Centre for Stem Cell Biology and Medicine

Lead Research Organisation: University of Cambridge
Department Name: Surgery

Abstract

Every year, thousands of patients die from organ failure because there are not enough matching donors for the transplants that they need. Also, thousands of others suffer from the effects of diabetes, even though they take insulin. Existing therapies for many diseases of the brain, such as Parkinson?s and multiple sclerosis, fall far short of a cure. Stem cells could possibly provide cures for these diseases. Embryonic stem (ES) cells are derived from embryos at the earliest stages of development, when the embryo is a microscopic, hollow ball of cells. They provide a promising means for generating many or perhaps all of the 200 specialised cell types of the body. Stem cells have been detected in other body tissues, such as the bone marrow and nervous system, and these also represent potential sources of therapeutic materials. The proposed research is designed to provide the foundations in basic knowledge of stem cell biology to build the clinical treatments that are likely to emerge from a fundamental understanding of this field.

Technical Summary

The mission of the Cambridge Centre for Stem Cell Biology and Medicine is to harness basic knowledge of cellular and developmental biology for therapy of human diseases through the use of stem cells. The Centre will accomplish this mission by fusing the University?s basic research efforts with its clinical expertise. The purpose of this union is to generate a stem cell research enterprise that not only expedites the translation of stem cell biology into clinical use, but also generates fundamental insights into mechanisms of normal development and their perturbation in birth defects and cancer. A basic aim is to understand how stem cells preserve their unique ability, known as pluripotency, to specialise into differentiated cell types. A related aim is to understand in greater depth how cells initiate differentiation into early tissue lineages and then use these insights to control the specialisation of stem cells into clinically useful cell types. Thirdly, research is proposed to understand how cells committed to specific lineages maintain their proliferative status during embryonic development and to apply this information to generate the large cell populations needed to study cell transplantation therapy for diseases in model systems. The cell types selected for study are ones in which purified cell populations are likely to affect the disease processes, the central nervous system and the endocrine pancreas. A long-term multidisciplinary approach is needed because of the complexity of cells as therapeutic reagents. The proposed Centre will unify researchers in two Cambridge faculties (School of the Biological Sciences and School of Clinical Medicine) and materially assist them in translating their research into clinical use by providing them with dedicated stem cell research resources and a mechanism for their collaborative interaction, through use of the shared facilities, seminars and a training programme.

Organisations

Publications

10 25 50

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Pimanda JE (2007) Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development. in Proceedings of the National Academy of Sciences of the United States of America

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Torres-Padilla ME (2006) Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos. in The International journal of developmental biology

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Torres-Padilla ME (2006) Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote. in The Journal of cell biology

 
Description "Next Generation" fellowhip (Biology of induced pluripotency)
Amount £30,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description BBSRC - Industrial CASE studentship
Amount £70,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description BBSRC - Project Grant
Amount £358,869 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description BBSRC CSG - Synergy Grant
Amount £14,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description BSH - Early Stage Investigator Fellowship
Amount £129,246 (GBP)
Organisation British Society for Haematology 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Barker - Parkinson's UK
Amount £34,795 (GBP)
Funding ID K-1011 
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Barker - Parkinson's UK Project grant
Amount £178,118 (GBP)
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Cambridge Centre for Myelin Repair Renewal
Amount £2,141,907 (GBP)
Organisation Multiple Sclerosis Society 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Can the metabolomic profiling of urine and serum in patients with Parkinson's disease be used to better diagnose and define disease progression as well as be informative about underlying pathogenic processes?
Amount £170,329 (GBP)
Funding ID G-0616 
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Characterising the heterogeneity in Parkinson's Disease using a multimodal approach and its clinical significance for the implementation of novel therapies
Amount £90,000 (GBP)
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description EC - Advanced Investigator award
Amount £2,200,000 (GBP)
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start  
 
Description EC - Framework 6 - Xemone: engineering of the porcine genome for xenotransplantation studies in promates: a step towards clinical application
Amount £392,514 (GBP)
Funding ID 37377 
Organisation Sixth Framework Programme (FP6) 
Sector Public
Country European Union (EU)
Start  
 
Description EC - ate mapping of precursor cells following CNS demyelination
Amount £148,549 (GBP)
Funding ID 24644 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start  
 
Description ERC Starting Grant FP7
Amount £1,244,710 (GBP)
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 12/2010 
End 11/2015
 
Description Fight for Sight - Project Grant
Amount £159,936 (GBP)
Organisation Fight for Sight 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Full Centre Grant
Amount £1,809,044 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2009 
End 12/2011
 
Description GSK Clinician Scientist Fellowship
Amount £500,000 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start  
 
Description Hemberger - BBSRC Project Grant
Amount £483,108 (GBP)
Funding ID BB/I008764/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description Hemberger - CSG Synergy Grant
Amount £181,284 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description Hemberger - CSG Synergy Grant
Amount £7,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description Hemberger - Centre for Trophoblast Research, Cambridge University
Amount £24,827 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start  
 
Description Hemberger - Centre for Trophoblast Research, Cambridge University
Amount £5,000 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start  
 
Description Human Frontiers Science Programme (HFSP)/European Commission (EC) $
Amount £300,000 (GBP)
Organisation Human Frontier Science Program (HFSP) 
Sector Charity/Non Profit
Country France
Start  
 
Description KKLF
Amount £1,632,075 (GBP)
Organisation The Kay Kendall Leukaemia Fund 
Sector Academic/University
Country United Kingdom
Start  
 
