaken jointly in a full collaborative fashion. This built on a previous collaboration between ourselves and Allison Goates group from Washington University which spanned over a decade.
Collaborator Contribution Our collaborative group including Celera Diagnostics, Allison Goate and John Hardys research groups undertook a genomewide association study of Alzheimer's disease using genetic pooling and also tested associations with candidate genes. Celera Diagnostics through a sub-contract with MERCK paid for the genomewide association genotyping. Our group took the lead on some studies and contributed samples and intellectual input on others but at all stages all decisions about research design etc were undertaken jointly in a full collaborative fashion. This built on a previous collaboration between ourselves and Allison Goates group from Washington University which spanned over a decade.
Impact 17949987 17492769 17725986 18063669 16161859 16385451 16278862 16847012 17317784
 
Description Genome-wide Association Studies 
Organisation National Center for Biotechnology Information (NCBI)
Country United States 
Sector Public 
PI Contribution Led and co-ordinated the study that involved the work of the following collaborators: 1 MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK. 2 NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Kings College, London, UK. 3 Department of Neuroscience, Institute of Psychiatry, Kings College, London, UK. 4 Institute of Public Health, University of Cambridge, Cambridge, UK. 5 Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. 6 Mercer's Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland. 7 Institute of Genetics, Queen's Medical Centre, University of Nottingham, NG7 2UH, UK. 8 Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK. 9 Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK. 10 Clinical Neuroscience Research Group, Greater Manchester Neurosciences Centre, University of Manchester, Salford, UK. 11 Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Level 4, John Radcliffe Hospital, Oxford OX3 9DU, UK. 12 Dementia Research Group, University of Bristol Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK. 13 Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, UK. 14 MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. 15 Dementia Research Centre, Department of Neurodegenerative Diseases, University College London, Institute of Neurology, London, UK. 16 Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany. 17 Institute of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Germany. 18 Department of Psychiatry, Charité Berlin, Germany. 19 Department of Psychiatry and Psychotherapy, University of Erlangen-Nüremberg, Germany. 20 LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, University Duisburg-Essen, Germany. 21 Institute for Stroke and Dementia Reserach, Klinikum der Universität München, Marchioninistr. 15, 81377, Munich, Germany. 22 Department of Neurology, Klinikum der Universität München, Marchioninistr. 15, 81377, Munich, Germany. 23 Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Square J5, D-68161 Mannheim, Germany. 24 Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Laboratory of Neuroimaging & Biomarker Research, Trinity College, University of Dublin, Ireland. 25 Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig-Maximilian University, Munich, Germany. 26 Centre for Geriatric Medicine and Section of Gerontopsychiatry and Neuropsychology, Medical School, University of Freiburg, Germany. 27 Departments of Psychiatry, Neurology and Genetics, Washington University School of Medicine, St Louis, MO 63110, US. 28 Department of Biology, Brigham Young University, Provo, UT, 84602, USA. 29 Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerpen, Belgium. 30 Institute Born-Bunge and University of Antwerp; Antwerpen, Belgium. 31 Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen, Belgium. 32 Department of Mental Health Sciences, University College London, UK. 33 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. 34 MRC Centre for Neurodegeneration Research, Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London, SE5 8AF, UK. 35 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece. 36 Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA. 37 Department of Genomics, Life & Brain Center, University of Bonn, Sigmund-Freud-Str. 25, D-53127 Bonn, Germany. 38 Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, D-53111 Bonn, Germany. 39 Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Hufelandstr. 55, D-45147 Essen, Germany. 40 Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany. 41 Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany. 42 Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA. 43 Division of Biomedical Statistics and Informatics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
Collaborator Contribution This group of 45 collaborators all contributed towards the centres Genome-wide association study
Impact The study, published in Nature Genetics (PubMed ID 19734902), has uncovered two new genes associated with Alzheimer's disease. Previously only one gene, APOE4, had been shown to be a risk factor for Alzheimer's disease. The study reveals, for the first time, that two further genes, CLU and PICALM, are related to Alzheimer's disease. This has led to worldwide media coverage. The data produced is still used in new studies with requests coming in to the host institution every few weeks.
Start Year 2009
 
Description Genomics England 
Organisation Genomics England
Country United Kingdom 
Sector Public 
PI Contribution We are in the very early stages of discussion with Genomics England, but we hope to be able to use their facilities for whole Genome sequencing. This will mean that we generate valuable data on the largest EOAD cohort world-wide.
Collaborator Contribution Genomics England have the equipment and infrastructure set up for the very expensive and technical whole exome sequencing.
Impact None yet
Start Year 2015
 
