Centre for Stem Cell Biology and Medicine
Lead Research Organisation:
University of Cambridge
Department Name: Surgery
Abstract
Every year, thousands of patients die from organ failure because there are not enough matching donors for the transplants that they need. Also, thousands of others suffer from the effects of diabetes, even though they take insulin. Existing therapies for many diseases of the brain, such as Parkinson?s and multiple sclerosis, fall far short of a cure. Stem cells could possibly provide cures for these diseases. Embryonic stem (ES) cells are derived from embryos at the earliest stages of development, when the embryo is a microscopic, hollow ball of cells. They provide a promising means for generating many or perhaps all of the 200 specialised cell types of the body. Stem cells have been detected in other body tissues, such as the bone marrow and nervous system, and these also represent potential sources of therapeutic materials. The proposed research is designed to provide the foundations in basic knowledge of stem cell biology to build the clinical treatments that are likely to emerge from a fundamental understanding of this field.
Technical Summary
The mission of the Cambridge Centre for Stem Cell Biology and Medicine is to harness basic knowledge of cellular and developmental biology for therapy of human diseases through the use of stem cells. The Centre will accomplish this mission by fusing the University?s basic research efforts with its clinical expertise. The purpose of this union is to generate a stem cell research enterprise that not only expedites the translation of stem cell biology into clinical use, but also generates fundamental insights into mechanisms of normal development and their perturbation in birth defects and cancer. A basic aim is to understand how stem cells preserve their unique ability, known as pluripotency, to specialise into differentiated cell types. A related aim is to understand in greater depth how cells initiate differentiation into early tissue lineages and then use these insights to control the specialisation of stem cells into clinically useful cell types. Thirdly, research is proposed to understand how cells committed to specific lineages maintain their proliferative status during embryonic development and to apply this information to generate the large cell populations needed to study cell transplantation therapy for diseases in model systems. The cell types selected for study are ones in which purified cell populations are likely to affect the disease processes, the central nervous system and the endocrine pancreas. A long-term multidisciplinary approach is needed because of the complexity of cells as therapeutic reagents. The proposed Centre will unify researchers in two Cambridge faculties (School of the Biological Sciences and School of Clinical Medicine) and materially assist them in translating their research into clinical use by providing them with dedicated stem cell research resources and a mechanism for their collaborative interaction, through use of the shared facilities, seminars and a training programme.
Organisations
- University of Cambridge, United Kingdom (Lead Research Organisation)
- University College London, United Kingdom (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- Sanford Burnham Medical Research Inst (Collaboration)
- Royal Netherlands Academy of Arts and Sciences (Collaboration)
- University of Kentucky (Collaboration)
- Harvard University (Collaboration)
- Imperial Cancer Research Fund (Collaboration)
- University of Salento (Collaboration)
- Queen Mary, University of London, United Kingdom (Collaboration)
- Albert Ludwig University of Freiburg (Collaboration)
- Weizmann Institute of Science, Israel (Collaboration)
- University of Cambridge (Collaboration)
- Babraham Institute (Collaboration)
- St Jude Children's Hospital (Collaboration)
- University of Queensland, Australia (Collaboration)
- San Raffaele Hospital (Collaboration)
- Agency for Science, Technology and Research (A*STAR) (Collaboration)
- University of New South Wales (Collaboration)
- University of Virginia, United States (Collaboration)
- Valencia University, Spain (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- Washington University in St. Louis (Collaboration)
- European Molecular Biology Laboratory (Collaboration)
- Griffith University (Collaboration)
- University of Warwick, United Kingdom (Collaboration)
- Laval University, Canada (Collaboration)
- Karolinska Institute, Sweden (Collaboration)
- University of California, San Francisco, United States (Collaboration)
- Yeshiva University (Collaboration)
- Erasmus University Rotterdam (EUR) (Collaboration)
- Cancer Research UK Cambridge Institute (Collaboration)
- Yale University (Collaboration)
- Medical Research Council (Collaboration)
- National Institutes of Health, United States (Collaboration)
- British Heart Foundation (BHF) (Collaboration)
- Wellcome Trust, LONDON (Collaboration)
- IRCCS Oasi Maria SS (Collaboration)
- Bellvitge Biomedical Research Institute (Collaboration)
- Charité - University of Medicine Berlin (Collaboration)
- University of Manchester, Manchester, United Kingdom (Collaboration)
- Johns Hopkins University, United States (Collaboration)
- EMBL - European Bioinformatics Institute, United Kingdom (Collaboration)
Publications
Perea-Gomez A
(2007)
Regionalization of the mouse visceral endoderm as the blastocyst transforms into the egg cylinder.
in BMC developmental biology
Pimanda JE
(2007)
Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development.
in Proceedings of the National Academy of Sciences of the United States of America
Roper S
(2009)
Defining pathways that enforce cell lineage specification in early development and stem cells.
in Cell cycle (Georgetown, Tex.)
Smith JR
(2008)
Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm.
in Developmental biology
Smith JR
(2008)
Robust, persistent transgene expression in human embryonic stem cells is achieved with AAVS1-targeted integration.
in Stem cells (Dayton, Ohio)
Soh BS
(2007)
Pleiotrophin enhances clonal growth and long-term expansion of human embryonic stem cells.
in Stem cells (Dayton, Ohio)
Torres-Padilla M
(2006)
Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos
in The International Journal of Developmental Biology
Torres-Padilla M
(2007)
The anterior visceral endoderm of the mouse embryo is established from both preimplantation precursor cells and by de novo gene expression after implantation
in Developmental Biology
Torres-Padilla ME
(2007)
Histone arginine methylation regulates pluripotency in the early mouse embryo.
