CancerGRID-Final Application

Lead Research Organisation: University of Cambridge
Department Name: Oncology

Abstract

CancerGRID will contribute to activities such as open days to engage the public in cancer research. CancerGRID will also aim at engaging patient representatives and will closely integrate with activities from the NHS that impinge on cancer care delivery.

Technical Summary

CancerGRID is a consortium to develop open standards for clinical cancer informatics. The Consortium will concentrate on breast cancer translational clinical trials, but since all informatics tools will be developed using open source, open access, open development and a federated structure it is anticipated that solutions will be portable to other clinical scenarios. The Goal of our application is to use a modular approach to provide solutions for ?simple? problems using grid-based informatics: 1-Developing a template for e-clinical trials using a translational clinical trial already ongoing as a pilot (NeoTANGO); 2-Linking existing clinical trial data with molecular profiling information obtained from paraffin-embedded tumour samples; 3- Linking genetic epidemiology data with molecular pathology and clinical outcome data; ; and 4-Using GRID-based collaborative tools to run clinical trials. The Consortium will develop: i) template forms, vocabularies, common data elements and biomedical objects for prospective running of multicentric translational clinical trials using the grid; ii) vocabularies, common data elements and biomedical objects for retrospective analysis of phase III clinical trials with integrated molecular analysis of paraffin-embedded samples and integration with cancer registry; iii) tools to link genetic epidemiology data, with molecular pathology, clinical trials and cancer outcome data using ABC as a demonstrator project; iv) a telemedicine infrastructure for running and managing translational clinical trials.

Publications

10 25 50
 
Description CANCER-ID: Cancer treatment and monitoring through identification of circulating tumour cells and tumour related nucleic acids in blood
Amount € 319,000 (EUR)
Funding ID 115749 
Organisation European Commission 
Department Innovative Medicines Initiative (IMI)
Sector Public
Country Belgium
Start  
 
Description Discipline Hopping Awards - Exploiting Astrogrid / Cancergrid systems
Amount £92,304 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description European Research Council Advanced Grant
Amount € 2,497,660 (EUR)
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 01/2017 
End 12/2021
 
Description Extending Pathgrid miniPIPSS
Amount £108,741 (GBP)
Organisation Science and Technologies Facilities Council (STFC) 
Sector Public
Country United Kingdom
Start  
 
Description Genentech
Amount $450,000 (USD)
Organisation Genentech, Inc 
Sector Private
Country United States
Start 09/2014 
End 09/2016
 
Description Grand Challenge
Amount £20,000,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 01/2023
 
Description H2020
Amount € 4,000,000 (EUR)
Organisation European Union 
Sector Public
Country European Union (EU)
Start 01/2018 
End 12/2022
 
Description Innovative Technologies for Stratified and Experimental Medicine, Co-I (PI: Patrick Maxwell, other Co-Is: Fiona Gilbert, Kevin Brindle, Stephen O'Rahilly, Edward Bullmore, James Brenton)
Amount £14,624,435 (GBP)
Funding ID MR/M009041/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2015 
End 03/2016
 
Description Project grant
Amount £703,000 (GBP)
Organisation AstraZeneca 
Sector Private
Country United Kingdom
Start 10/2016 
End 10/2019
 
Description Project grant
Amount £1,163,000 (GBP)
Organisation Addenbrooke's Charitable Trust (ACT) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2015 
End 04/2018
 
Description Project grant
Amount € 306,547 (EUR)
Organisation Servier Laboratories 
Sector Private
Country France
Start 10/2017 
End 09/2019
 
Description Project grant
Amount £277,000 (GBP)
Organisation Roche Pharmaceuticals 
Sector Private
Country Global
Start 06/2016 
End 04/2018
 
Description Project grant
Amount £34,964 (GBP)
Organisation Susan G. Komen Foundation 
Sector Charity/Non Profit
Country United States
Start 09/2016 
End 09/2018
 
