Recognition of Plasmodium falciparum-infected red blood cells by human Natural Killer cells

Lead Research Organisation: London Sch of Hygiene and Trop Medicine
Department Name: Infectious and Tropical Diseases

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Horowitz A (2013) Activation of human NK cells by Plasmodium-infected red blood cells. in Methods in molecular biology (Clifton, N.J.)

 
Description Imperial College 
Organisation Imperial College London
Department Department of Bioengineering
Country United Kingdom 
Sector Academic/University 
PI Contribution We carried out the pathoegn-related aspects of exploring NK cell Biology. Prof Dan Davis at Imperial carried out the NK cell cloning and microspcopy aspects of the projects.
Collaborator Contribution Access to NK cell cloning and imaging technologies
Impact We have published 3 papers (see publications list) and another is currently under review.
 
Description Stanford University 
Organisation Muhimbili University of Health and Allied Sciences
Department Department of Microbiology and Immunology
Country Tanzania, United Republic of 
Sector Academic/University 
PI Contribution We carry out phenotypic analysis of NK cells to various infectious stimuli. We provide cells for CyTOF analysis and DNA for genetic analysis
Collaborator Contribution Genetic analysis of diversity in human KIR genes and their relationship to NK cell function Access to KIR genotyping technologies and KIR diversity data for our study participants Access to CyTOF technology
Impact 4 published papers 14607943 17694054 19411600 19414796
 
Description Stanford University 
Organisation Stanford University
Country United States 
Sector Academic/University 
PI Contribution We carry out phenotypic analysis of NK cells to various infectious stimuli. We provide cells for CyTOF analysis and DNA for genetic analysis
Collaborator Contribution Genetic analysis of diversity in human KIR genes and their relationship to NK cell function Access to KIR genotyping technologies and KIR diversity data for our study participants Access to CyTOF technology
Impact 4 published papers 14607943 17694054 19411600 19414796