Description MRC AD Cohort 
Organisation King's College London
Department Institute of Psychiatry, Psychology & Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution We contributed DNA, clinical follow up information, genotyping and other laboratory work and complex data analysis.
Collaborator Contribution The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.
Impact 16970641 17322133 17530621 17440948 17440933 17373700 17999207 18163421
 
Description MRC AD Cohort 
Organisation Medical Research Council (MRC)
Department MRC Centre for Developmental Neurobiology
Country United Kingdom 
Sector Public 
PI Contribution We contributed DNA, clinical follow up information, genotyping and other laboratory work and complex data analysis.
Collaborator Contribution The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.
Impact 16970641 17322133 17530621 17440948 17440933 17373700 17999207 18163421
 
Description MRC AD Cohort 
Organisation Trinity College Dublin
Country Ireland 
Sector Academic/University 
PI Contribution We contributed DNA, clinical follow up information, genotyping and other laboratory work and complex data analysis.
Collaborator Contribution The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.
Impact 16970641 17322133 17530621 17440948 17440933 17373700 17999207 18163421
 
Description MRC AD Cohort 
Organisation University of Cambridge
Department Department of Medical Genetics
Country United Kingdom 
Sector Academic/University 
PI Contribution We contributed DNA, clinical follow up information, genotyping and other laboratory work and complex data analysis.
Collaborator Contribution The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.
Impact 16970641 17322133 17530621 17440948 17440933 17373700 17999207 18163421
 
Description MRC AD Cohort 
Organisation University of Cambridge
Department Department of Public Health and Primary Care
Country United Kingdom 
Sector Academic/University 
PI Contribution We contributed DNA, clinical follow up information, genotyping and other laboratory work and complex data analysis.
Collaborator Contribution The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question. The MRC AD cohort was collected with MRC funding in a previous grant. This collaboration continues to function looking at candidate genes and candidate regions testing for association with AD and further enriching our clinical data longitudinally, on the remaining members of the cohort. A proportion of this research was directly funded by the MRC grant in question.
Impact 16970641 17322133 17530621 17440948 17440933 17373700 17999207 18163421
 
Description PROTECT / CHARIOT-Pro / Cardiff DPUK 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Genotyping of 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be completed by Cardiff Univ as part of a collaboration funded by Dementias Platform UK. Polygenic risk scores will be calculated for these individuals and data made available via DPUK Platform.
Collaborator Contribution DNA samples from 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be sent to Cardiff Univ for genotyping
Impact None to date - work in progress. Collaboration is multi-disciplinary - Neurology, Neuroepidemiology & Ageing; Genetics & Genomics; Psychiatry
Start Year 2018
 
Description PROTECT / CHARIOT-Pro / Cardiff DPUK 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Genotyping of 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be completed by Cardiff Univ as part of a collaboration funded by Dementias Platform UK. Polygenic risk scores will be calculated for these individuals and data made available via DPUK Platform.
Collaborator Contribution DNA samples from 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be sent to Cardiff Univ for genotyping
Impact None to date - work in progress. Collaboration is multi-disciplinary - Neurology, Neuroepidemiology & Ageing; Genetics & Genomics; Psychiatry
Start Year 2018
 
Description PROTECT / CHARIOT-Pro / Cardiff DPUK 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Genotyping of 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be completed by Cardiff Univ as part of a collaboration funded by Dementias Platform UK. Polygenic risk scores will be calculated for these individuals and data made available via DPUK Platform.
Collaborator Contribution DNA samples from 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be sent to Cardiff Univ for genotyping
Impact None to date - work in progress. Collaboration is multi-disciplinary - Neurology, Neuroepidemiology & Ageing; Genetics & Genomics; Psychiatry
Start Year 2018
 
Title Diagnosis of Alzheimer's Disease 
Description The work has also been published and has achieved a huge amount of media coverage. This discovery of three further genes associated with Alzheimer's disease could provide valuable new leads in the race to find treatments and possibly cures for the devastating condition. This patent application resulted from Julie Williams, Professor of Neuropsychological Genetics and Professor Mike Owen, Professor and Head of MRC Centre, completing the largest-ever joint Alzheimer's disease genome-wide association study (GWAS) involving 16,000 individuals. The patenting of theseSNPS is still in progress and a reveiew is currently underway to identify the best route to exploitation of the technology. 
IP Reference WO2011001135 
Protection Patent granted
Year Protection Granted 2012
Licensed No
Impact This has had huge worldwide impact through media coverage and was originally highlighted in the press with the discovery of an additional 5 genes. We are currently in the process of seeking a licencee for the patented technology which encompasses a diagnostic test for the protected gene SNPs. Recent advances include generation of a polygenic score including the licensed SNPs for the detection of AD risk. We are working together with industry on basic genetic testing, cohort studies, cognitive test providers and pathway specific therapies for new ways in which to combat Alzheimer's disease.
 