Description KKLF - Intermediate Fellowship KKL469
Amount £616,867 (GBP)
Organisation The Kay Kendall Leukaemia Fund 
Sector Academic/University
Country United Kingdom
Start  
 
Description Leukaemia Research - Clinical Research Fellowship for Dr P Beer: the role of HDAC8 in the pathogenesis of the myeloproliferative disorders
Amount £182,871 (GBP)
Organisation Leukaemia and Lymphoma Research 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Leukaemia Research - Regulation of SCL gene expression in normal and leukaemic T cell differentiation
Amount £620,155 (GBP)
Organisation Leukaemia and Lymphoma Research 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description MRC - Investigating the role of cyclin B1 in early cell divisions
Amount £347,000 (GBP)
Funding ID G0701184 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description MRC - The effect of injury on stem cells in the adult brain
Amount £300,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Marie Curie - Initial Training Network
Amount £219,751 (GBP)
Organisation Marie Sklodowska-Curie Actions 
Sector Charity/Non Profit
Country Global
Start  
 
Description Michael J Fox Foundation - Rapid Response Innovation Award/Michael J Fox Foundation $
Amount £126,000 (GBP)
Organisation Michael J Fox Foundation 
Sector Charity/Non Profit
Country United States
Start  
 
Description NIHR i4I grant (Barker)
Amount £740,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR i4i Invention for Innovation (i4i) Programme
Sector Public
Country United Kingdom
Start  
 
Description Pfizer Ltd - UK Glaucoma Treatment Study
Amount £80,000 (GBP)
Organisation Pfizer Ltd 
Sector Private
Country United Kingdom
Start  
 
Description Pluchino - AISM/FISM
Amount £90,280 (GBP)
Organisation Italian Multiple Sclerosis Society (AISM) 
Sector Charity/Non Profit
Country Italy
Start  
 
Description Pluchino - EU 7th Framework programme - Implantable organic nano-electronics (iONE) (5m euros across 10 participants)
Amount £401,800 (GBP)
Funding ID 280772 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 01/2012 
End 12/2013
 
Description Pluchino - FinLombarda
Amount £150,500 (GBP)
Organisation Finlombarda S.P.A. 
Sector Private
Country Italy
Start  
 
Description Pluchino - Regeneration of the injured spinal cord with somatic neural stem cells and microencapsultated glial scar inhibitors
Amount £120,350 (GBP)
Organisation Wings for Life Spinal Cord Research Foundation 
Sector Private
Country Austria
Start  
 
Description Pluchino - Van Geest
Amount £360,000 (GBP)
Organisation University of Leicester 
Department John and Lucille van Geest Foundation
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Pluchino - Young Investigator Award GR08-7 - Italian Ministry of Health
Amount £503,800 (GBP)
Organisation Government of Italy 
Sector Public
Country Italy
Start  
 
Description Pluchino- Somatic neural stem cell transplantation as novel therapeutic approach for the treatment of multiple sclerosis
Amount £171,292 (GBP)
Organisation Gruppo Bancario Banca Agricola Popolare di Ragusa 
Department Banca Agricola Popolare di Ragusa (BAPR)
Sector Private
Country Italy
Start  
 
Description Research Bennett Senior Fellowship 10015
Amount £589,400 (GBP)
Organisation Leukaemia and Lymphoma Research 
Department Bennett Fellowship
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Royal Society - Neurotransmitter mediated white matter damage in leukodystrophies and ischaemia
Amount £15,000 (GBP)
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description TRANSEURO Innovative Approach for the Treatment of Parkinson's Disease (12m euros across 14 participants)
Amount £702,511 (GBP)
Funding ID 242003 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start  
 
Description Themed Research Grant
Amount £1,100,000 (GBP)
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Themed Research Grant
Amount £436,239 (GBP)
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Wellcome Trust - Stem cell renewal and lineage selection in adult mammalian epidermis
Amount £2,998,125 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Wellcome Trust - The Road from Pluripotency to lineage determination
Amount £1,736,222 (GBP)
Funding ID 091484 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Wellcome Trust - The role of S1P5 in CNS myelination and remyelination
Amount £188,623 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Wellcome Trust - Zygote viability judged by image analysis
Amount £200,000 (GBP)
Funding ID 085107 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Title Epiblast stem cell lines 
Description We generated pluripotent stem cell lines from mouse and rat late epiblast (Brons et al. publication, 2007). The epiblast stem cell lines of the mouse were distributed. 
Type Of Material Cell line 
Year Produced 2008 
Provided To Others? Yes  
Impact This discovery has provided the conceptual basis for understanding the considerable differences between mouse embryonic stem cells and human embryonic stem cells. 
 
Description Adams Group (Z-G) 
Organisation University of Cambridge
Department Department of Physiology, Development and Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Following dynamics of cell movements in the mouse embryo
Collaborator Contribution Academic/shared research
Impact 19422818
Start Year 2009
 
Description Analysis of Affymetrix Exon microarray data (A Smith) 
Organisation Wellcome Trust
Department Wellcome - MRC Cambridge Stem Cell Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Advice on analysis of TLDA card data, advice on use of online genomic analysis tools, statistical analysis of Affymetrix Exon microarray data. Research into computational analysis of TLDA card data.
Collaborator Contribution Access to data
Impact work on-going
Start Year 2009
 
Description Analysis of ChiP-chip studies (Frye) 
Organisation University of Edinburgh
Department MRC Centre for Regenerative Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysis of ChiP-chip studies, including tuition and provision of analysis scripts to Ph.D student
Collaborator Contribution Academic/shared research
Impact manuscript in preparation
Start Year 2009
 
