Avoiding conflict of interest between clinical and research scientists in human embryonic stem cell derivation.

Lead Research Organisation: Newcastle University
Department Name: Institute of Cellular Medicine

Abstract

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Publications

10 25 50
 
Description HFEA research regulation.
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a national consultation
 
Description House of Commons Science and Technology Committee
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
 
Description The Hinxton Group
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guidance committee
 
Description MRC Research Grant (Improving the efficiency of human somatic cell nuclear transfer)
Amount £466,845 (GBP)
Funding ID G0601157 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2007 
End 03/2010
 
Description MRC Research Grant (Recruiting donors for stem cell research - national collaboration of hESC coordinators)
Amount £1,343,770 (GBP)
Funding ID G0700092 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2007 
End 02/2010
 
Description Epigenetics of human pre-implantation embryos 
Organisation Babraham Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Human embryos were fixed in Newcastle and sent to Cambridge for analysis of DNA methylation. Both centres have made a significnat contribution to a recently submitted manuscript.
Collaborator Contribution Dr Wendy Dean (the Reik Laboratory) has extensive expertise in characterising DNA methylation profiles in mammalian embryos. The collaboration enabled us to extend this to human emrbryos and has enabled us to make a significant advance in our understadning of the effect of ICSI treatment on DNA methylation in human blastocysts.
Impact We found that DNA methylation patterns in human blastocysts were similar to those obsered in other speices and did nto differ between IVF and ICSI. This is important as it has been suggeted that childer born as a result of ICSI treatment are at increased risk of diseases associated with aberrant imprinting. Our data indicate that this is not a consequence of altered patterns of DNA methylation at the blastocyst stage. This adds new knowledge to the field and a manuscript reporting these data has been submitted.
 
Description Preventing transmission of mitochondrial DNA disease 
Organisation Newcastle University
Department Mitochondrial Research Group
Country United Kingdom 
Sector Academic/University 
PI Contribution The grant enabled us to establish a robust infrastructutre for embryo donation, which faciliated the donation of embryos to research into the development of techniques to prevent the transmission of mitochondrial DNA disease in collaboration with Prof Doug Tunrbull
Collaborator Contribution The partnership with Prof Turnbull and his team has enabled us to develop a research programme programme to prevent transmission of mutated mitochondrial DNA. We are now at teh stage of offering IVF-based treament to couples whose children are at risk. We are one of a very small number of centres across Europe offering this service.
Impact In collaboration with Prof Turnbull we have domonstrated the feasibility of nuclear transfer between oocytes and zygotes to minimise the risk of transmission of mutated mitochondrial DNA. This has resulted in 2 grants from the Muscular Dystrophy Campaign and in submisison of a manuscript, which is currently in review. This is a very important area of work as diseases associated with mitochondrial DNA mutations affect 1in 5-10,000 people in the UK and there are no known treatments. In addition to our research work, we have campaigned for the legalisation of treatments to prevent transmission of mitochondrial DNA disease. The new HFE Act permits this under Regulations.
 
Description UK Stem Cell Bank 
Organisation National Institute for Biological Standards and Control (NIBSC)
Department UK Stem Cell Bank
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Embryonic stem cells lines derived have been deposited in the UKSCB. This makes them available to other researchers.
Collaborator Contribution Understanding of the regulatory requirements for ES cell banking.
Impact Of the 14 research grade lines currently available to distribution to any other researchers, 5 were derived by our team.
 
Description British Society for Gene Therapy, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Lecture to learned society

The aim of the lecture was to disseminate information about embryo based research from the viewpoint of the donors and the associated ethical and regulation concerns. Emphasis was placed on the clinical context of the audience.
Year(s) Of Engagement Activity 2006
 
Description Cambridge University Government policy programme, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Presentation at study day for senior civil servants and policy advisors.

Provision of a realistic understanding of the impact of legislation and regulation on scientific progress.
Year(s) Of Engagement Activity 2006
 
Description Catholic Schools Study Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Lecture to school children from several catholic schools and their staff.

The aim of the lecture was to disseminate information about embryo based research from the viewpoint of the donors, the potential benefits to society and the associated ethical and regulation concerns. This was in the specific context of a Catholic School.
Year(s) Of Engagement Activity 2006
 
Description ESHRE Stem Cell Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Study day by Committee members of the European Society for Human reproduction and Embryology to consider whether or not embryonic stem cell research should remain within the remit of the society.

A decision was made that this research was relevant to the scoiety.
Year(s) Of Engagement Activity 2009
 
Description Joint visit with Chief Exec of HFEA to USA 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Visit arranged by FCO to Centre for American Progress (Washington), Capitol Hill Briefing, NIH Stem Cell Task Force.

The explore differences between USA and UK regulation in stem cells and make appropraite links.
Year(s) Of Engagement Activity 2006
 
Description Manchester Medical Society 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact Lecture within Society meetings programme.

The aim of the lecture was to disseminate information about embryo based research from the viewpoint of the donors, the potential benefits to society and the associated ethical and regulation concerns.
Year(s) Of Engagement Activity 2006
 
Description Media work 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Newspaper news and feature articles, TV and radio news, documentary and program participation; national and international.

The aim has been to present this ethically sensitive subject to the public in a way that not only helps their understanding but reassures them that the ethical issues are addressed appropriately.
Year(s) Of Engagement Activity 2006,2007,2008,2009
 
Description National Council of Women 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Invited Lecturer

The aim of the lecture was to disseminate information about embryo based research from the viewpoint of the donors, the potential benefits to society and the associated ethical and regulation concerns.
Year(s) Of Engagement Activity 2007
 
Description National Science Learning Centre, York 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Lecture to school teachers

To provide and understanding and teachers material to enable teachers to infornmchildren about embryo research and stem cells.
Year(s) Of Engagement Activity 2006
 
Description New York Stem Cell Foundation, New York 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Fund raising and policy informing for stem cell research.

Inform the public in USA about legal, regulatory and practical progress that is being achieved in UK.
Year(s) Of Engagement Activity 2006
 
Description Presentation to USA Congressional Stem Cell Committee, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Seminar presentation to visiting USA Congressmen and Policy advisors on Stem Cells.

Provide information and respond to questions about how the UK has managed stem cell research from the legal, regulatory and ethical viewpoint.
Year(s) Of Engagement Activity 2006
 
Description Westminster Forum Public Meeting, London 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Public meeting about stem cell regulation.

The aim of the lecture was to disseminate information about embryo based research from the viewpoint of the donors, the potential benefits to society and the associated ethical and regulation concerns.
Year(s) Of Engagement Activity 2007