Description "Novel Approach to gene-based analysis of Alzheimer's Disease Informed by Genetics of Psychiatric Disorders" Presentation by Emily Baker, Alzheimer's Association International Conference, London 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Presentation to discuss novel approaches to the genetic analysis of Alzheimer's Disease, subsequently presenting data obtained using these methods to fellow geneticists, Alzheimer's Disease researchers and clinicians.
Year(s) Of Engagement Activity 2017
URL http://www.alzheimersanddementia.com/article/S1552-5260(17)30993-7/abstract
 
Description "POLARIS: Polygenic LD-Adjusted Risk Score approach for analysis of GWAS data" Presentation by Emily Baker, American Society of Human Genetics, Orlando 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Presentation to discuss novel approaches to the genetic analysis of Alzheimer's Disease, subsequently presenting data obtained using these methods to fellow geneticists, Alzheimer's Disease researchers and clinicians.
Year(s) Of Engagement Activity 2017
URL https://ep70.eventpilotadmin.com/web/page.php?page=IntHtml&project=ASHG17&id=170120507
 
Description 2 new genetic variations linked with Alzheimer's 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact An international collaboration of scientists, including expertise from Cardiff University, has uncovered two new genetic variations linked with Alzheimer's, opening up new research avenues into the disease. The two newly discovered genetic variations do not predict a person's risk of developing Alzheimer's, but the authors of the paper, which appears in The Journal of the American Medical Association (JAMA) speak of new valuable insights for scientists working on the disease. Professor Julie Williams, Cardiff University, is a principal investigator of the study, led by Professor Monique Breteler, University Medical Center Rotterdam. The research also builds on the discovery led by Professor Williams last year of the first new genes associated with Alzheimer's in a generation.


Unknown
Year(s) Of Engagement Activity 2010
 
Description ART - Westminster 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Dissemination of research findings to parliamentarians

not known
Year(s) Of Engagement Activity 2010
 
Description ART Event - Bournemouth 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact Disseminating research findings to research participants

not know
Year(s) Of Engagement Activity 2009
 
Description ART Public Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Presented research findings as part of the ART public lecture "New Alzheimer's genes: What do they mean?"

Not Known
Year(s) Of Engagement Activity 2010
 
Description ARUK 2014 Annual Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation keynote/invited speaker
Geographic Reach National
Primary Audience Other audiences
Results and Impact Julie Williams took part in a debate at the 2014 ARUK conference titled: Alzheimer's disease: The relative importance of Genes and Environment

The conference audience took part in the debate and positive feedback was recieved about this part of the conference.
Year(s) Of Engagement Activity 2014
URL http://www.alzheimersresearchuk.org/conference-programme/
 
Description ARUK Iceland donation press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A press release was issued announcing new funding from ARUK raised by Iceland foods

The press release mentioned research investigating Early Onset AD, this resulted in an increase in enquiries about research
Year(s) Of Engagement Activity 2014
URL http://www.alzheimersresearchuk.org/news-detail/10984/Cardiff-researchers-lead-global-hunt-for-early...
 
Description ARUK Public Engagement open day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Public engagement
Year(s) Of Engagement Activity 2015
 
Description ARUK Scientific meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Scientific meeting
Year(s) Of Engagement Activity 2015
 
Description Alzheimer's gene study achieves landmark breakthrough 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Cardiff University publicised publication in Nature Genetics "Genetic meta-analysis of diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing" - aiming to raise public awareness of research being undertaken at UK Dementia Research Institute Cardiff
Year(s) Of Engagement Activity 2019
 
Description Alzheimers Society Visit 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Health professionals
Results and Impact presented research findings to representatives of ART at a visit hosted by the Dean of Medicine, Cardiff University

not known
Year(s) Of Engagement Activity 2010
 
Description Annual ART Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact Attended and presented at the annual ART conference

not known
Year(s) Of Engagement Activity 2010
 
Description Awarded £800K to lead new genetic research into Alzheimer's 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Professor Julie Williams, School of Medicine, has been awarded £800K to lead new genetic research into Alzheimer's (Business Weekly, 14.10.10)