Description Analysis of Illumina BeadArray (Hendrich) 
Organisation University of Edinburgh
Department MRC Centre for Regenerative Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Participation in design of ChIP-Seq experiments. Analysis of illumina BeadArray microarray gene expression profiling
Collaborator Contribution Academic/shared research
Impact on-going
Start Year 2010
 
Description Analysis of placental phenotype (Hemberger) 
Organisation University of Edinburgh
Department MRC Centre for Regenerative Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution On-going
Collaborator Contribution Academic/shared research
Impact no as yet
Start Year 2010
 
Description Areneas Group (RB) 
Organisation University of Virginia (UVa)
Department Department of Neurology
Country United States 
Sector Academic/University 
PI Contribution Shared research
Collaborator Contribution Academic/shared research
Impact 20142523
Start Year 2008
 
Description Barker group projects 
Organisation University of Cambridge
Department Department of Physiology, Development and Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Research input to the application of contemporary pattern recognition methods to a 700 patient corpus from Parkinson's Disease clinic, to extract phenotypic information regarding disease progression
Collaborator Contribution Academic/shared research
Impact manuscript prepared
Start Year 2009
 
Description Barts and London - Jensen 
Organisation Queen Mary University of London
Department Barts and The London School of Medicine and Dentistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Characterised the Mouse model
Collaborator Contribution Expertise in intestinal stem cell biology and required reagents to analyse archival material.
Impact none yet
Start Year 2010
 
Description Biochemical characterisation (Hendrich) 
Organisation University of Cambridge
Department Department of Biochemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysis of NuRD complexes
Collaborator Contribution Academic/shared research
Impact Award of Sir Henry Wellcome Postdoctoral Fellowship
Start Year 2010
 
Description Blood stem cell enhancers (Ottersbach) 
Organisation University of New South Wales
Country Australia 
Sector Academic/University 
PI Contribution Reagents, data and intellectual input provided by Cambridge lab
Collaborator Contribution Academic/shared research
Impact manuscript in preparation
Start Year 2008
 
Description Bruneau 
Organisation University of California, San Francisco
Department Gladstone Institute of Neurological Disease
Country United States 
Sector Academic/University 
PI Contribution We provided reporter human embryonic stem cell lines generated in our laboratory for analysis by the collaborating laboratory.
Collaborator Contribution Our collaborator carried out transcriptional profiling using RNA-seq on the materials provided and shared the findings with ourselves for inclusion in a future publication.
Impact No outputs yet
Start Year 2012
 
Description Cambridge Cardio-Vascular Consortium 
Organisation British Heart Foundation (BHF)
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Cell culture, etc
Collaborator Contribution Collaboration of researchers
Impact Publications
Start Year 2010
 
Description Chandran group 
Organisation University of Cambridge
Department Department of Physiology, Development and Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Extraction and manipulation of data comprising medical records of 80,000 patients from the General Practitioners Records Database prior to epidemiological analysis.
Collaborator Contribution Academic/shared research
Impact ongoing
Start Year 2008
 
Description Design, procurement and analysis of single-cell microarray profiling experiments (Watt) 
Organisation University of Edinburgh
Department MRC Centre for Regenerative Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Design, procurement and analysis of single-cell microarray profiling experiments
Collaborator Contribution Academic/shared research
Impact manuscript in preparation
Start Year 2010
 
Description Dlk1 in HSC emergence (Ottersbach) 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Reagents provided by collaborator
Collaborator Contribution Academic/shared research
Impact manuscript in revision
Start Year 2007
 
Description Early embryonic devpt of mouse - Nichols 
Organisation Wellcome Trust
Department Wellcome - MRC Cambridge Stem Cell Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Early embryonic development of the mouse, and effects of genetic and chemical manipulation on lineage segregation and establishment of pluripotency
Collaborator Contribution Shared resources and expertise
Impact 18942890, 19710168, 19703398, 18097409
Start Year 2006
 
Description Epigenetic Analysis of trophoblast-like cell types (Hemberger) 
Organisation University of Edinburgh
Department MRC Centre for Regenerative Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution On-going
Collaborator Contribution Academic/shared research
Impact not yet
Start Year 2010
 
Description Epigenetics collaboration 
Organisation University of Cambridge
Department Department of Physiology, Development and Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution We provided pluripotent stem cell lines and my PhD student was the primary conduit of collaboration.
Collaborator Contribution Co-mentorship of PhD student
Impact See coauthored publications with Anne Ferguson-Smith. Multidisciplinary: Stem cells + Epigenetics
 
Description Fawcett Group (KM) 
Organisation University of Cambridge
Department School of Clinical Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Integrin engineering project to aid retinal pigment epithelial cell adhesion in age-related macular degeneration' and 'Slow release of chondroitinase from engineered fibrin matrices'
Collaborator Contribution Academic/shared research
Impact 20159768 and 20620180
Start Year 2008
 
Description Gata3 in the HSC microenvironment (Ottersbach) 
Organisation University of New South Wales
Country Australia 
Sector Academic/University 
PI Contribution Protocols and intellectual input from Cambridge lab
Collaborator Contribution Academic/shared research
Impact ongoing
Start Year 2010
 
Description Global Analysis of NuRD activity in ES cells (Hendrich) 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom 
Sector Academic/University 
PI Contribution Access to Solexa Sequencing factily, and bioinformatics expertise
Collaborator Contribution Academic/shared research
Impact not as yet
Start Year 2009
 
Description Glover Group (Z-G) 
Organisation University of Cambridge
Department Department of Genetics
Country United Kingdom 
Sector Academic/University 
PI Contribution Spindle orientation in the oocyte and early mouse embryo
Collaborator Contribution Academic/shared research
Impact 20308546
Start Year 2009
 
