Zebrafish models Of Parkinson's And Alzheimer's disease
Lead Research Organisation:
University of Cambridge
Department Name: Cambridge Institute for Medical Research
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Anichtchik O
(2008)
Loss of PINK1 function affects development and results in neurodegeneration in zebrafish.
in The Journal of neuroscience : the official journal of the Society for Neuroscience
Futter M
(2009)
Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors.
in Journal of medical genetics
Williams A
(2008)
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.
in Nature chemical biology
| Description | MRC Skills Gap Award |
| Amount | £231,312 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2010 |
| End | 12/2011 |
| Description | Tau consortium |
| Amount | $666,900 (USD) |
| Organisation | Tau Consortium |
| Sector | Private |
| Country | Global |
| Start | 10/2011 |
| End | 09/2014 |
| Title | Multiple constructs |
| Description | multiple cDNA constructs |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2006 |
| Provided To Others? | Yes |
| Impact | Over the years we have generated many cDNA constructs. These have now been deposited in Addgene to allow distribution worldwide with ease. |
| Title | zebrafish models of Huntington disease and tauopathies |
| Description | zebrafish models of Huntington disease and tauopathies |
| Type Of Material | Model of mechanisms or symptoms - non-mammalian in vivo |
| Provided To Others? | No |
| Impact | We now have the potential for prescreening therapeutic compounds in the zebrafish models before commencing rodent work |
| Description | 15 international conferences in 2016 - speaker |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | conference presentations at internationa; meetings: Black Forest Winter Conference: "Autophagic Membrane Trafficking & Dynamics in Ageing and Disease" (Freiburg 2016), CHDI's 11th Annual Therapeutics Conference (Palm Springs 2016), International Congress of Human Genetics (Kyoto, 2016), Neuroscience School of Advanced Studies - Autophagy and neuroprotection (Cortona - lecture course 2016), International Society for Developmental Neuroscience (2016, Juan les Pins), European Neuroscience Institute 15th Anniversary Symposium (Gottingen 2016), Keystone Autophagy symposium (Whistler, 2016), Mitochondria: balancing health and disease (London 2016), Nobel conference - The Cell Cycle and Cell Death in Disease (Stockholm, 2016), Centre for Translational Cell Research opening sympiosium (Freiburg 2016), PhD graduate Symposium Cologne Graduate School of Aging Research (2016), Cold Spring Harbor meeting: Neurodegenerative Diseases: Biology & Therapeutics (Cold Spring Harbor 2016), Milner Therapeutics Institute Symposium (Cambridge 2016), 26th Annual Meeting of the Network for European CNS Transplantation & Restoration (NECTAR), Cambridge 2016) |
| Year(s) Of Engagement Activity | 2016 |
| Description | Public talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | More than 200 people at talk, youtube film interest in field |
| Year(s) Of Engagement Activity | 2013 |
| Description | Talks at international conferences |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | India-EMBO Autophagy Symposium (Bubaneswar 2017), Autophagy as a Common Pathway in Diseases (NIH, Bethesda 2018), Gordon Conference -Autophagy in Stress, Development and Disease (Il Ciocco, 2018), Interact (Munich, 2018), Autophagy and Neuroprotection (Teaching course, Venice 2018), 83rd Harden Conference Autophagy - from Molecules to Disease (Warwick 2018), Gordon conference - Neurobiology of Brain Disorders (Castelldefels, Spain, 2018), Workshop on Autophagy in model organisms (Budapest, 2018), Autophagy in the healthy and diseased brain - Lake Como School of Advanced Studies (2018), 7th International Student Symposium conducted by the International Max Planck Research School in Chemical and Molecular Biology (Dortmund) (2018) |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talks at international conferences |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keystone Symposium: Autophagy: From Model Systems to Therapeutic Opportunities (Santa Fe 2019), Autophagy, Inflammation & Metabolism Annual Meeting & Symposium (Albuquerque (2019), British Inflammation Research Association meeting on Autophagy (2019), FASEB - The Protein Aggregation Conference (Snowmass, 2019), Gordon Research Conference on Stress Proteins in Growth, Development and Disease (Barga, 2019), Imperial College Alzheimer's Research Network Symposium (London 2019), EMBO Autophagy Workshop 2019 (Crieff, Scotland), European Society of Neurochemistry 2019 (Milan), Basel Life - Aging and drug discovery and AI (Basel, 2019), Inaugural International Symposium of Cell Fate Determination (Shanghai 2019) |
| Year(s) Of Engagement Activity | 2019 |
| Description | Talks for Medical Students societies |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | St Johns College Medical Society Cambridge (2017) Trinity College Medical Society (2019) |
| Year(s) Of Engagement Activity | 2017,2019 |
| Description | Talks for lay audiences/patients |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Addenbrooke's Hospital Huntington's disease patients (2018); Addenbrooke's Hospital Parkinson's disease patients (2018) |
| Year(s) Of Engagement Activity | 2018 |