Unknown
Year(s) Of Engagement Activity 2010
 
Description BBC (online and local news) 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Prof Julie Williams on AD gene study
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/news/uk-wales-36286847
 
Description BBC Panorama 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Prof Julie Williams Research Team were approached to be involved in a BBC documentary. The documentary followed one of our research participants and his family through everyday life with Alzheimer's disease. Field workers and laboratory staff were also filmed in their roles. The documentary was screened on BBC1 in Panorama on 2nd June 2016.
Year(s) Of Engagement Activity 2016
 
Description BBC Wales Dementia Week 2016 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Filming with BBC Wales's Owain Clarke on Thursday (12th May, 10-12). Interview is part of a package he's doing for Alzheimer's Awareness Week. Owain will be asking Prof Williams about Wales's research contribution; her own specific research and; look ahead at what's next.
Various excerpts were screened on BBC news throughout the week, featuring a number of different staff from the team at Cardiff. This raised awareness of our work and the profile of the team.
Year(s) Of Engagement Activity 2016
 
Description BBC Wales evening news UK DRI Cardiff official opening 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Interview of Professor Julie Williams to publicise official opening of UK DRI Cardiff. Prof Williams explained the purpose of the DRI, its multi-targeted approach, and the funding that had enabled attraction of world class scientists to Cardiff.
Year(s) Of Engagement Activity 2018
URL https://www.bbc.co.uk/iplayer/episode/b0bp0k0t/bbc-wales-today-evening-news-25102018#
 
Description BBC panorama 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact BBC Panorama are following an EOAD participant. The initial interview was filmed by the BBC
Year(s) Of Engagement Activity 2016
 
Description BBC radio interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Radio interview BBC Forty research groups led by scientists in Cardiff, France and the United States have been working more closely together and have now pooled a worldwide database of 90,000 samples. "We're about to submit a paper that is enormously exciting and which I think will really change, without a doubt, what we think of Alzheimer's disease going forward," Professor Julie Williams, head of the research team at Cardiff University, said. "Over the last five or six years we've been successful in identifying 30 genes that increase - or decrease - your risk for Alzheimer's disease. Now this is telling us what some of the major components in disease development are. It's new, it's exciting; it's a different perspective on what Alzheimer's disease is."
Year(s) Of Engagement Activity 2018
URL http://www.bbc.co.uk/news/uk-wales-36286847
 
Description British Science Festival 2016 Workshops 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact We used VR tools to demonstrate the impact of dementia on people's everyday lives. These included using the experiences "A Walk Through Dementia", our citizen science game "Sea Hero Quest", some activities from out children's website, as well as hands on activities and memory games.
Year(s) Of Engagement Activity 2016
URL https://www.britishsciencefestival.org/
 
Description CADR Annual Public Conference, 5th October 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Centre for Aging and Dementia Research (CADR) annual public meeting was held on 5th October in City Hall, Cardiff. A variety of individuals attended including the general public, and NHS staff working in dementia. Feedback received indicated that the event was regarded as training for NHS staff. Discussion groups were lively, and focused on clinical dementia. A number of information stands were manned during the meeting, including an ARUK stand, a Cardiff University Alzheimer's Team Recruitment stand, a Join Dementia Research (JDR) Stand, and a variety of others. The Cardiff research team have had an increased number of volunteer queries. We have also furthered collaborations with CFAS Wales, Dr John Hindle (DLB/PD expert) and others as a direct result of this meeting.
Year(s) Of Engagement Activity 2016
URL http://www.cadr.cymru/en/
 
Description CADR Presentation to Minister 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact The Welsh Assembly Government Minister for Health visited Swansea University on 15th August, 2016. CADR staff/scientific leads were asked to prepare short presentations to inform the Minister of the on-going work of the research teams involved in CADR. Prof Julie Williams gave a brief presentation about the research of her team
Year(s) Of Engagement Activity 2016
 
Description Cardiff Scientific Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talk entitled - The Genetics underlying late-onset Alzheimer's Disease

Not Known
Year(s) Of Engagement Activity 2010
 
Description Cardiff experts call for Alzheimer's action 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Cardiff experts have been at the forefront of calls to step up the battle against Alzheimer's Disease in the press and on national television following a leading international conference on the disease. Nationwide media coverage including the BBC news