Description Godovac-Zimmermann group 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Analytical methods for detection of differential protein abundance applied to a large disease study undertaken between UCL and Inserm, Paris.
Collaborator Contribution Academic/shared research
Impact manuscript submitted (Science)
Start Year 2010
 
Description Gottgens group projects 
Organisation University of Cambridge
Department Department of Haematology
Country United Kingdom 
Sector Academic/University 
PI Contribution Shared research
Collaborator Contribution Academic/shared research
Impact Papers
Start Year 2007
 
Description Hemberger - Burton 
Organisation University of Cambridge
Department Department of Physiology, Development and Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Project leader - main experimentalist
Collaborator Contribution Placental samples and expertise in human placental anatomy/histology
Impact not known
Start Year 2009
 
Description Hemberger - Laval Uni 
Organisation University of Laval
Department Poirier/Gagne Labs Laval
Country Canada 
Sector Academic/University 
PI Contribution Scientific rationale for analysis and characterisation of Parp-mutant ES cells
Collaborator Contribution Mass spectrometric analysis of stem cell lysates to identify all poly(ADP-ribosyl)ated nuclear proteins
Impact not known
Start Year 2009
 
Description Hemberger-Babraham 
Organisation Babraham Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Project leadership, Ph.D studentship
Collaborator Contribution Advice and reagents on signalling pathways
Impact not yet
Start Year 2009
 
Description Hemberger-Colucci 
Organisation University of Cambridge
Department Department of Pathology
Country United Kingdom 
Sector Academic/University 
PI Contribution Joint project leader, joint postdoc supervision
Collaborator Contribution Expertise and project guidance for uNK cell aspects of study
Impact not known
Start Year 2009
 
Description Hemberger-Pedersen 
Organisation Medical Research Council (MRC)
Department MRC Centre For Stem Cell Biology
Country United Kingdom 
Sector Academic/University 
PI Contribution DNA methylation analysis of ELF5 upon hESC culture in various conditions
Collaborator Contribution Project leadership
Impact not known
Start Year 2009
 
Description Hemberger-Wutz 
Organisation Wellcome Trust
Department Wellcome - MRC Cambridge Stem Cell Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Detailed histological and gene expression analysis of affected and control placentas
Collaborator Contribution Main project leaders, mouse model and analysis
Impact not known
Start Year 2009
 
Description Hendrich-Bellvitge 
Organisation Bellvitge Biomedical Research Institute
Country Spain 
Sector Academic/University 
PI Contribution Provided reagents
Collaborator Contribution Analysis of our cells
Impact Manuscript in preparation
Start Year 2010
 
Description Hendrich-Biochemistry 
Organisation University of Cambridge
Department Department of Biochemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution On going collaboration exchange of information and reagents
Collaborator Contribution Exchange of information and reagents in relation to NuRD structure and function
Impact EU FP7 Large Scale integrated project 4DCellFate.
Start Year 2008
 
Description Hendrich-CRUK 
Organisation Cancer Research UK
Department Cancer Research UK London Research Institute (LRI)
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided reagents and expertise
Collaborator Contribution Provided reeagents and expertise
Impact 21196933
Start Year 2009
 
Description Hendrich-CRUK2 
Organisation Cancer Research UK
Department Cancer Research UK London Research Institute (LRI)
Country United Kingdom 
Sector Academic/University 
PI Contribution Received reagents
Collaborator Contribution Received reagents
Impact Manuscript in press in EMBO Journal, and another in revision in Cell Stem Cell
Start Year 2009
 
Description Hendrich-EMBL-EBI 
Organisation European Molecular Biology Laboratory
Country Germany 
Sector Academic/University 
PI Contribution Received expertise in bioinformatic analysis
Collaborator Contribution Bioinformatic analysis of transcriptional silencing in ES cells
Impact Manuscript in press in EMBO journal
Start Year 2009
 
Description Hendrich-Erasmus 
Organisation Erasmus University Rotterdam
Country Netherlands 
Sector Academic/University 
PI Contribution On going projects
Collaborator Contribution Jereon Demmers provides mass spectrometry for our group
Impact Manuscript in preparation and other on-going projects
Start Year 2007
 
Description Hendrich-Frye 
Organisation Wellcome Trust
Department Wellcome - MRC Cambridge Stem Cell Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided mouse line
Collaborator Contribution Provided mouse line
Impact Manuscript in press in Nature Cell Biology
Start Year 2009
 
Description Hendrich-Huntly 
Organisation University of Cambridge
Department Department of Haematology
Country United Kingdom 
Sector Academic/University 
PI Contribution On going collaboration involving exchange of reagents
Collaborator Contribution Exchange of reagents
Impact on going collaboration.
Start Year 2011
 
Description Hendrich-Livesey 
Organisation University of Cambridge
Department Gurdon Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Exchange of information and expertise
Collaborator Contribution Exchange of information and expertise
Impact Manuscript in preparation
Start Year 2008
 
Description Hendrich-Silva 
Organisation Wellcome Trust
Department Wellcome - MRC Cambridge Stem Cell Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Cell lines and reagents
Collaborator Contribution Cell lines and reagents to Silva group
Impact not known
Start Year 2011
 
Description Holden group 
Organisation University of Cambridge
Department Computer Laboratory
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaborative research with members of the Artificial Intelligence group, concerning the application of state-of-the-art machine learning techniques to extract information from high-throughput biological experiments. Further planned work will involve image analysis and the fusion of various data sources to improve the definition of phenotypic stem cell states
Collaborator Contribution Academic/shared research
Impact 3 manuscripts in preparation
Start Year 2008
 
