PsyGrid: e-Science to Improve the Understanding and Treatment of People in their First Episode of Psychosis

Lead Research Organisation: University of Manchester
Department Name: Medical and Human Sciences

Abstract

Establishing an e-community on the basis of the Mental Health Research Network will have as one of its longer term aims a promotion of new ways to engage the public in issues concerning mental health research. Public education and engagement is part of the wider brief of the National Institute for Mental Health (England) and this proposal fits in closely to this.

Technical Summary

Severe mental illness (psychosis) is a major public health challenge. Current health policy has a focus on early intervention in the first episode of psychosis as a way of improving outcomes. The evidence for which interventions are best is patchy. Improving this evidence base is a core rationale for the newly formed Mental Health Research Network (MHRN www.mhrn.info) of the National Institute of Mental Health England. The twin aims of this proposal are:- 1) to establish an e-Science framework and functioning e-community which integrates academic and NHS partners in MHRN, so as to enhance research and development capability in routine mental health service settings; 2) to set up an information system to ascertain and characterise a large, representative cohort of individuals with first episode psychosis to enable hypothesis-driven epidemiological and intervention research, particularly into predicting and preventing adverse outcomes. PsyGrid will provide a flexible e-Science/Grid infrastructure deployed over NHSnet using existing governance arrangements for handling clinical data. We will leverage as much existing e-Science software development as possible, working closely with our e-Science Centres and our industrial partner (Microsoft). The PsyGrid e-Science platform will inform, launch and facilitate future externally-funded, hypothesis-driven research in four priority areas in this field: longitudinal studies of risk and protective factors for long-term outcomes, including aetiological inquiry; clinical trials in early psychosis; biological studies of the nature of clinical progression; and new methodologies for evidence-based service developments.

Publications

10 25 50

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Mok PL (2014) Longitudinal trajectories of peer relations in children with specific language impairment. in Journal of child psychology and psychiatry, and allied disciplines

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Palmier-Claus JE (2011) Experience sampling research in individuals with mental illness: reflections and guidance. in Acta psychiatrica Scandinavica

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Palmier-Claus JE (2013) Affective instability prior to and after thoughts about self-injury in individuals with and at-risk of psychosis: a mobile phone based study. in Archives of suicide research : official journal of the International Academy for Suicide Research

 
Description mhrn
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
Impact support for mental health research networks
 
Description Lundbeck commercial/academic
Amount £237,068 (GBP)
Organisation P1vital Consortium 
Sector Private
Country United Kingdom
Start 06/2012 
End 12/2013
 
Description P1Vital; Sunovion Ltd
Amount £450,000 (GBP)
Organisation P1vital Consortium 
Sector Private
Country United Kingdom
Start 09/2014 
End 03/2016
 
Description mrc dpfs
Amount £400,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 11/2010 
End 10/2012
 
Title First episode psychosis data 
Description PsyGrid was a project that collected data from patients suffering from thier first episode of psychosis. Patients were sought, consented and data collected. A body of data now exists collected using many standard assessment forms. 
Type Of Material Database/Collection of Data/Biological Samples 
Provided To Others? No  
Impact In progress - data collection at follow up finishes may 2010 
 
Title OpenCDMS 
Description OpenCDMS is a clinical data collection tool that allows the accurate and secure gathering of data for service evlauation or research purposes. 
Type Of Material Improvements to research infrastructure 
Year Produced 2007 
Provided To Others? Yes  
Impact Many studies both within and outside of MRC funding now use the software: including the Mental Health Research Network for mostof their studies; the Diabetes Research Network; and several independant studies. The use of validation and provenance has proved to be very useful to all of these organisations. 
 
Description NIHR Diabetes Research Network 
Organisation National Institute for Health Research
Department NIHR Diabetes Research Network
Country United Kingdom 
Sector Public 
PI Contribution Project support
Collaborator Contribution First actual demonstration that the software tool could be used across various fields of research. This was important to the group as it shows the versitiy of the software we create.
Impact Multiple project support
Start Year 2007
 
Description NIHR Mental Health Research Network 
Organisation King's College London
Department School of Medicine KCL
Country United Kingdom 
Sector Academic/University 
PI Contribution Design and support of Psygrid/OpenCDMS platform
Collaborator Contribution Psygrid (Open-CDMS) has become the project management platform for NIHR MHRN and as of Dec 09 hosts 14 large scale externally funded projects and trials.Financial contribution to clinical data collection on large cohort of first episode psychosis patients (n=900) with follow up (Outlook study)
Impact Database and project management for MHRN studies
 
Description NIHR Mental Health Research Network 
Organisation National Institute for Health Research
Department INVOLVE
Country United Kingdom 
Sector Public 
PI Contribution Design and support of Psygrid/OpenCDMS platform
Collaborator Contribution Psygrid (Open-CDMS) has become the project management platform for NIHR MHRN and as of Dec 09 hosts 14 large scale externally funded projects and trials.Financial contribution to clinical data collection on large cohort of first episode psychosis patients (n=900) with follow up (Outlook study)
Impact Database and project management for MHRN studies
 
Description Swedish equivalent 
Organisation Karolinska University Hospital
Country Sweden 
Sector Hospitals 
PI Contribution Data from our study has been compared with theirs
Collaborator Contribution data
Impact None yet
Start Year 2012
 
Title OpenCDMS 
Description Software for managing clinical data arising from studies and trials 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted
Licensed Yes
Impact Improve data quality and security.
 
Title Minocycline 
Description Clinical trial of minocycline added to treatment as usual for early schizophrenia primary efficacy end point - improvement of negative symptoms over 12 months; primary mechanistic end point - prevention of grey matter loss using imaging in early psychosis. 207 patients recruited within 24 months to target and on time 
Type Therapeutic Intervention - Drug
Current Stage Of Development Initial development
Year Development Stage Completed 2016
Development Status Closed
Clinical Trial? Yes
Impact The results are being analysed 
URL http://www.isrctn.com/ISRCTN49141214
 
Description European Congress of Psychiatry. Madrid 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 100 plus professional
Year(s) Of Engagement Activity 2016
 
Description conference presentations 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact conference presentations
Year(s) Of Engagement Activity 2007,2008,2009