Will lead to increased public awareness
Year(s) Of Engagement Activity 2010
 
Description Defining the genetic architecture of AD 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Rome 28th February 2011 - Invited speaker


Unknown
Year(s) Of Engagement Activity 2011
 
Description Defining the genetic architecture of Alzheimer's disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Alzheimer's Research Trust Research Day - Manchester ART Centre, Chancellors conference centre 27th January 2011 - Keynote speaker


Unknown
Year(s) Of Engagement Activity 2011
 
Description Distribution of news letter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact We distribute a 4-8 page newsletter annually to participants in our research, their families and healthcare professionals At present just over 1000 people receive our newsletter.

The newsletter helps engage the public in our research and we receive a large amount of positive feedback from it. We also hope that the newsletter has a positive impact on retention of participants in longitudinal aspects of our research.
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
 
Description EISA Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Delivered talk entitled - Dementia and Cognitive Dysfunction

Unknown
Year(s) Of Engagement Activity 2010
 
Description Funding for Alzheimer's research 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Scientists in Wales researching the causes of dementia are at a "major disadvantage" because the nation does not fund such projects says Professor Julie Williams, School of Medicine. (Western Mail, 4/2/10, p14) Professor Williams is also interviewed about funding for Alzheimer's research.  (BBC Wales News, 4/2/10)


Unknown
Year(s) Of Engagement Activity 2009
 
Description Funding for Alzheimer's research 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Professor Julie Williams, School of Medicine, is interviewed regarding funding for Alzheimer's research.  (BBC Radio Wales, 2.2.10)


Unknown
Year(s) Of Engagement Activity 2010
 
Description Genome wide association study of Alzheimer's disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Invited Plenary - International Conference on Alzheimer's disease (ICAD) - Vienna - July 2009


Unknown
Year(s) Of Engagement Activity 2009
 
Description Global media coverage 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact In September 2009 we published evidence of two new genes which are associated with susceptibility to Alzheimer's disease. This research generated substantial media interest both nationally and internationally. To see the BBC coverage of this story please visit: http://news.bbc.co.uk/1/hi/wales/8239773.stm. The story was covered in over 70 high quality publications (a full list is provided at the bottom this text). In addition, these findings have recently been recognised as one of the world's top 10 scientific breakthroughs of 2009 by Time magazine. See: http://www.time.com/time/specials/packages/article/0,28804,1945379_1944376_1944408,00.html Publications: Sky News Channel 4 News BBC Wales News ITV Wales Pittsburgh post - Gazette Daily Express Swansea Sound Washington Post New York Times Daily Telegraph Western Mail South Wales Echo The Independent The Irish Times Financial Times Sydney Morning Herald Ottawa Citizen Daily Mail Guardian The Mirror Nottingham Journal The Money Times The Sun Sindh Today Science Daily Belfast Telegraph Emax Health Malaysia News net Digital Journal Cambridge News Online Alzheimer's Society Real Radio Red Dragon Boston Globe Calgary Sun Norwich Evening News The Gov Monitor The Spokesman Review Food consumer Times of India Science News Medical News Today Top News NHS News Nature.com Blog Efitness.now Merinews Science Alert Pulse Today AHN Richmond Times - Dispatch The Birmingham News, Alabama Newsday, Melville NY The San Diego Union - Tribune, California El Nuevo Herald The Daily Gazette, New York St Paul's Pioneer Press Valley News Dispatch Chattanooga Times Free Press St Petersburg Times The Virginian - Pilot The Providence Journal The Gainsville Sun San Jose Mercury News The Journal Gazette Daily Times - Call The Tribune Visit Bulgaria Australian Ageing Agenda The News - Enterprise Ethiopian Review The Times - Tribune, PA South Florida Sun Sentinel ABC7 St Charles County Business Record The St Louis Countian

Such extensive media coverage has raised the profile of Alzheimer's disease and dementia research. Since the articles were published we have received numerous enquiries from members of the public wanting to contribute to our research. It has also promoted our own research nationally and internationally and we have developed collaborations as a direct result of this media coverage.
Year(s) Of Engagement Activity 2009
 
Description Health and Care Research Wales Public Engagement talk 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Institute of Psychological Medicine and Clinical Neurosciences staff at Cardiff University School of Medicine were required to attend a one hour presentation on the importance of engaging with the public in scientific research. The aim was to give staff a greater appreciation of public involvement, and the benefits of this in research.
Year(s) Of Engagement Activity 2016
URL http://www.healthandcareresearch.gov.wales/involving-the-public-in-your-research
 
