Quantitative high throughput proteomics for biomedical research

Lead Research Organisation: University of Liverpool
Department Name: Biomedical Sciences

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50
 
Description CRUK Project Grant - combined genetic and proteomic screening for early detection of pancreatic cancer
Amount £123,405 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2007 
End 09/2011
 
Description Liverpool CRUK Centre
Amount £1,300,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2009 
End 03/2014
 
Description MRC Centre Grant
Amount £3,647,630 (GBP)
Funding ID G0700654 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 12/2008 
End 03/2015
 
Description NIHR Project grant
Amount £263,394 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description NWCR Project grant - Neil Kitteringham
Amount £111,147 (GBP)
Organisation North West Cancer Research (NWCR) 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2014 
End 02/2016
 
Description SENSIT-IV Project grant
Amount £1,209,270 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start  
 
Title Absolute quantification of protein 
Description Method for the absolute quanitification of proteins using stable isotope labels. 
Type Of Material Technology assay or reagent 
Year Produced 2006 
Provided To Others? Yes  
Impact We have continued to develop and exploit this type of approach for the analysis of cancer progression, metastasis and drug toxicity. 
 
Description Burkholderia / John Smalley 
Organisation University of Liverpool
Department Department of Medical Microbiology
Country United Kingdom 
Sector Academic/University 
PI Contribution Technological expertise to enable identification of proteins involved in infection by burkholderia in cystic fibrosis patients.
Impact PMID: 17371508
Start Year 2006
 
Description Drug toxicity / Andrew Stachulski 
Organisation University of Bath
Department Department of Chemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Ongoing long term collaboration to elucidate mechanisms of drug toxicity. We have provided expertise in protein mass spectrometry to complement their expertise in low molecular weight mass spectrometry.
Collaborator Contribution Chemical expertise has made significant contributions to our understanding of protein biochemistry in adverse drug reactions. They have also been involved in synthesising reagents for protein quantification.
Impact PMID: 17985860
 
Description Head & neck cancer / Terry Jones 
Organisation Aintree University Hospital NHS Foundation Trust
Country United Kingdom 
Sector Hospitals 
PI Contribution Technological expertise to enable identification of proteins involved in diagnosis of head and neck cyst versus head and neck cancer.
Collaborator Contribution Contribution of patient samples for protein profiling.
Impact PhD thesis pending for a Clinical Research Fellow (Paul Goodyear).
Start Year 2007
 
Description Mass Spectrometry Interactions 
Organisation Life Technologies
Department Applied Biosystems
Country United States 
Sector Private 
PI Contribution Feedback on technical issues with mass spectrometry equipment. Guidance as to the future direction of software development.
Collaborator Contribution Technical expertise in advanced mass spectrometry and associated software.
Impact 19041286 16479536 Also produced technical notes on quantitation of proteins
 
Description Tumour development / Mark Boyd 
Organisation University of Liverpool
Department Medicine and Surgery
Country United Kingdom 
Sector Academic/University 
PI Contribution Technological expertise to enable identification of proteins involved in tumour development.
Impact PMID: 18451149 Collaboration continues looking for binding partners of MDM2 in the regulation of cell cycle progression
Start Year 2006