Description Hubrecht Institute - Jensen 
Organisation Royal Netherlands Academy of Arts and Sciences
Department Hubrecht Institute
Country Netherlands 
Sector Academic/University 
PI Contribution Mouse model characterised.
Collaborator Contribution Expertise in intestinal stem cell biology and provided reagents to analyse archival material.
Impact not yet
Start Year 2010
 
Description JAK2 Signalling in haematopoietic progenitors (Kouzarides) 
Organisation University of Cambridge
Department Department of Biochemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Shared research
Collaborator Contribution Academic/shared research
Impact 1978398
Start Year 2007
 
Description Jensen group projects 
Organisation University of Cambridge
Department Department of Oncology
Country United Kingdom 
Sector Academic/University 
PI Contribution Desgin, procurement and analysis of microarray profiling experiment. Contribution of expertise to grant applications
Collaborator Contribution Academic/shared research
Impact manuscript in revision (Nature)
Start Year 2010
 
Description Kotter group projects 
Organisation University of Cambridge
Department Department of Physiology, Development and Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysis of externally-procured mRNA and miRAN microarray profiling data; contribution of expertise to grant applications
Collaborator Contribution Academic/shared research
Impact Material presented at conferences, manuscript in preparation
Start Year 2010
 
Description Lilley group projects 
Organisation University of Cambridge
Department Department of Biochemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Research into the computational analysis of data output by a novel protein-localisation platform. Platform development, grant writing and manuscript preparation, Further research into wider proteomics methods, of potential use to stem cell biology eg SILAC labelling for protein abundance studies.
Collaborator Contribution Academic/shared research
Impact BBSRC Tools and Resources Development fund award 2010 £158,590 EU FP-7 £616,503 (approx) start 2011
Start Year 2009
 
Description Lio Group 
Organisation University of Cambridge
Department Computer Laboratory
Country United Kingdom 
Sector Academic/University 
PI Contribution Investigation of involvement of genomic locality in transcriptional events during stem cell differentiation. Spatio-temporal analysis methods are applied to microarray profiling of a stem cell differentiation towards a pancreatic lineage time-course with the aim of indentifying the co-expression of neighbouring transcriptional effectors.
Collaborator Contribution Academic/shared research
Impact manuscript in preparation
Start Year 2009
 
Description Martin - Fawcett 
Organisation University of Cambridge
Department School of Clinical Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Shared expertise
Collaborator Contribution shared knowledge
Impact 20159768, 20620180
Start Year 2008
 
Description Martin - Freiberg 
Organisation Albert Ludwig University of Freiburg
Country Germany 
Sector Academic/University 
PI Contribution Collaboration on imaging project and optic nerve transport
Collaborator Contribution Collaboration on imaging project and optic nerve transport
Impact 21546535
Start Year 2011
 
Description Martin - Johns Hopkins 
Organisation Johns Hopkins University
Country United States 
Sector Academic/University 
PI Contribution Collaboration on a number of projects
Collaborator Contribution Collaboration on mesenchymal stem cells for neuroprotection in glaucoma
Impact 21686079, 21562584, 21345987, 19933193, 19850833
Start Year 2009
 
Description Martin - NIH 
Organisation National Eye Institute (NEI)
Country United States 
Sector Academic/University 
PI Contribution Collaboration on the use of stem cell transplantation for glaucoma
Collaborator Contribution Shared Ph.D student via NIH graduate partners programme. Joint grant applications
Impact 19933193
Start Year 2007
 
Description Matrix scaffolds (Sinha/Cameron/Best) 
Organisation University of Cambridge
Department Department of Engineering
Country United Kingdom 
Sector Academic/University 
PI Contribution Research expertise
Collaborator Contribution Research assistance
Impact BHF New Horizons Award £298000
Start Year 2010
 
Description Murry 
Organisation University of Washington
Country United States 
Sector Academic/University 
PI Contribution We provided reporter human embryonic stem cell lines to our collaborator for possible use in small molecule screening activities.
Collaborator Contribution Our collaborator will carry out the small molecule screening activities.
Impact No outputs yet
Start Year 2011
 
Description NOD ES cells and diabetes 
Organisation University of Cambridge
Department Department of Pathology
Country United Kingdom 
Sector Academic/University 
PI Contribution Generated NOD ES cells for analysis and chimaera formation
Collaborator Contribution Academic/shared research
Impact 19491843
Start Year 2007
 
Description Neuroscience collaboration 
Organisation University of Cambridge
Department Department of Physiology, Development and Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution We provided space and stem cell culture expertise for the collaboration.
Collaborator Contribution Provision of postdoctoral fellow for collaborative effort.
Impact See co-authored paper with Lupo and Harris. Multidisciplinary: Neuroscience and stem cells
Start Year 2007
 
Description Nichols - Embryonic Pluripotency 
Organisation Wellcome Trust
Department Wellcome - MRC Cambridge Stem Cell Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Joint research
Collaborator Contribution Several joint grants with PRof Austin Smith - MRC, WT and BBSRC
Impact 18837461, 19224983, 19497275, 21138972, 20519324, 20147374, 19951688
Start Year 2006
 
Description Pathogenesis of myeloproliferative neoplasms (Campbell) 
Organisation University of Cambridge
Department Cambridge Institute for Medical Research (CIMR)
Country United Kingdom 
Sector Academic/University 
PI Contribution Ph.Supervision
Collaborator Contribution Academic/shared research
Impact 16963707
Start Year 2006
 