in Nature
| Description | "Next Generation" fellowhip (Biology of induced pluripotency) |
| Amount | £30,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | BBSRC - Industrial CASE studentship |
| Amount | £70,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | BBSRC - Project Grant |
| Amount | £358,869 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | BBSRC CSG - Synergy Grant |
| Amount | £14,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | BSH - Early Stage Investigator Fellowship |
| Amount | £129,246 (GBP) |
| Organisation | British Society for Haematology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Barker - Parkinson's UK |
| Amount | £34,795 (GBP) |
| Funding ID | K-1011 |
| Organisation | Parkinson's UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Barker - Parkinson's UK Project grant |
| Amount | £178,118 (GBP) |
| Organisation | Parkinson's UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Cambridge Centre for Myelin Repair Renewal |
| Amount | £2,141,907 (GBP) |
| Organisation | Multiple Sclerosis Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Can the metabolomic profiling of urine and serum in patients with Parkinson's disease be used to better diagnose and define disease progression as well as be informative about underlying pathogenic processes? |
| Amount | £170,329 (GBP) |
| Funding ID | G-0616 |
| Organisation | Parkinson's UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Characterising the heterogeneity in Parkinson's Disease using a multimodal approach and its clinical significance for the implementation of novel therapies |
| Amount | £90,000 (GBP) |
| Organisation | Parkinson's UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | EC - Advanced Investigator award |
| Amount | £2,200,000 (GBP) |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | |
| Description | EC - Framework 6 - Xemone: engineering of the porcine genome for xenotransplantation studies in promates: a step towards clinical application |
| Amount | £392,514 (GBP) |
| Funding ID | 37377 |
| Organisation | Sixth Framework Programme (FP6) |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | EC - ate mapping of precursor cells following CNS demyelination |
| Amount | £148,549 (GBP) |
| Funding ID | 24644 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | ERC Starting Grant FP7 |
| Amount | £1,244,710 (GBP) |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 12/2010 |
| End | 11/2015 |
| Description | Fight for Sight - Project Grant |
| Amount | £159,936 (GBP) |
| Organisation | Fight for Sight |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Full Centre Grant |
| Amount | £1,809,044 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2009 |
| End | 12/2011 |
| Description | GSK Clinician Scientist Fellowship |
| Amount | £500,000 (GBP) |
| Organisation | GlaxoSmithKline (GSK) |
| Sector | Private |
| Country | Global |
| Start | |
| Description | Hemberger - BBSRC Project Grant |
| Amount | £483,108 (GBP) |
| Funding ID | BB/I008764/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Hemberger - CSG Synergy Grant |
| Amount | £7,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Hemberger - CSG Synergy Grant |
| Amount | £181,284 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Hemberger - Centre for Trophoblast Research, Cambridge University |
| Amount | £5,000 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Hemberger - Centre for Trophoblast Research, Cambridge University |
| Amount | £24,827 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Human Frontiers Science Programme (HFSP)/European Commission (EC) $ |
| Amount | £300,000 (GBP) |
| Organisation | Human Frontier Science Program (HFSP) |
| Sector | Charity/Non Profit |
| Country | France |
| Start | |
| Description | KKLF |
| Amount | £1,632,075 (GBP) |
| Organisation | The Kay Kendall Leukaemia Fund |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | KKLF - Intermediate Fellowship KKL469 |
| Amount | £616,867 (GBP) |
| Organisation | The Kay Kendall Leukaemia Fund |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Leukaemia Research - Clinical Research Fellowship for Dr P Beer: the role of HDAC8 in the pathogenesis of the myeloproliferative disorders |
| Amount | £182,871 (GBP) |
| Organisation | Leukaemia and Lymphoma Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Leukaemia Research - Regulation of SCL gene expression in normal and leukaemic T cell differentiation |
| Amount | £620,155 (GBP) |
| Organisation | Leukaemia and Lymphoma Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | MRC - Investigating the role of cyclin B1 in early cell divisions |
| Amount | £347,000 (GBP) |
| Funding ID | G0701184 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | MRC - The effect of injury on stem cells in the adult brain |
| Amount | £300,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Marie Curie - Initial Training Network |
| Amount | £219,751 (GBP) |
| Organisation | Marie Sklodowska-Curie Actions |
| Sector | Charity/Non Profit |
| Country | Global |
| Start | |
| Description | Michael J Fox Foundation - Rapid Response Innovation Award/Michael J Fox Foundation $ |
| Amount | £126,000 (GBP) |
| Organisation | Michael J Fox Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | |
| Description | NIHR i4I grant (Barker) |
| Amount | £740,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR i4i Invention for Innovation (i4i) Programme |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Pfizer Ltd - UK Glaucoma Treatment Study |
| Amount | £80,000 (GBP) |
| Organisation | Pfizer Ltd |
| Sector | Private |
| Country | United Kingdom |
| Start | |
| Description | Pluchino - AISM/FISM |
| Amount | £90,280 (GBP) |
| Organisation | Italian Multiple Sclerosis Society (AISM) |
| Sector | Charity/Non Profit |
| Country | Italy |
| Start | |
| Description | Pluchino - EU 7th Framework programme - Implantable organic nano-electronics (iONE) (5m euros across 10 participants) |
| Amount | £401,800 (GBP) |
| Funding ID | 280772 |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2012 |
| End | 12/2013 |
| Description | Pluchino - FinLombarda |
| Amount | £150,500 (GBP) |
| Organisation | Finlombarda S.P.A. |
| Sector | Private |
| Country | Italy |
| Start | |
| Description | Pluchino - Regeneration of the injured spinal cord with somatic neural stem cells and microencapsultated glial scar inhibitors |
| Amount | £120,350 (GBP) |
| Organisation | Wings for Life Spinal Cord Research Foundation |
| Sector | Private |
| Country | Austria |
| Start | |
| Description | Pluchino - Van Geest |
| Amount | £360,000 (GBP) |
| Organisation | University of Leicester |
| Department | John and Lucille van Geest Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Pluchino - Young Investigator Award GR08-7 - Italian Ministry of Health |
| Amount | £503,800 (GBP) |
| Organisation | Government of Italy |
| Sector | Public |
| Country | Italy |
| Start | |
| Description | Pluchino- Somatic neural stem cell transplantation as novel therapeutic approach for the treatment of multiple sclerosis |
| Amount | £171,292 (GBP) |
| Organisation | Gruppo Bancario Banca Agricola Popolare di Ragusa |
| Department | Banca Agricola Popolare di Ragusa (BAPR) |
| Sector | Private |
| Country | Italy |
| Start | |
| Description | Research Bennett Senior Fellowship 10015 |
| Amount | £589,400 (GBP) |
| Organisation | Leukaemia and Lymphoma Research |