Description ITV Wales - DRI interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Professor Julie Williams from the Dementia Research Institute and Dr Claudia Metzler-Baddeley and Umesh Rudrapatna from CUBRIC were featured on Wales This Week: Memory Matters (ITV Wales)
Year(s) Of Engagement Activity 2018
 
Description ITV Wales interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Interview with James Crichton-Smith at ITV Wales - ITV Wales are running a piece on early onset Alzheimers.
Year(s) Of Engagement Activity 2015
 
Description ITV Wales interview Dec. 2015 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview with James Crichton-Smith at ITV Wales - ITV Wales are running a piece on early onset Alzheimers.
Year(s) Of Engagement Activity 2015
 
Description IWA's Agenda magazine 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Professor Julie Williams' Alzheimer's research is featured in the summer edition of IWA's Agenda magazine (Agenda, No 41 Agenda, Front Page and Pgs 48-49)


Unknown
Year(s) Of Engagement Activity 2010
 
Description Interview for national news 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interview on national TV which is broadcast worldwide describing set up of Cardiff Univ receiving funding to set up as a UK dementia centre
Year(s) Of Engagement Activity 2018
URL http://www.bbc.co.uk/news/uk-wales-south-east-wales-39646667
 
Description Interview for national news 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Official opening of UK DRI Cardiff, attended by 300+ guests, including funders, Welsh government officials, members of the public taking part in dementia research studies, postgraduates. Widely publicised on national BBC and ITV news and radio
Year(s) Of Engagement Activity 2018
URL https://www.bbc.co.uk/news/uk-wales-45942094
 
Description Interview for regional news 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Interview on regional news to discuss setting up of new DRI UK laboratories in Cardiff and work on dementia research
Year(s) Of Engagement Activity 2018
URL http://www.itv.com/news/wales/2017-04-20/dementia-centre-to-offer-step-change-in-research/
 
Description Interview with ITV news 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Julie Williams was interviewed by ITV news in the HEB labs regarding Alzheimer's disease research
Year(s) Of Engagement Activity 2015
 
Description It is time to make mental health research a funding priority 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Media (as a channel to the public)
Results and Impact Professor Julie Williams, School of Medicine, argues in an essay that it is time to make mental health research a funding priority. Cardiff University has committed to this in creating the new Neuroscience and Mental Health Research Institute - and Professor Williams calls on other decision makers and funders to do likewise. (W.Mail, 9.8.10 p26)


Unknown
Year(s) Of Engagement Activity 2010
 
Description Keynote speech Sutcliffe Kerr Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Keynote speech at annual Walton Centre, Sutcliffe Kerr Lecture
Year(s) Of Engagement Activity 2019
 
Description Kings College London Seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Delivered talk entitled - Psychiatric Genetics: Everything you always wanted to know but were afraid to ask

Unknown
Year(s) Of Engagement Activity 2010
 
Description Llandough Hospital 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact Dissemination of recent findings

not known
Year(s) Of Engagement Activity 2009
 
Description Local news item on brain donation for dementia research 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Older people in Wales are being urged to think about donating their brains after they die to help scientists researching dementia. This has sparked questions and debates - 80 comments within 24 hours. It will definitely influence people by raising awareness of the disease, the process of donation, benefits of donation/research and also opting in/out law change. We are confident this will increase the number of healthy/diseased donations and positively impact research field.
Year(s) Of Engagement Activity 2018
URL http://www.bbc.co.uk/news/uk-wales-43084710
 
Description MRC CNGG/NCMH/CADR stand at the Wales Gene park's Genetics and Genomics Conference 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Representatives from the Alzheimer's Genetics Team manned a stand at the Wales Gene Park's Genetics and Genomics Conference on 22nd June, 2016. A number of individuals were interested in discussing the research environment, and how participants could help with discovery science.
Year(s) Of Engagement Activity 2016
URL https://www.eventbrite.co.uk/e/genetics-and-genomics-for-the-3rd-generation-tickets-24871582573
 
Description Marshall Scholars 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact A talk entitled "New genetic findings in Alzheimers Disease" was presented to a group of Marshall Scholars

not known
Year(s) Of Engagement Activity 2010
 
Description Medical Women's Federation Spring Conference 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation on 'Finding the causes of Alzheimer's disease'
Year(s) Of Engagement Activity 2018
 