Title Cancergrid Metadata Registry 
Description An ISO11179-compliant metadata registry 
Type Of Material Improvements to research infrastructure 
Year Produced 2006 
Provided To Others? Yes  
Impact The metadata registry is the central component of the MRC Data Support Service gateway (project in progress) providing variable level documentation for important MRC population studies to support data sharing an reuse activities. The metadata registry is also in use by the US National Blood Marrow Donor Program to rationalise and document variables from their clinical and laboratory forms so that they may become caBIG compliant. The registry has been taken on by Ohio State University (openMDR) for wider use in clinical research outside the cancer arena in the US. The METABRIC project has utilised this tool to standardise and integrate clinical data from five different data sources for meta-analysis. This work was published and is described in the publication section. It has also been used to support for standardisation of tissue microarray (TMA) at the CRUK-Cambridge Research Institute and collaborating institutions, such as Strangeways Research Laboratory, University of Cambridge. This standardisation of data has facilitated the high-throughput flow of tissue data between the collaborating laboratories. It has been adopted for use within the US caBIG initiative, and is being evaluated by a number of organisations within the UK and around the world including Sage Bionetworks, MD Anderson Cancer Clinic, and the Scottish Government. 
 
Title Deep Zoom Image Converter 
Description This server-side application enables the conversion of images from an image store into deep-zoom images which can be presented by the Image Scorer application. 
Type Of Material Improvements to research infrastructure 
Year Produced 2010 
Provided To Others? Yes  
Impact This has enabled patholgists to view images on-screen, enabling the user to zoom and pan around images, mimicing the experience of viewing images with a microscope. 
 
Title Query Service Manager Plugins 
Description Plugins and addins for Enterprise Architect, Microsoft Excel 2007 and Microsoft InfoPath 2007. These plugins enable the communication of metadata to and from the CancerGrid Metadata Registry. 
Type Of Material Improvements to research infrastructure 
Year Produced 2006 
Provided To Others? Yes  
Impact The plugins are the foundation of the National Bone Marrow Donor Program collaboration in which spreadsheets that describe form variables are annotated using these plugins against the metadata registry component 
 
Title SQIV 
Description The SQIV toolset allows for the processing of data marked up with meta-data into RDF. That a toolkit has been used for clinical data transformation and integration. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This toolkit has been utilised to support the retrospective analysis of data collected to different standards, drawn from five centres in the Anglo-Canadian METABRIC project. The use of the tool for the management and integration of this data was described in BMC Medical Genomics 2009, 2:66. 
 
Title Tissue Microarray Image Scorer 
Description A tool that enables high-throughput scoring of tissue microarray images via the internet. 
Type Of Material Improvements to research infrastructure 
Year Produced 2010 
Provided To Others? Yes  
Impact Has enabled multi-site scoring of tissue microarray images. For example in the international Breast Cancer Consortium it was used by pathologists based at Addenbrookes in Cambridge and the National Insititute of Health in Washington for the viewing and scoring of images to enable validation of automated scoring methods being developed at CRUK Cambridge Research Institute. We plan to make the tool available to pathologists at additional sites to further collaboration and increase the throughput of data collection in these multi-site studies. An abstract was submitted at the Breakthrough Breast Cancer conference 2011, which described the analysis of data collected using this tool in the Breast Cancer Association Consortium (BCAC). We have made the source code available at sourceforge (http://sourceforge.net/projects/cancergrid-tma/) to encourage further development and use by other groups. Our manuscript describing the functionality and use of this tool is currently under review at BMC Bioinformatics. 
URL http://sourceforge.net/projects/cancergrid-tma/
 