| Department | Bennett Fellowship |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Royal Society - Neurotransmitter mediated white matter damage in leukodystrophies and ischaemia |
| Amount | £15,000 (GBP) |
| Organisation | The Royal Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | TRANSEURO Innovative Approach for the Treatment of Parkinson's Disease (12m euros across 14 participants) |
| Amount | £702,511 (GBP) |
| Funding ID | 242003 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | Themed Research Grant |
| Amount | £436,239 (GBP) |
| Organisation | Parkinson's UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Themed Research Grant |
| Amount | £1,100,000 (GBP) |
| Organisation | Parkinson's UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Wellcome Trust - Stem cell renewal and lineage selection in adult mammalian epidermis |
| Amount | £2,998,125 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Wellcome Trust - The Road from Pluripotency to lineage determination |
| Amount | £1,736,222 (GBP) |
| Funding ID | 091484 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Wellcome Trust - The role of S1P5 in CNS myelination and remyelination |
| Amount | £188,623 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Wellcome Trust - Zygote viability judged by image analysis |
| Amount | £200,000 (GBP) |
| Funding ID | 085107 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Title | Epiblast stem cell lines |
| Description | We generated pluripotent stem cell lines from mouse and rat late epiblast (Brons et al. publication, 2007). The epiblast stem cell lines of the mouse were distributed. |
| Type Of Material | Cell line |
| Year Produced | 2008 |
| Provided To Others? | Yes |
| Impact | This discovery has provided the conceptual basis for understanding the considerable differences between mouse embryonic stem cells and human embryonic stem cells. |
| Description | Adams Group (Z-G) |
| Organisation | University of Cambridge |
| Department | Department of Physiology, Development and Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Following dynamics of cell movements in the mouse embryo |
| Collaborator Contribution | Academic/shared research |
| Impact | 19422818 |
| Start Year | 2009 |
| Description | Analysis of Affymetrix Exon microarray data (A Smith) |
| Organisation | Wellcome Trust |
| Department | Wellcome - MRC Cambridge Stem Cell Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Advice on analysis of TLDA card data, advice on use of online genomic analysis tools, statistical analysis of Affymetrix Exon microarray data. Research into computational analysis of TLDA card data. |
| Collaborator Contribution | Access to data |
| Impact | work on-going |
| Start Year | 2009 |
| Description | Analysis of ChiP-chip studies (Frye) |
| Organisation | University of Edinburgh |
| Department | MRC Centre for Regenerative Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Analysis of ChiP-chip studies, including tuition and provision of analysis scripts to Ph.D student |
| Collaborator Contribution | Academic/shared research |
| Impact | manuscript in preparation |
| Start Year | 2009 |
| Description | Analysis of Illumina BeadArray (Hendrich) |
| Organisation | University of Edinburgh |
| Department | MRC Centre for Regenerative Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Participation in design of ChIP-Seq experiments. Analysis of illumina BeadArray microarray gene expression profiling |
| Collaborator Contribution | Academic/shared research |
| Impact | on-going |
| Start Year | 2010 |
| Description | Analysis of placental phenotype (Hemberger) |
| Organisation | University of Edinburgh |
| Department | MRC Centre for Regenerative Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | On-going |
| Collaborator Contribution | Academic/shared research |
| Impact | no as yet |
| Start Year | 2010 |
| Description | Areneas Group (RB) |
| Organisation | University of Virginia (UVa) |
| Department | Department of Neurology |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Shared research |
| Collaborator Contribution | Academic/shared research |
| Impact | 20142523 |
| Start Year | 2008 |
| Description | Barker group projects |
| Organisation | University of Cambridge |
| Department | Department of Physiology, Development and Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research input to the application of contemporary pattern recognition methods to a 700 patient corpus from Parkinson's Disease clinic, to extract phenotypic information regarding disease progression |
| Collaborator Contribution | Academic/shared research |
| Impact | manuscript prepared |
| Start Year | 2009 |
| Description | Barts and London - Jensen |
| Organisation | Queen Mary University of London |
| Department | Barts and The London School of Medicine and Dentistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Characterised the Mouse model |
| Collaborator Contribution | Expertise in intestinal stem cell biology and required reagents to analyse archival material. |
| Impact | none yet |
| Start Year | 2010 |
| Description | Biochemical characterisation (Hendrich) |
| Organisation | University of Cambridge |
| Department | Department of Biochemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Analysis of NuRD complexes |
| Collaborator Contribution | Academic/shared research |
| Impact | Award of Sir Henry Wellcome Postdoctoral Fellowship |
| Start Year | 2010 |
| Description | Blood stem cell enhancers (Ottersbach) |
| Organisation | University of New South Wales |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Reagents, data and intellectual input provided by Cambridge lab |
| Collaborator Contribution | Academic/shared research |
| Impact | manuscript in preparation |
| Start Year | 2008 |
| Description | Bruneau |
| Organisation | University of California, San Francisco |
| Department | Gladstone Institute of Neurological Disease |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | We provided reporter human embryonic stem cell lines generated in our laboratory for analysis by the collaborating laboratory. |
| Collaborator Contribution | Our collaborator carried out transcriptional profiling using RNA-seq on the materials provided and shared the findings with ourselves for inclusion in a future publication. |
| Impact | No outputs yet |
| Start Year | 2012 |
| Description | Cambridge Cardio-Vascular Consortium |
| Organisation | British Heart Foundation (BHF) |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Cell culture, etc |
| Collaborator Contribution | Collaboration of researchers |
| Impact | Publications |
| Start Year | 2010 |
| Description | Chandran group |
| Organisation | University of Cambridge |
| Department | Department of Physiology, Development and Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Extraction and manipulation of data comprising medical records of 80,000 patients from the General Practitioners Records Database prior to epidemiological analysis. |
| Collaborator Contribution | Academic/shared research |
| Impact | ongoing |
| Start Year | 2008 |
| Description | Design, procurement and analysis of single-cell microarray profiling experiments (Watt) |
| Organisation | University of Edinburgh |
| Department | MRC Centre for Regenerative Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Design, procurement and analysis of single-cell microarray profiling experiments |
| Collaborator Contribution | Academic/shared research |