Description NGFN Symposium - Bonn 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Delivered talk entitled - Molecular Genetics in Alzheimer's Dementia

Unknown
Year(s) Of Engagement Activity 2010
 
Description New Alzheimer's genes revealed 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Two potentially key genes linked to the development of Alzheimer's disease have been uncovered by UK researchers. Covered by major news channels including the BBC

Nationwide media coverage will lead to increased public knowledge
Year(s) Of Engagement Activity 2010
 
Description New susceptibility genes for Alzheimer's disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Invited speaker - Eisai Symposium in Neuroscience (Dementia and Cognitive Dysfunction) - May 2010


Unknown
Year(s) Of Engagement Activity 2010
 
Description Oxford Seminar Series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Invited speaker - Seminar Series,University of Oxford - June 2010


Unknown
Year(s) Of Engagement Activity 2010
 
Description Plenary Speaker at the Alzheimer's Association International Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The plenary speech described our scientific advances in gene discovery and AD risk prediction. This reached an audience of several thousand researchers, clinicians, families, policy makers and funders in the dementia area.
Year(s) Of Engagement Activity 2017
 
Description Presentation and Questions at Carers Group. Participant = Alun Meggy (AD Team) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Carers attend weekly groups that cover a variety or topics about dementia. We were invited to talk about research. The group organiser asked for a further talk in the future
Year(s) Of Engagement Activity 2017
 
Description Presentation and Questions at Torfaen Carers Centre. Participants = Alun Meggy, Jack Beaumont (AD Team) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Study participants or study members
Results and Impact People with dementia and their carers/ families attended a talk to understand why research is important in the field of dementia
Year(s) Of Engagement Activity 2017
 
Description Public Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact We hosted a public meeting, supported by the Alzheimer's Research Trust, in September 2007. In addition to events hosted within the University we have also presented our research findings to carers, and individuals with AD at Alzheimer's Society regional meetings in Cardiff, Swansea, Blackwood and Caerleon and to the members of the Newport Carers Group and County Hosptial Carers Group, Pontypool.

These meetings contribute substantially to engaging the public in our research.
Year(s) Of Engagement Activity 2007
 
Description Quote for This is Wales publication 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Quotation provided on the subject of innovation in Wales for trade magazine, emphasising research focus on dementia, specifically Alzheimer's disease
Year(s) Of Engagement Activity 2018
 
Description Radio Cymru Discussion on Alzheimer's disease. Participant = Alun Meggy, AD Team 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Mr Alun Meggy took part in a Welsh discussion group broadcast live on Radio Cymru on 17th February 2017. Alun spoke in Welsh regarding Alzhiemer's disease research, and how we are working hard to develop our knowledge of this debilitating disease.
Year(s) Of Engagement Activity 2017
 
Description Recorded interview ARUK conference March 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact An interview with Video Journal Dementia at ARUK Conference 2018 discussing work at Cardiff DRI UK - online publication aimed at healthcare professionals
Year(s) Of Engagement Activity 2018
URL https://vjdementia.com/speaker/julie-williams
 
Description Researchers Find Two More Genetic Risk Factors For Alzheimer's Disease 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Widespread worldwide broadcast, press and online coverage of a major new study into Alzheimer's led by researchers at Cardiff University. Including BBC, Channel 4, SKY and ABC news, The Telegraph, The Times, The Telegraph, The New York Times and all over major news channels / papers.

"The MRC Centre and research like this is changing our understanding of what causes the common form of Alzheimer's disease and provides valuable new leads in the race to find treatments and possibly cures.

"It also shows that other genes can be identified using this method, and we are already planning a larger study involving 60,000 people, which can be achieved within the next year.

"It is also important to recognise the contribution many Welsh people who have acted as subjects for this research over the years."
Year(s) Of Engagement Activity 2009,2010
 
Description SciScreen Dementia Event 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Dr Rebecca Sims gave a public presentation on Dementia research before a free screening of the film "Away from Her", post-film discussion and free drinks reception. The purpose of the event is for scientists to engage with the general public for mutual benefit. The presentation was well received, and the discussions were lively.
Year(s) Of Engagement Activity 2016
 
Description Science Cafe talk 10th May 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact A talk was given by PhD student and Neurologist, Dr Jude Harrison. Science Cafe events are designed to encourage the general public to engage with science in an informal environment.
Year(s) Of Engagement Activity 2016
 