Description BCAC 
Organisation Institute of Cancer Research UK
Country United Kingdom 
Sector Academic/University 
PI Contribution Software engineering expertise. Providing the Tissue Microarray Image Scoring application (see Research Materials) to enable multi-site scoring of images. Providing a processing pipeline to track tissue sample identifiers to enable scoring data to be linked back to clinical data.
Collaborator Contribution Providing a user group for the Tissue Microarray Image Scoring Application, enabling testing and use of the software by multiple international partners in the Breast Cancer International Consortium (BCAC).
Impact Collected tissue microarray data from 10 different international centres in the Breast Cancer Association Consortium (BCAC). The data collected has been analysed and a manuscript is in preparation to describe the results.
Start Year 2009
 
Description NCRI Informatics 
Organisation National Cancer Research Institute (NCRI)
Department NCRI Informatics Inititive
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Brought Cancergrid expertise to the NCRI efforts in data sharing. Several of the Cancergrid investigators were members of the NCRI Informatics Task Force, which provides a forum for consultation with the scientific, medical and informatics communities.
Collaborator Contribution The NCRI Informatics Initiative together with caBIG have organised annual joint conferences which have been an excellent forum for collaboration between ourselves and international efforts on data sharing.
Impact Active discussions throughout the Cancergrid project and attendence at NCRI and caBIG joint conferences enabled Cancergrid to adapt and tailor our software development efforts to the needs of the scientific and medical communities, whilst keeping abreast of complimentary efforts to develop and use data standards in the cancer field. Our efforts were rewarded in several poster awards at the NCRI-caBIG joint conference in 2008 (see Awards and Recognition section).
 
Description OCRe 
Organisation University of California, San Francisco
Department School of Medicine (UCSF)
Country United States 
Sector Academic/University 
PI Contribution Members of our research team initiated the ontology development and acted as ontology editor in collaboration with Stanford, UCSF and Manchester University. Contribution to the ontology content in OWL using Protégé. Co-authored a web-based publication.
Collaborator Contribution Expertise in ontology creation
Impact The published ontology is available from Bioportal: http://bioportal.bioontology.org/ontologies/39291
Start Year 2007
 
Description Pathgrid 
Organisation University of Cambridge
Department Institute of Astronomy
Country United Kingdom 
Sector Academic/University 
PI Contribution Cancergrid staff from both the University fo Cambridge and University of Oxford have taken part in discussions to drive the implementation of this software. Cancergrid staff at Cambridge have been responsible from provision of images and metadata for image analysis. Cancergrid staff have been responsible for deployment of the software at the Cambridge Research Institute, and long-term planning for provision of appropriate databases to store the results of image analysis for downstream statistical analysis.
Collaborator Contribution Collaborators at the Insititute of Astronomy have provided expertise in image analysis algorthims. Discussions between Cancergrid software developers, image analysis experts, pathologists and clinicians have led to the development of an analysis pipeline, incorporating metadata describing tissue images and adapting astronomical workflows and image analysis algorthims developed for the AstroGrid project for the high-throughput analysis of tissue microarray images.
Impact The collaboration led to a publication in 2010 (Pubmed ID: 20643686). The collaboration is multi-disciplinary involving Astronomers, Oncologists, Pathologists, Image Analysis experts, software developers and statisticians. A second manuscript is in preparation which describes the results of applying image analysis algorithms developed through this collaboration for analysing thousands of breast cancer tissue microrray images.
Start Year 2007
 
Description caBIG 
Organisation National Institutes of Health (NIH)
Department National Cancer Institute (NCI)
Country United States 
Sector Public 
PI Contribution Software engineering expertise, providing a light-weight metadata repository and other software tools (see Research Materials - Cancergrid Metadata Registry and Query Service Manager Plugins). Providing Common Data Element defintions for breast cancer clinical trials and minimum information collection for antibody experiments.
Collaborator Contribution Expertise on caDSR to enable integration of the US NCI metadata elements with those used in the the UK Cancergrid project. Provision of NCI Common Data Element browser.
Impact Delivered a presentation on evolving health informatics at Microsoft eScience workshop in 2008. Paper published for data standards in antibody experiments (PMID: 19224941).
 