| Impact | manuscript in preparation |
| Start Year | 2010 |
| Description | Dlk1 in HSC emergence (Ottersbach) |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Reagents provided by collaborator |
| Collaborator Contribution | Academic/shared research |
| Impact | manuscript in revision |
| Start Year | 2007 |
| Description | Early embryonic devpt of mouse - Nichols |
| Organisation | Wellcome Trust |
| Department | Wellcome - MRC Cambridge Stem Cell Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Early embryonic development of the mouse, and effects of genetic and chemical manipulation on lineage segregation and establishment of pluripotency |
| Collaborator Contribution | Shared resources and expertise |
| Impact | 18942890, 19710168, 19703398, 18097409 |
| Start Year | 2006 |
| Description | Epigenetic Analysis of trophoblast-like cell types (Hemberger) |
| Organisation | University of Edinburgh |
| Department | MRC Centre for Regenerative Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | On-going |
| Collaborator Contribution | Academic/shared research |
| Impact | not yet |
| Start Year | 2010 |
| Description | Epigenetics collaboration |
| Organisation | University of Cambridge |
| Department | Department of Physiology, Development and Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We provided pluripotent stem cell lines and my PhD student was the primary conduit of collaboration. |
| Collaborator Contribution | Co-mentorship of PhD student |
| Impact | See coauthored publications with Anne Ferguson-Smith. Multidisciplinary: Stem cells + Epigenetics |
| Description | Fawcett Group (KM) |
| Organisation | University of Cambridge |
| Department | School of Clinical Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Integrin engineering project to aid retinal pigment epithelial cell adhesion in age-related macular degeneration' and 'Slow release of chondroitinase from engineered fibrin matrices' |
| Collaborator Contribution | Academic/shared research |
| Impact | 20159768 and 20620180 |
| Start Year | 2008 |
| Description | Gata3 in the HSC microenvironment (Ottersbach) |
| Organisation | University of New South Wales |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Protocols and intellectual input from Cambridge lab |
| Collaborator Contribution | Academic/shared research |
| Impact | ongoing |
| Start Year | 2010 |
| Description | Global Analysis of NuRD activity in ES cells (Hendrich) |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Access to Solexa Sequencing factily, and bioinformatics expertise |
| Collaborator Contribution | Academic/shared research |
| Impact | not as yet |
| Start Year | 2009 |
| Description | Glover Group (Z-G) |
| Organisation | University of Cambridge |
| Department | Department of Genetics |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Spindle orientation in the oocyte and early mouse embryo |
| Collaborator Contribution | Academic/shared research |
| Impact | 20308546 |
| Start Year | 2009 |
| Description | Godovac-Zimmermann group |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Analytical methods for detection of differential protein abundance applied to a large disease study undertaken between UCL and Inserm, Paris. |
| Collaborator Contribution | Academic/shared research |
| Impact | manuscript submitted (Science) |
| Start Year | 2010 |
| Description | Gottgens group projects |
| Organisation | University of Cambridge |
| Department | Department of Haematology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Shared research |
| Collaborator Contribution | Academic/shared research |
| Impact | Papers |
| Start Year | 2007 |
| Description | Hemberger - Burton |
| Organisation | University of Cambridge |
| Department | Department of Physiology, Development and Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project leader - main experimentalist |
| Collaborator Contribution | Placental samples and expertise in human placental anatomy/histology |
| Impact | not known |
| Start Year | 2009 |
| Description | Hemberger - Laval Uni |
| Organisation | University of Laval |
| Department | Poirier/Gagne Labs Laval |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Scientific rationale for analysis and characterisation of Parp-mutant ES cells |
| Collaborator Contribution | Mass spectrometric analysis of stem cell lysates to identify all poly(ADP-ribosyl)ated nuclear proteins |
| Impact | not known |
| Start Year | 2009 |
| Description | Hemberger-Babraham |
| Organisation | Babraham Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Project leadership, Ph.D studentship |
| Collaborator Contribution | Advice and reagents on signalling pathways |
| Impact | not yet |
| Start Year | 2009 |
| Description | Hemberger-Colucci |
| Organisation | University of Cambridge |
| Department | Department of Pathology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Joint project leader, joint postdoc supervision |
| Collaborator Contribution | Expertise and project guidance for uNK cell aspects of study |
| Impact | not known |
| Start Year | 2009 |
| Description | Hemberger-Pedersen |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Centre For Stem Cell Biology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | DNA methylation analysis of ELF5 upon hESC culture in various conditions |
| Collaborator Contribution | Project leadership |
| Impact | not known |
| Start Year | 2009 |
| Description | Hemberger-Wutz |
| Organisation | Wellcome Trust |
| Department | Wellcome - MRC Cambridge Stem Cell Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Detailed histological and gene expression analysis of affected and control placentas |
| Collaborator Contribution | Main project leaders, mouse model and analysis |
| Impact | not known |
| Start Year | 2009 |
| Description | Hendrich-Bellvitge |
| Organisation | Bellvitge Biomedical Research Institute |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Provided reagents |
| Collaborator Contribution | Analysis of our cells |
| Impact | Manuscript in preparation |
| Start Year | 2010 |
| Description | Hendrich-Biochemistry |
| Organisation | University of Cambridge |
| Department | Department of Biochemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | On going collaboration exchange of information and reagents |
| Collaborator Contribution | Exchange of information and reagents in relation to NuRD structure and function |
| Impact | EU FP7 Large Scale integrated project 4DCellFate. |
| Start Year | 2008 |
| Description | Hendrich-CRUK |
| Organisation | Cancer Research UK |
| Department | Cancer Research UK London Research Institute (LRI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided reagents and expertise |
| Collaborator Contribution | Provided reeagents and expertise |
| Impact | 21196933 |
| Start Year | 2009 |
| Description | Hendrich-CRUK2 |
| Organisation | Cancer Research UK |
| Department | Cancer Research UK London Research Institute (LRI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Received reagents |
| Collaborator Contribution | Received reagents |
| Impact | Manuscript in press in EMBO Journal, and another in revision in Cell Stem Cell |
| Start Year | 2009 |
| Description | Hendrich-EMBL-EBI |
| Organisation | European Molecular Biology Laboratory |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Received expertise in bioinformatic analysis |
| Collaborator Contribution | Bioinformatic analysis of transcriptional silencing in ES cells |