Description Pathogenesis of myeloproliferative neoplasms (Lodish/Gilliland) 
Organisation Harvard University
Department Harvard Medical School
Country United States 
Sector Academic/University 
PI Contribution Shared research
Collaborator Contribution Academic/shared research
Impact 19571317, 12438646
Start Year 2007
 
Description Pedersen post-docs 
Organisation St Jude Children's Hospital
Department Department of Surgery
Country United States 
Sector Hospitals 
PI Contribution Design of ChIP-Seq experiments; desgin procurement and analysis of microarray profiling experiments; analysis of legacy/externally procured microarray data; collaboration in design of a protocol for unbiased microarray profiling of small (10-100 cell) embryonic extracts; Tuition and advice to various students and post-docs regarding use of common bioinformatic tools.
Collaborator Contribution Academic/shared research
Impact 17597762; and manuscripts submitted/in preparation
Start Year 2008
 
Description Philpott - Harvard 
Organisation Harvard University
Department Harvard Medical School
Country United States 
Sector Academic/University 
PI Contribution collaborative experiments
Collaborator Contribution Exchange of ideas, collaborative experiments
Impact 21852393
Start Year 2008
 
Description Philpott - NIMR 
Organisation Medical Research Council (MRC)
Department MRC National Institute for Medical Research (NIMR)
Country United Kingdom 
Sector Academic/University 
PI Contribution Generation of mouse model together
Collaborator Contribution Generation of mouse model together
Impact 21852393
Start Year 2006
 
Description Philpott - Warwick Uni 
Organisation University of Warwick
Department Warwick Medical School
Country United Kingdom 
Sector Academic/University 
PI Contribution Reagent and ideas exchanged
Collaborator Contribution Reagent and ideas exchange
Impact 20347968
Start Year 2006
 
Description Philpott - Winton 
Organisation Cancer Research UK Cambridge Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Generation of mouse model together
Collaborator Contribution Generation of mouse model together
Impact not yet
Start Year 2008
 
Description Pluchino - IRCCS 
Organisation IRCCS Oasi Maria SS
Country Italy 
Sector Academic/University 
PI Contribution Role of Wnt/beta-catenin in post-injury neurogenesis in experimental PD
Collaborator Contribution shared expertise
Impact 21056667, 21752258
Start Year 2007
 
Description Pluchino - Kentucky 
Organisation University of Kentucky
Country United States 
Sector Academic/University 
PI Contribution Ph.D development of next generation RNA nanostructures for CNS repair
Impact not yet
Start Year 2010
 
Description Pluchino - Salento, Lecce 
Organisation University of Salento
Department Department of Engineering for Innovation
Country Italy 
Sector Academic/University 
PI Contribution Development of PLGE based biodegradable microspheres for controlled release of glial inhibitors in experimental spinal cord injury
Collaborator Contribution Development of PLGE based biodegradable microspheres for controlled release of glial inhibitors in experimental spinal cord injury
Impact on-going
 
Description Pluchino group projects 
Organisation University of Cambridge
Department Department of Physiology, Development and Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Various computational proteomics analysis methods applied to cell biology research primarily concerning mechanisms of extra-cellular signalling.
Collaborator Contribution Academic/shared research
Impact none as yet
Start Year 2010
 
Description Pluchino-Griffith Uni 
Organisation Griffith University
Department National Centre for Adult Stem Cell Research
Country Australia 
Sector Academic/University 
PI Contribution Development of phase I clinical trials with autologous olfactory ensheathing cells in humans with spinal cord injuries
Collaborator Contribution Development of phase I clinical trials with autologous olfactory ensheathing cells in humans with spinal cord injuries
Impact on going
Start Year 2008
 
Description Pluchino-La Jolla 
Organisation Sanford-Burnham Medical Research Institute
Country United States 
Sector Charity/Non Profit 
PI Contribution Shared research
Collaborator Contribution study of the therapeutic potential of human ES cell-derived neural progenitors in experimental Multiple Sclerosis
Impact 21186263
Start Year 2007
 
Description Pluchino-Queensland 
Organisation University of Queensland
Department Institute for Molecular Bioscience
Country Australia 
Sector Academic/University 
PI Contribution Identification of RNA cargoes being experted with exosomes in neural stem cells
Collaborator Contribution Identification of RNA cargoes being experted with exosomes in neural stem cells
Impact not yet
Start Year 2009
 
Description Pluchino-San Raffaele Hospital 
Organisation San Raffaele Hospital
Department San Raffaele Scientific Institute (SRSI)
Country Italy 
Sector Academic/University 
PI Contribution Development of phase 1 clinical trials with somatic cells in humans with spinal cord injuries
Collaborator Contribution Development of phase 1 clinical trials with somatic cells in humans with spinal cord injuries
Impact on-going
 
Description Pluchino-Valencia 
Organisation University of Valencia
Country Spain 
Sector Academic/University 
PI Contribution Ph.D Ultrastructural analysis of atypical perivascular stem cell niches
Impact on going
 
Description Pluchino-Weizmann 
Organisation Weizmann Institute of Science
Department Laboratory of Body and Mind Immunology Weizmann
Country Israel 
Sector Academic/University 
PI Contribution Interactions betweeen transplanted neural stem cells and endogenous myeloid cells in experimental spinal cord injury
Collaborator Contribution Interactions betweeen transplanted neural stem cells and endogenous myeloid cells in experimental spinal cord injury
Impact on-going
 