Title Metadata Services and Tools for Semantic Interoperability 
Description Grid, Cloud, and Web-based services, tools, and databases for the efficient annotation and generation of forms and other artifacts for the acquisition and processing of clinical research information. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2006
Licensed Yes
Impact This technology has been used to run clinical studies - e.g. for pneumoccal vaccines in Nepal - and as a platform for future semantic interoperability in organisations such as the Scottish Government, NATO, and the MRC's own Data Support Service.
 
Description 10th Anniversary Open Day for press and general public at CRUK Cambridge Institute 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Caldas Goup participated in the 10th Anniversary Open Day for press and general public at CRUK Cambridge Institute. Additional information was requested on the work of the Caldas Group.
Year(s) Of Engagement Activity 2017
 
Description 3rd Annual EUROCAN Platform meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and future collaborators.
Year(s) Of Engagement Activity 2013
 
Description 8th International Heinrich F.C. Behr Symposium in Heidelberg 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and possible future collaborators.
Year(s) Of Engagement Activity 2014
URL http://www.dkfz.de/en/behr-symposium-2014/index.html
 
Description AACR Annual Meeting in San Diego 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and future collaborators.
Year(s) Of Engagement Activity 2014
URL http://www.aacr.org/Meetings/Pages/MeetingDetail.aspx?EventItemID=8
 
Description AACR Annual Meeting in Washington DC 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact Open discussions with peers and future collaborators.
Year(s) Of Engagement Activity 2013
URL http://www.aacr.org/Pages/Home.aspx
 
Description AACR Molecular Targets and Cancer Therapeutics Conference in Boston 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and future collaborators.
Year(s) Of Engagement Activity 2013
URL http://www.eortc.org/conferences-and-courses/aacr-nci-eortc-international-conference-molecular-targe...
 
Description ASEICA 14th International Congress 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description Alejandra Bruna and Elham Esmaeilishirazifard attended a EurOPDX Workshop in Weggis, Switzerland October 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Alejandra Bruna, Associate Scientist, and Elham Esmaeilishirazifard, Research Assistant, attended the EurOPDX workshop in Weggis 1st - 3rd October 2018. Alejandra updated the scientific community on our latest research and explored opportunities for collaboration.
Year(s) Of Engagement Activity 2018
 
Description Alejandra Bruna attended a collaboration meeting and talk at KU Leuven University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Alejandra Bruna attended a collaboration meeting and talk at KU Leuven University March 2018. Alejandra updated the scientific community on our latest research and explored opportunities for collaboration.
Year(s) Of Engagement Activity 2018
 
Description All Party Parliamentary evidence session on How will AI benefit NHS cancer patients. October 2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Carlos Caldas, Group Leader, spoke at a Personalised Medicine All Party Parliamentary Group. Carlos updated the group on our latest research and explored opportunities for collaboration.
Year(s) Of Engagement Activity 2018
 
Description Breast Group Educational Meeting in Newmarket 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Open discussion with peers and future collaborators.
Year(s) Of Engagement Activity 2014
 
Description CRUK Researchers Retreat 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and collaborators.


Open discussions with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description Cafe Scientifique Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The talk provoked discussion about the impact of translational research and the potential benefits for society as a whole.

Important dissemination activity in informing members of the public how clinical evidence is collected and the potential benefits of clinical trials to society as a whole.
Year(s) Of Engagement Activity 2007
 
Description Cancer Core Europe Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and future collaborators.
Year(s) Of Engagement Activity 2014
 
Description Cancer Imaging Centre Steering Committee Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description Carlos Caldas and members of the Caldas Group were interviewed for a web article on the Breast cancer DNA 'barcoding' programme 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Carlos Caldas and members of the Caldas Group were interviewed for a web article on the Breast cancer DNA 'barcoding' programme
Year(s) Of Engagement Activity 2018
URL https://crukcambridgecentre.org.uk/news/breast-cancer-dna-'barcoding'-programme-be-rolled-out
 