| Impact | Manuscript in press in EMBO journal |
| Start Year | 2009 |
| Description | Hendrich-Erasmus |
| Organisation | Erasmus University Rotterdam |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | On going projects |
| Collaborator Contribution | Jereon Demmers provides mass spectrometry for our group |
| Impact | Manuscript in preparation and other on-going projects |
| Start Year | 2007 |
| Description | Hendrich-Frye |
| Organisation | Wellcome Trust |
| Department | Wellcome - MRC Cambridge Stem Cell Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided mouse line |
| Collaborator Contribution | Provided mouse line |
| Impact | Manuscript in press in Nature Cell Biology |
| Start Year | 2009 |
| Description | Hendrich-Huntly |
| Organisation | University of Cambridge |
| Department | Department of Haematology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | On going collaboration involving exchange of reagents |
| Collaborator Contribution | Exchange of reagents |
| Impact | on going collaboration. |
| Start Year | 2011 |
| Description | Hendrich-Livesey |
| Organisation | University of Cambridge |
| Department | Gurdon Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Exchange of information and expertise |
| Collaborator Contribution | Exchange of information and expertise |
| Impact | Manuscript in preparation |
| Start Year | 2008 |
| Description | Hendrich-Silva |
| Organisation | Wellcome Trust |
| Department | Wellcome - MRC Cambridge Stem Cell Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Cell lines and reagents |
| Collaborator Contribution | Cell lines and reagents to Silva group |
| Impact | not known |
| Start Year | 2011 |
| Description | Holden group |
| Organisation | University of Cambridge |
| Department | Computer Laboratory |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaborative research with members of the Artificial Intelligence group, concerning the application of state-of-the-art machine learning techniques to extract information from high-throughput biological experiments. Further planned work will involve image analysis and the fusion of various data sources to improve the definition of phenotypic stem cell states |
| Collaborator Contribution | Academic/shared research |
| Impact | 3 manuscripts in preparation |
| Start Year | 2008 |
| Description | Hubrecht Institute - Jensen |
| Organisation | Royal Netherlands Academy of Arts and Sciences |
| Department | Hubrecht Institute |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Mouse model characterised. |
| Collaborator Contribution | Expertise in intestinal stem cell biology and provided reagents to analyse archival material. |
| Impact | not yet |
| Start Year | 2010 |
| Description | JAK2 Signalling in haematopoietic progenitors (Kouzarides) |
| Organisation | University of Cambridge |
| Department | Department of Biochemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Shared research |
| Collaborator Contribution | Academic/shared research |
| Impact | 1978398 |
| Start Year | 2007 |
| Description | Jensen group projects |
| Organisation | University of Cambridge |
| Department | Department of Oncology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Desgin, procurement and analysis of microarray profiling experiment. Contribution of expertise to grant applications |
| Collaborator Contribution | Academic/shared research |
| Impact | manuscript in revision (Nature) |
| Start Year | 2010 |
| Description | Kotter group projects |
| Organisation | University of Cambridge |
| Department | Department of Physiology, Development and Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Analysis of externally-procured mRNA and miRAN microarray profiling data; contribution of expertise to grant applications |
| Collaborator Contribution | Academic/shared research |
| Impact | Material presented at conferences, manuscript in preparation |
| Start Year | 2010 |
| Description | Lilley group projects |
| Organisation | University of Cambridge |
| Department | Department of Biochemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research into the computational analysis of data output by a novel protein-localisation platform. Platform development, grant writing and manuscript preparation, Further research into wider proteomics methods, of potential use to stem cell biology eg SILAC labelling for protein abundance studies. |
| Collaborator Contribution | Academic/shared research |
| Impact | BBSRC Tools and Resources Development fund award 2010 £158,590 EU FP-7 £616,503 (approx) start 2011 |
| Start Year | 2009 |
| Description | Lio Group |
| Organisation | University of Cambridge |
| Department | Computer Laboratory |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Investigation of involvement of genomic locality in transcriptional events during stem cell differentiation. Spatio-temporal analysis methods are applied to microarray profiling of a stem cell differentiation towards a pancreatic lineage time-course with the aim of indentifying the co-expression of neighbouring transcriptional effectors. |
| Collaborator Contribution | Academic/shared research |
| Impact | manuscript in preparation |
| Start Year | 2009 |
| Description | Martin - Fawcett |
| Organisation | University of Cambridge |
| Department | School of Clinical Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Shared expertise |
| Collaborator Contribution | shared knowledge |
| Impact | 20159768, 20620180 |
| Start Year | 2008 |
| Description | Martin - Freiberg |
| Organisation | Albert Ludwig University of Freiburg |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Collaboration on imaging project and optic nerve transport |
| Collaborator Contribution | Collaboration on imaging project and optic nerve transport |
| Impact | 21546535 |
| Start Year | 2011 |
| Description | Martin - Johns Hopkins |
| Organisation | Johns Hopkins University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Collaboration on a number of projects |
| Collaborator Contribution | Collaboration on mesenchymal stem cells for neuroprotection in glaucoma |
| Impact | 21686079, 21562584, 21345987, 19933193, 19850833 |
| Start Year | 2009 |
| Description | Martin - NIH |
| Organisation | National Institutes of Health (NIH) |
| Department | National Eye Institute (NEI) |
| Country | United States |
| Sector | Public |
| PI Contribution | Collaboration on the use of stem cell transplantation for glaucoma |
| Collaborator Contribution | Shared Ph.D student via NIH graduate partners programme. Joint grant applications |
| Impact | 19933193 |
| Start Year | 2007 |
| Description | Matrix scaffolds (Sinha/Cameron/Best) |
| Organisation | University of Cambridge |
| Department | Department of Engineering |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research expertise |
| Collaborator Contribution | Research assistance |
| Impact | BHF New Horizons Award £298000 |
| Start Year | 2010 |
| Description | Murry |
| Organisation | University of Washington |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | We provided reporter human embryonic stem cell lines to our collaborator for possible use in small molecule screening activities. |
| Collaborator Contribution | Our collaborator will carry out the small molecule screening activities. |
| Impact | No outputs yet |
| Start Year | 2011 |
| Description | NOD ES cells and diabetes |
| Organisation | University of Cambridge |