Description Priller Group (RB) 
Organisation Charité - University of Medicine Berlin
Country Germany 
Sector Academic/University 
PI Contribution Shared research
Collaborator Contribution Academic/shared research
Impact 20890398
Start Year 2008
 
Description RNA splicing - Sinha/Chris Smith 
Organisation University of Cambridge
Department Faculty of Biology
Country United Kingdom 
Sector Academic/University 
PI Contribution Part of research
Collaborator Contribution Named collaborator
Impact Named collaborator on WT Programme Grant (Austin Smith)
Start Year 2009
 
Description Robson Group (Z-G) 
Organisation Agency for Science, Technology and Research (A*STAR)
Department Genome Institute of Singapore
Country Singapore 
Sector Academic/University 
PI Contribution Analysis of spatial pattern of gene expression with real-time PCR
Collaborator Contribution Academic/shared research
Impact 20430022 and 20308546
Start Year 2009
 
Description Role of Lrig1 - Jensen 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Jensen Lab supplies tissue samples from Lrig 1 KO and control littermates
Collaborator Contribution Dr Sam Janes carries out the functional characterisation of Lrig 1 in vivo and in vitro
Impact none yet
Start Year 2010
 
Description Role of NuRD - Nichols 
Organisation Wellcome Trust
Department Wellcome - MRC Cambridge Stem Cell Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Role of NuRD proteins in early embryonic development and pluripotency
Collaborator Contribution Joint funding WT, MRC and BBSRC Partnering award
Impact 17287250
Start Year 2007
 
Description Role of Polycomb complexes (Wutz) 
Organisation Medical Research Council (MRC)
Department MRC Human Genetics Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution The role of polycomb complexes in chromatin organisation in stem cells
Collaborator Contribution Academic/shared research
Impact 20471950
Start Year 2009
 
Description Sharkey/Moffatt groups 
Organisation University of Cambridge
Department Department of Pathology
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysis of hybridization microarray experiments comparing villous to extravillous trophoblast extracts.
Collaborator Contribution Academic/shared research
Impact 21075446
Start Year 2010
 
Description Sinha grou - Vallier 
Organisation St Jude Children's Hospital
Department Department of Surgery
Country United States 
Sector Hospitals 
PI Contribution Joint research
Collaborator Contribution Generation of Marfans iPS cells
Impact Evelyn Trust project grant 110000
Start Year 2010
 
Description Sinha group - Bennett 
Organisation University of Cambridge
Department Department of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution joint research
Collaborator Contribution Development of mouse models of vascular disease
Impact BHF Project grant £192000
Start Year 2010
 
Description Sinha group - Farndale 
Organisation University of Cambridge
Department Department of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution joint research
Collaborator Contribution Use of biogels for cell transplants studies
Impact Ongoing
Start Year 2010
 
Description Sinha group - Kielty 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution joint research
Collaborator Contribution Development of an iPS cell based model of Marfan syndrome
Impact model produced
Start Year 2010
 
Description Sinha group - Pedersen 
Organisation St Jude Children's Hospital
Department Department of Surgery
Country United States 
Sector Hospitals 
PI Contribution Joint working
Collaborator Contribution Development of mesoderm from huESC
Impact Publication
Start Year 2008
 
Description Sinha group projects 
Organisation University of Cambridge
Department Department of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Advice regarding transcriptional profiling, both hybridization and NGS. Contribution to grant application - letter of collaboration
Collaborator Contribution Academic/shared research
Impact Grant application submitted
Start Year 2010
 
Description Sinha/Pedersen/Trotter 
Organisation University of Cambridge
Department Department of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Research expertise
Collaborator Contribution Research expertise
Impact Publication, patent pending
Start Year 2010
 
Description Stromal elements in the HSC niche 
Organisation Albert Einstein College of Medicine
Country United States 
Sector Academic/University 
PI Contribution Data provided by Cambridge lab
Collaborator Contribution Academic/shared research
Impact ongoing
Start Year 2010
 
Description Teratomas 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution We generated the stem cell cultures that were used in these collaborations.
Collaborator Contribution Dr. Richter carried out the teratoma assays for several studies in collaboration with our groups.
Impact See publications in which Arhlund-Richter is a co-author.
Start Year 2006
 
Description Thomas & Ziman groups (RB) 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Shared research
Collaborator Contribution Academic/shared research
Impact 20626049
Start Year 2008
 
Description Tomarev group (KM) 
Organisation University of Cambridge
Department School of Clinical Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Shared Ph.D student via NIH Graduate Partners Program. Collaboration on the use of stem cell transplantation for glaucoma
Collaborator Contribution Academic/shared research
Impact Joint grant applications and 19933193
Start Year 2007
 
Description Univ Cambridge (RB) 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Shared research
Collaborator Contribution Academic/shared research
Impact Various
Start Year 2008
 
Description University of Cambridge - Jensen 
Organisation St Jude Children's Hospital
Department Department of Surgery
Country United States 
Sector Hospitals 
PI Contribution Characterisation of phenotypical changes in embryonic and neonatal murine samples
Collaborator Contribution Expertise in HES cells differentiation and endoderm specification.
Impact None yet
Start Year 2010
 
Description Vallier group projects 
Organisation St Jude Children's Hospital
Department Department of Surgery
Country United States 
Sector Hospitals 
PI Contribution Design, analysis and storage of ChIP-Seq experiments; Design, procurement and analysis of microarray profiling experiments; analysis of mRNA and mi-RNA microarray profiling experiments; Tuition and advice to various students and post-docs regarding use of common bioinformatic methods; contribution of expertise to grant applications.
Collaborator Contribution Academic/shared research
Impact 19564924, 19279133
Start Year 2008
 