Description Carlos Caldas attended a Nature Roundtable at Curious 2018 in Darmstadt July 2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Carlos Caldas, Group Leader, attended a Nature Roundtable at Curious 2018 in Darmstadt July 2018. Carlos updated the scientific community on our latest research and explored opportunities for collaboration.
Year(s) Of Engagement Activity 2018
 
Description Carlos Caldas attended a Nature Roundtable at ESMO Congress 2018 in Munich October 2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Carlos Caldas, Group Leader, took part in a Nature Roundtable at ESMO 2018 in Munich October 2018. Carlos updated the scientific community on our latest research and explored opportunities for collaboration.
Year(s) Of Engagement Activity 2018
 
Description Carlos Caldas attended a Vatican Pontifical Academy of Sciences meeting - A mission-oriented approach to cancer in Europe, Vatican, November 2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Carlos Caldas, Group Leader, attended the Vatican Pontifical Academy of Sciences meeting - A mission-oriented approach to cancer in Europe, Vatican, November 2018 during this meeting Carlos updated the scientific community on our latest research and explored opportunities for collaboration.
Year(s) Of Engagement Activity 2018
 
Description Carlos Caldas attended an EU Cancer Mission Meeting - Heidelberg July 2019 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Carlos Caldas, Senior Group Leader, was invited to participate in an EU Cancer Mission Meeting held in Heidelberg 10th July 2019
Year(s) Of Engagement Activity 2019
 
Description Consensus Conference on Hereditary Gastric Cancer 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Open discussion with peers and future collaborators.
Year(s) Of Engagement Activity 2014
 
Description Dutch Breast Cancer Synmposium 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and future collaborators.
Year(s) Of Engagement Activity 2013
 
Description EACR23 Meeting 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? Yes
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and possible future collaborators.
Year(s) Of Engagement Activity 2014
URL http://eacr23.eacr.org/
 
Description ECCO Meeting 2013 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description ECMC Annual Meeting 2013 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description EMBO Workshop, Stem cells and epigenetics in cancer 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion and met with possible future collaborators.

Possible future collaborators
Year(s) Of Engagement Activity 2014
URL http://events.embo.org/14-csc-epigenetics/
 
Description ENA Congresss Barcelona 2014 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and collaborators.
Year(s) Of Engagement Activity 2014
URL http://www.ecco-org.eu/Events/EORTC_NCI_AACR_2014
 
Description ESMO Congress 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions and possible future collaborators.
Year(s) Of Engagement Activity 2014
URL http://www.esmo.org/Conferences/ESMO-2014-Congress
 
Description Elham Shirazi presented the PDX project to a public audience during a CRUK-CI Funders Tour in July 2018 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact Dr Elham Shirazi presented the PDX project to a public audience during a CRUK-CI Funders Tour in July 2018, during the presentation Elham updated the attendees on our latest research and explored opportunities for further engagement.
Year(s) Of Engagement Activity 2018
 
Description Elham Shirazi was interviewed on "Personalised Medicine" by Cambridge Independent Weekly Newspaper which was published on 18th July 2018 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Elham Shirazi was interviewed on "Personalised Medicine" by Cambridge Independent Weekly Newspaper which was published on 18th July 2018, page 26. The article updated the scientific and local community on our latest research and explored opportunities for collaboration and further engagement.
Year(s) Of Engagement Activity 2018
 
Description Emma Beddowes spoke at the British Breast Group National meeting on 1st February 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Dr Emma Beddowes, Academic Medical Oncology Consultant, spoke at the British Breast Group National Meeting on 'Tracking treatment response and resistance in metastatic HER2 positive patients' during the course of the meeting Emma updated the scientific community on our latest research and explored opportunities for collaboration.
Year(s) Of Engagement Activity 2019
 
Description Eurocan Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and future collaborators.
Year(s) Of Engagement Activity 2014
 