| Department | Department of Pathology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Generated NOD ES cells for analysis and chimaera formation |
| Collaborator Contribution | Academic/shared research |
| Impact | 19491843 |
| Start Year | 2007 |
| Description | Neuroscience collaboration |
| Organisation | University of Cambridge |
| Department | Department of Physiology, Development and Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We provided space and stem cell culture expertise for the collaboration. |
| Collaborator Contribution | Provision of postdoctoral fellow for collaborative effort. |
| Impact | See co-authored paper with Lupo and Harris. Multidisciplinary: Neuroscience and stem cells |
| Start Year | 2007 |
| Description | Nichols - Embryonic Pluripotency |
| Organisation | Wellcome Trust |
| Department | Wellcome - MRC Cambridge Stem Cell Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Joint research |
| Collaborator Contribution | Several joint grants with PRof Austin Smith - MRC, WT and BBSRC |
| Impact | 18837461, 19224983, 19497275, 21138972, 20519324, 20147374, 19951688 |
| Start Year | 2006 |
| Description | Pathogenesis of myeloproliferative neoplasms (Campbell) |
| Organisation | University of Cambridge |
| Department | Cambridge Institute for Medical Research (CIMR) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Ph.Supervision |
| Collaborator Contribution | Academic/shared research |
| Impact | 16963707 |
| Start Year | 2006 |
| Description | Pathogenesis of myeloproliferative neoplasms (Lodish/Gilliland) |
| Organisation | Harvard University |
| Department | Harvard Medical School |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Shared research |
| Collaborator Contribution | Academic/shared research |
| Impact | 19571317, 12438646 |
| Start Year | 2007 |
| Description | Pedersen post-docs |
| Organisation | St Jude Children's Hospital |
| Department | Department of Surgery |
| Country | United States |
| Sector | Hospitals |
| PI Contribution | Design of ChIP-Seq experiments; desgin procurement and analysis of microarray profiling experiments; analysis of legacy/externally procured microarray data; collaboration in design of a protocol for unbiased microarray profiling of small (10-100 cell) embryonic extracts; Tuition and advice to various students and post-docs regarding use of common bioinformatic tools. |
| Collaborator Contribution | Academic/shared research |
| Impact | 17597762; and manuscripts submitted/in preparation |
| Start Year | 2008 |
| Description | Philpott - Harvard |
| Organisation | Harvard University |
| Department | Harvard Medical School |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | collaborative experiments |
| Collaborator Contribution | Exchange of ideas, collaborative experiments |
| Impact | 21852393 |
| Start Year | 2008 |
| Description | Philpott - NIMR |
| Organisation | Medical Research Council (MRC) |
| Department | MRC National Institute for Medical Research (NIMR) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Generation of mouse model together |
| Collaborator Contribution | Generation of mouse model together |
| Impact | 21852393 |
| Start Year | 2006 |
| Description | Philpott - Warwick Uni |
| Organisation | University of Warwick |
| Department | Warwick Medical School |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Reagent and ideas exchanged |
| Collaborator Contribution | Reagent and ideas exchange |
| Impact | 20347968 |
| Start Year | 2006 |
| Description | Philpott - Winton |
| Organisation | Cancer Research UK Cambridge Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Generation of mouse model together |
| Collaborator Contribution | Generation of mouse model together |
| Impact | not yet |
| Start Year | 2008 |
| Description | Pluchino - IRCCS |
| Organisation | IRCCS Oasi Maria SS |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | Role of Wnt/beta-catenin in post-injury neurogenesis in experimental PD |
| Collaborator Contribution | shared expertise |
| Impact | 21056667, 21752258 |
| Start Year | 2007 |
| Description | Pluchino - Kentucky |
| Organisation | University of Kentucky |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Ph.D development of next generation RNA nanostructures for CNS repair |
| Impact | not yet |
| Start Year | 2010 |
| Description | Pluchino - Salento, Lecce |
| Organisation | University of Salento |
| Department | Department of Engineering for Innovation |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | Development of PLGE based biodegradable microspheres for controlled release of glial inhibitors in experimental spinal cord injury |
| Collaborator Contribution | Development of PLGE based biodegradable microspheres for controlled release of glial inhibitors in experimental spinal cord injury |
| Impact | on-going |
| Description | Pluchino group projects |
| Organisation | University of Cambridge |
| Department | Department of Physiology, Development and Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Various computational proteomics analysis methods applied to cell biology research primarily concerning mechanisms of extra-cellular signalling. |
| Collaborator Contribution | Academic/shared research |
| Impact | none as yet |
| Start Year | 2010 |
| Description | Pluchino-Griffith Uni |
| Organisation | Griffith University |
| Department | National Centre for Adult Stem Cell Research |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Development of phase I clinical trials with autologous olfactory ensheathing cells in humans with spinal cord injuries |
| Collaborator Contribution | Development of phase I clinical trials with autologous olfactory ensheathing cells in humans with spinal cord injuries |
| Impact | on going |
| Start Year | 2008 |
| Description | Pluchino-La Jolla |
| Organisation | Sanford-Burnham Medical Research Institute |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Shared research |
| Collaborator Contribution | study of the therapeutic potential of human ES cell-derived neural progenitors in experimental Multiple Sclerosis |
| Impact | 21186263 |
| Start Year | 2007 |
| Description | Pluchino-Queensland |
| Organisation | University of Queensland |
| Department | Institute for Molecular Bioscience |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Identification of RNA cargoes being experted with exosomes in neural stem cells |
| Collaborator Contribution | Identification of RNA cargoes being experted with exosomes in neural stem cells |
| Impact | not yet |
| Start Year | 2009 |
| Description | Pluchino-San Raffaele Hospital |
| Organisation | San Raffaele Hospital |
| Department | San Raffaele Scientific Institute (SRSI) |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | Development of phase 1 clinical trials with somatic cells in humans with spinal cord injuries |
| Collaborator Contribution | Development of phase 1 clinical trials with somatic cells in humans with spinal cord injuries |
| Impact | on-going |
| Description | Pluchino-Valencia |
| Organisation | University of Valencia |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Ph.D Ultrastructural analysis of atypical perivascular stem cell niches |
| Impact | on going |
| Description | Pluchino-Weizmann |
| Organisation | Weizmann Institute of Science |
| Department | Laboratory of Body and Mind Immunology Weizmann |
| Country | Israel |
| Sector | Academic/University |
