Role of the imprinted XLalphaS in postnatal physiology and its interaction with Gs-alpha

Lead Research Organisation: Babraham Institute
Department Name: Epigenetics

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50
 
Description XLas and PHP1b 
Organisation Massachusetts General Hospital
Department Endocrine Unit
Country United States 
Sector Hospitals 
PI Contribution Provision of knock-out mouse line for collaborative study that has resulted in a joint publication
Collaborator Contribution Genetic cross between our and their knock-out models and physiological assessment
Impact Joint paper published: Fernandez-Rebollo et al. 2012 PNAS 109:6638-43.
Start Year 2008
 
Title XLalphaS and leptin sensitivity 
Description Relates to the identification that mice deficient in XLalphaS are resistent to diet-induced obesity and have increased sensitivity to leptin. Related to the predictions of the intracellular pathways in leptin-senstitive neurons in the hypothalamus linking leptin signalling and signalling via XLalphaS, and that inhibition of XLalphaS could help mitigate against leptin resistance in obesity. 
IP Reference WO2010142981 
Protection Patent granted
Year Protection Granted 2010
Licensed No
Impact None yet
 
Description BBSRC In Business 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Contribution to article on obesity featuring early life and epigenetic contributions, based in part on work on metabolic phenotypes of imprinted gene knock-out mice.

Unknown
Year(s) Of Engagement Activity 2006
 
Description IASO Stock Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Presentation of research and raising awareness of imprinting and epigenetics at influential meeting series (Stock Conference) run by the International Association for the Study of Obesity.

Establishment of potentially important contacts for future research and translation possibilities
Year(s) Of Engagement Activity 2006
 
Description Pfizer-sponsored Expert Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Presentation of research and significance of epigenetics and imprinting at KIGS/KIMS Expert Meeting: Genetics in growth disorders & Pituitary tumorigenesis.

Establishment of useful new collaborations.
Year(s) Of Engagement Activity 2008
 
Description Visit by Food Standards Agency 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact Presentation of highlights of research to members of the Foods Standards Agency during visit to the Institute

Stimulation of discussion
Year(s) Of Engagement Activity 2008