Description Eurocan Mid-Term meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and future collaborators
Year(s) Of Engagement Activity 2014
 
Description Eurocan workshop and meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and possible future collaborators.
Year(s) Of Engagement Activity 2014
 
Description European Breast Cancer Conference in Glasgow 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and future collaborators.
Year(s) Of Engagement Activity 2014
URL http://www.ecco-org.eu/EBCC9
 
Description GSK Course in Madrid 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Open discussion with peers and future collaborators.
Year(s) Of Engagement Activity 2014
 
Description Gates Foundation visit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Bill Gates visited Oxford and spent 30 minutes - in a small meeting - discussing the software and the approach to clinical trials management with two of the CancerGrid investigators. He asked that they should visit Microsoft once more to meet with the metadata experts leading Office development.

The subsequent meeting in Redmond led to a proposal for deployment, and to new channels for providing input into product development at Microsoft, as well as into open source bioinformatics tools (such as Microsoft's new "Microsoft Biology Foundation").
Year(s) Of Engagement Activity 2009
 
Description German Society of Senology Meeting 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and future collaborators.
Year(s) Of Engagement Activity 2014
 
Description Grant proposal review for Deutscher Sparkassen und Giroverband in Bonn 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description IAC Meeting in Milan 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description IMI Cancer Kick Off Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Decision making with peers
Year(s) Of Engagement Activity 2014
 
Description IMI Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and future collaborators
Year(s) Of Engagement Activity 2014
 
Description International Lisbon Surgical Meeting 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact Open discussions with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description Leaping Forward Congress in Lisbon 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact Open discussion with peers and future collaborators.
Year(s) Of Engagement Activity 2014
URL http://www.essaude.pt/pt/profissionais/leaping-forward/
 
Description Meeting at Academy of Medical Sciences with the European Academy of Cancer Sciences 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Open discussions with peers and future collaborators.
Year(s) Of Engagement Activity 2013
 
Description Meeting at Calouste Gulbenkian Foundation 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and future collaborators.
Year(s) Of Engagement Activity 2014
 
Description Member of the Caldas Group attended a press conference and workshop at Cancer Research Malaysia held in November 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Study participants or study members
Results and Impact Oscar Rueda, Senior Bioinformatician, and Suet-Feung Chin, Associate Scientist, in the Caldas Group attended a press conference and workshop at Cancer Research Malaysia. Future funding, collaboration and press coverage were achieved.
Year(s) Of Engagement Activity 2017
 
Description NATO 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The interoperability taskforce within NATO is adopting the CancerGrid tools for prototyping purposes, linking data definitions and promoting data standards across different partners in the organisation. A wider deployment is being considered.

The existing "metadata repository" used by the NATO taskforce is likely to be withdrawn, and replaced by a more sophisticated solution based on UK CancerGrid/ US NCI approaches.
Year(s) Of Engagement Activity 2009,2010
 
Description NCRI Informatics Task Force 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The NCRI Informatics Initiative has taken a more data- and semantics-driven approach to data sharing and to facilitating communication and collaboration across the UK community.

The results of this work will be informing part of the new Stratified Medicines Initiative.
Year(s) Of Engagement Activity 2006,2007,2008
 
Description NIHR Senior Investigators Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Health professionals
Results and Impact Open discussion with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description OECI Board Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Board decisions with peers
Year(s) Of Engagement Activity 2014
 
Description OECI Board Meeting 2013 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description OECI Board Meeting December 2013 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description OECI General Meeting 2013 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description OMICS to Novel Therapies in Cancer Meeting 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and future collaborators.
Year(s) Of Engagement Activity 2014
URL http://10times.com/omics-berlin
 
Description Oscar Rueda, Senior Research Associate, attended and presented at the AACR Project GENIE Meeting, July 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oscar Rueda, Senior Research Associate, attended and presented at the AACR Project GENIE Meeting, July 2018 during the meeting Oscar updated the scientific community on our latest research and explored opportunities for collaboration.
Year(s) Of Engagement Activity 2018
 