| PI Contribution | Interactions betweeen transplanted neural stem cells and endogenous myeloid cells in experimental spinal cord injury |
| Collaborator Contribution | Interactions betweeen transplanted neural stem cells and endogenous myeloid cells in experimental spinal cord injury |
| Impact | on-going |
| Description | Priller Group (RB) |
| Organisation | Charité - University of Medicine Berlin |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Shared research |
| Collaborator Contribution | Academic/shared research |
| Impact | 20890398 |
| Start Year | 2008 |
| Description | RNA splicing - Sinha/Chris Smith |
| Organisation | University of Cambridge |
| Department | Faculty of Biology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Part of research |
| Collaborator Contribution | Named collaborator |
| Impact | Named collaborator on WT Programme Grant (Austin Smith) |
| Start Year | 2009 |
| Description | Robson Group (Z-G) |
| Organisation | Agency for Science, Technology and Research (A*STAR) |
| Department | Genome Institute of Singapore |
| Country | Singapore |
| Sector | Academic/University |
| PI Contribution | Analysis of spatial pattern of gene expression with real-time PCR |
| Collaborator Contribution | Academic/shared research |
| Impact | 20430022 and 20308546 |
| Start Year | 2009 |
| Description | Role of Lrig1 - Jensen |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Jensen Lab supplies tissue samples from Lrig 1 KO and control littermates |
| Collaborator Contribution | Dr Sam Janes carries out the functional characterisation of Lrig 1 in vivo and in vitro |
| Impact | none yet |
| Start Year | 2010 |
| Description | Role of NuRD - Nichols |
| Organisation | Wellcome Trust |
| Department | Wellcome - MRC Cambridge Stem Cell Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Role of NuRD proteins in early embryonic development and pluripotency |
| Collaborator Contribution | Joint funding WT, MRC and BBSRC Partnering award |
| Impact | 17287250 |
| Start Year | 2007 |
| Description | Role of Polycomb complexes (Wutz) |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Human Genetics Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The role of polycomb complexes in chromatin organisation in stem cells |
| Collaborator Contribution | Academic/shared research |
| Impact | 20471950 |
| Start Year | 2009 |
| Description | Sharkey/Moffatt groups |
| Organisation | University of Cambridge |
| Department | Department of Pathology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Analysis of hybridization microarray experiments comparing villous to extravillous trophoblast extracts. |
| Collaborator Contribution | Academic/shared research |
| Impact | 21075446 |
| Start Year | 2010 |
| Description | Sinha grou - Vallier |
| Organisation | St Jude Children's Hospital |
| Department | Department of Surgery |
| Country | United States |
| Sector | Hospitals |
| PI Contribution | Joint research |
| Collaborator Contribution | Generation of Marfans iPS cells |
| Impact | Evelyn Trust project grant 110000 |
| Start Year | 2010 |
| Description | Sinha group - Bennett |
| Organisation | University of Cambridge |
| Department | Department of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | joint research |
| Collaborator Contribution | Development of mouse models of vascular disease |
| Impact | BHF Project grant £192000 |
| Start Year | 2010 |
| Description | Sinha group - Farndale |
| Organisation | University of Cambridge |
| Department | Department of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | joint research |
| Collaborator Contribution | Use of biogels for cell transplants studies |
| Impact | Ongoing |
| Start Year | 2010 |
| Description | Sinha group - Kielty |
| Organisation | University of Manchester |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | joint research |
| Collaborator Contribution | Development of an iPS cell based model of Marfan syndrome |
| Impact | model produced |
| Start Year | 2010 |
| Description | Sinha group - Pedersen |
| Organisation | St Jude Children's Hospital |
| Department | Department of Surgery |
| Country | United States |
| Sector | Hospitals |
| PI Contribution | Joint working |
| Collaborator Contribution | Development of mesoderm from huESC |
| Impact | Publication |
| Start Year | 2008 |
| Description | Sinha group projects |
| Organisation | University of Cambridge |
| Department | Department of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Advice regarding transcriptional profiling, both hybridization and NGS. Contribution to grant application - letter of collaboration |
| Collaborator Contribution | Academic/shared research |
| Impact | Grant application submitted |
| Start Year | 2010 |
| Description | Sinha/Pedersen/Trotter |
| Organisation | University of Cambridge |
| Department | Department of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research expertise |
| Collaborator Contribution | Research expertise |
| Impact | Publication, patent pending |
| Start Year | 2010 |
| Description | Stromal elements in the HSC niche |
| Organisation | Albert Einstein College of Medicine |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Data provided by Cambridge lab |
| Collaborator Contribution | Academic/shared research |
| Impact | ongoing |
| Start Year | 2010 |
| Description | Teratomas |
| Organisation | Karolinska Institute |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | We generated the stem cell cultures that were used in these collaborations. |
| Collaborator Contribution | Dr. Richter carried out the teratoma assays for several studies in collaboration with our groups. |
| Impact | See publications in which Arhlund-Richter is a co-author. |
| Start Year | 2006 |
| Description | Thomas & Ziman groups (RB) |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Shared research |
| Collaborator Contribution | Academic/shared research |
| Impact | 20626049 |
| Start Year | 2008 |
| Description | Tomarev group (KM) |
| Organisation | University of Cambridge |
| Department | School of Clinical Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Shared Ph.D student via NIH Graduate Partners Program. Collaboration on the use of stem cell transplantation for glaucoma |
| Collaborator Contribution | Academic/shared research |
| Impact | Joint grant applications and 19933193 |
| Start Year | 2007 |
| Description | Univ Cambridge (RB) |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Shared research |
| Collaborator Contribution | Academic/shared research |
| Impact | Various |
| Start Year | 2008 |
| Description | University of Cambridge - Jensen |
| Organisation | St Jude Children's Hospital |
| Department | Department of Surgery |
| Country | United States |
| Sector | Hospitals |
| PI Contribution | Characterisation of phenotypical changes in embryonic and neonatal murine samples |
| Collaborator Contribution | Expertise in HES cells differentiation and endoderm specification. |
| Impact | None yet |
| Start Year | 2010 |
| Description | Vallier group projects |
| Organisation | St Jude Children's Hospital |
| Department | Department of Surgery |
| Country | United States |
| Sector | Hospitals |
| PI Contribution | To investigate the localisation of alpha1-antitrypsin in healthy and diseased cells derived from patient-specific IPSC lines, using the methods developed in collaborations between groups |
| Collaborator Contribution | Academic/shared research |
| Impact | ongoing |
| Start Year | 2010 |