Description Scientists at Cardiff University say they are a step closer to understanding the causes of dementia 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Scientists at Cardiff University say they are a step closer to understanding the causes of dementia, thanks to a grant of nearly £250,000. The money will fund its brain bank, a centre which encourages people to donate their brains for medical research. Professor Julie Williams comments (BBC Wales On-line, 04.07.2013

Unknown
Year(s) Of Engagement Activity 2013
URL http://www.bbc.co.uk/news/uk-wales-22288025
 
Description Tenby Observer 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talk by Prof Julie Williams (at Oriel y Parc, 5 Aug) advertised
Year(s) Of Engagement Activity 2016
URL http://www.tenby-today.co.uk/article.cfm?id=105748&headline=Oriel%20y%20Parc%20to%20host%20second%20...
 
Description The International Genomics of Alzheimer's Project (IGAP) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A leading University expert in identifying genes that cause Alzheimer's disease will meet with some of the world's other figures for the first-time in Paris (Friday 19th November) in a bid help share knowledge and speed-up the genetic fight against the disease. The International Genomics of Alzheimer's Project (IGAP) is a major international consortium which brings together for the first time four of the world's leading research centres - including  Professor Julie Williams, School of Medicine, who leads the Genetic and Environmental Risk in Alzheimer's Disease (GERAD).


Unknown
Year(s) Of Engagement Activity 2010
 
Description The Today Programme 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact JW on BBC Radio 4's Today programme talking
about her discovery of two new genes associated with Alzheimer's disease which could provide
valuable new leads in the race to find treatments and possibly cures for the devastating condition

Unknown
Year(s) Of Engagement Activity 2009
 
Description Time Magazine - Medical breakthroughs of 2009 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A key University study which helped uncover two new genes associated with Alzheimer's disease has been recognised as one of the top 10 medical breakthroughs of 2009 by TIME Magazine.

International acknowledgement of research findings.
Year(s) Of Engagement Activity 2009
 
Description U3A Brecon 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact Dissemination of Alzheimers research findings

not known
Year(s) Of Engagement Activity 2010
 
Description UN Older Persons Day - Cardiff 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Delivered talk entitled - Will identifying susceptibility genes for Alzheimer's Disease increase healthy aging?

Unknown
Year(s) Of Engagement Activity 2010
 
Description WAG Seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact Presented recent research findings to policy makers

not known
Year(s) Of Engagement Activity 2010
 
Description Welsh language champions in NHS health boards 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Media (as a channel to the public)
Results and Impact Professor Julie Williams, School of Medicine comments on plans to appoint Welsh language champions in NHS health boards. (Western Mail, 7/6/10, p25)


Unknown
Year(s) Of Engagement Activity 2010
 
Description Welsh presentation (Cardiff Science Society) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact A presentation was given in Welsh, by Alzheimer's Field Worker, Alun Meggy to the Cardiff Science Society on 21st November 2016. This was followed by questions and a discussion.
Year(s) Of Engagement Activity 2016
URL http://www.cymdeithaswyddonolcaerdydd.org
 
Description Westminster visit - Dementia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Dissemination of research findings to parliamentarians

not known
Year(s) Of Engagement Activity 2009
 
Description Will identifying susceptibility genes for Alzheimer's disease increase healthy ageing? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Invited speaker - United Nations Older Person's Day - Promoting active and healthy ageing - Cardiff, 30th September 2010


Unknown
Year(s) Of Engagement Activity 2010
 
Description Will members of my family develop Alzheimers disease?' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Dr Rebecca Sims presented "Will members of my family develop Alzheimer's disease?" at CADR Meeting Swansea, 2/8/2018. This reached an audience of 50 persons including general public, medical professionals, researchers and carers. This generated a number of questions and discussion after the talk, and was part of a wider discussion following other presentations focusing on similar topics.
Year(s) Of Engagement Activity 2018
 
Description Young Onset Dementia: Different impact, positive solutions conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact This public meeting was held on 27th September, 2016. This was a recruitment opportunity.
Year(s) Of Engagement Activity 2016
URL https://www.youngdementiauk.org/sites/default/files/Young%20Dementia%202016%20programme.pdf
 
Description Zeurs Austria - Drugs Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Presented talk entitled - Defining the genetic architecture for AD

not known
Year(s) Of Engagement Activity 2009
 
Description alt.Cardiff blog entry 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Journalist Jessica Phillips interviews Julie Williams for an article on her blog
Year(s) Of Engagement Activity 2015