Description Parliamentary Reception 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Invite to attend a Parliamentary Reception on Cambridge's Role in Keeping Britain at the Forefront of Global Medical Research
Year(s) Of Engagement Activity 2014
 
Description Persephone Trial Investigators Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Carlos Caldas, Group Leader, presented and attended the Persephone Trial results meeting at Warwick University.
Year(s) Of Engagement Activity 2018
 
Description Play to Cure Press Launch 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Discussions and media coverage
Year(s) Of Engagement Activity 2014
 
Description Precision Medicines in Breast Cancer Meeting 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description Predect Review Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description RAGM 14 - GEICAM Review of Advances in Breast Cancer Press Conference 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Open discussion with press, peers and future collaborators.
Year(s) Of Engagement Activity 2014
 
Description RATHER Annual Meeting 2013 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description Raquel Manzano Garcia volunteered at the University of Cambridge Science fair 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Raquel Manzano Garcia volunteered at the University of Cambridge Science fair 2018. During the event Raquel updated the attendees on our latest research and explored opportunities for further engagement.
Year(s) Of Engagement Activity 2018
URL https://www.sciencefestival.cam.ac.uk/
 
Description Royal College of Radiologists/Wellcome Trusts Research Day 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description Seminar at NKI (Amsterdam) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Visit and seminar at NKI resulted in new collaboration opportunities.
Year(s) Of Engagement Activity 2014
 
Description Speaking at CRUK Manchester Institute 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and future collaborators.
Year(s) Of Engagement Activity 2014
 
Description Speaking at IARC in Lyon 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description Speaking at IRCC in Turin 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and future collaborators.
Year(s) Of Engagement Activity 2014
 
Description Speaking at Phillips Research in Eindhoven 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and future collaborators.
Year(s) Of Engagement Activity 2013
 
Description Speaking at SERVIER and Curie Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and future collaborators
Year(s) Of Engagement Activity 2014
 
Description Speaking at the Memorial Sloan-Kettering Cancer Centre 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and future collaborators.
Year(s) Of Engagement Activity 2014
 
Description TAT Conference Washington DC 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and future collaborators.
Year(s) Of Engagement Activity 2014
URL http://tatcongress.org/previous-tat-congresses/tat-2014/
 
Description Talk given at Genentech, San Francisco, October 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Carlos Caldas, Group Leader, gave a talk at Genentech in San Francisco, 25th - 28th October 2019 where he updated the scientific community on our latest research and explored opportunities for collaboration.
Year(s) Of Engagement Activity 2018
 
Description The Frontiers in Translational Cancer Research Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and future collaborators.
Year(s) Of Engagement Activity 2014
URL https://www.fimm.fi/en/events/frontiers-translational-cancer-research-symposium
 
Description Translational Cancer Gemonics Meeting in Amsterdam 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussion with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description VI PhD Students Meeting at University of Lisbon 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Open discussion with PhD Students.
Year(s) Of Engagement Activity 2013
 
Description WIN 2013 Symposium 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Open discussions with peers and collaborators.
Year(s) Of Engagement Activity 2013
 
Description Wellcome Trust PhD Programme for Clinicians 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Open discussions with students.
Year(s) Of Engagement Activity 2013
 
Description YES - Young European Scientist Meeting in Porto 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Open discussion with young scientists.
Year(s) Of Engagement Activity 2014
URL http://yesmeeting.org/
 
Description eGovernment 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Development of guidelines and recommendations for the development of government interoperability initiatives related to both open government and internal government efficiency

Continued ongoing contact with civil servants
Year(s) Of Engagement Activity 2008,2009,2010
 
Description eHealth 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Participation in technical and specification work for record design in the NHS, representing interests of clinical researchers in the approach and design of medical records in England

Participation remains ongoing - developing opportunities to provide cancergrid tools to record designers
Year(s) Of Engagement Activity 2008,2009,2010