Description Vallier group projects 
Organisation St Jude Children's Hospital
Department Department of Surgery
Country United States 
Sector Hospitals 
PI Contribution To investigate the localisation of alpha1-antitrypsin in healthy and diseased cells derived from patient-specific IPSC lines, using the methods developed in collaborations between groups
Collaborator Contribution Academic/shared research
Impact ongoing
Start Year 2010
 
Description Vascular grafts from ES cells - Sinha 
Organisation Yale University
Country United States 
Sector Academic/University 
PI Contribution Developments of tissue engineered vascular grafts derived from human ES cells
Collaborator Contribution Shared knowledge
Impact None yet
Start Year 2010
 
Description Watt Lab - Jensen 
Organisation Cancer Research UK Cambridge Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Characterised the mouse model
Collaborator Contribution CRUK animals facility helped derive a new mouse model
Impact None yet
Start Year 2010
 
Description Winton Lab - Jensen 
Organisation Cancer Research UK Cambridge Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Characterised the mouse model
Collaborator Contribution Expertise in intestinal stem cell biology.
Impact none yet
Start Year 2010
 
Description Wnt Signalling (AMA) 
Organisation University of Edinburgh
Department MRC Centre for Regenerative Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution practical collaboration
Collaborator Contribution Academic/shared research
Impact 19582141,
Start Year 2009
 
Title Epiblast stem cells 
Description We established a method for deriving pluripotent stem cells from the late epiblast layer of mouse embryos 
IP Reference WO2008056173 
Protection Patent application published
Year Protection Granted 2008
Licensed No
Impact We have distributed the epiblast stem cells to numerous other investigators under the auspices of an MTA.
 
Company Name Cellcentric Ltd 
Description Engaged in medical applications resulting from advances in epigenetic mechanisms. 
Year Established 2005 
Impact Close links with Takeda for investigations on targets of cancers such as prostate.
Website http://www.cellcentric.com/
 
Description A Stem Cell Story' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Participation in a film made on behalf of EuroStemCell Open Meeting on Public Engagement in Stem Cell Research

Available on internet
Year(s) Of Engagement Activity 2008
 
Description Babraham Institute Sixth Form 2007 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact Sixth form Symposium

Requested to participate again next year
Year(s) Of Engagement Activity 2007
 
Description Brussels Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Policymakers/politicians
Results and Impact Discussion about Stem Cells

Informing policymakers
Year(s) Of Engagement Activity 2008
 
Description C Enterprise Breakfast 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Talk and questions on 'Epiblast stem cells: this novel type of pluripotent stem cells derived from mammalian embryos will enable production of 'reporter' cell lines for differentiation along distinct tissue pathways, and it can potenitally provide access to the genome of domestic species'

unknown
Year(s) Of Engagement Activity 2007
 
Description CUDO 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Initial contact meetings with post and potential future donors, and preparation of proposal documents for potential donors

Possible donations, no direct results
Year(s) Of Engagement Activity 2006
 
Description Cambridge Enterprise 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Liaison with Hermann Hauser and East of England Stem Cell Network

Future collaborations and further funding for stem cell initiatives
Year(s) Of Engagement Activity 2008
 
Description Dept Medical Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Seminar 'Mechanisms of pluripotency and differentiation in embryonic stem cells'

Requested to speak again next year
Year(s) Of Engagement Activity 2008
 
Description Grant holders workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Cross-Research Council Stem Cell Grant holders workshop

Networking, and future collaborations possible
Year(s) Of Engagement Activity 2007
 
Description Horizon Forum 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Primary Audience Policymakers/politicians
Results and Impact Chairing session on Cell Material interface

n/a
Year(s) Of Engagement Activity 2007
 
Description Jackson Labs 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Jackson Labs, Bar Harbor, ME, USA (Lecture and demonstration)

Establishing useful links for future collaborations
Year(s) Of Engagement Activity 2008
 
Description Linacre Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact What is 'stemness' and where does it come from?'

Public and academic
Year(s) Of Engagement Activity 2007
 
Description MRC Site Visit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Participants in your research and patient groups
Results and Impact Presentations (x 2) to MRC Centre Grant reviewers

Award of Centre Grant
Year(s) Of Engagement Activity 2008
 
Description NESCI Research Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Participants in your research and patient groups
Results and Impact Seminar in Durham, UK

Well received, no direct feedback, networking opportunity
Year(s) Of Engagement Activity 2007
 
Description Naked Scientist 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Naked Scientist broadcast on BBC Radio Cambridgeshire + podcast of programme

Public and media exposure
Year(s) Of Engagement Activity 2008
 
Description Nature podcast 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Podcast following Nature paper

Public understanding - well received
Year(s) Of Engagement Activity 2007
 
Description Radio Cambridgeshire 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Phone-in programme 'Stem cells, cloning and embryo research' interview and answering questions from the public

increased visibility for Centre
Year(s) Of Engagement Activity 2007
 
Description Research Horizons 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Research Horizons article

Explaining to wider University community what the Stem Cell Initiative is about
Year(s) Of Engagement Activity 2008
 
Description Sackler Colloquium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Lecture at Irvine, CA, USA

No direct feedback, but well received
Year(s) Of Engagement Activity 2007
 
Description St George's School, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact Presentation and discussion leader on stem cells

Recruitment of future scientists
Year(s) Of Engagement Activity 2007
 
Description UKNSCN Singapore 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Lecture at meeting in Singapore

International network, contacts valuable
Year(s) Of Engagement Activity 2007