| Description | Vallier group projects |
| Organisation | St Jude Children's Hospital |
| Department | Department of Surgery |
| Country | United States |
| Sector | Hospitals |
| PI Contribution | Design, analysis and storage of ChIP-Seq experiments; Design, procurement and analysis of microarray profiling experiments; analysis of mRNA and mi-RNA microarray profiling experiments; Tuition and advice to various students and post-docs regarding use of common bioinformatic methods; contribution of expertise to grant applications. |
| Collaborator Contribution | Academic/shared research |
| Impact | 19564924, 19279133 |
| Start Year | 2008 |
| Description | Vascular grafts from ES cells - Sinha |
| Organisation | Yale University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Developments of tissue engineered vascular grafts derived from human ES cells |
| Collaborator Contribution | Shared knowledge |
| Impact | None yet |
| Start Year | 2010 |
| Description | Watt Lab - Jensen |
| Organisation | Cancer Research UK Cambridge Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Characterised the mouse model |
| Collaborator Contribution | CRUK animals facility helped derive a new mouse model |
| Impact | None yet |
| Start Year | 2010 |
| Description | Winton Lab - Jensen |
| Organisation | Cancer Research UK Cambridge Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Characterised the mouse model |
| Collaborator Contribution | Expertise in intestinal stem cell biology. |
| Impact | none yet |
| Start Year | 2010 |
| Description | Wnt Signalling (AMA) |
| Organisation | University of Edinburgh |
| Department | MRC Centre for Regenerative Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | practical collaboration |
| Collaborator Contribution | Academic/shared research |
| Impact | 19582141, |
| Start Year | 2009 |
| Title | PLURIPOTENT CELLS FROM THE MAMMALIAN LATE EPIBLAST LAYER |
| Description | This invention relates to the isolation and propagation of pluripotent cells isolated from the mammalian late epiblast layer, termed Epiblast Stem Cells' (EpiSCs). These cells are useful in a range of applications, including the generation of transgenic animal species. |
| IP Reference | WO2008056173 |
| Protection | Patent application published |
| Year Protection Granted | 2008 |
| Licensed | No |
| Impact | We have distributed the epiblast stem cells to numerous other investigators under the auspices of an MTA. |
| Company Name | Cellcentric Ltd |
| Description | Engaged in medical applications resulting from advances in epigenetic mechanisms. |
| Year Established | 2005 |
| Impact | Close links with Takeda for investigations on targets of cancers such as prostate. |
| Website | http://www.cellcentric.com/ |
| Description | A Stem Cell Story' |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Participation in a film made on behalf of EuroStemCell Open Meeting on Public Engagement in Stem Cell Research Available on internet |
| Year(s) Of Engagement Activity | 2008 |
| Description | Babraham Institute Sixth Form 2007 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Schools |
| Results and Impact | Sixth form Symposium Requested to participate again next year |
| Year(s) Of Engagement Activity | 2007 |
| Description | Brussels Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Discussion about Stem Cells Informing policymakers |
| Year(s) Of Engagement Activity | 2008 |
| Description | C Enterprise Breakfast |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk and questions on 'Epiblast stem cells: this novel type of pluripotent stem cells derived from mammalian embryos will enable production of 'reporter' cell lines for differentiation along distinct tissue pathways, and it can potenitally provide access to the genome of domestic species' unknown |
| Year(s) Of Engagement Activity | 2007 |
| Description | CUDO |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Initial contact meetings with post and potential future donors, and preparation of proposal documents for potential donors Possible donations, no direct results |
| Year(s) Of Engagement Activity | 2006 |
| Description | Cambridge Enterprise |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Liaison with Hermann Hauser and East of England Stem Cell Network Future collaborations and further funding for stem cell initiatives |
| Year(s) Of Engagement Activity | 2008 |
| Description | Dept Medical Genetics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Seminar 'Mechanisms of pluripotency and differentiation in embryonic stem cells' Requested to speak again next year |
| Year(s) Of Engagement Activity | 2008 |
| Description | Grant holders workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Cross-Research Council Stem Cell Grant holders workshop Networking, and future collaborations possible |
| Year(s) Of Engagement Activity | 2007 |
| Description | Horizon Forum |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Chairing session on Cell Material interface n/a |
| Year(s) Of Engagement Activity | 2007 |
| Description | Jackson Labs |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Jackson Labs, Bar Harbor, ME, USA (Lecture and demonstration) Establishing useful links for future collaborations |
| Year(s) Of Engagement Activity | 2008 |
| Description | Linacre Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | What is 'stemness' and where does it come from?' Public and academic |
| Year(s) Of Engagement Activity | 2007 |
| Description | MRC Site Visit |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Presentations (x 2) to MRC Centre Grant reviewers Award of Centre Grant |
| Year(s) Of Engagement Activity | 2008 |
| Description | NESCI Research Day |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Seminar in Durham, UK Well received, no direct feedback, networking opportunity |
| Year(s) Of Engagement Activity | 2007 |
| Description | Naked Scientist |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Naked Scientist broadcast on BBC Radio Cambridgeshire + podcast of programme Public and media exposure |
| Year(s) Of Engagement Activity | 2008 |
| Description | Nature podcast |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Podcast following Nature paper Public understanding - well received |
| Year(s) Of Engagement Activity | 2007 |
| Description | Radio Cambridgeshire |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Phone-in programme 'Stem cells, cloning and embryo research' interview and answering questions from the public increased visibility for Centre |
| Year(s) Of Engagement Activity | 2007 |
| Description | Research Horizons |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Research Horizons article Explaining to wider University community what the Stem Cell Initiative is about |
| Year(s) Of Engagement Activity | 2008 |
| Description | Sackler Colloquium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Lecture at Irvine, CA, USA No direct feedback, but well received |
| Year(s) Of Engagement Activity | 2007 |
| Description | St George's School, Edinburgh |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Schools |
| Results and Impact | Presentation and discussion leader on stem cells Recruitment of future scientists |
| Year(s) Of Engagement Activity | 2007 |
| Description | UKNSCN Singapore |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Lecture at meeting in Singapore International network, contacts valuable |
| Year(s) Of Engagement Activity | 2007 |