Zebrafish models Of Parkinson's And Alzheimer's disease

Lead Research Organisation: University of Cambridge
Department Name: Cambridge Institute for Medical Research

Abstract

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Publications

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Anichtchik O (2008) Loss of PINK1 function affects development and results in neurodegeneration in zebrafish. in The Journal of neuroscience : the official journal of the Society for Neuroscience

 
Description MRC Skills Gap Award
Amount £231,312 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2010 
End 12/2011
 
Description Tau consortium
Amount $666,900 (USD)
Organisation Tau Consortium 
Sector Private
Country Global
Start 10/2011 
End 09/2014
 
Title Multiple constructs 
Description multiple cDNA constructs 
Type Of Material Technology assay or reagent 
Year Produced 2006 
Provided To Others? Yes  
Impact Over the years we have generated many cDNA constructs. These have now been deposited in Addgene to allow distribution worldwide with ease. 
 
Title zebrafish models of Huntington disease and tauopathies 
Description zebrafish models of Huntington disease and tauopathies 
Type Of Material Model of mechanisms or symptoms - non-mammalian in vivo 
Provided To Others? No  
Impact We now have the potential for prescreening therapeutic compounds in the zebrafish models before commencing rodent work 
 
Description 15 international conferences in 2016 - speaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact conference presentations at internationa; meetings: Black Forest Winter Conference: "Autophagic Membrane Trafficking & Dynamics in Ageing and Disease" (Freiburg 2016), CHDI's 11th Annual Therapeutics Conference (Palm Springs 2016), International Congress of Human Genetics (Kyoto, 2016), Neuroscience School of Advanced Studies - Autophagy and neuroprotection (Cortona - lecture course 2016), International Society for Developmental Neuroscience (2016, Juan les Pins), European Neuroscience Institute 15th Anniversary Symposium (Gottingen 2016), Keystone Autophagy symposium (Whistler, 2016), Mitochondria: balancing health and disease (London 2016), Nobel conference - The Cell Cycle and Cell Death in Disease (Stockholm, 2016), Centre for Translational Cell Research opening sympiosium (Freiburg 2016), PhD graduate Symposium Cologne Graduate School of Aging Research (2016), Cold Spring Harbor meeting: Neurodegenerative Diseases: Biology & Therapeutics (Cold Spring Harbor 2016), Milner Therapeutics Institute Symposium (Cambridge 2016), 26th Annual Meeting of the Network for European CNS Transplantation & Restoration (NECTAR), Cambridge 2016)
Year(s) Of Engagement Activity 2016
 
Description Public talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact More than 200 people at talk, youtube film

interest in field
Year(s) Of Engagement Activity 2013
 
Description Talks at international conferences 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact India-EMBO Autophagy Symposium (Bubaneswar 2017), Autophagy as a Common Pathway in Diseases (NIH, Bethesda 2018), Gordon Conference -Autophagy in Stress, Development and Disease (Il Ciocco, 2018), Interact (Munich, 2018), Autophagy and Neuroprotection (Teaching course, Venice 2018), 83rd Harden Conference Autophagy - from Molecules to Disease (Warwick 2018), Gordon conference - Neurobiology of Brain Disorders (Castelldefels, Spain, 2018), Workshop on Autophagy in model organisms (Budapest, 2018), Autophagy in the healthy and diseased brain - Lake Como School of Advanced Studies (2018), 7th International Student Symposium conducted by the International Max Planck Research School in Chemical and Molecular Biology (Dortmund) (2018)
Year(s) Of Engagement Activity 2018
 
Description Talks at international conferences 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keystone Symposium: Autophagy: From Model Systems to Therapeutic Opportunities (Santa Fe 2019), Autophagy, Inflammation & Metabolism Annual Meeting & Symposium (Albuquerque (2019), British Inflammation Research Association meeting on Autophagy (2019), FASEB - The Protein Aggregation Conference (Snowmass, 2019), Gordon Research Conference on Stress Proteins in Growth, Development and Disease (Barga, 2019), Imperial College Alzheimer's Research Network Symposium (London 2019), EMBO Autophagy Workshop 2019 (Crieff, Scotland), European Society of Neurochemistry 2019 (Milan), Basel Life - Aging and drug discovery and AI (Basel, 2019), Inaugural International Symposium of Cell Fate Determination (Shanghai 2019)
Year(s) Of Engagement Activity 2019
 
Description Talks for Medical Students societies 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact St Johns College Medical Society Cambridge (2017)
Trinity College Medical Society (2019)
Year(s) Of Engagement Activity 2017,2019
 
Description Talks for lay audiences/patients 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Addenbrooke's Hospital Huntington's disease patients (2018); Addenbrooke's Hospital Parkinson's disease patients (2018)
Year(s) Of Engagement Activity 2018