Zebrafish models Of Parkinson's And Alzheimer's disease

Lead Research Organisation: University of Cambridge
Department Name: Cambridge Institute for Medical Research


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Anichtchik O (2008) Loss of PINK1 function affects development and results in neurodegeneration in zebrafish. in The Journal of neuroscience : the official journal of the Society for Neuroscience

Description MRC Skills Gap Award
Amount £231,312 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2010 
End 12/2011
Description Tau consortium
Amount $666,900 (USD)
Organisation Tau Consortium 
Sector Private
Country Global
Start 10/2011 
End 09/2014
Title Multiple constructs 
Description multiple cDNA constructs 
Type Of Material Technology assay or reagent 
Year Produced 2006 
Provided To Others? Yes  
Impact Over the years we have generated many cDNA constructs. These have now been deposited in Addgene to allow distribution worldwide with ease. 
Title zebrafish models of Huntington disease and tauopathies 
Description zebrafish models of Huntington disease and tauopathies 
Type Of Material Model of mechanisms or symptoms - non-mammalian in vivo 
Provided To Others? No  
Impact We now have the potential for prescreening therapeutic compounds in the zebrafish models before commencing rodent work 
Description 15 international conferences in 2016 - speaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact conference presentations at internationa; meetings: Black Forest Winter Conference: "Autophagic Membrane Trafficking & Dynamics in Ageing and Disease" (Freiburg 2016), CHDI's 11th Annual Therapeutics Conference (Palm Springs 2016), International Congress of Human Genetics (Kyoto, 2016), Neuroscience School of Advanced Studies - Autophagy and neuroprotection (Cortona - lecture course 2016), International Society for Developmental Neuroscience (2016, Juan les Pins), European Neuroscience Institute 15th Anniversary Symposium (Gottingen 2016), Keystone Autophagy symposium (Whistler, 2016), Mitochondria: balancing health and disease (London 2016), Nobel conference - The Cell Cycle and Cell Death in Disease (Stockholm, 2016), Centre for Translational Cell Research opening sympiosium (Freiburg 2016), PhD graduate Symposium Cologne Graduate School of Aging Research (2016), Cold Spring Harbor meeting: Neurodegenerative Diseases: Biology & Therapeutics (Cold Spring Harbor 2016), Milner Therapeutics Institute Symposium (Cambridge 2016), 26th Annual Meeting of the Network for European CNS Transplantation & Restoration (NECTAR), Cambridge 2016)
Year(s) Of Engagement Activity 2016
Description Public talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact More than 200 people at talk, youtube film

interest in field
Year(s) Of Engagement Activity 2013